Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-09-18

AUTHORS

C Massard, J-J Voigt, A Laplanche, S Culine, A Lortholary, R Bugat, C Theodore, F Priou, M-C Kaminsky, T Lesimple, X Pivot, B Coudert, J-Y Douillard, Y Merrouche, K Fizazi

ABSTRACT

Carcinomas of an unknown primary site (CUP) are heterogeneous tumours with a median survival of only 8 months. Tyrosine kinase inhibitors are promising new drugs. The aim of this study was to determine the expression of EGF-receptor, Her-2/neu, and c-Kit tyrosine kinases in CUP. Paraffin-embedded specimens were obtained from 54 patients with a CUP who were included in the GEFCAPI 01 randomised phase II trial. Immunohistochemistry was performed using the Dako autostainer with antibodies directed against HER-2/neu protein, EGFR protein, and c-Kit protein (CD117). EGFR expression was found in 36 out of 54 samples (66%). In contrast, Her-2/neu overexpression and c-Kit positivity were only detected in 4 and 10% of patients, respectively. No significant association was found between the expression of the tyrosine kinase receptors and prognosis. EGFR expression was significantly associated with response to cisplatin-based chemotherapy: the response rates were 50 and 22% in patients with EGFR-positive tumours and EGFR-negative tumours, respectively (P<0.05). This study shows that EGFR is frequently expressed in CUP. This finding may prompt clinical trials investigating EGFR inhibitors in this setting. In contrast, c-Kit expression and Her-2/neu overexpression occur infrequently in CUP. EGFR expression was correlated to tumour chemosensitivity. More... »

