Circulating levels of leptin, adiposity and breast cancer risk View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

M-H Wu, Y-C Chou, W-Y Chou, G-C Hsu, C-H Chu, C-P Yu, J-C Yu, C-A Sun

ABSTRACT

The present case-control study was to investigate the relationships of plasma leptin level and anthropometric measures of adiposity with the risk of breast cancer. Questionnaire information, anthropometric measures and blood samples were taken before treatment from 297 incident cases with breast cancer and 593 controls admitted for health examination at the Tri-Service General Hospital, Taipei, between 2004 and 2006. Plasma levels of leptin were measured by RIA. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for assessing the associations. Overall, higher leptin concentrations were significantly associated with an increased risk of breast cancer (OR (95% CI) for top vs bottom tertile of leptin was 1.63 (1.07-2.49), P(trend)=0.009). Waist circumference was a significant anthropometric factor for breast cancer in both pre- and postmenopausal women. Furthermore, the associations of leptin with breast cancer risk remained after adjustment for obesity indices. These results suggest that leptin may have an independent role in breast tumorigenesis. Regardless of the impact of circulating leptin, more research is needed to elucidate molecular mechanisms and local leptin levels that are critical for the development of breast cancers. More... »

PAGES

578

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604913

DOI

http://dx.doi.org/10.1038/sj.bjc.6604913

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051508888

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19223908


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adiposity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leptin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taiwan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Waist Circumference", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Defense Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.260565.2", 
          "name": [
            "Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "M-H", 
        "id": "sg:person.0725026315.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725026315.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.260565.2", 
          "name": [
            "School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "Y-C", 
        "id": "sg:person.0613671210.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613671210.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fu Jen Catholic University", 
          "id": "https://www.grid.ac/institutes/grid.256105.5", 
          "name": [
            "Department of Public Health, College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "W-Y", 
        "id": "sg:person.01041254715.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041254715.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tri-Service General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.278244.f", 
          "name": [
            "Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "G-C", 
        "id": "sg:person.01030127031.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030127031.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tri-Service General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.278244.f", 
          "name": [
            "Headquarter, Tri-Service General Hospital, Taipei, Taiwan, ROC", 
            "Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chu", 
        "givenName": "C-H", 
        "id": "sg:person.01345257105.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345257105.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tri-Service General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.278244.f", 
          "name": [
            "Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "C-P", 
        "id": "sg:person.01301367307.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301367307.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tri-Service General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.278244.f", 
          "name": [
            "Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "J-C", 
        "id": "sg:person.01135357762.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135357762.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fu Jen Catholic University", 
          "id": "https://www.grid.ac/institutes/grid.256105.5", 
          "name": [
            "Department of Public Health, College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "C-A", 
        "id": "sg:person.01356776746.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356776746.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)06348-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000494218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0083-6729(05)71012-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001305919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0083-6729(05)71012-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001305919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:brea.0000036782.11945.d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002978166", 
          "https://doi.org/10.1023/b:brea.0000036782.11945.d7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.22.1704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004685140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<523::aid-ijc7>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004880455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m313191200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005585411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000111097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006911895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.05.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007766350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012754131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012754131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012957837", 
