Ontology type: schema:ScholarlyArticle Open Access: True
2008-07-01
AUTHORSP Armaroli, F Gallo, A Bellomi, S Ciatto, D Consonni, D Davi, P Giorgi-Rossi, A Iossa, E Mancini, C Naldoni, E Polla, G Ronco, M Serafini, V Vergini, L Zanier, M Zappa, N Segnan
ABSTRACTTo assess the adequacy of a routine screening to identify cervical intraepithelial neoplasia 2 or worse (CIN2+) in women over 50 years of age, a retrospective cohort was set in six Italian organised population-based screening programmes. In all, 287 330 women (1 714 550 person-years of observation, 1110 cases) screened at age 25–64, with at least two cytological screening tests, the first negative, were followed from their first negative smear until a biopsy proven CIN2+ lesion or their last negative smear. For women aged 25–49 and 50–64 years, crude and age-standardised detection rate (DR), cumulative risk (CR), adjusted hazard risk for number of previous negative screens, probability of false-positive CIN2+ after two or more smear tests were calculated. Detection rate is significantly lower over 50 years of age. Multivariable analysis shows a significant protective effect from four screening episodes (DR=0.70, 95% CI: 0.51–0.97); the effect of age ⩾50 is 0.29 (95% CI: 0.24–0.35). The CR of CIN2+ is at least eightfold higher in women <50 (CR=2.06, 95% CI: 1.88–2.23) after one previous negative test than in women ⩾50 years with four screens (CR=0.23, 95% CI: 0.00–0.46). Over 50 years of age, after four tests at least three false-positive cases are diagnosed for every true positive. Benefits arising from cytological screening is uncertain in well-screened older women. More... »
PAGES239-244
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604455
DOIhttp://dx.doi.org/10.1038/sj.bjc.6604455
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1052803029
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18594534
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