PAGES

857-861

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603942

DOI

http://dx.doi.org/10.1038/sj.bjc.6603942

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011514429

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17876336


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Unknown Primary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France", 
          "id": "http://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Massard", 
        "givenName": "C", 
        "id": "sg:person.0602371716.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602371716.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Centre Claudius Regaud, Toulouse, France", 
          "id": "http://www.grid.ac/institutes/grid.417829.1", 
          "name": [
            "Department of Pathology, Centre Claudius Regaud, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voigt", 
        "givenName": "J-J", 
        "id": "sg:person.0766536565.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766536565.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Statistics, Institut Gustave Roussy, Villejuif, France", 
          "id": "http://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Statistics, Institut Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laplanche", 
        "givenName": "A", 
        "id": "sg:person.01315625314.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315625314.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre Val d'Aurelle, Montpellier, France", 
          "id": "http://www.grid.ac/institutes/grid.418189.d", 
          "name": [
            "Department of Medicine, Centre Val d'Aurelle, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Culine", 
        "givenName": "S", 
        "id": "sg:person.01135615153.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135615153.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre Paul Papin, Anger, France", 
          "id": "http://www.grid.ac/institutes/grid.418191.4", 
          "name": [
            "Department of Medicine, Centre Paul Papin, Anger, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lortholary", 
        "givenName": "A", 
        "id": "sg:person.01130363736.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130363736.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Institut Claudius Regaud, Toulouse, France", 
          "id": "http://www.grid.ac/institutes/grid.417829.1", 
          "name": [
            "Department of Medicine, Institut Claudius Regaud, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bugat", 
        "givenName": "R", 
        "id": "sg:person.0626363216.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626363216.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France", 
          "id": "http://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Theodore", 
        "givenName": "C", 
        "id": "sg:person.013607432017.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013607432017.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre Hospitalier La Roche/Yon, La Roche/Yon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Medicine, Centre Hospitalier La Roche/Yon, La Roche/Yon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Priou", 
        "givenName": "F", 
        "id": "sg:person.01302261163.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302261163.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine Centre Alexis Vautrin, Nancy, France", 
          "id": "http://www.grid.ac/institutes/grid.410527.5", 
          "name": [
            "Department of Medicine Centre Alexis Vautrin, Nancy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaminsky", 
        "givenName": "M-C", 
        "id": "sg:person.0725456003.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725456003.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre Eug\u00e8ne Marquis, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Department of Medicine, Centre Eug\u00e8ne Marquis, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lesimple", 
        "givenName": "T", 
        "id": "sg:person.0730534622.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730534622.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre Hospitalier Universitaire, Besan\u00e7on, France", 
          "id": "http://www.grid.ac/institutes/grid.411158.8", 
          "name": [
            "Department of Medicine, Centre Hospitalier Universitaire, Besan\u00e7on, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pivot", 
        "givenName": "X", 
        "id": "sg:person.0717173510.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717173510.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre G.F. Leclerc, Dijon, France", 
          "id": "http://www.grid.ac/institutes/grid.418037.9", 
          "name": [
            "Department of Medicine, Centre G.F. Leclerc, Dijon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coudert", 
        "givenName": "B", 
        "id": "sg:person.0727212634.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727212634.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Centre Ren\u00e9 Gauducheau, Nantes, France", 
