Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01-23

AUTHORS

H Noda, Y Miyaji, A Nakanishi, F Konishi, Y Miki

ABSTRACT

Recent studies have suggested that epigenetic inactivation of tumour-related genes by promoter methylation participates in the development of gastric cancer. We newly identified the frequently aberrant promoter methylation of alpha-1B-adrenergic receptor (ADRA1B) in colorectal cancer by methylation-sensitive representational difference analysis (MS-RDA) and examined the methylation status of the ADRA1B promoter in 34 paired samples of colorectal cancer and surrounding epithelial tissue, and 34 paired samples of gastric cancer and surrounding epithelial tissue. In colorectal cancers, only four of 34 (11.8%) tumours showed ADRA1B promoter methylation. In contrast, ADRA1B promoter methylation was detected in 24 of 34 (70.6%) gastric cancers and in 14 of 34 (41.2%) surrounding epithelial tissues. The frequency of ADRA1B promoter methylation was higher in gastric epithelial tissues with intestinal metaplasia (41.6%) than in those without intestinal metaplasia (25.0%). Reverse transcription–PCR detected reduced ADRA1B expression in 12 of 18 (66.7%) gastric cancers, and its promoter methylation was detected in 11 of these 12 (91.7%) gastric cancers with reduced ADRA1B expression. Thus, ADRA1B promoter is frequently methylated in gastric cancer. Our results suggest that the ADRA1B gene is an important tumour-related gene frequently involved in the development and progression of gastric cancer. More... »

PAGES

383-390

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603555

DOI

http://dx.doi.org/10.1038/sj.bjc.6603555

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007035574

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17242706


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Adrenergic, alpha-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
            "Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noda", 
        "givenName": "H", 
        "id": "sg:person.01146404317.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146404317.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyaji", 
        "givenName": "Y", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakanishi", 
        "givenName": "A", 
        "id": "sg:person.0674046432.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674046432.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konishi", 
        "givenName": "F", 
        "id": "sg:person.01272216415.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272216415.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
            "Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miki", 
        "givenName": "Y", 
        "id": "sg:person.01006505566.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006505566.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1207932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025339350", 
          "https://doi.org/10.1038/sj.onc.1207932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033439560", 
          "https://doi.org/10.1038/sj.onc.1204940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.lab.0000067481.08984.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019671818", 
          "https://doi.org/10.1097/01.lab.0000067481.08984.3f"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045401391", 
          "https://doi.org/10.1038/sj.onc.1206799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045593549", 
          "https://doi.org/10.1038/sj.onc.1206403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001180407", 
          "https://doi.org/10.1038/labinvest.3780072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0795-686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016345098", 
          "https://doi.org/10.1038/nm0795-686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032292099", 
          "https://doi.org/10.1038/labinvest.3700060"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-01-23", 
    "datePublishedReg": "2007-01-23", 
    "description": "Recent studies have suggested that epigenetic inactivation of tumour-related genes by promoter methylation participates in the development of gastric cancer. We newly identified the frequently aberrant promoter methylation of alpha-1B-adrenergic receptor (ADRA1B) in colorectal cancer by methylation-sensitive representational difference analysis (MS-RDA) and examined the methylation status of the ADRA1B promoter in 34 paired samples of colorectal cancer and surrounding epithelial tissue, and 34 paired samples of gastric cancer and surrounding epithelial tissue. In colorectal cancers, only four of 34 (11.8%) tumours showed ADRA1B promoter methylation. In contrast, ADRA1B promoter methylation was detected in 24 of 34 (70.6%) gastric cancers and in 14 of 34 (41.2%) surrounding epithelial tissues. The frequency of ADRA1B promoter methylation was higher in gastric epithelial tissues with intestinal metaplasia (41.6%) than in those without intestinal metaplasia (25.0%). Reverse transcription\u2013PCR detected reduced ADRA1B expression in 12 of 18 (66.7%) gastric cancers, and its promoter methylation was detected in 11 of these 12 (91.7%) gastric cancers with reduced ADRA1B expression. Thus, ADRA1B promoter is frequently methylated in gastric cancer. Our results suggest that the ADRA1B gene is an important tumour-related gene frequently involved in the development and progression of gastric cancer.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.bjc.6603555", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "96"
      }
    ], 
    "keywords": [
      "gastric cancer", 
      "colorectal cancer", 
      "intestinal metaplasia", 
      "aberrant promoter methylation", 
      "promoter methylation", 
      "alpha 1B", 
      "adrenergic receptors", 
      "tumor-related genes", 
      "epithelial tissues", 
      "gastric epithelial tissues", 
      "cancer", 
      "reduced expression", 
      "transcription-PCR", 
      "metaplasia", 
      "tissue", 
      "epigenetic inactivation", 
      "receptors", 
      "methylation status", 
      "Recent studies", 
      "representational difference analysis", 
      "expression", 
      "tumors", 
      "important tumor-related genes", 
      "progression", 
      "genes", 
      "difference analysis", 
      "methylation", 
      "methylation-sensitive representational difference analysis", 
      "status", 
      "promoter", 
      "inactivation", 
      "samples", 
      "development", 
      "study", 
      "contrast", 
      "frequency", 
      "analysis", 
      "results"
    ], 
    "name": "Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers", 
    "pagination": "383-390", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007035574"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6603555"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17242706"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6603555", 
      "https://app.dimensions.ai/details/publication/pub.1007035574"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_432.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.bjc.6603555"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603555'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603555'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603555'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603555'


