Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01-06

AUTHORS

J P Neoptolemos, D D Stocken, C Tudur Smith, C Bassi, P Ghaneh, E Owen, M Moore, R Padbury, R Doi, D Smith, M W Büchler

ABSTRACT

The ESPAC-1, ESPAC-1 plus, and early ESPAC-3(v1) results (458 randomized patients; 364 deaths) were used to estimate the effectiveness of adjuvant 5FU/FA vs resection alone for pancreatic cancer using meta-analysis. The pooled hazard ratio of 0.70 (95% CI=0.55–0.88) P=0.003, and the median survival of 23.2 (95% CI=20.1–26.5) months with 5FU/FA vs 16.8 (95% CI=14.3–19.2) months with resection alone supports the use of adjuvant 5FU/FA in pancreatic cancer. More... »

PAGES

246-250

Journal

TITLE

British Journal of Cancer

ISSUE

2

VOLUME

100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604838

DOI

http://dx.doi.org/10.1038/sj.bjc.6604838

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009957314

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19127260


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