REporting recommendations for tumour MARKer prognostic studies (REMARK) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-08

AUTHORS

L M McShane, D G Altman, W Sauerbrei, S E Taube, M Gion, G M Clark

ABSTRACT

Despite years of research and hundreds of reports on tumour markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodological problems have been cited to explain these discrepancies. Unfortunately, many tumour marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalisability of the study results. The development of guidelines for the reporting of tumour marker studies was a major recommendation of the US National Cancer Institute and the European Organisation for Research and Treatment of Cancer (NCI-EORTC) First International Meeting on Cancer Diagnostics in 2000. Similar to the successful CONSORT initiative for randomised trials and the STARD statement for diagnostic studies, we suggest guidelines to provide relevant information about the study design, preplanned hypotheses, patient and specimen characteristics, assay methods, and statistical analysis methods. In addition, the guidelines suggest helpful presentations of data and important elements to include in discussions. The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply. More... »

PAGES

6602678

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6602678

DOI

http://dx.doi.org/10.1038/sj.bjc.6602678

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028545719

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16106245


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomedical Research", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Information Dissemination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "US National Cancer Institute, Bethesda, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McShane", 
        "givenName": "L M", 
        "id": "sg:person.01111206713.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111206713.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altman", 
        "givenName": "D G", 
        "id": "sg:person.012465277217.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012465277217.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut fuer Medizinische Biometrie und Medizinische Informatik, Universitaetsklinikum Freiburg, 79104 Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sauerbrei", 
        "givenName": "W", 
        "id": "sg:person.0601752406.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601752406.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "US National Cancer Institute, Bethesda, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taube", 
        "givenName": "S E", 
        "id": "sg:person.01273550513.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273550513.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Centro Regionale Indicatori Biochimici di Tumoure, Ospedale Civile, 30122 Venezia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gion", 
        "givenName": "M", 
        "id": "sg:person.0636054072.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636054072.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Astellas Pharma (United States)", 
          "id": "https://www.grid.ac/institutes/grid.423286.9", 
          "name": [
            "OSI Pharmaceuticals, Inc., Boulder, CO 80301, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clark", 
        "givenName": "G M", 
        "id": "sg:person.011111740402.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011111740402.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/bmj.323.7306.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004206454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/sonc.2002.32890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006568878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19931115)72:10<3131::aid-cncr2820721039>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009960325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.11.852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010730561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006102021879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011591680", 
          "https://doi.org/10.1023/a:1006102021879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.11.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015062444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/49.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015854220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016366834", 
          "https://doi.org/10.1038/bjc.1994.192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016366834", 
          "https://doi.org/10.1038/bjc.1994.192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-2797(01)00250-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020687880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200201000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020756703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200201000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020756703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200201000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020756703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/83.3.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022414289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022503669", 
          "https://doi.org/10.1038/sj.bjc.6600886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022503669", 
          "https://doi.org/10.1038/sj.bjc.6600886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.15.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023723086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/0f58-0grx-fk4r-a6va", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027341980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/sonc.2002.32896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027786063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470693926.ch13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028855696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)00500-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029695570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)00500-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029695570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030273173", 
          "https://doi.org/10.1038/sj.bjc.6601907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030273173", 
          "https://doi.org/10.1038/sj.bjc.6601907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032504390", 
          "https://doi.org/10.1038/bjc.1995.364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032504390", 