          "https://doi.org/10.1038/bjc.1994.157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012957837", 
          "https://doi.org/10.1038/bjc.1994.157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9150(00)00755-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013977616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016553091", 
          "https://doi.org/10.1038/sj.onc.1207751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016553091", 
          "https://doi.org/10.1038/sj.onc.1207751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2001.25490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019837977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008903727238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022593002", 
          "https://doi.org/10.1023/a:1008903727238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-0297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025108128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-789x.2007.00396.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026434458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/152.6.514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031388372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(96)90011-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031811370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199602013340503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032220112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/endo:26:1:019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039167303", 
          "https://doi.org/10.1385/endo:26:1:019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1540285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039688746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09513590400027372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040260001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-005-9139-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043009334", 
          "https://doi.org/10.1007/s10549-005-9139-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-005-9139-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043009334", 
          "https://doi.org/10.1007/s10549-005-9139-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044450278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044450278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047068478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc-06-0089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047236463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199909163411211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047483226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050080408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.05.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051323319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpendmet0456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052069549", 
          "https://doi.org/10.1038/ncpendmet0456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)00205-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052771356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19970815)80:4<725::aid-cncr11>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053620405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2004-814490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057429641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5383.1683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.5.4.421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071509093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075267201", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076838003", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077493163", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00029330-200709020-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077493163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082899708", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-02", 
    "datePublishedReg": "2009-02-01", 
    "description": "The present case-control study was to investigate the relationships of plasma leptin level and anthropometric measures of adiposity with the risk of breast cancer. Questionnaire information, anthropometric measures and blood samples were taken before treatment from 297 incident cases with breast cancer and 593 controls admitted for health examination at the Tri-Service General Hospital, Taipei, between 2004 and 2006. Plasma levels of leptin were measured by RIA. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for assessing the associations. Overall, higher leptin concentrations were significantly associated with an increased risk of breast cancer (OR (95% CI) for top vs bottom tertile of leptin was 1.63 (1.07-2.49), P(trend)=0.009). Waist circumference was a significant anthropometric factor for breast cancer in both pre- and postmenopausal women. Furthermore, the associations of leptin with breast cancer risk remained after adjustment for obesity indices. These results suggest that leptin may have an independent role in breast tumorigenesis. Regardless of the impact of circulating leptin, more research is needed to elucidate molecular mechanisms and local leptin levels that are critical for the development of breast cancers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6604913", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "100"
      }
    ], 
    "name": "Circulating levels of leptin, adiposity and breast cancer risk", 
