Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT–PCR detection of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-04

AUTHORS

L Tao, M Lefèvre, S Ricci, P Saintigny, P Callard, S Périé, R Lacave, J-F Bernaudin, J Lacau St Guily

ABSTRACT

The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 and 2005 were prospectively evaluated by routine haematoxylin-eosin-safran (HES) staining, immunohistochemistry (IHC) and real-time Taqman reverse-transcriptase polymerase chain reaction (real-time RT-PCR) assay. Amplification of cytokeratin 19 (CK19) mRNA transcripts using real-time RT-PCR was used to quantify cervical micrometastatic burden. The cervical lymph node metastatic rates determined by routine HES staining and real-time RT-PCR assay were 16.3 and 36.0%, respectively (P<0.0001). A potential change in the nodal status was observed in 13 (42.0%) of the 31 patients and an atypical pattern of lymphatic spread was identified in four patients (12.9%). Moreover, CK19 mRNA expression values in histologically positive lymph nodes were significantly higher than those observed in histologically negative lymph nodes (P<0.0001). These results indicate that real-time RT-PCR assay for the detection of CK19 mRNA is a sensitive and reliable method for the detection of carcinomatous cells in lymph nodes. This type of method could be used to reassess lymph node status according to occult lymphatic spread in patients with HNSCC. More... »

