Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-05

AUTHORS

G Bocci, A Falcone, A Fioravanti, P Orlandi, A Di Paolo, G Fanelli, P Viacava, A G Naccarato, R S Kerbel, R Danesi, M Del Tacca, G Allegrini

ABSTRACT

Metronomic chemotherapy refers to the administration of chemotherapy at low, nontoxic doses on a frequent schedule with no prolonged breaks. The aim of the study is to rationally develop a CPT-11 metronomic regimen in preclinical settings of colon cancer. In vitro cell proliferation, apoptosis and thrombospondin-1/vascular endothelial growth factor (TSP-1/VEGF) expression analyses were performed on endothelial (HUVEC, HMVEC-d) and colorectal cancer (HT-29, SW620) cells exposed for 144 h to metronomic concentrations of SN-38, the active metabolite of CPT-11. HT-29 human colorectal cancer xenograft model was used, and tumour growth, microvessel density and VEGF/TSP-1 quantification was performed in tumours. In vitro and in vivo combination studies with the tyrosine inhibitor semaxinib were also performed. SN-38 preferentially inhibited endothelial cell proliferation alone and interacted synergistically with semaxinib; it induced apoptosis and increased the expression and secretion of TSP-1. Metronomic CPT-11 alone and combined with semaxinib significantly inhibits tumour growth in the absence of toxicity, which was accompanied by decreases in microvessel density and increases in TSP-1 gene expression in tumour tissues. In vitro results show the antiangiogenic properties of low-concentration SN-38, suggesting a key role of TSP-1 in this effect. In vivo, the CPT-11 metronomic schedule is effective against tumour and microvessel growth without toxic effect on mice. More... »

