Ontology type: schema:ScholarlyArticle Open Access: True
2006-03-14
AUTHORSP C Simmonds, J N Primrose, J L Colquitt, O J Garden, G J Poston, M Rees
ABSTRACTNo consensus on the indications for surgical resection of colorectal liver metastases exists. This systematic review has been undertaken to assess the published evidence for its efficacy and safety and to identify prognostic factors. Studies were identified by computerised and hand searches of the literature, scanning references and contacting investigators. The outcome measures were overall survival, disease-free survival, postoperative morbidity and mortality, quality of life and cost effectiveness, and a qualitative summary of the trends across all studies was produced. Only 30 of 529 independent studies met all the eligibility criteria for the review, and data on 30-day mortality and morbidity only were included from a further nine studies. The best available evidence came from prospective case series, but only two studies reported outcomes for all patients undergoing surgery. The remainder reported outcomes for selected groups of patients: those undergoing hepatic resection or those undergoing curative resection. Postoperative mortality rates were generally low (median 2.8%). The majority of studies described only serious postoperative morbidity, the most common being bile leak and associated perihepatic abscess. Approximately 30% of patients remained alive 5 years after resection and around two-thirds of these are disease free. The quality of the majority of published papers was poor and ascertaining the benefits of surgical resection of colorectal hepatic metastases is difficult in the absence of randomised trials. However, it is clear that there is group of patients with liver metastases who may become long-term disease- free survivors following hepatic resection. Such survival is rare in apparently comparable patients who do not have surgical treatment. Further work is needed to more accurately define this group of patients and to determine whether the addition of adjuvant treatments results in improved survival. More... »
PAGES982-999
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6603033
DOIhttp://dx.doi.org/10.1038/sj.bjc.6603033
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1051210499
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16538219
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hepatectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Morbidity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Postoperative Complications",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quality Control",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quality of Life",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Randomized Controlled Trials as Topic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Cancer Research UK Clinical Centre, MP824, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK",
"id": "http://www.grid.ac/institutes/grid.123047.3",
"name": [
"Cancer Research UK Clinical Centre, MP824, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK"
],
"type": "Organization"
},
"familyName": "Simmonds",
"givenName": "P C",
"id": "sg:person.01250766267.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250766267.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Surgery, F Level Centre Block (MP816), Southampton General Hospital, SO16 6YD, Southampton, UK",
"id": "http://www.grid.ac/institutes/grid.123047.3",
"name": [
"University Surgery, F Level Centre Block (MP816), Southampton General Hospital, SO16 6YD, Southampton, UK"
],
"type": "Organization"
},
"familyName": "Primrose",
"givenName": "J N",
"id": "sg:person.01250744256.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250744256.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Research UK Clinical Centre, MP824, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK",
"id": "http://www.grid.ac/institutes/grid.123047.3",
"name": [
"Cancer Research UK Clinical Centre, MP824, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK"
],
"type": "Organization"
},
"familyName": "Colquitt",
"givenName": "J L",
"id": "sg:person.01044036674.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044036674.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, EH16 4SA, Edinburgh, Scotland, UK",
"id": "http://www.grid.ac/institutes/grid.418716.d",
"name": [
"Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, EH16 4SA, Edinburgh, Scotland, UK"
],
"type": "Organization"
},
"familyName": "Garden",
"givenName": "O J",
"id": "sg:person.015442464064.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015442464064.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, University Hospital Aintree, L9 7AL, Longmoor Lane, Liverpool, UK",
"id": "http://www.grid.ac/institutes/grid.411255.6",
"name": [
"Department of Surgery, University Hospital Aintree, L9 7AL, Longmoor Lane, Liverpool, UK"
],
"type": "Organization"
},
"familyName": "Poston",
"givenName": "G J",
"id": "sg:person.0607370647.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hepatobiliary Surgery Unit, North Hampshire Hospital, Aldermaston Road, RG24 9NA, Basingstoke, UK",
"id": "http://www.grid.ac/institutes/grid.414262.7",
"name": [
"Hepatobiliary Surgery Unit, North Hampshire Hospital, Aldermaston Road, RG24 9NA, Basingstoke, UK"
],
"type": "Organization"
},
"familyName": "Rees",
"givenName": "M",
"id": "sg:person.0660705073.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660705073.11"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf02307088",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029055275",