          "https://doi.org/10.1038/bjc.1995.364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19921101)70:9<2367::aid-cncr2820700927>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032724740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.285.15.1987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033111438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/49.1.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035532244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-1051-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035661738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006193704132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038073605", 
          "https://doi.org/10.1023/a:1006193704132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.122.3.1037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041194713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.122.3.1037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041194713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.1999.00862.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041838521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.20.1456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044315439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01840833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045571013", 
          "https://doi.org/10.1007/bf01840833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)04149-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049432046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9781420027761.pt4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052203091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.15.1206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/86.11.829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-118-3-199302010-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073697140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-134-8-200104170-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073704783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.2.470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074265641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089901400301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074553089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460089901400301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074553089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074641666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.6.1865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074783941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5301/jbm.2008.3652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075270902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471463736.tnmp03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090054694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471463736.tnmp03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090054694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471463736.tnmp03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090054694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471463736.tnmp03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090054694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460080301800107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100640964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/172460080301800107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100640964"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-08", 
    "datePublishedReg": "2005-08-01", 
    "description": "Despite years of research and hundreds of reports on tumour markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodological problems have been cited to explain these discrepancies. Unfortunately, many tumour marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalisability of the study results. The development of guidelines for the reporting of tumour marker studies was a major recommendation of the US National Cancer Institute and the European Organisation for Research and Treatment of Cancer (NCI-EORTC) First International Meeting on Cancer Diagnostics in 2000. Similar to the successful CONSORT initiative for randomised trials and the STARD statement for diagnostic studies, we suggest guidelines to provide relevant information about the study design, preplanned hypotheses, patient and specimen characteristics, assay methods, and statistical analysis methods. In addition, the guidelines suggest helpful presentations of data and important elements to include in discussions. The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6602678", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "93"
      }
    ], 
    "name": "REporting recommendations for tumour MARKer prognostic studies (REMARK)", 
    "pagination": "6602678", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "87fbbfa544f289d54a019e3a5160fdb5014e6206c0310bc777078a7afb9cfc78"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16106245"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6602678"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028545719"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6602678", 
      "https://app.dimensions.ai/details/publication/pub.1028545719"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118327_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/6602678"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602678'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602678'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602678'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602678'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      77 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6602678 schema:about N028706a7f7eb4aa3956a9739bce41425
2 N0b48b74141b2499ca04ffdbb92336757
3 N551608a2d1f944fbaf30f000fdb1563e
4 N88ab0e652c6e4a89af981fbd2f9d40f4
5 Nf860cbaacd984ca38575fc0a06cec8f3
6 Nfbb8e660c0a54562a601a1b1df4093b6
7 anzsrc-for:11
8 anzsrc-for:1112
9 schema:author Nc72747825eb148a3aee31c4606965690
10 schema:citation sg:pub.10.1007/bf01840833
11 sg:pub.10.1023/a:1006102021879
12 sg:pub.10.1023/a:1006193704132
13 sg:pub.10.1038/bjc.1994.192
14 sg:pub.10.1038/bjc.1995.364
15 sg:pub.10.1038/sj.bjc.6600886
16 sg:pub.10.1038/sj.bjc.6601907
17 https://app.dimensions.ai/details/publication/pub.1074641666
18 https://doi.org/10.1001/jama.283.15.2008
19 https://doi.org/10.1001/jama.285.15.1987
20 https://doi.org/10.1002/0471463736.tnmp03
21 https://doi.org/10.1002/1097-0142(19921101)70:9<2367::aid-cncr2820700927>3.0.co;2-b
22 https://doi.org/10.1002/1097-0142(19931115)72:10<3131::aid-cncr2820721039>3.0.co;2-j
23 https://doi.org/10.1002/9780470693926.ch13
24 https://doi.org/10.1016/s0140-6736(99)04149-5
25 https://doi.org/10.1016/s0959-8049(02)00500-2
26 https://doi.org/10.1016/s1047-2797(01)00250-2
27 https://doi.org/10.1046/j.1365-2559.1999.00862.x
28 https://doi.org/10.1053/sonc.2002.32890
29 https://doi.org/10.1053/sonc.2002.32896
30 https://doi.org/10.1093/jnci/83.3.154