 

This table displays all metadata directly associated to this object as RDF triples.

211 TRIPLES      22 PREDICATES      83 URIs      67 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6603555 schema:about N18bff6e6d63a44fba26d112c4f1d09ee
2 N2c8ecbdeb2c54bf4ba1321f955cbad9e
3 N586db80b9ffb4966bdca6a8e74301a80
4 N9699d6460c2f40f1b90a7311a6783fe4
5 Na1869cc62967461aad12cc0962960f4d
6 Na77fc079b5164cc09863f986f1843082
7 Ndd5528028f404a1099f72902bebcf3d8
8 Ndffadbfebb8e421ab74becc447986036
9 Ne03db9bb0a3a4662a3a2626bcab0af46
10 Neac681a6bfc0478d80dcf26d33594a74
11 Nf6165a7872b840bba1addf075a72afcb
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author Nba69784380214dd89f4cd9846a3a6822
15 schema:citation sg:pub.10.1038/labinvest.3700060
16 sg:pub.10.1038/labinvest.3780072
17 sg:pub.10.1038/nm0795-686
18 sg:pub.10.1038/sj.onc.1204940
19 sg:pub.10.1038/sj.onc.1206403
20 sg:pub.10.1038/sj.onc.1206799
21 sg:pub.10.1038/sj.onc.1207932
22 sg:pub.10.1097/01.lab.0000067481.08984.3f
23 schema:datePublished 2007-01-23
24 schema:datePublishedReg 2007-01-23
25 schema:description Recent studies have suggested that epigenetic inactivation of tumour-related genes by promoter methylation participates in the development of gastric cancer. We newly identified the frequently aberrant promoter methylation of alpha-1B-adrenergic receptor (ADRA1B) in colorectal cancer by methylation-sensitive representational difference analysis (MS-RDA) and examined the methylation status of the ADRA1B promoter in 34 paired samples of colorectal cancer and surrounding epithelial tissue, and 34 paired samples of gastric cancer and surrounding epithelial tissue. In colorectal cancers, only four of 34 (11.8%) tumours showed ADRA1B promoter methylation. In contrast, ADRA1B promoter methylation was detected in 24 of 34 (70.6%) gastric cancers and in 14 of 34 (41.2%) surrounding epithelial tissues. The frequency of ADRA1B promoter methylation was higher in gastric epithelial tissues with intestinal metaplasia (41.6%) than in those without intestinal metaplasia (25.0%). Reverse transcription–PCR detected reduced ADRA1B expression in 12 of 18 (66.7%) gastric cancers, and its promoter methylation was detected in 11 of these 12 (91.7%) gastric cancers with reduced ADRA1B expression. Thus, ADRA1B promoter is frequently methylated in gastric cancer. Our results suggest that the ADRA1B gene is an important tumour-related gene frequently involved in the development and progression of gastric cancer.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree true
29 schema:isPartOf N73f70d4c142846e1aaac441331822a30
30 Nbf360954899640b4947a95e15cae5001
31 sg:journal.1017082
32 schema:keywords Recent studies
33 aberrant promoter methylation
34 adrenergic receptors
35 alpha 1B
36 analysis
37 cancer
38 colorectal cancer
39 contrast
40 development
41 difference analysis
42 epigenetic inactivation
43 epithelial tissues
44 expression
45 frequency
46 gastric cancer
47 gastric epithelial tissues
48 genes
49 important tumor-related genes
50 inactivation
51 intestinal metaplasia
52 metaplasia
53 methylation
54 methylation status
55 methylation-sensitive representational difference analysis
56 progression
57 promoter
58 promoter methylation
59 receptors
60 reduced expression
61 representational difference analysis
62 results
63 samples
64 status
65 study
66 tissue
67 transcription-PCR
68 tumor-related genes
69 tumors