"https://doi.org/10.1007/bf02307088"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002689900381",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042270745",
"https://doi.org/10.1007/s002689900381"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02303827",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019191907",
"https://doi.org/10.1007/bf02303827"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002689900404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045324470",
"https://doi.org/10.1007/s002689900404"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02348736",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000331937",
"https://doi.org/10.1007/bf02348736"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00316981",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038122014",
"https://doi.org/10.1007/bf00316981"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-642-51873-7_12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1089790174",
"https://doi.org/10.1007/978-3-642-51873-7_12"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001040050484",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046632077",
"https://doi.org/10.1007/s001040050484"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-03-14",
"datePublishedReg": "2006-03-14",
"description": "No consensus on the indications for surgical resection of colorectal liver metastases exists. This systematic review has been undertaken to assess the published evidence for its efficacy and safety and to identify prognostic factors. Studies were identified by computerised and hand searches of the literature, scanning references and contacting investigators. The outcome measures were overall survival, disease-free survival, postoperative morbidity and mortality, quality of life and cost effectiveness, and a qualitative summary of the trends across all studies was produced. Only 30 of 529 independent studies met all the eligibility criteria for the review, and data on 30-day mortality and morbidity only were included from a further nine studies. The best available evidence came from prospective case series, but only two studies reported outcomes for all patients undergoing surgery. The remainder reported outcomes for selected groups of patients: those undergoing hepatic resection or those undergoing curative resection. Postoperative mortality rates were generally low (median 2.8%). The majority of studies described only serious postoperative morbidity, the most common being bile leak and associated perihepatic abscess. Approximately 30% of patients remained alive 5 years after resection and around two-thirds of these are disease free. The quality of the majority of published papers was poor and ascertaining the benefits of surgical resection of colorectal hepatic metastases is difficult in the absence of randomised trials. However, it is clear that there is group of patients with liver metastases who may become long-term disease- free survivors following hepatic resection. Such survival is rare in apparently comparable patients who do not have surgical treatment. Further work is needed to more accurately define this group of patients and to determine whether the addition of adjuvant treatments results in improved survival.",
"genre": "article",
"id": "sg:pub.10.1038/sj.bjc.6603033",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "94"
}
],
"keywords": [
"group of patients",
"surgical resection",
"postoperative morbidity",
"liver metastases",
"hepatic resection",
"hepatic metastases",
"systematic review",
"long-term disease-free survivors",
"serious postoperative morbidity",
"adjuvant treatments results",
"colorectal liver metastases",
"postoperative mortality rate",
"disease-free survival",
"disease-free survivors",
"prospective case series",
"colorectal hepatic metastases",
"quality of life",
"perihepatic abscess",
"curative resection",
"bile leak",
"comparable patients",
"overall survival",
"prognostic factors",
"surgical treatment",
"case series",
"colorectal cancer",
"outcome measures",
"resection",
"eligibility criteria",
"patients",
"mortality rate",
"treatment results",
"hand search",
"majority of studies",
"metastasis",
"morbidity",
"available evidence",
"survival",
"scanning references",
"mortality",
"two-thirds",
"qualitative summary",
"outcomes",
"cost effectiveness",
"review",
"group",
"independent studies",
"such survival",
"abscess",
"surgery",
"majority",
"study",
"cancer",
"disease",
"survivors",
"trials",
"further work",
"evidence",
"efficacy",
"treatment",
"indications",
"leak",
"safety",
"investigators",
"years",
"remainder",
"factors",
"absence",
"consensus",
"quality",
"criteria",
"summary",
"life",
"benefits",
"measures",
"rate",
"search",
"literature",
"data",
"addition",
"effectiveness",
"series",
"results",
"trends",
"reference",
"work",
"paper"
],
"name": "Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies",
"pagination": "982-999",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1051210499"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6603033"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16538219"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6603033",
"https://app.dimensions.ai/details/publication/pub.1051210499"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_428.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/sj.bjc.6603033"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603033'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603033'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603033'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603033'
This table displays all metadata directly associated to this object as RDF triples.
275 TRIPLES
22 PREDICATES
133 URIs
117 LITERALS
19 BLANK NODES