          "id": "http://www.grid.ac/institutes/grid.418191.4", 
          "name": [
            "Department of Medicine, Centre Ren\u00e9 Gauducheau, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Douillard", 
        "givenName": "J-Y", 
        "id": "sg:person.0603666346.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603666346.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Institut de Canc\u00e9rologie de la Loire, Saint-Etienne, France", 
          "id": "http://www.grid.ac/institutes/grid.488279.8", 
          "name": [
            "Department of Medicine, Institut de Canc\u00e9rologie de la Loire, Saint-Etienne, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Merrouche", 
        "givenName": "Y", 
        "id": "sg:person.01311315124.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311315124.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France", 
          "id": "http://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fizazi", 
        "givenName": "K", 
        "id": "sg:person.01126535135.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126535135.46"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2007-09-18", 
    "datePublishedReg": "2007-09-18", 
    "description": "Carcinomas of an unknown primary site (CUP) are heterogeneous tumours with a median survival of only 8 months. Tyrosine kinase inhibitors are promising new drugs. The aim of this study was to determine the expression of EGF-receptor, Her-2/neu, and c-Kit tyrosine kinases in CUP. Paraffin-embedded specimens were obtained from 54 patients with a CUP who were included in the GEFCAPI 01 randomised phase II trial. Immunohistochemistry was performed using the Dako autostainer with antibodies directed against HER-2/neu protein, EGFR protein, and c-Kit protein (CD117). EGFR expression was found in 36 out of 54 samples (66%). In contrast, Her-2/neu overexpression and c-Kit positivity were only detected in 4 and 10% of patients, respectively. No significant association was found between the expression of the tyrosine kinase receptors and prognosis. EGFR expression was significantly associated with response to cisplatin-based chemotherapy: the response rates were 50 and 22% in patients with EGFR-positive tumours and EGFR-negative tumours, respectively (P<0.05). This study shows that EGFR is frequently expressed in CUP. This finding may prompt clinical trials investigating EGFR inhibitors in this setting. In contrast, c-Kit expression and Her-2/neu overexpression occur infrequently in CUP. EGFR expression was correlated to tumour chemosensitivity.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.bjc.6603942", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "97"
      }
    ], 
    "keywords": [
      "HER-2/neu", 
      "EGFR expression", 
      "neu overexpression", 
      "HER-2/neu overexpression", 
      "EGFR-negative tumors", 
      "unknown primary site", 
      "phase II trial", 
      "cisplatin-based chemotherapy", 
      "tyrosine kinase inhibitors", 
      "c-kit positivity", 
      "EGFR-positive tumors", 
      "c-kit tyrosine kinase", 
      "c-kit expression", 
      "c-kit protein", 
      "II trial", 
      "median survival", 
      "tyrosine kinase receptors", 
      "unknown primary", 
      "clinical trials", 
      "response rate", 
      "primary site", 
      "neu protein", 
      "significant association", 
      "EGFR inhibitors", 
      "heterogeneous tumors", 
      "Dako Autostainer", 
      "patients", 
      "kinase inhibitors", 
      "tumors", 
      "new drugs", 
      "potential target", 
      "kinase receptors", 
      "EGFR protein", 
      "carcinoma", 
      "EGF receptor", 
      "neu", 
      "trials", 
      "receptors", 
      "tyrosine kinase", 
      "expression", 
      "inhibitors", 
      "overexpression", 
      "chemotherapy", 
      "prognosis", 
      "therapy", 
      "immunohistochemistry", 
      "chemosensitivity", 
      "EGFR", 
      "protein", 
      "months", 
      "autostainer", 
      "antibodies", 
      "positivity", 
      "drugs", 
      "survival", 
      "cup", 
      "study", 
      "association", 
      "paraffin", 
      "contrast", 
      "primary", 
      "aim", 
      "findings", 
      "setting", 
      "response", 
      "kinase", 
      "target", 
      "specimens", 
      "rate", 
      "tyrosine", 
      "samples", 
      "sites"
    ], 
    "name": "Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy?", 
    "pagination": "857-861", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011514429"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6603942"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17876336"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6603942", 