PAGES

6603073

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603073

DOI

http://dx.doi.org/10.1038/sj.bjc.6603073

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050488035

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16622440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Node Excision", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Eye & ENT Hospital of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.411079.a", 
          "name": [
            "Service d'ORL et Chirurgie Cervico-Faciale, Universit\u00e9 Pierre et Marie Curie, Paris VI, H\u00f4pital Tenon APHP, 4 rue de la Chine, Paris 75020, France", 
            "Histologie-Biologie Tumorale, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France", 
            "Department of Otolaryngology-HNS, Eye and ENT Hospital of Fudan University, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tao", 
        "givenName": "L", 
        "id": "sg:person.0614504473.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614504473.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Anatomie-Pathologique, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lef\u00e8vre", 
        "givenName": "M", 
        "id": "sg:person.01112674525.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112674525.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Histologie-Biologie Tumorale, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ricci", 
        "givenName": "S", 
        "id": "sg:person.01274454161.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274454161.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Histologie-Biologie Tumorale, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saintigny", 
        "givenName": "P", 
        "id": "sg:person.0766417314.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766417314.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Anatomie-Pathologique, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Callard", 
        "givenName": "P", 
        "id": "sg:person.01074403442.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074403442.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service d'ORL et Chirurgie Cervico-Faciale, Universit\u00e9 Pierre et Marie Curie, Paris VI, H\u00f4pital Tenon APHP, 4 rue de la Chine, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9ri\u00e9", 
        "givenName": "S", 
        "id": "sg:person.01231312040.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231312040.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Histologie-Biologie Tumorale, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacave", 
        "givenName": "R", 
        "id": "sg:person.01222250364.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222250364.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Histologie-Biologie Tumorale, EA 3499 Universit\u00e9 Pierre et Marie Curie Paris VI, H\u00f4pital Tenon APHP, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernaudin", 
        "givenName": "J-F", 
        "id": "sg:person.0630606100.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630606100.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service d'ORL et Chirurgie Cervico-Faciale, Universit\u00e9 Pierre et Marie Curie, Paris VI, H\u00f4pital Tenon APHP, 4 rue de la Chine, Paris 75020, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "St Guily", 
        "givenName": "J Lacau", 
        "id": "sg:person.016063465261.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016063465261.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archotol.130.8.937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001500420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(00)00574-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002494671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-8375(02)00049-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004191758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-8375(02)00049-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004191758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004886658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2004.09.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006465733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990105)80:1<119::aid-ijc22>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008261633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91386-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91386-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000027749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010535726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/msy.2000.100881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011002094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.130.1.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011688752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19991215)86:12<2668::aid-cncr11>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012182456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012940925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-199903000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014184712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-199903000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014184712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-199903000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014184712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-199903000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014184712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017107824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348940211100207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018789596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000348940211100207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018789596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.128.7.751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020788475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023692980", 
          "https://doi.org/10.1038/sj.bjc.6601248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023692980", 
          "https://doi.org/10.1038/sj.bjc.6601248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4975(01)02520-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029067509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990301)85:5<1098::aid-cncr13>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029620244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000071206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031964803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200305000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036009678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200305000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036009678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280000199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036211121", 
