ASPP: a new family of oncogenes and tumour suppressor genes View Full Text


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Article Info

DATE

2007-01

AUTHORS

A Sullivan, X Lu

ABSTRACT

The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1). So far, the best-known function of the ASPP family members is their ability to regulate the apoptotic function of p53 and its family members, p63 and p73. Biochemical and genetic evidence has shown that ASPP1 and ASPP2 activate, whereas iASPP inhibits, the apoptotic but not the cell-cycle arrest function of p53. The p53 tumour suppressor gene, one of the most frequently mutated genes in human cancer, is capable of suppressing tumour growth through its ability to induce apoptosis or cell-cycle arrest. Thus, the ASPP family of proteins helps to determine how cells choose to die and may therefore be a novel target for cancer therapy. More... »

PAGES

6603525

References to SciGraph publications

  • 2006-10. iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53 in NATURE GENETICS
  • 2005-04. Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene in CELL DEATH & DIFFERENTIATION
  • 2006-05. The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo in ONCOGENE
  • 2003-02. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human in NATURE GENETICS
  • 1999-09. NF-κB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2 in ONCOGENE
  • 2004-11. Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans in CELL DEATH & DIFFERENTIATION
  • 2005-04. ASPP1 and ASPP2 are new transcriptional targets of E2F in CELL DEATH & DIFFERENTIATION
  • 2004-12. Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors in NATURE MEDICINE
  • 2004-04. Abnormal mRNA expression of ASPP members in leukemia cell lines in LEUKEMIA
  • 2005-04. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F in CELL DEATH & DIFFERENTIATION
  • 2006-03. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia in ONCOGENE
  • 1995-07. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603525

    DOI

    http://dx.doi.org/10.1038/sj.bjc.6603525

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011233561

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17211478


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