Arterial phase enhancement and body mass index are predictors of response to chemoembolisation for liver metastases of endocrine tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12-12

AUTHORS

F Marrache, M P Vullierme, C Roy, Y El Assoued, A Couvelard, D O'Toole, E Mitry, O Hentic, P Hammel, P Lévy, P Ravaud, P Rougier, P Ruszniewski

ABSTRACT

Transcatheter arterial chemoembolisation (TACE) has been reported to be an efficient treatment of liver metastases of endocrine tumours in short series of patients. However, several factors seem to affect its results. The aim of this work is to identify predictors of response to TACE for liver metastases of endocrine tumours. A total of 163 TACE procedures were performed in 67 patients between 1994 and 2004. Forty-four patients were treated with streptozotocin and 23 with doxorubicin. Primary tumour was located in the pancreas for 19 patients, and had been removed in 43. Thirty-eight tumours were functioning. Response rate was 37% (confidence interval [CI] 95%: 28-49%). Median time to progression (TTP) was 14.5 months (CI 95%: 9-41). In multivariate analysis (n=43), predictors of tumour response were body mass index (BMI) (odds ratio [OR]: 1.3; CI 95%: 1.04-1.63; P=0.022), functioning type of tumour (OR: 7.31; CI 95%: 1.26-42.5; P=0.027), arterial phase enhancement on abdominal computed tomography (CT) (OR: 8.11; CI 95%:1.06-62; P=0.044) and use of streptozotocin for cytotoxic agent (OR: 21.3; CI 95%: 1.48-306; P=0.025). Analysis of TTP predictors showed that BMI (hazard ratio [HR]: 0.85; CI 95%: 0.76-0.86; P=0.01) and arterial phase enhancement (HR: 0.3; CI 95%: 0.12-0.73; P=0.008) were associated with delayed progression. This large study confirms the previously reported results of TACE regarding its efficacy for the treatment of liver metastases of endocrine tumours. Arterial phase enhancement on abdominal CT and BMI are predictors of treatment's efficacy. Streptozotocin should be the preferred cytotoxic agent in order to save anthracycline for systemic chemotherapy. More... »

PAGES

49-55

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603526

DOI

http://dx.doi.org/10.1038/sj.bjc.6603526

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020529487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17164755


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32 schema:description Transcatheter arterial chemoembolisation (TACE) has been reported to be an efficient treatment of liver metastases of endocrine tumours in short series of patients. However, several factors seem to affect its results. The aim of this work is to identify predictors of response to TACE for liver metastases of endocrine tumours. A total of 163 TACE procedures were performed in 67 patients between 1994 and 2004. Forty-four patients were treated with streptozotocin and 23 with doxorubicin. Primary tumour was located in the pancreas for 19 patients, and had been removed in 43. Thirty-eight tumours were functioning. Response rate was 37% (confidence interval [CI] 95%: 28-49%). Median time to progression (TTP) was 14.5 months (CI 95%: 9-41). In multivariate analysis (n=43), predictors of tumour response were body mass index (BMI) (odds ratio [OR]: 1.3; CI 95%: 1.04-1.63; P=0.022), functioning type of tumour (OR: 7.31; CI 95%: 1.26-42.5; P=0.027), arterial phase enhancement on abdominal computed tomography (CT) (OR: 8.11; CI 95%:1.06-62; P=0.044) and use of streptozotocin for cytotoxic agent (OR: 21.3; CI 95%: 1.48-306; P=0.025). Analysis of TTP predictors showed that BMI (hazard ratio [HR]: 0.85; CI 95%: 0.76-0.86; P=0.01) and arterial phase enhancement (HR: 0.3; CI 95%: 0.12-0.73; P=0.008) were associated with delayed progression. This large study confirms the previously reported results of TACE regarding its efficacy for the treatment of liver metastases of endocrine tumours. Arterial phase enhancement on abdominal CT and BMI are predictors of treatment's efficacy. Streptozotocin should be the preferred cytotoxic agent in order to save anthracycline for systemic chemotherapy.
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41 abdominal computed tomography
42 agents
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45 anthracyclines
46 arterial chemoembolisation
47 arterial phase enhancement
48 body mass index
49 chemoembolisation
50 chemotherapy
51 computed tomography
52 cytotoxic agents
53 doxorubicin
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56 endocrine tumors
57 enhancement
58 factors
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61 liver metastases
62 mass index
63 median time
64 metastasis
65 months
66 multivariate analysis
67 order
68 pancreas
69 patients
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71 predictors
72 predictors of response
73 preferred cytotoxic agent
74 primary tumor
75 procedure
76 progression
77 rate
78 response
79 response rate
80 results
81 results of TACE
82 series
83 short series
84 streptozotocin
85 study
86 systemic chemotherapy
87 time
88 tomography
89 total
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91 treatment
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93 tumor response
94 tumors
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