          "https://doi.org/10.1007/s004280000199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-59524-0_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037794192", 
          "https://doi.org/10.1007/978-3-642-59524-0_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200211000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038057149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005537-200211000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038057149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038465737", 
          "https://doi.org/10.1038/sj.bjc.6690377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038465737", 
          "https://doi.org/10.1038/sj.bjc.6690377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1054/bjom.1999.0037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039081048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)03566-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041828180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80554-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048713925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0347(199701)19:1<14::aid-hed3>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050920133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199710233371702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051683232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074500199", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074893521", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074963970", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082982251", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-04", 
    "datePublishedReg": "2006-04-01", 
    "description": "The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 and 2005 were prospectively evaluated by routine haematoxylin-eosin-safran (HES) staining, immunohistochemistry (IHC) and real-time Taqman reverse-transcriptase polymerase chain reaction (real-time RT-PCR) assay. Amplification of cytokeratin 19 (CK19) mRNA transcripts using real-time RT-PCR was used to quantify cervical micrometastatic burden. The cervical lymph node metastatic rates determined by routine HES staining and real-time RT-PCR assay were 16.3 and 36.0%, respectively (P<0.0001). A potential change in the nodal status was observed in 13 (42.0%) of the 31 patients and an atypical pattern of lymphatic spread was identified in four patients (12.9%). Moreover, CK19 mRNA expression values in histologically positive lymph nodes were significantly higher than those observed in histologically negative lymph nodes (P<0.0001). These results indicate that real-time RT-PCR assay for the detection of CK19 mRNA is a sensitive and reliable method for the detection of carcinomatous cells in lymph nodes. This type of method could be used to reassess lymph node status according to occult lymphatic spread in patients with HNSCC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6603073", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "94"
      }
    ], 
    "name": "Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT\u2013PCR detection of cytokeratin 19 mRNA", 
    "pagination": "6603073", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f0823dd329a94d029236038ee8456e6bb91a3f8f1a672027cea9a1018832646a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16622440"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6603073"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050488035"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6603073", 
      "https://app.dimensions.ai/details/publication/pub.1050488035"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54014_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/6603073"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603073'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603073'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603073'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603073'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      21 PREDICATES      82 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6603073 schema:about N3f2ae34f08cf4256a75bd79700b9ff58
2 N40ea8ad3e9d14eb8b18fb8eb36984cdb
3 N4ecc0db8ad7049c08eb3382e3aad8bfe
4 N578edb95a7b3493da9ca21680347f847
5 N6e5bf0a4e29e4f6b96a8599f052be835
6 N7263b0b43e2a4b39bb2d5da713a41705
7 N7796de27cdaa4e7d9842fa642f2debe8
8 N82608a7550ce4a3ab419fd950bc51205
9 N8c48f1a5704a4b94bf85aa1d77e5ccdc
10 N98fe7932601c4870967313344d207534
11 N99aee7a8ac2e45b7ae333aeba0699d9e
12 Na4f881309d89437bbc0141149ed966a5
13 Nb639f7e98d634a008939527ec23a8cc9
14 Nc054c9b1ced245d881441d3be9ae8b07
15 Nc813ced5494c4250bb29040ffc9acf69
16 Ne5663a1ee7a54963bd52c068460874b3
17 Neabd2e8f627344d091882ce28dd6dfeb
18 Nfb77924a254b4e019b7ca58dc37f503f
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N937e0ed5719e4b54978e8f2d7fe71143
22 schema:citation sg:pub.10.1007/978-3-642-59524-0_3
23 sg:pub.10.1007/s004280000199
24 sg:pub.10.1038/sj.bjc.6601248
25 sg:pub.10.1038/sj.bjc.6690377
26 https://app.dimensions.ai/details/publication/pub.1074500199
27 https://app.dimensions.ai/details/publication/pub.1074893521
28 https://app.dimensions.ai/details/publication/pub.1074963970
29 https://app.dimensions.ai/details/publication/pub.1082982251
30 https://doi.org/10.1001/archotol.128.7.751
31 https://doi.org/10.1001/archotol.130.1.21
32 https://doi.org/10.1001/archotol.130.8.937
33 https://doi.org/10.1002/(sici)1097-0142(19990301)85:5<1098::aid-cncr13>3.0.co;2-n
34 https://doi.org/10.1002/(sici)1097-0142(19991215)86:12<2668::aid-cncr11>3.0.co;2-r
35 https://doi.org/10.1002/(sici)1097-0215(19990105)80:1<119::aid-ijc22>3.0.co;2-x
36 https://doi.org/10.1002/(sici)1097-0347(199701)19:1<14::aid-hed3>3.0.co;2-y
37 https://doi.org/10.1002/ijc.20343
38 https://doi.org/10.1002/ijc.20942
39 https://doi.org/10.1006/meth.2001.1262
40 https://doi.org/10.1016/0140-6736(90)91386-o
41 https://doi.org/10.1016/j.ejca.2004.09.021
42 https://doi.org/10.1016/s0002-9610(05)80554-9
43 https://doi.org/10.1016/s0003-4975(01)02520-6
44 https://doi.org/10.1016/s0140-6736(00)03566-2
45 https://doi.org/10.1016/s0304-3835(00)00574-7
46 https://doi.org/10.1016/s1368-8375(02)00049-0
47 https://doi.org/10.1054/bjom.1999.0037
48 https://doi.org/10.1056/nejm199710233371702
49 https://doi.org/10.1067/msy.2000.100881
50 https://doi.org/10.1097/00005537-199903000-00023
51 https://doi.org/10.1097/00005537-200211000-00011
52 https://doi.org/10.1097/00005537-200305000-00022
53 https://doi.org/10.1158/0008-5472.can-04-3717
54 https://doi.org/10.1159/000027749
55 https://doi.org/10.1159/000071206
56 https://doi.org/10.1177/000348940211100207
57 schema:datePublished 2006-04
58 schema:datePublishedReg 2006-04-01