31 https://doi.org/10.1093/jnci/85.15.1206
32 https://doi.org/10.1093/jnci/86.11.829
33 https://doi.org/10.1093/jnci/88.20.1456
34 https://doi.org/10.1093/jnci/94.11.852
35 https://doi.org/10.1093/jnci/94.11.855
36 https://doi.org/10.1097/00000658-200201000-00003
37 https://doi.org/10.1136/bmj.323.7306.224
38 https://doi.org/10.1158/1078-0432.ccr-1051-2
39 https://doi.org/10.1177/172460080301800107
40 https://doi.org/10.1177/172460089901400301
41 https://doi.org/10.1200/jco.1999.17.2.470
42 https://doi.org/10.1200/jco.2001.19.6.1865
43 https://doi.org/10.1200/jco.2004.05.064
44 https://doi.org/10.1201/9781420027761.pt4
45 https://doi.org/10.1309/0f58-0grx-fk4r-a6va
46 https://doi.org/10.1373/49.1.1
47 https://doi.org/10.1373/49.1.7
48 https://doi.org/10.1378/chest.122.3.1037
49 https://doi.org/10.5301/jbm.2008.3652
50 https://doi.org/10.7326/0003-4819-118-3-199302010-00009
51 https://doi.org/10.7326/0003-4819-134-8-200104170-00012
52 schema:datePublished 2005-08
53 schema:datePublishedReg 2005-08-01
54 schema:description Despite years of research and hundreds of reports on tumour markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodological problems have been cited to explain these discrepancies. Unfortunately, many tumour marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalisability of the study results. The development of guidelines for the reporting of tumour marker studies was a major recommendation of the US National Cancer Institute and the European Organisation for Research and Treatment of Cancer (NCI-EORTC) First International Meeting on Cancer Diagnostics in 2000. Similar to the successful CONSORT initiative for randomised trials and the STARD statement for diagnostic studies, we suggest guidelines to provide relevant information about the study design, preplanned hypotheses, patient and specimen characteristics, assay methods, and statistical analysis methods. In addition, the guidelines suggest helpful presentations of data and important elements to include in discussions. The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N210af4cc8b7644ba9b7bd8cc81b7d6b0
59 Ne6b6eb20547d497b9206ddd121df8b0a
60 sg:journal.1017082
61 schema:name REporting recommendations for tumour MARKer prognostic studies (REMARK)
62 schema:pagination 6602678
63 schema:productId N2cb9ceba2a0c477eb9966d8fb3f3fbd8
64 N4f319d7778dd4a59a1a4a8b130f7e5a2
65 Nbbb9f261dd4d485e8ebe6bab14f15305
66 Ne62d34f260ff4dffa67c330ad7f248b3
67 Neab3d829531e4d8dbe8cd0c5d9eafbbc
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028545719
69 https://doi.org/10.1038/sj.bjc.6602678
70 schema:sdDatePublished 2019-04-11T12:05
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N078903f11620434192a95f870349478e
73 schema:url http://www.nature.com/articles/6602678
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N028706a7f7eb4aa3956a9739bce41425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Biomedical Research
79 rdf:type schema:DefinedTerm
80 N078903f11620434192a95f870349478e schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N0b48b74141b2499ca04ffdbb92336757 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Humans
84 rdf:type schema:DefinedTerm
85 N210af4cc8b7644ba9b7bd8cc81b7d6b0 schema:volumeNumber 93
86 rdf:type schema:PublicationVolume
87 N2cb9ceba2a0c477eb9966d8fb3f3fbd8 schema:name doi
88 schema:value 10.1038/sj.bjc.6602678
89 rdf:type schema:PropertyValue
90 N2d532e0172a44ac2abdfd4247fadb270 rdf:first sg:person.0636054072.19
91 rdf:rest Nad11c0bf431d468d9fd6a9424d7ff49a
92 N4f319d7778dd4a59a1a4a8b130f7e5a2 schema:name dimensions_id
93 schema:value pub.1028545719
94 rdf:type schema:PropertyValue
95 N551608a2d1f944fbaf30f000fdb1563e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Biomarkers, Tumor
97 rdf:type schema:DefinedTerm
98 N66461a49bf52441cbbd537fc1947e159 rdf:first sg:person.0601752406.84
99 rdf:rest N7990290a63154ad4843da73237c599e7
100 N7990290a63154ad4843da73237c599e7 rdf:first sg:person.01273550513.01
101 rdf:rest N2d532e0172a44ac2abdfd4247fadb270
102 N82db003d7fb847ab8177b6f357630655 rdf:first sg:person.012465277217.06
103 rdf:rest N66461a49bf52441cbbd537fc1947e159
104 N88ab0e652c6e4a89af981fbd2f9d40f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Research Design
106 rdf:type schema:DefinedTerm
107 Nad11c0bf431d468d9fd6a9424d7ff49a rdf:first sg:person.011111740402.54
108 rdf:rest rdf:nil
109 Nbac71221b21b45dfb908d79f6c389153 schema:name Centro Regionale Indicatori Biochimici di Tumoure, Ospedale Civile, 30122 Venezia, Italy
110 rdf:type schema:Organization
111 Nbbb9f261dd4d485e8ebe6bab14f15305 schema:name readcube_id
112 schema:value 87fbbfa544f289d54a019e3a5160fdb5014e6206c0310bc777078a7afb9cfc78
113 rdf:type schema:PropertyValue
114 Nc72747825eb148a3aee31c4606965690 rdf:first sg:person.01111206713.59
115 rdf:rest N82db003d7fb847ab8177b6f357630655
116 Nd0a468ce160d4e03bd5be4e024154c73 schema:name Institut fuer Medizinische Biometrie und Medizinische Informatik, Universitaetsklinikum Freiburg, 79104 Freiburg, Germany
117 rdf:type schema:Organization
118 Ne62d34f260ff4dffa67c330ad7f248b3 schema:name pubmed_id
119 schema:value 16106245
120 rdf:type schema:PropertyValue
121 Ne6b6eb20547d497b9206ddd121df8b0a schema:issueNumber 4
122 rdf:type schema:PublicationIssue
123 Neab3d829531e4d8dbe8cd0c5d9eafbbc schema:name nlm_unique_id
124 schema:value 0370635
125 rdf:type schema:PropertyValue
126 Nf860cbaacd984ca38575fc0a06cec8f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Information Dissemination
128 rdf:type schema:DefinedTerm
129 Nfbb8e660c0a54562a601a1b1df4093b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neoplasms
131 rdf:type schema:DefinedTerm
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
136 schema:name Oncology and Carcinogenesis
137 rdf:type schema:DefinedTerm
138 sg:journal.1017082 schema:issn 0007-0920
139 1532-1827
140 schema:name British Journal of Cancer
141 rdf:type schema:Periodical
142 sg:person.011111740402.54 schema:affiliation https://www.grid.ac/institutes/grid.423286.9
143 schema:familyName Clark
144 schema:givenName G M
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011111740402.54
146 rdf:type schema:Person
147 sg:person.01111206713.59 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
148 schema:familyName McShane
149 schema:givenName L M
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111206713.59
151 rdf:type schema:Person
152 sg:person.012465277217.06 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
153 schema:familyName Altman
154 schema:givenName D G
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012465277217.06
156 rdf:type schema:Person
157 sg:person.01273550513.01 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
158 schema:familyName Taube
159 schema:givenName S E
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273550513.01
161 rdf:type schema:Person
162 sg:person.0601752406.84 schema:affiliation Nd0a468ce160d4e03bd5be4e024154c73