PAGES

6604352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604352

DOI

http://dx.doi.org/10.1038/sj.bjc.6604352

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047310733

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18443598


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenesis Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HT29 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microcirculation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrroles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombospondin 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bocci", 
        "givenName": "G", 
        "id": "sg:person.01066531307.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066531307.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Medical Oncology, General Hospital of Livorno, Department of Oncology, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falcone", 
        "givenName": "A", 
        "id": "sg:person.01006230145.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fioravanti", 
        "givenName": "A", 
        "id": "sg:person.01307504107.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307504107.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orlandi", 
        "givenName": "P", 
        "id": "sg:person.01355617307.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355617307.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Paolo", 
        "givenName": "A", 
        "id": "sg:person.01014555007.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014555007.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fanelli", 
        "givenName": "G", 
        "id": "sg:person.01163416344.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163416344.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viacava", 
        "givenName": "P", 
        "id": "sg:person.01256032251.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256032251.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naccarato", 
        "givenName": "A G", 
        "id": "sg:person.01023405063.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023405063.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada", 
            "Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerbel", 
        "givenName": "R S", 
        "id": "sg:person.0673064574.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673064574.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Danesi", 
        "givenName": "R", 
        "id": "sg:person.0704167507.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704167507.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Del Tacca", 
        "givenName": "M", 
        "id": "sg:person.0101712630.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0101712630.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Division of Medical Oncology, General Hospital of Livorno, Department of Oncology, University of Pisa, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allegrini", 
        "givenName": "G", 
        "id": "sg:person.0623002156.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623002156.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-07-0584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000560904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002268239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0402-349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004091227", 
          "https://doi.org/10.1038/nm0402-349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0402-349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004091227", 
          "https://doi.org/10.1038/nm0402-349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.58.3.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004815059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007182625", 
          "https://doi.org/10.1038/sj.cdd.4401615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007182625", 
          "https://doi.org/10.1038/sj.cdd.4401615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.1939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007277658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-006-0075-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008370656", 
          "https://doi.org/10.1007/s00109-006-0075-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-006-0075-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008370656", 
          "https://doi.org/10.1007/s00109-006-0075-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.07.093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008723372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2004.07.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019080834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019159796", 
          "https://doi.org/10.1038/nrc1369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019159796", 
          "https://doi.org/10.1038/nrc1369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021374434", 
          "https://doi.org/10.1038/sj.bjc.6602720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021374434", 
          "https://doi.org/10.1038/sj.bjc.6602720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022489746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002800051007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024854717", 
          "https://doi.org/10.1007/s002800051007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0163-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026409148", 
          "https://doi.org/10.1007/s00280-005-0163-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0163-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026409148", 
          "https://doi.org/10.1007/s00280-005-0163-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-004-0642-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035512347", 