      "https://app.dimensions.ai/details/publication/pub.1011514429"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.bjc.6603942"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603942'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603942'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603942'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603942'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      20 PREDICATES      113 URIs      105 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6603942 schema:about N07718b18985643b5a927a3c4c96b8ee0
2 N0de6294654b04916aacd6b5ded6a30b0
3 N13026907e38d4204afdae917269bd86b
4 N28bb8f1897534de988b7e4d0f1277dbf
5 N45ff2140e9be4694b622491a02dbbdf6
6 N4a81a593e6d3483d8eb19b473432c34d
7 N526716646ec04e1e9d0fdefabb7a5f5d
8 N76f52ef0a03041b6985f10eed394c5ef
9 N8b874b9f7e5b4b2293186c38e343e56f
10 Na003933dd51d48c99be1eec773dacb0e
11 Na1b5fd1584a84854a1eb8d1dc6ef14b5
12 Nbecad8ecc80b45cf857e9d93aa9c1ce5
13 Nce3bdf9429c44ce191844fd458e80b30
14 Ndb2c8d72226e467d82f129cb7246ff11
15 Ne73fdfb616314f488ec9e958099cadee
16 Nf96338000adc4fb08d5d7045f57368fb
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N6219c5ebe2c54fbc90453ed00af1e6c1
20 schema:datePublished 2007-09-18
21 schema:datePublishedReg 2007-09-18
22 schema:description Carcinomas of an unknown primary site (CUP) are heterogeneous tumours with a median survival of only 8 months. Tyrosine kinase inhibitors are promising new drugs. The aim of this study was to determine the expression of EGF-receptor, Her-2/neu, and c-Kit tyrosine kinases in CUP. Paraffin-embedded specimens were obtained from 54 patients with a CUP who were included in the GEFCAPI 01 randomised phase II trial. Immunohistochemistry was performed using the Dako autostainer with antibodies directed against HER-2/neu protein, EGFR protein, and c-Kit protein (CD117). EGFR expression was found in 36 out of 54 samples (66%). In contrast, Her-2/neu overexpression and c-Kit positivity were only detected in 4 and 10% of patients, respectively. No significant association was found between the expression of the tyrosine kinase receptors and prognosis. EGFR expression was significantly associated with response to cisplatin-based chemotherapy: the response rates were 50 and 22% in patients with EGFR-positive tumours and EGFR-negative tumours, respectively (P<0.05). This study shows that EGFR is frequently expressed in CUP. This finding may prompt clinical trials investigating EGFR inhibitors in this setting. In contrast, c-Kit expression and Her-2/neu overexpression occur infrequently in CUP. EGFR expression was correlated to tumour chemosensitivity.
23 schema:genre article
24 schema:isAccessibleForFree true
25 schema:isPartOf Nb318b902931e4d229855cfb9790d77df
26 Nff530626525240e9bc1d6ac58d1ba798
27 sg:journal.1017082
28 schema:keywords Dako Autostainer
29 EGF receptor
30 EGFR
31 EGFR expression
32 EGFR inhibitors
33 EGFR protein
34 EGFR-negative tumors
35 EGFR-positive tumors
36 HER-2/neu
37 HER-2/neu overexpression
38 II trial
39 aim
40 antibodies
41 association
42 autostainer
43 c-kit expression
44 c-kit positivity
45 c-kit protein
46 c-kit tyrosine kinase
47 carcinoma
48 chemosensitivity
49 chemotherapy
50 cisplatin-based chemotherapy
51 clinical trials
52 contrast
53 cup
54 drugs
55 expression
56 findings
57 heterogeneous tumors
58 immunohistochemistry
59 inhibitors
60 kinase
61 kinase inhibitors
62 kinase receptors
63 median survival
64 months
65 neu
66 neu overexpression
67 neu protein
68 new drugs
69 overexpression
70 paraffin
71 patients
72 phase II trial
73 positivity
74 potential target
75 primary
76 primary site
77 prognosis
78 protein
79 rate
80 receptors
81 response
82 response rate
83 samples
84 setting
85 significant association
86 sites
87 specimens
88 study
89 survival
90 target
91 therapy
92 trials
93 tumors
94 tyrosine
95 tyrosine kinase
96 tyrosine kinase inhibitors
97 tyrosine kinase receptors
98 unknown primary
99 unknown primary site
100 schema:name Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy?
101 schema:pagination 857-861
102 schema:productId N21a010400b47403fbc089f5d21a0e7a3
103 N63c862652cff45b09f64d81f5d5823e7
104 Neef0a63f4ad440fbb883f579bf9dd574
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011514429
106 https://doi.org/10.1038/sj.bjc.6603942
107 schema:sdDatePublished 2022-09-02T15:51
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N857180ba0b014793b5c38090118d1cf2
110 schema:url https://doi.org/10.1038/sj.bjc.6603942
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N07718b18985643b5a927a3c4c96b8ee0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N0de6294654b04916aacd6b5ded6a30b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adult
119 rdf:type schema:DefinedTerm
120 N100b2c4c32df49d4baa9277b0686a1c4 rdf:first sg:person.013607432017.21
121 rdf:rest N56233f0c75bf44b9b58869d3a994e8ba
122 N13026907e38d4204afdae917269bd86b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Prospective Studies
124 rdf:type schema:DefinedTerm
125 N21a010400b47403fbc089f5d21a0e7a3 schema:name pubmed_id
126 schema:value 17876336
127 rdf:type schema:PropertyValue
128 N28bb8f1897534de988b7e4d0f1277dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Proto-Oncogene Proteins c-kit
130 rdf:type schema:DefinedTerm
131 N33f1efa4f0d64e63acf1372000410c42 rdf:first sg:person.0730534622.96