    "pagination": "578", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f55dd97a8ec49d87d13301c6f5d967085c377b9a43bf6f1c3ed674e938d4b1b3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19223908"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6604913"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051508888"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6604913", 
      "https://app.dimensions.ai/details/publication/pub.1051508888"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6604913"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604913'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604913'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604913'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604913'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      83 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6604913 schema:about N0eab7bcab321462e9dd66181b8857ed0
2 N15925c1296844e5cacf307d2701f463c
3 N3c4c6d73266a42a886d78040845ff650
4 N3f95348caa0f4563aa4ec93dea4f89d5
5 N47f6fbfe58eb4f5c96cad04074ae441d
6 N484262fc3611456c93f1017ff0718ba4
7 N55badc1e11d9468bbdff1ae2c7149f7b
8 N776cb532d929437b92a9da52dc83a7b5
9 Nabb831d1be02497184b95b869ebeed66
10 Nba495998d6a845d0bc56da789a4cda62
11 Nc7c5e1e1af31426e8a76c1238d11d881
12 Nd6bac847b12843c896d592a050be5b4b
13 Nedd0983a3dd64d1597eb1f8b36ea84b5
14 Nf634745bd2284dbfa00aac1b3ac4c52c
15 anzsrc-for:11
16 anzsrc-for:1117
17 schema:author Nb7add3d270614ce288489dbae22795e2
18 schema:citation sg:pub.10.1007/s10549-005-9139-y
19 sg:pub.10.1023/a:1008903727238
20 sg:pub.10.1023/b:brea.0000036782.11945.d7
21 sg:pub.10.1038/bjc.1994.157
22 sg:pub.10.1038/ncpendmet0456
23 sg:pub.10.1038/sj.onc.1207751
24 sg:pub.10.1385/endo:26:1:019
25 https://app.dimensions.ai/details/publication/pub.1075267201
26 https://app.dimensions.ai/details/publication/pub.1076838003
27 https://app.dimensions.ai/details/publication/pub.1077493163
28 https://app.dimensions.ai/details/publication/pub.1082899708
29 https://doi.org/10.1002/(sici)1097-0142(19970815)80:4<725::aid-cncr11>3.0.co;2-v
30 https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<523::aid-ijc7>3.0.co;2-c
31 https://doi.org/10.1002/jcp.20472
32 https://doi.org/10.1016/j.canlet.2005.05.041
33 https://doi.org/10.1016/j.canlet.2005.05.047
34 https://doi.org/10.1016/s0006-291x(02)00205-x
35 https://doi.org/10.1016/s0021-9150(00)00755-3
36 https://doi.org/10.1016/s0026-0495(96)90011-6
37 https://doi.org/10.1016/s0083-6729(05)71012-8
38 https://doi.org/10.1016/s0140-6736(97)06348-4
39 https://doi.org/10.1053/gast.2001.25490
40 https://doi.org/10.1055/s-2004-814490
41 https://doi.org/10.1056/nejm199602013340503
42 https://doi.org/10.1056/nejm199909163411211
43 https://doi.org/10.1074/jbc.m313191200
44 https://doi.org/10.1080/09513590400027372
45 https://doi.org/10.1093/aje/152.6.514
46 https://doi.org/10.1093/jnci/94.22.1704
47 https://doi.org/10.1097/00029330-200709020-00009
48 https://doi.org/10.1111/j.1467-789x.2007.00396.x
49 https://doi.org/10.1126/science.281.5383.1683
50 https://doi.org/10.1158/0008-5472.can-04-0655
51 https://doi.org/10.1158/1078-0432.ccr-03-0749
52 https://doi.org/10.1158/1078-0432.ccr-05-1913
53 https://doi.org/10.1159/000111097
54 https://doi.org/10.1210/jc.2004-0297
55 https://doi.org/10.1677/erc-06-0089
56 https://doi.org/10.1677/joe.0.1540285
57 https://doi.org/10.3892/ijmm.5.4.421
58 schema:datePublished 2009-02
59 schema:datePublishedReg 2009-02-01
60 schema:description The present case-control study was to investigate the relationships of plasma leptin level and anthropometric measures of adiposity with the risk of breast cancer. Questionnaire information, anthropometric measures and blood samples were taken before treatment from 297 incident cases with breast cancer and 593 controls admitted for health examination at the Tri-Service General Hospital, Taipei, between 2004 and 2006. Plasma levels of leptin were measured by RIA. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for assessing the associations. Overall, higher leptin concentrations were significantly associated with an increased risk of breast cancer (OR (95% CI) for top vs bottom tertile of leptin was 1.63 (1.07-2.49), P(trend)=0.009). Waist circumference was a significant anthropometric factor for breast cancer in both pre- and postmenopausal women. Furthermore, the associations of leptin with breast cancer risk remained after adjustment for obesity indices. These results suggest that leptin may have an independent role in breast tumorigenesis. Regardless of the impact of circulating leptin, more research is needed to elucidate molecular mechanisms and local leptin levels that are critical for the development of breast cancers.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N0be838ab654f4539aa579b3fc9ab8461
65 Ne4d1f4d343604eb0a7996eea0eb3afc0
66 sg:journal.1017082
67 schema:name Circulating levels of leptin, adiposity and breast cancer risk
68 schema:pagination 578
69 schema:productId N3bdac93df3f4479497ef081098ca9662
70 N4605bf7eae644a418d8a31b14f7d6ee3
71 N8021bccbeb55464dab61945871f7cc84
72 Na2b116ae0c39445692781c4ca11e1699
73 Ne5da992586f349668242b1688322ad04
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051508888
75 https://doi.org/10.1038/sj.bjc.6604913
76 schema:sdDatePublished 2019-04-10T19:45
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N861f748e95494b13a278366c0f2b16b9
79 schema:url https://www.nature.com/articles/6604913
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0be838ab654f4539aa579b3fc9ab8461 schema:issueNumber 4
84 rdf:type schema:PublicationIssue
85 N0eab7bcab321462e9dd66181b8857ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Breast Neoplasms
87 rdf:type schema:DefinedTerm
88 N15925c1296844e5cacf307d2701f463c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Adiposity
90 rdf:type schema:DefinedTerm
