Interleukin-6 gene amplification and shortened survival in glioblastoma patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-02

AUTHORS

A Tchirkov, T Khalil, E Chautard, K Mokhtari, L Véronèse, B Irthum, P Vago, J-L Kémény, P Verrelle

ABSTRACT

Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival.

PAGES

6603586

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603586

DOI

http://dx.doi.org/10.1038/sj.bjc.6603586

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047560907

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17224923


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