59 schema:description The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 and 2005 were prospectively evaluated by routine haematoxylin-eosin-safran (HES) staining, immunohistochemistry (IHC) and real-time Taqman reverse-transcriptase polymerase chain reaction (real-time RT-PCR) assay. Amplification of cytokeratin 19 (CK19) mRNA transcripts using real-time RT-PCR was used to quantify cervical micrometastatic burden. The cervical lymph node metastatic rates determined by routine HES staining and real-time RT-PCR assay were 16.3 and 36.0%, respectively (P<0.0001). A potential change in the nodal status was observed in 13 (42.0%) of the 31 patients and an atypical pattern of lymphatic spread was identified in four patients (12.9%). Moreover, CK19 mRNA expression values in histologically positive lymph nodes were significantly higher than those observed in histologically negative lymph nodes (P<0.0001). These results indicate that real-time RT-PCR assay for the detection of CK19 mRNA is a sensitive and reliable method for the detection of carcinomatous cells in lymph nodes. This type of method could be used to reassess lymph node status according to occult lymphatic spread in patients with HNSCC.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf Nbcf7024b30ff483a82bb4b499c72434f
64 Nc076f5d0bfef4534a7e94b5d6be39571
65 sg:journal.1017082
66 schema:name Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT–PCR detection of cytokeratin 19 mRNA
67 schema:pagination 6603073
68 schema:productId N1d8ad5a020134ecb9c4117dabe2a735e
69 N8b2a6041497242669d8545704ea87805
70 N8ce7cf68d63a4ce4b1d884d4ee71f111
71 Na97a0a475920427586776fd9c9bc7b2c
72 Nce85ec3a58b343b3b5c005ebc59775f6
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050488035
74 https://doi.org/10.1038/sj.bjc.6603073
75 schema:sdDatePublished 2019-04-11T12:15
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Na9388f7909024c8e9f5be37438ca9598
78 schema:url http://www.nature.com/articles/6603073
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N015a57d8d05a49ed876ca55721e88f6d rdf:first sg:person.0630606100.74
83 rdf:rest N27483d3661954d93a41d30f68b19f79f
84 N1d8ad5a020134ecb9c4117dabe2a735e schema:name readcube_id
85 schema:value f0823dd329a94d029236038ee8456e6bb91a3f8f1a672027cea9a1018832646a
86 rdf:type schema:PropertyValue
87 N1f3bc902c5874f77b34bdf2482d8f984 rdf:first sg:person.01074403442.52
88 rdf:rest N58cfc731cc3d4b5f814b09de62906e74
89 N27483d3661954d93a41d30f68b19f79f rdf:first sg:person.016063465261.15
90 rdf:rest rdf:nil
91 N3f2ae34f08cf4256a75bd79700b9ff58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Head and Neck Neoplasms
93 rdf:type schema:DefinedTerm
94 N40ea8ad3e9d14eb8b18fb8eb36984cdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Lymph Nodes
96 rdf:type schema:DefinedTerm
97 N4ecc0db8ad7049c08eb3382e3aad8bfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Middle Aged
99 rdf:type schema:DefinedTerm
100 N578edb95a7b3493da9ca21680347f847 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Aged
102 rdf:type schema:DefinedTerm
103 N58cfc731cc3d4b5f814b09de62906e74 rdf:first sg:person.01231312040.49
104 rdf:rest N973a47437b04468db737e9850f9c8c9e
105 N6868c13534574984863c33081825b807 rdf:first sg:person.0766417314.20
106 rdf:rest N1f3bc902c5874f77b34bdf2482d8f984
107 N6e5bf0a4e29e4f6b96a8599f052be835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Reverse Transcriptase Polymerase Chain Reaction
109 rdf:type schema:DefinedTerm
110 N7263b0b43e2a4b39bb2d5da713a41705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Neoplasm Staging
112 rdf:type schema:DefinedTerm
113 N76c6252728ef4209b7493a70cb402155 schema:name Service d'ORL et Chirurgie Cervico-Faciale, Université Pierre et Marie Curie, Paris VI, Hôpital Tenon APHP, 4 rue de la Chine, Paris 75020, France
114 rdf:type schema:Organization
115 N7796de27cdaa4e7d9842fa642f2debe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adult
117 rdf:type schema:DefinedTerm
118 N82608a7550ce4a3ab419fd950bc51205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Immunohistochemistry
120 rdf:type schema:DefinedTerm
121 N8b2a6041497242669d8545704ea87805 schema:name pubmed_id
122 schema:value 16622440
123 rdf:type schema:PropertyValue
124 N8c48f1a5704a4b94bf85aa1d77e5ccdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Lymphatic Metastasis
126 rdf:type schema:DefinedTerm
127 N8ce7cf68d63a4ce4b1d884d4ee71f111 schema:name doi
128 schema:value 10.1038/sj.bjc.6603073
129 rdf:type schema:PropertyValue
130 N937e0ed5719e4b54978e8f2d7fe71143 rdf:first sg:person.0614504473.20
131 rdf:rest Na9570eaa2f6f439da33af7846b096de7
132 N973a47437b04468db737e9850f9c8c9e rdf:first sg:person.01222250364.66
133 rdf:rest N015a57d8d05a49ed876ca55721e88f6d
134 N98fe7932601c4870967313344d207534 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Lymph Node Excision
136 rdf:type schema:DefinedTerm
137 N99aee7a8ac2e45b7ae333aeba0699d9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Carcinoma, Squamous Cell
139 rdf:type schema:DefinedTerm
140 Na4f881309d89437bbc0141149ed966a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Keratins
142 rdf:type schema:DefinedTerm
143 Na9388f7909024c8e9f5be37438ca9598 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Na9570eaa2f6f439da33af7846b096de7 rdf:first sg:person.01112674525.11
146 rdf:rest Nb81bac3436154235b51687e6e167ebca
147 Na97a0a475920427586776fd9c9bc7b2c schema:name nlm_unique_id
148 schema:value 0370635
149 rdf:type schema:PropertyValue
150 Nb639f7e98d634a008939527ec23a8cc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 Nb81bac3436154235b51687e6e167ebca rdf:first sg:person.01274454161.38
154 rdf:rest N6868c13534574984863c33081825b807
155 Nbcf7024b30ff483a82bb4b499c72434f schema:issueNumber 8
156 rdf:type schema:PublicationIssue
157 Nc054c9b1ced245d881441d3be9ae8b07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Prospective Studies
159 rdf:type schema:DefinedTerm
160 Nc076f5d0bfef4534a7e94b5d6be39571 schema:volumeNumber 94
161 rdf:type schema:PublicationVolume
162 Nc813ced5494c4250bb29040ffc9acf69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Sensitivity and Specificity
164 rdf:type schema:DefinedTerm
165 Nce85ec3a58b343b3b5c005ebc59775f6 schema:name dimensions_id
166 schema:value pub.1050488035
167 rdf:type schema:PropertyValue
168 Ne5663a1ee7a54963bd52c068460874b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 Neabd2e8f627344d091882ce28dd6dfeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 Nebbd7a8896124cbb8ec83bb757816601 schema:name Service d'ORL et Chirurgie Cervico-Faciale, Université Pierre et Marie Curie, Paris VI, Hôpital Tenon APHP, 4 rue de la Chine, Paris 75020, France
175 rdf:type schema:Organization
176 Nfb77924a254b4e019b7ca58dc37f503f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name RNA, Messenger
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
183 schema:name Oncology and Carcinogenesis
184 rdf:type schema:DefinedTerm
185 sg:journal.1017082 schema:issn 0007-0920
186 1532-1827
187 schema:name British Journal of Cancer
188 rdf:type schema:Periodical
189 sg:person.01074403442.52 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
190 schema:familyName Callard
191 schema:givenName P
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074403442.52
193 rdf:type schema:Person
194 sg:person.01112674525.11 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
195 schema:familyName Lefèvre
196 schema:givenName M
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112674525.11