          "https://doi.org/10.1007/s00432-004-0642-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-004-0642-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035512347", 
          "https://doi.org/10.1007/s00432-004-0642-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-004-0642-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035512347", 
          "https://doi.org/10.1007/s00432-004-0642-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci8829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036426384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036484474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-003-0712-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037447804", 
          "https://doi.org/10.1007/s00280-003-0712-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(00)00092-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037928079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040580466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041229486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyi229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041646441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.06.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044211768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045554672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047832996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2135406100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050157278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157488406778249307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069214048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.3.4.735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074623639", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074984083", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075055329", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075198244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075258336", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075329243", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077410180", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083379587", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-05", 
    "datePublishedReg": "2008-05-01", 
    "description": "Metronomic chemotherapy refers to the administration of chemotherapy at low, nontoxic doses on a frequent schedule with no prolonged breaks. The aim of the study is to rationally develop a CPT-11 metronomic regimen in preclinical settings of colon cancer. In vitro cell proliferation, apoptosis and thrombospondin-1/vascular endothelial growth factor (TSP-1/VEGF) expression analyses were performed on endothelial (HUVEC, HMVEC-d) and colorectal cancer (HT-29, SW620) cells exposed for 144 h to metronomic concentrations of SN-38, the active metabolite of CPT-11. HT-29 human colorectal cancer xenograft model was used, and tumour growth, microvessel density and VEGF/TSP-1 quantification was performed in tumours. In vitro and in vivo combination studies with the tyrosine inhibitor semaxinib were also performed. SN-38 preferentially inhibited endothelial cell proliferation alone and interacted synergistically with semaxinib; it induced apoptosis and increased the expression and secretion of TSP-1. Metronomic CPT-11 alone and combined with semaxinib significantly inhibits tumour growth in the absence of toxicity, which was accompanied by decreases in microvessel density and increases in TSP-1 gene expression in tumour tissues. In vitro results show the antiangiogenic properties of low-concentration SN-38, suggesting a key role of TSP-1 in this effect. In vivo, the CPT-11 metronomic schedule is effective against tumour and microvessel growth without toxic effect on mice.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6604352", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "98"
      }
    ], 
    "name": "Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib", 
    "pagination": "6604352", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e15fb8096b0796524ddfb61d84371b7660ee0400526e2dabcedce8e2049af4ac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18443598"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6604352"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047310733"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6604352", 
      "https://app.dimensions.ai/details/publication/pub.1047310733"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/6604352"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604352'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604352'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604352'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604352'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      88 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6604352 schema:about N0aa1448be7db4c748b576c1496c2a4d5
2 N136c83ac3736437aaaaac015d19f7162
3 N2216fd368eea423d91bd912aba14c4ab
4 N292ed9c211ad4436988f17930a4c36ed
5 N41221ec852f04843896728cb5e52b911
6 N4556534cc79640eda646692c6722e7ba
7 N4601602bd879403b9ff5ce31c51366ef
8 N4857d941c112487fb4de9be336e6e3b8
9 N4c5c85a70bea4a208955c42b421a57ae
10 N5c8259821d8b40efa7c2fd2eba81f496
11 N5d12406ac5c2420f8b19bc957fda9dbb
12 N5ef162b6e3784c85836766e990455ada
13 N6755ec2304d24638b9818fa2b4f1e7bc
14 N6765b5fbc54b4c528f46ed7ec5f6fc3e
15 N6f23260d9e084222807154bc2adc6507
16 N6f837866bc2a444b98cda15315f4b5f3
17 N87bc1f9870ed43a2a9247c50388d2476
18 N95297644cc5d4244bcf320386bb270e9
19 N95e456407a5b4ac6816ea8d20bd3d843
20 Nac7f0aec4b424765827ec98d357bf1b2
21 Nad2d28e7cf1c4bc89d307df2d85f67ac
22 Nd40059cb1a2347c3bc1e0e0e4b662ac7
23 Ne07d948980d54f4e9b71e45897b1e145
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author N5c1a7b2b27b841c1b62cccc46c4f51c9
27 schema:citation sg:pub.10.1007/s00109-006-0075-z
28 sg:pub.10.1007/s00280-003-0712-y
