Second primary malignancies in patients with male breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-04

AUTHORS

K Hemminki, G Scélo, P Boffetta, L Mellemkjaer, E Tracey, A Andersen, D H Brewster, E Pukkala, M McBride, E V Kliewer, K-S Chia, V Pompe-Kirn, C Martos, J G Jonasson, X Li, P Brennan

ABSTRACT

An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk. More... »

PAGES

1288

References to SciGraph publications

  • 2001-03. Second primary breast cancer in men in BREAST CANCER RESEARCH AND TREATMENT
  • 1998-05. Risk Factors for Male Breast Cancer (United States) in CANCER CAUSES & CONTROL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bjc.6602505

    DOI

    http://dx.doi.org/10.1038/sj.bjc.6602505

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15798766


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