Ontology type: schema:ScholarlyArticle Open Access: True
2009-04
AUTHORSC Lemos, I Kathmann, E Giovannetti, C Calhau, G Jansen, G J Peters
ABSTRACTThe effect of folate status on breast cancer resistance protein (BCRP)-mediated drug resistance to epidermal growth factor receptor (EGFR)-targeted drugs, such as gefitinib and erlotinib, was investigated in two human colon cancer cell lines, WiDr and Caco-2, of which the latter displayed greater sensitivity to these drugs due to high EGFR expression. Caco-2 LF/LV cells, growing under low-folate (LF) conditions, showed increased BCRP protein expression compared with the high-folate (HF) counterpart, which was associated with 1.8-fold resistance to gefitinib. Of note, the BCRP-specific inhibitor Ko143 completely reverted this phenotype. WiDr LF cells also showed slightly increased BCRP expression compared with the HF cells, but no differences in gefitinib sensitivity were observed. Both Caco-2 LF/LV and WiDr LF cells showed 2.4- and 2.3-fold resistance to erlotinib, respectively, compared with their HF counterparts, which mechanistically seemed BCRP unrelated, as Ko143 had no effect on erlotinib activity. In conclusion, our data suggest that in EGFR-expressing Caco-2 cells, BCRP is one of the determinants of gefitinib resistance but not of erlotinib resistance. Beyond this, folate depletion can provoke an additional decrease in gefitinib and erlotinib activity by mechanisms dependent or independent of BCRP modulation. More... »
PAGES1120
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604980
DOIhttp://dx.doi.org/10.1038/sj.bjc.6604980
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025022176
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19277036
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ATP Binding Cassette Transporter, Subfamily G, Member 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ATP-Binding Cassette Transporters",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caco-2 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ErbB Receptors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Erlotinib Hydrochloride",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Folic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gefitinib",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphorylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-akt",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quinazolines",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal",
"Department of Medical Oncology, VU University Medical Center, Amsterdam 1081 HV, The Netherlands"
],
"type": "Organization"
},
"familyName": "Lemos",
"givenName": "C",
"id": "sg:person.0764042303.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764042303.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, Amsterdam 1081 HV, The Netherlands"
],
"type": "Organization"
},
"familyName": "Kathmann",
"givenName": "I",
"id": "sg:person.0600545135.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600545135.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, Amsterdam 1081 HV, The Netherlands"
],
"type": "Organization"
},
"familyName": "Giovannetti",
"givenName": "E",
"id": "sg:person.0577505063.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577505063.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Porto",
"id": "https://www.grid.ac/institutes/grid.5808.5",
"name": [
"Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Porto 4200-319, Portugal"
],
"type": "Organization"
},
"familyName": "Calhau",
"givenName": "C",
"id": "sg:person.0674335567.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674335567.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Rheumatology, VU University Medical Center, Amsterdam 1081 HV, The Netherlands"
],
"type": "Organization"
},
"familyName": "Jansen",
"givenName": "G",
"id": "sg:person.01273433134.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273433134.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, Amsterdam 1081 HV, The Netherlands"
],
"type": "Organization"
},
"familyName": "Peters",
"givenName": "G J",
"id": "sg:person.01255301342.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.drup.2006.09.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004515166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-07-2250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008405751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-07-2250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008405751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2004-04-1398",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010410997"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-03-3344",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012493355"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-03-3344",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012493355"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.23677",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014563942"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1991.202",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016256084",
"https://doi.org/10.1038/bjc.1991.202"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1991.202",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016256084",
"https://doi.org/10.1038/bjc.1991.202"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/erc.1.00999",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020233004"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0141-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022250800",
"https://doi.org/10.1007/s00280-005-0141-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0141-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022250800",
"https://doi.org/10.1007/s00280-005-0141-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.biochem.71.102301.093055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022925891"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.202607599",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023066236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-3303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023571584"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2404638",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025136515",
"https://doi.org/10.1038/sj.leu.2404638"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(02)00813-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026284585"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(02)00813-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026284585"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-006-9227-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028230153",
"https://doi.org/10.1245/s10434-006-9227-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2006-02-003145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029415214"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-03-2417",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034238651"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-2686",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037830372"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0277-5379(91)90142-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038362006"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2005.04.039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038625366"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042547314",
"https://doi.org/10.1038/sj.bjc.6604213"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m401725200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043974010"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10555-007-9042-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051227501",
"https://doi.org/10.1007/s10555-007-9042-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10555-007-9042-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051227501",
"https://doi.org/10.1007/s10555-007-9042-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/theoncologist.8-6-576",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051227853"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djj469",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051887085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-10-4020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052062539"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2004.04.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052790315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2003.01.504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064203363"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cbt.6.3.3763",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072294503"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074769910",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074801145",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074892319",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075202662",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075203199",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075319106",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076892411",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082845581",
"type": "CreativeWork"
}
],
"datePublished": "2009-04",
"datePublishedReg": "2009-04-01",
"description": "The effect of folate status on breast cancer resistance protein (BCRP)-mediated drug resistance to epidermal growth factor receptor (EGFR)-targeted drugs, such as gefitinib and erlotinib, was investigated in two human colon cancer cell lines, WiDr and Caco-2, of which the latter displayed greater sensitivity to these drugs due to high EGFR expression. Caco-2 LF/LV cells, growing under low-folate (LF) conditions, showed increased BCRP protein expression compared with the high-folate (HF) counterpart, which was associated with 1.8-fold resistance to gefitinib. Of note, the BCRP-specific inhibitor Ko143 completely reverted this phenotype. WiDr LF cells also showed slightly increased BCRP expression compared with the HF cells, but no differences in gefitinib sensitivity were observed. Both Caco-2 LF/LV and WiDr LF cells showed 2.4- and 2.3-fold resistance to erlotinib, respectively, compared with their HF counterparts, which mechanistically seemed BCRP unrelated, as Ko143 had no effect on erlotinib activity. In conclusion, our data suggest that in EGFR-expressing Caco-2 cells, BCRP is one of the determinants of gefitinib resistance but not of erlotinib resistance. Beyond this, folate depletion can provoke an additional decrease in gefitinib and erlotinib activity by mechanisms dependent or independent of BCRP modulation.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.bjc.6604980",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "100"
}
],
"name": "Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib",
"pagination": "1120",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"77344860bf676831d58bc903527bcb562a664e9d1efa824a2071def06f7fcd72"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"19277036"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0370635"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6604980"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025022176"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6604980",
"https://app.dimensions.ai/details/publication/pub.1025022176"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:09",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47963_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/6604980"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604980'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604980'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604980'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604980'
This table displays all metadata directly associated to this object as RDF triples.
283 TRIPLES
21 PREDICATES
82 URIs
38 LITERALS
26 BLANK NODES