132 rdf:rest N78544cc40bf94f68bcd0c23f5ec62360
133 N3fd2dea7d0b2411298356e3941ff1733 rdf:first sg:person.0766536565.31
134 rdf:rest N50f96469adcf467486e0b41778a8ac8f
135 N43665e36c1624f5894256f47058c0aca rdf:first sg:person.0626363216.61
136 rdf:rest N100b2c4c32df49d4baa9277b0686a1c4
137 N45ff2140e9be4694b622491a02dbbdf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Survival Rate
139 rdf:type schema:DefinedTerm
140 N4639aedadffd4469901b19d11b92c931 rdf:first sg:person.01130363736.78
141 rdf:rest N43665e36c1624f5894256f47058c0aca
142 N4a81a593e6d3483d8eb19b473432c34d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 N50f96469adcf467486e0b41778a8ac8f rdf:first sg:person.01315625314.27
146 rdf:rest Nc061bca0446a45d68ae35749bff367af
147 N526716646ec04e1e9d0fdefabb7a5f5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Aged
149 rdf:type schema:DefinedTerm
150 N56233f0c75bf44b9b58869d3a994e8ba rdf:first sg:person.01302261163.11
151 rdf:rest Nddc2e6d1d1584083acbd31fe0fdf9fe3
152 N571d1d64d36845d9896c32101e5e4a1f rdf:first sg:person.0727212634.00
153 rdf:rest Ndbce9b818c50428ab4d3ba2523899685
154 N6219c5ebe2c54fbc90453ed00af1e6c1 rdf:first sg:person.0602371716.50
155 rdf:rest N3fd2dea7d0b2411298356e3941ff1733
156 N63c862652cff45b09f64d81f5d5823e7 schema:name dimensions_id
157 schema:value pub.1011514429
158 rdf:type schema:PropertyValue
159 N76f52ef0a03041b6985f10eed394c5ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Neoplasm Staging
161 rdf:type schema:DefinedTerm
162 N78544cc40bf94f68bcd0c23f5ec62360 rdf:first sg:person.0717173510.96
163 rdf:rest N571d1d64d36845d9896c32101e5e4a1f
164 N801e6f3ad0a5498199ed73122510c300 rdf:first sg:person.01311315124.71
165 rdf:rest Ncd216d8f8db54884bca200d413779f06
166 N857180ba0b014793b5c38090118d1cf2 schema:name Springer Nature - SN SciGraph project
167 rdf:type schema:Organization
168 N8b874b9f7e5b4b2293186c38e343e56f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Receptor, ErbB-2
170 rdf:type schema:DefinedTerm
171 Na003933dd51d48c99be1eec773dacb0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Prognosis
173 rdf:type schema:DefinedTerm
174 Na1b5fd1584a84854a1eb8d1dc6ef14b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name ErbB Receptors
176 rdf:type schema:DefinedTerm
177 Nb318b902931e4d229855cfb9790d77df schema:volumeNumber 97
178 rdf:type schema:PublicationVolume
179 Nbecad8ecc80b45cf857e9d93aa9c1ce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Neoplasms, Unknown Primary
181 rdf:type schema:DefinedTerm
182 Nc061bca0446a45d68ae35749bff367af rdf:first sg:person.01135615153.17
183 rdf:rest N4639aedadffd4469901b19d11b92c931
184 Ncd216d8f8db54884bca200d413779f06 rdf:first sg:person.01126535135.46
185 rdf:rest rdf:nil
186 Nce3bdf9429c44ce191844fd458e80b30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Female
188 rdf:type schema:DefinedTerm
189 Ndb2c8d72226e467d82f129cb7246ff11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Biomarkers, Tumor
191 rdf:type schema:DefinedTerm
192 Ndbce9b818c50428ab4d3ba2523899685 rdf:first sg:person.0603666346.79
193 rdf:rest N801e6f3ad0a5498199ed73122510c300
194 Nddc2e6d1d1584083acbd31fe0fdf9fe3 rdf:first sg:person.0725456003.16
195 rdf:rest N33f1efa4f0d64e63acf1372000410c42
196 Ne73fdfb616314f488ec9e958099cadee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Carcinoma, Papillary
198 rdf:type schema:DefinedTerm
199 Neef0a63f4ad440fbb883f579bf9dd574 schema:name doi
200 schema:value 10.1038/sj.bjc.6603942
201 rdf:type schema:PropertyValue
202 Nf96338000adc4fb08d5d7045f57368fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Middle Aged
204 rdf:type schema:DefinedTerm
205 Nff530626525240e9bc1d6ac58d1ba798 schema:issueNumber 7
206 rdf:type schema:PublicationIssue
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
211 schema:name Clinical Sciences
212 rdf:type schema:DefinedTerm
213 sg:journal.1017082 schema:issn 0007-0920
214 1532-1827
215 schema:name British Journal of Cancer
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.01126535135.46 schema:affiliation grid-institutes:grid.14925.3b
219 schema:familyName Fizazi
220 schema:givenName K
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126535135.46
222 rdf:type schema:Person
223 sg:person.01130363736.78 schema:affiliation grid-institutes:grid.418191.4
224 schema:familyName Lortholary
225 schema:givenName A
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130363736.78
227 rdf:type schema:Person
228 sg:person.01135615153.17 schema:affiliation grid-institutes:grid.418189.d
229 schema:familyName Culine
230 schema:givenName S
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135615153.17
232 rdf:type schema:Person
233 sg:person.01302261163.11 schema:affiliation grid-institutes:None
234 schema:familyName Priou
235 schema:givenName F
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302261163.11
237 rdf:type schema:Person
238 sg:person.01311315124.71 schema:affiliation grid-institutes:grid.488279.8
239 schema:familyName Merrouche
240 schema:givenName Y
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311315124.71