70 schema:name Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers
71 schema:pagination 383-390
72 schema:productId N302d8dfdda454e529c8a55d21b72a61a
73 Nb305c840f60846338ca8e83881e79d09
74 Nce7883b60f87477ab120af0b215abcd6
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007035574
76 https://doi.org/10.1038/sj.bjc.6603555
77 schema:sdDatePublished 2022-05-20T07:24
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N6960b77a156f43a4804bed0b0277906f
80 schema:url https://doi.org/10.1038/sj.bjc.6603555
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0a007c8ebe0642d592f00cdd05a75f8c rdf:first sg:person.01272216415.22
85 rdf:rest N5465f60cb88f44f8b96b37f82486b610
86 N0a36a8aa07044dc08c88d8517c5c3ba1 rdf:first Nb4563282a9d24645ad9c06a7b79eee6e
87 rdf:rest Na4fe6075549a4b51b6f22f18875db1db
88 N18bff6e6d63a44fba26d112c4f1d09ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Receptors, Adrenergic, alpha-1
90 rdf:type schema:DefinedTerm
91 N2c8ecbdeb2c54bf4ba1321f955cbad9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Colorectal Neoplasms
93 rdf:type schema:DefinedTerm
94 N302d8dfdda454e529c8a55d21b72a61a schema:name pubmed_id
95 schema:value 17242706
96 rdf:type schema:PropertyValue
97 N5465f60cb88f44f8b96b37f82486b610 rdf:first sg:person.01006505566.74
98 rdf:rest rdf:nil
99 N586db80b9ffb4966bdca6a8e74301a80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name DNA Methylation
101 rdf:type schema:DefinedTerm
102 N6960b77a156f43a4804bed0b0277906f schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N73f70d4c142846e1aaac441331822a30 schema:volumeNumber 96
105 rdf:type schema:PublicationVolume
106 N9699d6460c2f40f1b90a7311a6783fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Loss of Heterozygosity
108 rdf:type schema:DefinedTerm
109 Na1869cc62967461aad12cc0962960f4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Promoter Regions, Genetic
111 rdf:type schema:DefinedTerm
112 Na4fe6075549a4b51b6f22f18875db1db rdf:first sg:person.0674046432.82
113 rdf:rest N0a007c8ebe0642d592f00cdd05a75f8c
114 Na77fc079b5164cc09863f986f1843082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Chromosomes, Human, Pair 5
116 rdf:type schema:DefinedTerm
117 Nb305c840f60846338ca8e83881e79d09 schema:name dimensions_id
118 schema:value pub.1007035574
119 rdf:type schema:PropertyValue
120 Nb4563282a9d24645ad9c06a7b79eee6e schema:affiliation grid-institutes:grid.410807.a
121 schema:familyName Miyaji
122 schema:givenName Y
123 rdf:type schema:Person
124 Nba69784380214dd89f4cd9846a3a6822 rdf:first sg:person.01146404317.27
125 rdf:rest N0a36a8aa07044dc08c88d8517c5c3ba1
126 Nbf360954899640b4947a95e15cae5001 schema:issueNumber 2
127 rdf:type schema:PublicationIssue
128 Nce7883b60f87477ab120af0b215abcd6 schema:name doi
129 schema:value 10.1038/sj.bjc.6603555
130 rdf:type schema:PropertyValue
131 Ndd5528028f404a1099f72902bebcf3d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Base Sequence
133 rdf:type schema:DefinedTerm
134 Ndffadbfebb8e421ab74becc447986036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Reverse Transcriptase Polymerase Chain Reaction
136 rdf:type schema:DefinedTerm
137 Ne03db9bb0a3a4662a3a2626bcab0af46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Stomach Neoplasms
139 rdf:type schema:DefinedTerm
140 Neac681a6bfc0478d80dcf26d33594a74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name DNA Primers
142 rdf:type schema:DefinedTerm
