Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07

AUTHORS

K Talvinen, J Tuikkala, O Nevalainen, A Rantanen, P Hirsimäki, J Sundström, P Kronqvist

ABSTRACT

We introduce a new proliferation marker, securin (pituitary tumour-transforming 1 (PTTG1)), analysed in invasive ductal breast carcinomas by cDNA microarrays and immunohistochemistry. In cDNA microarray of a total of 4000 probes of genes, securin was revealed with a significant change in expression among the several proliferation-related genes studied. The value of securin as a proliferation marker was verified immunohistochemically (n=44) in invasive ductal breast cancer. In follow-up analyses of the sample of patients, the prognostic value of securin was compared with the established markers of breast cancer proliferation, Ki-67 and mitotic activity index (MAI). Our results of a small sample of patients suggest that low securin expression identifies a distinct subgroup of more favourable outcome among patients with high Ki-67 immunoexpression or high MAI. In univariate analysis of Cox's regression, 10-unit increment of securin immunopositivity was associated with a 2.3-fold overall risk of death due to breast cancer and a 7.1-fold risk of death due to breast cancer in the sample of patients stratified according to the cutoff points of 10 and 20% of securin immunopositivity. We suggest that securin immunostaining is a promising and clinically applicable proliferation marker. The finding urges further prognostic studies with a large sample of patients. More... »

PAGES

335

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604475

DOI

http://dx.doi.org/10.1038/sj.bjc.6604475

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001045862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18594525


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