242 rdf:type schema:Person
243 sg:person.01315625314.27 schema:affiliation grid-institutes:grid.14925.3b
244 schema:familyName Laplanche
245 schema:givenName A
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315625314.27
247 rdf:type schema:Person
248 sg:person.013607432017.21 schema:affiliation grid-institutes:grid.14925.3b
249 schema:familyName Theodore
250 schema:givenName C
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013607432017.21
252 rdf:type schema:Person
253 sg:person.0602371716.50 schema:affiliation grid-institutes:grid.14925.3b
254 schema:familyName Massard
255 schema:givenName C
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602371716.50
257 rdf:type schema:Person
258 sg:person.0603666346.79 schema:affiliation grid-institutes:grid.418191.4
259 schema:familyName Douillard
260 schema:givenName J-Y
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603666346.79
262 rdf:type schema:Person
263 sg:person.0626363216.61 schema:affiliation grid-institutes:grid.417829.1
264 schema:familyName Bugat
265 schema:givenName R
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626363216.61
267 rdf:type schema:Person
268 sg:person.0717173510.96 schema:affiliation grid-institutes:grid.411158.8
269 schema:familyName Pivot
270 schema:givenName X
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717173510.96
272 rdf:type schema:Person
273 sg:person.0725456003.16 schema:affiliation grid-institutes:grid.410527.5
274 schema:familyName Kaminsky
275 schema:givenName M-C
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725456003.16
277 rdf:type schema:Person
278 sg:person.0727212634.00 schema:affiliation grid-institutes:grid.418037.9
279 schema:familyName Coudert
280 schema:givenName B
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727212634.00
282 rdf:type schema:Person
283 sg:person.0730534622.96 schema:affiliation grid-institutes:grid.417988.b
284 schema:familyName Lesimple
285 schema:givenName T
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730534622.96
287 rdf:type schema:Person
288 sg:person.0766536565.31 schema:affiliation grid-institutes:grid.417829.1
289 schema:familyName Voigt
290 schema:givenName J-J
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766536565.31
292 rdf:type schema:Person
293 grid-institutes:None schema:alternateName Department of Medicine, Centre Hospitalier La Roche/Yon, La Roche/Yon, France
294 schema:name Department of Medicine, Centre Hospitalier La Roche/Yon, La Roche/Yon, France
295 rdf:type schema:Organization
296 grid-institutes:grid.14925.3b schema:alternateName Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France
297 Department of Statistics, Institut Gustave Roussy, Villejuif, France
298 schema:name Department of Medicine, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif, France
299 Department of Statistics, Institut Gustave Roussy, Villejuif, France
300 rdf:type schema:Organization
301 grid-institutes:grid.410527.5 schema:alternateName Department of Medicine Centre Alexis Vautrin, Nancy, France
302 schema:name Department of Medicine Centre Alexis Vautrin, Nancy, France
303 rdf:type schema:Organization
304 grid-institutes:grid.411158.8 schema:alternateName Department of Medicine, Centre Hospitalier Universitaire, Besançon, France
305 schema:name Department of Medicine, Centre Hospitalier Universitaire, Besançon, France
306 rdf:type schema:Organization
307 grid-institutes:grid.417829.1 schema:alternateName Department of Medicine, Institut Claudius Regaud, Toulouse, France
308 Department of Pathology, Centre Claudius Regaud, Toulouse, France
309 schema:name Department of Medicine, Institut Claudius Regaud, Toulouse, France
310 Department of Pathology, Centre Claudius Regaud, Toulouse, France
311 rdf:type schema:Organization
312 grid-institutes:grid.417988.b schema:alternateName Department of Medicine, Centre Eugène Marquis, Rennes, France
313 schema:name Department of Medicine, Centre Eugène Marquis, Rennes, France
314 rdf:type schema:Organization
315 grid-institutes:grid.418037.9 schema:alternateName Department of Medicine, Centre G.F. Leclerc, Dijon, France
316 schema:name Department of Medicine, Centre G.F. Leclerc, Dijon, France
317 rdf:type schema:Organization
318 grid-institutes:grid.418189.d schema:alternateName Department of Medicine, Centre Val d'Aurelle, Montpellier, France
319 schema:name Department of Medicine, Centre Val d'Aurelle, Montpellier, France
320 rdf:type schema:Organization
321 grid-institutes:grid.418191.4 schema:alternateName Department of Medicine, Centre Paul Papin, Anger, France
322 Department of Medicine, Centre René Gauducheau, Nantes, France
323 schema:name Department of Medicine, Centre Paul Papin, Anger, France
324 Department of Medicine, Centre René Gauducheau, Nantes, France
325 rdf:type schema:Organization
326 grid-institutes:grid.488279.8 schema:alternateName Department of Medicine, Institut de Cancérologie de la Loire, Saint-Etienne, France
327 schema:name Department of Medicine, Institut de Cancérologie de la Loire, Saint-Etienne, France
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...