198 rdf:type schema:Person
199 sg:person.01222250364.66 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
200 schema:familyName Lacave
201 schema:givenName R
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222250364.66
203 rdf:type schema:Person
204 sg:person.01231312040.49 schema:affiliation N76c6252728ef4209b7493a70cb402155
205 schema:familyName Périé
206 schema:givenName S
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231312040.49
208 rdf:type schema:Person
209 sg:person.01274454161.38 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
210 schema:familyName Ricci
211 schema:givenName S
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274454161.38
213 rdf:type schema:Person
214 sg:person.016063465261.15 schema:affiliation Nebbd7a8896124cbb8ec83bb757816601
215 schema:familyName St Guily
216 schema:givenName J Lacau
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016063465261.15
218 rdf:type schema:Person
219 sg:person.0614504473.20 schema:affiliation https://www.grid.ac/institutes/grid.411079.a
220 schema:familyName Tao
221 schema:givenName L
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614504473.20
223 rdf:type schema:Person
224 sg:person.0630606100.74 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
225 schema:familyName Bernaudin
226 schema:givenName J-F
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630606100.74
228 rdf:type schema:Person
229 sg:person.0766417314.20 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
230 schema:familyName Saintigny
231 schema:givenName P
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766417314.20
233 rdf:type schema:Person
234 sg:pub.10.1007/978-3-642-59524-0_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037794192
235 https://doi.org/10.1007/978-3-642-59524-0_3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s004280000199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036211121
238 https://doi.org/10.1007/s004280000199
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/sj.bjc.6601248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023692980
241 https://doi.org/10.1038/sj.bjc.6601248
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/sj.bjc.6690377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038465737
244 https://doi.org/10.1038/sj.bjc.6690377
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1074500199 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1074893521 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1074963970 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1082982251 schema:CreativeWork
250 https://doi.org/10.1001/archotol.128.7.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020788475
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1001/archotol.130.1.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011688752
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1001/archotol.130.8.937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001500420
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/(sici)1097-0142(19990301)85:5<1098::aid-cncr13>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1029620244
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/(sici)1097-0142(19991215)86:12<2668::aid-cncr11>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1012182456
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/(sici)1097-0215(19990105)80:1<119::aid-ijc22>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008261633
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/(sici)1097-0347(199701)19:1<14::aid-hed3>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1050920133
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/ijc.20343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012940925
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/ijc.20942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017107824
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0140-6736(90)91386-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1009116988
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.ejca.2004.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006465733
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0002-9610(05)80554-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048713925
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0003-4975(01)02520-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029067509
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0140-6736(00)03566-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041828180
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0304-3835(00)00574-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002494671
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s1368-8375(02)00049-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004191758
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1054/bjom.1999.0037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039081048
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1056/nejm199710233371702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051683232
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1067/msy.2000.100881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011002094
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1097/00005537-199903000-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014184712
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/00005537-200211000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038057149
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/00005537-200305000-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036009678
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1158/0008-5472.can-04-3717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004886658
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1159/000027749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010535726
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1159/000071206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031964803
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1177/000348940211100207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018789596
303 rdf:type schema:CreativeWork
304 https://www.grid.ac/institutes/grid.411079.a schema:alternateName Eye & ENT Hospital of Fudan University
305 schema:name Department of Otolaryngology-HNS, Eye and ENT Hospital of Fudan University, Shanghai, China
306 Histologie-Biologie Tumorale, EA 3499 Université Pierre et Marie Curie Paris VI, Hôpital Tenon APHP, Paris 75020, France
307 Service d'ORL et Chirurgie Cervico-Faciale, Université Pierre et Marie Curie, Paris VI, Hôpital Tenon APHP, 4 rue de la Chine, Paris 75020, France
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.413483.9 schema:alternateName Tenon Hospital
310 schema:name Anatomie-Pathologique, EA 3499 Université Pierre et Marie Curie Paris VI, Hôpital Tenon APHP, Paris 75020, France
311 Histologie-Biologie Tumorale, EA 3499 Université Pierre et Marie Curie Paris VI, Hôpital Tenon APHP, Paris 75020, France
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...