91 N20115a97b0b74548a837262257a4992d rdf:first sg:person.01041254715.99
92 rdf:rest Nbae0db6a6dee49e0891d0bdeab5a6537
93 N3bdac93df3f4479497ef081098ca9662 schema:name readcube_id
94 schema:value f55dd97a8ec49d87d13301c6f5d967085c377b9a43bf6f1c3ed674e938d4b1b3
95 rdf:type schema:PropertyValue
96 N3c4c6d73266a42a886d78040845ff650 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Surveys and Questionnaires
98 rdf:type schema:DefinedTerm
99 N3f95348caa0f4563aa4ec93dea4f89d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Body Mass Index
101 rdf:type schema:DefinedTerm
102 N4605bf7eae644a418d8a31b14f7d6ee3 schema:name pubmed_id
103 schema:value 19223908
104 rdf:type schema:PropertyValue
105 N47d3d4c38ac04cbd884a9deeb4fc438c rdf:first sg:person.01301367307.42
106 rdf:rest N8503ad68b1b34fb99a76aca6442aa0e4
107 N47f6fbfe58eb4f5c96cad04074ae441d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N484262fc3611456c93f1017ff0718ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Adult
112 rdf:type schema:DefinedTerm
113 N55badc1e11d9468bbdff1ae2c7149f7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Risk Factors
115 rdf:type schema:DefinedTerm
116 N776cb532d929437b92a9da52dc83a7b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Female
118 rdf:type schema:DefinedTerm
119 N8021bccbeb55464dab61945871f7cc84 schema:name doi
120 schema:value 10.1038/sj.bjc.6604913
121 rdf:type schema:PropertyValue
122 N8503ad68b1b34fb99a76aca6442aa0e4 rdf:first sg:person.01135357762.11
123 rdf:rest Na7452fbe15164e4d80fc81233b7674c2
124 N861f748e95494b13a278366c0f2b16b9 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 Na2b116ae0c39445692781c4ca11e1699 schema:name dimensions_id
127 schema:value pub.1051508888
128 rdf:type schema:PropertyValue
129 Na7452fbe15164e4d80fc81233b7674c2 rdf:first sg:person.01356776746.29
130 rdf:rest rdf:nil
131 Na803a20d0e4b4002b29476d7128957c3 rdf:first sg:person.01345257105.55
132 rdf:rest N47d3d4c38ac04cbd884a9deeb4fc438c
133 Nabb831d1be02497184b95b869ebeed66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Taiwan
135 rdf:type schema:DefinedTerm
136 Nae068909adb64860970762a13df63cac rdf:first sg:person.0613671210.15
137 rdf:rest N20115a97b0b74548a837262257a4992d
138 Nb7add3d270614ce288489dbae22795e2 rdf:first sg:person.0725026315.19
139 rdf:rest Nae068909adb64860970762a13df63cac
140 Nba495998d6a845d0bc56da789a4cda62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Aged
142 rdf:type schema:DefinedTerm
143 Nbae0db6a6dee49e0891d0bdeab5a6537 rdf:first sg:person.01030127031.30
144 rdf:rest Na803a20d0e4b4002b29476d7128957c3
145 Nc7c5e1e1af31426e8a76c1238d11d881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Leptin
147 rdf:type schema:DefinedTerm
148 Nd6bac847b12843c896d592a050be5b4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Case-Control Studies
150 rdf:type schema:DefinedTerm
151 Ne4d1f4d343604eb0a7996eea0eb3afc0 schema:volumeNumber 100
152 rdf:type schema:PublicationVolume
153 Ne5da992586f349668242b1688322ad04 schema:name nlm_unique_id
154 schema:value 0370635
155 rdf:type schema:PropertyValue
156 Nedd0983a3dd64d1597eb1f8b36ea84b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Middle Aged
158 rdf:type schema:DefinedTerm
159 Nf634745bd2284dbfa00aac1b3ac4c52c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Waist Circumference
161 rdf:type schema:DefinedTerm
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
166 schema:name Public Health and Health Services
167 rdf:type schema:DefinedTerm
168 sg:journal.1017082 schema:issn 0007-0920
169 1532-1827
170 schema:name British Journal of Cancer
171 rdf:type schema:Periodical
172 sg:person.01030127031.30 schema:affiliation https://www.grid.ac/institutes/grid.278244.f
173 schema:familyName Hsu
174 schema:givenName G-C
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030127031.30
176 rdf:type schema:Person
177 sg:person.01041254715.99 schema:affiliation https://www.grid.ac/institutes/grid.256105.5
178 schema:familyName Chou
179 schema:givenName W-Y
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041254715.99
181 rdf:type schema:Person
182 sg:person.01135357762.11 schema:affiliation https://www.grid.ac/institutes/grid.278244.f
183 schema:familyName Yu
184 schema:givenName J-C
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135357762.11
186 rdf:type schema:Person
187 sg:person.01301367307.42 schema:affiliation https://www.grid.ac/institutes/grid.278244.f
188 schema:familyName Yu
189 schema:givenName C-P
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301367307.42
191 rdf:type schema:Person
192 sg:person.01345257105.55 schema:affiliation https://www.grid.ac/institutes/grid.278244.f
193 schema:familyName Chu
194 schema:givenName C-H
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345257105.55
196 rdf:type schema:Person
197 sg:person.01356776746.29 schema:affiliation https://www.grid.ac/institutes/grid.256105.5
198 schema:familyName Sun
199 schema:givenName C-A
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356776746.29
201 rdf:type schema:Person
202 sg:person.0613671210.15 schema:affiliation https://www.grid.ac/institutes/grid.260565.2
203 schema:familyName Chou
204 schema:givenName Y-C
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613671210.15
206 rdf:type schema:Person
207 sg:person.0725026315.19 schema:affiliation https://www.grid.ac/institutes/grid.260565.2
208 schema:familyName Wu
209 schema:givenName M-H
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725026315.19
211 rdf:type schema:Person
212 sg:pub.10.1007/s10549-005-9139-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043009334
213 https://doi.org/10.1007/s10549-005-9139-y
214 rdf:type schema:CreativeWork
215 sg:pub.10.1023/a:1008903727238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022593002
216 https://doi.org/10.1023/a:1008903727238
217 rdf:type schema:CreativeWork