143 Nf6165a7872b840bba1addf075a72afcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
150 schema:name Oncology and Carcinogenesis
151 rdf:type schema:DefinedTerm
152 sg:journal.1017082 schema:issn 0007-0920
153 1532-1827
154 schema:name British Journal of Cancer
155 schema:publisher Springer Nature
156 rdf:type schema:Periodical
157 sg:person.01006505566.74 schema:affiliation grid-institutes:grid.265073.5
158 schema:familyName Miki
159 schema:givenName Y
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006505566.74
161 rdf:type schema:Person
162 sg:person.01146404317.27 schema:affiliation grid-institutes:None
163 schema:familyName Noda
164 schema:givenName H
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146404317.27
166 rdf:type schema:Person
167 sg:person.01272216415.22 schema:affiliation grid-institutes:None
168 schema:familyName Konishi
169 schema:givenName F
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272216415.22
171 rdf:type schema:Person
172 sg:person.0674046432.82 schema:affiliation grid-institutes:grid.410807.a
173 schema:familyName Nakanishi
174 schema:givenName A
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674046432.82
176 rdf:type schema:Person
177 sg:pub.10.1038/labinvest.3700060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032292099
178 https://doi.org/10.1038/labinvest.3700060
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/labinvest.3780072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001180407
181 https://doi.org/10.1038/labinvest.3780072
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nm0795-686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016345098
184 https://doi.org/10.1038/nm0795-686
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/sj.onc.1204940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033439560
187 https://doi.org/10.1038/sj.onc.1204940
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/sj.onc.1206403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045593549
190 https://doi.org/10.1038/sj.onc.1206403
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/sj.onc.1206799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045401391
193 https://doi.org/10.1038/sj.onc.1206799
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/sj.onc.1207932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025339350
196 https://doi.org/10.1038/sj.onc.1207932
197 rdf:type schema:CreativeWork
198 sg:pub.10.1097/01.lab.0000067481.08984.3f schema:sameAs https://app.dimensions.ai/details/publication/pub.1019671818
199 https://doi.org/10.1097/01.lab.0000067481.08984.3f
200 rdf:type schema:CreativeWork
201 grid-institutes:None schema:alternateName Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, Japan
202 schema:name Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan
203 Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, Japan
204 rdf:type schema:Organization
205 grid-institutes:grid.265073.5 schema:alternateName Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
206 schema:name Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan
207 Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
208 rdf:type schema:Organization
209 grid-institutes:grid.410807.a schema:alternateName Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan
210 schema:name Department of Molecular Diagnosis, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, 135-8550, Tokyo, Japan
211 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...