The UK colorectal cancer screening pilot: results of the second round of screening in England View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

D Weller, D Coleman, R Robertson, P Butler, J Melia, C Campbell, R Parker, J Patnick, S Moss

ABSTRACT

An evaluation of the second round of faecal occult blood (FOB) screening in the English site of the UK Colorectal Cancer Screening Pilot (comprising the Bowel Cancer Screening Pilot based in Rugby, general practices in four Primary Care Trusts, and their associated hospitals) was carried out. A total of 127 746 men and women aged 50-69 and registered in participating general practices were invited to participate. In all, 15.9% were new invitees not included in the previous round. A total of 52.1% of invitees returned a screening kit. Uptake varied with gender, age, and level of deprivation; was lower than in the first round (51.9 vs 58.5% P<0.0001), but was high (81.1%) in those who had participated in the first round with a negative result. Test positivity was 1.77%, significantly higher than in the first round, and the detection rate of neoplasia similar (5.67 per 1000), resulting in a lower positive predictive value. The sensitivity of FOBt in the first round was estimated as 57.7-64.4%. There was a significant impact on workload, particularly on endoscopy services. The cancer detection rate (0.94 per 1000) was lower than in the first round. Effort will be required to minimise inequalities in uptake, and to ensure adequate capacity of endoscopy services. More... »

PAGES

6604089

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6604089

DOI

http://dx.doi.org/10.1038/sj.bjc.6604089

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008411735

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18026197


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