Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-09

AUTHORS

F Graziano, A Ruzzo, F Loupakis, D Santini, V Catalano, E Canestrari, P Maltese, R Bisonni, L Fornaro, G Baldi, G Masi, A Falcone, G Tonini, P Giordani, P Alessandroni, L Giustini, B Vincenzi, M Magnani

ABSTRACT

We investigated the association between thymidylate synthase (TS) germline polymorphisms and response to 5-fluorouracil-based chemotherapy in 80 patients with liver-only metastatic colorectal cancer (MCRC). The tandem repeat polymorphism (VNTR) in TS 5'-untranslated region (5'-UTR), which consists of two (2R) or three (3R) 28-bp repeated sequences, with or without a G/C nucleotide change in 3R carriers (3G or 3C) and a 6-bp insertion/deletion (6+/6-) in the TS 3'-UTR, was studied. The distinction between high (2R/3G, 3C/3G and 3G/3G) and low (2R/2R, 2R/3C and 3C/3C) TS expression genotypes according to the 5'-UTR VNTR+G/C nucleotide change showed significant association with tumour response (P=0.01). In particular, high TS expression genotypes were found in 8 out of 34 patients (23.5%) with complete or partial response and in 24 out of 46 patients (52%) with stable disease and disease progression. Liver-only MCRC patients are a homogeneous and clinical relevant subgroup that may represent an ideal setting for studying the actual influence of TS polymorphisms. More... »

PAGES

716

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604555

DOI

http://dx.doi.org/10.1038/sj.bjc.6604555

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036375147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18728661


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