163 schema:familyName Sauerbrei
164 schema:givenName W
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601752406.84
166 rdf:type schema:Person
167 sg:person.0636054072.19 schema:affiliation Nbac71221b21b45dfb908d79f6c389153
168 schema:familyName Gion
169 schema:givenName M
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636054072.19
171 rdf:type schema:Person
172 sg:pub.10.1007/bf01840833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045571013
173 https://doi.org/10.1007/bf01840833
174 rdf:type schema:CreativeWork
175 sg:pub.10.1023/a:1006102021879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011591680
176 https://doi.org/10.1023/a:1006102021879
177 rdf:type schema:CreativeWork
178 sg:pub.10.1023/a:1006193704132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038073605
179 https://doi.org/10.1023/a:1006193704132
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/bjc.1994.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016366834
182 https://doi.org/10.1038/bjc.1994.192
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/bjc.1995.364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032504390
185 https://doi.org/10.1038/bjc.1995.364
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/sj.bjc.6600886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022503669
188 https://doi.org/10.1038/sj.bjc.6600886
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/sj.bjc.6601907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030273173
191 https://doi.org/10.1038/sj.bjc.6601907
192 rdf:type schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1074641666 schema:CreativeWork
194 https://doi.org/10.1001/jama.283.15.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023723086
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1001/jama.285.15.1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033111438
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/0471463736.tnmp03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090054694
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/1097-0142(19921101)70:9<2367::aid-cncr2820700927>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1032724740
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/1097-0142(19931115)72:10<3131::aid-cncr2820721039>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1009960325
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/9780470693926.ch13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028855696
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0140-6736(99)04149-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049432046
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0959-8049(02)00500-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029695570
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s1047-2797(01)00250-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020687880
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1046/j.1365-2559.1999.00862.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041838521
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1053/sonc.2002.32890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006568878
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1053/sonc.2002.32896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027786063
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/jnci/83.3.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022414289
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/jnci/85.15.1206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818066
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/jnci/86.11.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818650
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/jnci/88.20.1456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044315439
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1093/jnci/94.11.852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010730561
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/jnci/94.11.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015062444
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1097/00000658-200201000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020756703
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1136/bmj.323.7306.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004206454
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1158/1078-0432.ccr-1051-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035661738
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1177/172460080301800107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100640964
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1177/172460089901400301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074553089
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1200/jco.1999.17.2.470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074265641
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1200/jco.2001.19.6.1865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074783941
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1200/jco.2004.05.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204175
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1201/9781420027761.pt4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052203091
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1309/0f58-0grx-fk4r-a6va schema:sameAs https://app.dimensions.ai/details/publication/pub.1027341980
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1373/49.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015854220
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1373/49.1.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035532244
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1378/chest.122.3.1037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041194713
255 rdf:type schema:CreativeWork
256 https://doi.org/10.5301/jbm.2008.3652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075270902
257 rdf:type schema:CreativeWork
258 https://doi.org/10.7326/0003-4819-118-3-199302010-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073697140
259 rdf:type schema:CreativeWork
260 https://doi.org/10.7326/0003-4819-134-8-200104170-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073704783
261 rdf:type schema:CreativeWork
262 https://www.grid.ac/institutes/grid.423286.9 schema:alternateName Astellas Pharma (United States)
263 schema:name OSI Pharmaceuticals, Inc., Boulder, CO 80301, USA
264 rdf:type schema:Organization
265 https://www.grid.ac/institutes/grid.48336.3a schema:alternateName National Cancer Institute
266 schema:name US National Cancer Institute, Bethesda, MD 20892, USA
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
269 schema:name Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, Wolfson College, Oxford OX2 6UD, UK
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...