29 sg:pub.10.1007/s00280-005-0163-8
30 sg:pub.10.1007/s002800051007
31 sg:pub.10.1007/s00432-004-0642-z
32 sg:pub.10.1038/nm0402-349
33 sg:pub.10.1038/nrc1369
34 sg:pub.10.1038/sj.bjc.6602720
35 sg:pub.10.1038/sj.cdd.4401615
36 https://app.dimensions.ai/details/publication/pub.1074623639
37 https://app.dimensions.ai/details/publication/pub.1074984083
38 https://app.dimensions.ai/details/publication/pub.1075055329
39 https://app.dimensions.ai/details/publication/pub.1075198244
40 https://app.dimensions.ai/details/publication/pub.1075258336
41 https://app.dimensions.ai/details/publication/pub.1075329243
42 https://app.dimensions.ai/details/publication/pub.1077410180
43 https://app.dimensions.ai/details/publication/pub.1083379587
44 https://doi.org/10.1002/path.1626
45 https://doi.org/10.1016/j.ejphar.2004.07.062
46 https://doi.org/10.1016/s0959-8049(00)00092-7
47 https://doi.org/10.1053/j.gastro.2005.06.023
48 https://doi.org/10.1073/pnas.2135406100
49 https://doi.org/10.1093/jjco/hyi229
50 https://doi.org/10.1124/pr.58.3.10
51 https://doi.org/10.1158/0008-5472.can-03-3126
52 https://doi.org/10.1158/0008-5472.can-04-0401
53 https://doi.org/10.1158/0008-5472.can-04-0580
54 https://doi.org/10.1158/0008-5472.can-04-2894
55 https://doi.org/10.1158/0008-5472.can-05-0765
56 https://doi.org/10.1158/1078-0432.ccr-05-0621
57 https://doi.org/10.1158/1535-7163.mct-07-0584
58 https://doi.org/10.1172/jci8829
59 https://doi.org/10.1200/jco.2005.07.093
60 https://doi.org/10.1200/jco.2007.12.1939
61 https://doi.org/10.2174/157488406778249307
62 https://doi.org/10.4161/cbt.3.4.735
63 schema:datePublished 2008-05
64 schema:datePublishedReg 2008-05-01
65 schema:description Metronomic chemotherapy refers to the administration of chemotherapy at low, nontoxic doses on a frequent schedule with no prolonged breaks. The aim of the study is to rationally develop a CPT-11 metronomic regimen in preclinical settings of colon cancer. In vitro cell proliferation, apoptosis and thrombospondin-1/vascular endothelial growth factor (TSP-1/VEGF) expression analyses were performed on endothelial (HUVEC, HMVEC-d) and colorectal cancer (HT-29, SW620) cells exposed for 144 h to metronomic concentrations of SN-38, the active metabolite of CPT-11. HT-29 human colorectal cancer xenograft model was used, and tumour growth, microvessel density and VEGF/TSP-1 quantification was performed in tumours. In vitro and in vivo combination studies with the tyrosine inhibitor semaxinib were also performed. SN-38 preferentially inhibited endothelial cell proliferation alone and interacted synergistically with semaxinib; it induced apoptosis and increased the expression and secretion of TSP-1. Metronomic CPT-11 alone and combined with semaxinib significantly inhibits tumour growth in the absence of toxicity, which was accompanied by decreases in microvessel density and increases in TSP-1 gene expression in tumour tissues. In vitro results show the antiangiogenic properties of low-concentration SN-38, suggesting a key role of TSP-1 in this effect. In vivo, the CPT-11 metronomic schedule is effective against tumour and microvessel growth without toxic effect on mice.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N3973b63bc0f540a4af47fd4e50997af8
70 N941c2b99cafe477ca0b79bc064d9818d
71 sg:journal.1017082
72 schema:name Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib
73 schema:pagination 6604352
74 schema:productId N026f0fe3f7694eb997816b27b0490fd7
75 N0b80fa66edbf40258d72fc3ed3eaf2b3
76 N89aef08c84864973b76880a9bd8c6e14
77 N9790a3936ac1489ab05ea2687f10adb8
78 Na31e577e7f114138bb4745b0482742e2
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047310733
80 https://doi.org/10.1038/sj.bjc.6604352
81 schema:sdDatePublished 2019-04-11T00:55
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N8ca7e052173c4cf5a8628fc13d618718
84 schema:url http://www.nature.com/articles/6604352
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N026f0fe3f7694eb997816b27b0490fd7 schema:name doi
89 schema:value 10.1038/sj.bjc.6604352
90 rdf:type schema:PropertyValue
91 N09175db5e1474390abd2b0d2bdc25740 rdf:first sg:person.01014555007.48
92 rdf:rest N64aafd8e22ec46a08a8429a67a6046c8
93 N0aa1448be7db4c748b576c1496c2a4d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Animals
95 rdf:type schema:DefinedTerm
96 N0b80fa66edbf40258d72fc3ed3eaf2b3 schema:name readcube_id
97 schema:value e15fb8096b0796524ddfb61d84371b7660ee0400526e2dabcedce8e2049af4ac
98 rdf:type schema:PropertyValue
99 N136c83ac3736437aaaaac015d19f7162 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Vascular Endothelial Growth Factor A
101 rdf:type schema:DefinedTerm
102 N2216fd368eea423d91bd912aba14c4ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Microcirculation
104 rdf:type schema:DefinedTerm
105 N292ed9c211ad4436988f17930a4c36ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N2beadb97fcc04393b2fa62bd285218d8 rdf:first sg:person.0673064574.73
109 rdf:rest Nc4a6c9fb36074062afb0de29ec8c74b7
110 N3939b65d921f4981a820e19f18f80d7d rdf:first sg:person.01006230145.44
111 rdf:rest N66d0c950764744079420b38c0aa96c9b
112 N3973b63bc0f540a4af47fd4e50997af8 schema:issueNumber 10
113 rdf:type schema:PublicationIssue
114 N41221ec852f04843896728cb5e52b911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Indoles
116 rdf:type schema:DefinedTerm
117 N41371a0f364d4ade95c2246859942fb3 rdf:first sg:person.01256032251.39
118 rdf:rest Nbb7e230334ec473eb3db510a6b4c0d24
119 N4556534cc79640eda646692c6722e7ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Immunohistochemistry
121 rdf:type schema:DefinedTerm
122 N4601602bd879403b9ff5ce31c51366ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mice, Nude
124 rdf:type schema:DefinedTerm
125 N4857d941c112487fb4de9be336e6e3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Camptothecin
127 rdf:type schema:DefinedTerm
128 N4c5c85a70bea4a208955c42b421a57ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Transplantation, Heterologous