218 sg:pub.10.1023/b:brea.0000036782.11945.d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002978166
219 https://doi.org/10.1023/b:brea.0000036782.11945.d7
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/bjc.1994.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012957837
222 https://doi.org/10.1038/bjc.1994.157
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/ncpendmet0456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052069549
225 https://doi.org/10.1038/ncpendmet0456
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/sj.onc.1207751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016553091
228 https://doi.org/10.1038/sj.onc.1207751
229 rdf:type schema:CreativeWork
230 sg:pub.10.1385/endo:26:1:019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039167303
231 https://doi.org/10.1385/endo:26:1:019
232 rdf:type schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1075267201 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1076838003 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1077493163 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1082899708 schema:CreativeWork
237 https://doi.org/10.1002/(sici)1097-0142(19970815)80:4<725::aid-cncr11>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1053620405
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<523::aid-ijc7>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1004880455
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/jcp.20472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044450278
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.canlet.2005.05.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051323319
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.canlet.2005.05.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007766350
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0006-291x(02)00205-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052771356
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0021-9150(00)00755-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013977616
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0026-0495(96)90011-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031811370
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0083-6729(05)71012-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001305919
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0140-6736(97)06348-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000494218
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1053/gast.2001.25490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019837977
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1055/s-2004-814490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057429641
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1056/nejm199602013340503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032220112
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1056/nejm199909163411211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047483226
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1074/jbc.m313191200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005585411
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1080/09513590400027372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040260001
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/aje/152.6.514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031388372
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/jnci/94.22.1704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004685140
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00029330-200709020-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077493163
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1467-789x.2007.00396.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026434458
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1126/science.281.5383.1683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562418
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/0008-5472.can-04-0655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047068478
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/1078-0432.ccr-03-0749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012754131
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/1078-0432.ccr-05-1913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050080408
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1159/000111097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006911895
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1210/jc.2004-0297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025108128
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1677/erc-06-0089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047236463
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1677/joe.0.1540285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039688746
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3892/ijmm.5.4.421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071509093
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.256105.5 schema:alternateName Fu Jen Catholic University
296 schema:name Department of Public Health, College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan, ROC
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.260565.2 schema:alternateName National Defense Medical Center
299 schema:name Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
300 School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.278244.f schema:alternateName Tri-Service General Hospital
303 schema:name Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan, ROC
304 Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan, ROC
305 Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan, ROC
306 Headquarter, Tri-Service General Hospital, Taipei, Taiwan, ROC
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...