Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-07

AUTHORS

C Bengala, V Guarneri, E Giovannetti, M Lencioni, E Fontana, V Mey, A Fontana, U Boggi, M Del Chiaro, R Danesi, S Ricci, F Mosca, M Del Tacca, P F Conte

ABSTRACT

This study aimed to define the maximum-tolerated dose (MTD) of fixed dose rate (FDR) of gemcitabine (2'-2'-difluorodeoxycitidine) infusion with circulating haemopoietic progenitor support and to evaluate the activity of the treatment. Secondary end points were pharmacokinetic of gemcitabine and difluorodeoxyuridina (dFdU) measured at first course and the activity andexpression profile of cytidine deaminase (CdA) on circulating mononuclear cells. Patients with advanced pancreatic carcinoma received escalating dose of gemcitabine 10 mg m(-2) min(-1) every 2 weeks with circulating haemopoietic progenitor support. First dose level was 3000 mg m(-2) and the doses were increased by 500 mg m(-2) until MTD. In all, 23 patients were enrolled. Toxicities were mild or moderate; the only patient treated at 7000 mg m(-2) died because of toxicity; therefore; the MTD was established at 6500 mg m(-2). The overall response rate was 22.2%. The AUC of gemcitabine showed a dose-dependent increase, while the AUC of dFdU reached a plateau at 4500 mg m(-2). A significant relationship was found between the AUC of dFdU and CdA expression and activity (P<0.05). Moreover, progression rate and survival were significantly related to CdA expression and activity levels. The activity of high-dose gemcitabine is not superior to that reported with less intensive FDR schedules. The predictive role of CdA expression and activity on outcome deserves further investigation. More... »

PAGES

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6602673

DOI

http://dx.doi.org/10.1038/sj.bjc.6602673

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049622684

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15986033


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602673'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602673'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602673'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602673'


 

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313 https://www.grid.ac/institutes/grid.7548.e schema:alternateName University of Modena and Reggio Emilia
314 schema:name Department of Oncology and Hematology, Division of Medical Oncology, University of Modena and Reggio Emilia, Via del Pozzo71, Modena 41100, Modena, Italy
315 rdf:type schema:Organization
 




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