130 rdf:type schema:DefinedTerm
131 N5c1a7b2b27b841c1b62cccc46c4f51c9 rdf:first sg:person.01066531307.37
132 rdf:rest N3939b65d921f4981a820e19f18f80d7d
133 N5c8259821d8b40efa7c2fd2eba81f496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Apoptosis
135 rdf:type schema:DefinedTerm
136 N5d12406ac5c2420f8b19bc957fda9dbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Enzyme-Linked Immunosorbent Assay
138 rdf:type schema:DefinedTerm
139 N5ef162b6e3784c85836766e990455ada schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cell Proliferation
141 rdf:type schema:DefinedTerm
142 N64aafd8e22ec46a08a8429a67a6046c8 rdf:first sg:person.01163416344.10
143 rdf:rest N41371a0f364d4ade95c2246859942fb3
144 N66d0c950764744079420b38c0aa96c9b rdf:first sg:person.01307504107.09
145 rdf:rest N94eb564a296547c899b3c7c730c04d18
146 N6755ec2304d24638b9818fa2b4f1e7bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mice
148 rdf:type schema:DefinedTerm
149 N6765b5fbc54b4c528f46ed7ec5f6fc3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Pyrroles
151 rdf:type schema:DefinedTerm
152 N687eb1a57b0642cbb57279a97f9c32cf rdf:first sg:person.0101712630.89
153 rdf:rest N6a93ac7aaec34d17bcfd3f1f2dbd04ce
154 N6a93ac7aaec34d17bcfd3f1f2dbd04ce rdf:first sg:person.0623002156.45
155 rdf:rest rdf:nil
156 N6f23260d9e084222807154bc2adc6507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Male
158 rdf:type schema:DefinedTerm
159 N6f837866bc2a444b98cda15315f4b5f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Angiogenesis Inhibitors
161 rdf:type schema:DefinedTerm
162 N87bc1f9870ed43a2a9247c50388d2476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Antineoplastic Combined Chemotherapy Protocols
164 rdf:type schema:DefinedTerm
165 N89aef08c84864973b76880a9bd8c6e14 schema:name nlm_unique_id
166 schema:value 0370635
167 rdf:type schema:PropertyValue
168 N8ca7e052173c4cf5a8628fc13d618718 schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 N941c2b99cafe477ca0b79bc064d9818d schema:volumeNumber 98
171 rdf:type schema:PublicationVolume
172 N94eb564a296547c899b3c7c730c04d18 rdf:first sg:person.01355617307.22
173 rdf:rest N09175db5e1474390abd2b0d2bdc25740
174 N95297644cc5d4244bcf320386bb270e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Colorectal Neoplasms
176 rdf:type schema:DefinedTerm
177 N95e456407a5b4ac6816ea8d20bd3d843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Thrombospondin 1
179 rdf:type schema:DefinedTerm
180 N9790a3936ac1489ab05ea2687f10adb8 schema:name dimensions_id
181 schema:value pub.1047310733
182 rdf:type schema:PropertyValue
183 Na31e577e7f114138bb4745b0482742e2 schema:name pubmed_id
184 schema:value 18443598
185 rdf:type schema:PropertyValue
186 Nac7f0aec4b424765827ec98d357bf1b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Antineoplastic Agents, Phytogenic
188 rdf:type schema:DefinedTerm
189 Nad2d28e7cf1c4bc89d307df2d85f67ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Immunoenzyme Techniques
191 rdf:type schema:DefinedTerm
192 Nbb7e230334ec473eb3db510a6b4c0d24 rdf:first sg:person.01023405063.60
193 rdf:rest N2beadb97fcc04393b2fa62bd285218d8
194 Nc4a6c9fb36074062afb0de29ec8c74b7 rdf:first sg:person.0704167507.01
195 rdf:rest N687eb1a57b0642cbb57279a97f9c32cf
196 Nd40059cb1a2347c3bc1e0e0e4b662ac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Gene Expression Regulation, Neoplastic
198 rdf:type schema:DefinedTerm
199 Ne07d948980d54f4e9b71e45897b1e145 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name HT29 Cells
201 rdf:type schema:DefinedTerm
202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical and Health Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
206 schema:name Oncology and Carcinogenesis
207 rdf:type schema:DefinedTerm
208 sg:journal.1017082 schema:issn 0007-0920
209 1532-1827
210 schema:name British Journal of Cancer
211 rdf:type schema:Periodical
212 sg:person.01006230145.44 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
213 schema:familyName Falcone
214 schema:givenName A
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
216 rdf:type schema:Person
217 sg:person.01014555007.48 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
218 schema:familyName Di Paolo
219 schema:givenName A
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014555007.48
221 rdf:type schema:Person
222 sg:person.0101712630.89 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
223 schema:familyName Del Tacca
224 schema:givenName M
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0101712630.89
226 rdf:type schema:Person
227 sg:person.01023405063.60 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
228 schema:familyName Naccarato
229 schema:givenName A G
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023405063.60
231 rdf:type schema:Person
232 sg:person.01066531307.37 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
233 schema:familyName Bocci
234 schema:givenName G
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066531307.37
236 rdf:type schema:Person
237 sg:person.01163416344.10 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
238 schema:familyName Fanelli
239 schema:givenName G
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163416344.10
241 rdf:type schema:Person
242 sg:person.01256032251.39 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
243 schema:familyName Viacava
244 schema:givenName P
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256032251.39
246 rdf:type schema:Person
247 sg:person.01307504107.09 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
248 schema:familyName Fioravanti
249 schema:givenName A
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307504107.09
251 rdf:type schema:Person
252 sg:person.01355617307.22 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
253 schema:familyName Orlandi
254 schema:givenName P
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355617307.22
