Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-10

AUTHORS

E Miranda, A Destro, A Malesci, E Balladore, P Bianchi, E Baryshnikova, G Franchi, E Morenghi, L Laghi, L Gennari, M Roncalli

ABSTRACT

Colorectal cancer (CRC) develops as multistep process, which involves genetic and epigenetic alterations. K-Ras, p53 and B-Raf mutations and RASSF1A, E-Cadherin and p16INK4A promoter methylation were investigated in 202 CRCs with and without lymph node and/or liver metastasis, to assess whether gene abnormalities are related to a metastogenic phenotype. K-Ras, B-Raf and p53 mutations were detected in 27, 3 and 32% of the cases, with K-Ras mutations significantly associated with metastatic tumour (P=0.019). RASSF1A, E-Cadherin and p16INK4A methylation was documented in 20, 44 and 33% of the cases with p16INK4A significantly associated with metastatic tumours (P=0.001). Overall, out of 202 tumours, 34 (17%) did not show any molecular change, 125 (62%) had one or two and 43 (21%) three or more. Primary but yet metastatic CRCs were prevalent in the latter group (P=0.023) where the most frequent combination was one genetic (K-Ras in particular) and two epigenetic alterations. In conclusion, this analysis provided to detect some molecular differences between primary metastatic and nonmetastatic CRCs, with K-Ras and p16INK4A statistically altered in metastatic tumours; particular gene combinations, such as coincidental K-Ras mutation with two methylated genes are associated to a metastogenic phenotype. More... »

PAGES

1101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603337

DOI

http://dx.doi.org/10.1038/sj.bjc.6603337

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046481038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16969349


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