256 rdf:type schema:Person
257 sg:person.0623002156.45 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
258 schema:familyName Allegrini
259 schema:givenName G
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623002156.45
261 rdf:type schema:Person
262 sg:person.0673064574.73 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
263 schema:familyName Kerbel
264 schema:givenName R S
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673064574.73
266 rdf:type schema:Person
267 sg:person.0704167507.01 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
268 schema:familyName Danesi
269 schema:givenName R
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704167507.01
271 rdf:type schema:Person
272 sg:pub.10.1007/s00109-006-0075-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1008370656
273 https://doi.org/10.1007/s00109-006-0075-z
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s00280-003-0712-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1037447804
276 https://doi.org/10.1007/s00280-003-0712-y
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s00280-005-0163-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026409148
279 https://doi.org/10.1007/s00280-005-0163-8
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s002800051007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024854717
282 https://doi.org/10.1007/s002800051007
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s00432-004-0642-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035512347
285 https://doi.org/10.1007/s00432-004-0642-z
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nm0402-349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004091227
288 https://doi.org/10.1038/nm0402-349
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nrc1369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019159796
291 https://doi.org/10.1038/nrc1369
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/sj.bjc.6602720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021374434
294 https://doi.org/10.1038/sj.bjc.6602720
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/sj.cdd.4401615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007182625
297 https://doi.org/10.1038/sj.cdd.4401615
298 rdf:type schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1074623639 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1074984083 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1075055329 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1075198244 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1075258336 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1075329243 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1077410180 schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1083379587 schema:CreativeWork
307 https://doi.org/10.1002/path.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036484474
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.ejphar.2004.07.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019080834
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0959-8049(00)00092-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037928079
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1053/j.gastro.2005.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044211768
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.2135406100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050157278
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/jjco/hyi229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041646441
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1124/pr.58.3.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004815059
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1158/0008-5472.can-03-3126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047832996
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1158/0008-5472.can-04-0401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040580466
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1158/0008-5472.can-04-0580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041229486
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1158/0008-5472.can-04-2894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002268239
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1158/0008-5472.can-05-0765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045554672
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1158/1078-0432.ccr-05-0621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022489746
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/1535-7163.mct-07-0584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000560904
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1172/jci8829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036426384
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1200/jco.2005.07.093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008723372
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1200/jco.2007.12.1939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007277658
340 rdf:type schema:CreativeWork
341 https://doi.org/10.2174/157488406778249307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069214048
342 rdf:type schema:CreativeWork
343 https://doi.org/10.4161/cbt.3.4.735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293359
344 rdf:type schema:CreativeWork
345 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
346 schema:name Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
347 Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.5395.a schema:alternateName University of Pisa
350 schema:name Division of Medical Oncology, General Hospital of Livorno, Department of Oncology, University of Pisa, Pisa, Italy
351 Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
352 Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
353 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...