Ontology type: schema:ScholarlyArticle Open Access: True
2004-10-19
AUTHORST Chiba, H Ohtani, T Mizoi, Y Naito, E Sato, H Nagura, A Ohuchi, K Ohuchi, K Shiiba, Y Kurokawa, S Satomi
ABSTRACTT-cell infiltration into human cancer tissues can be a manifestation of host immune responses to cancer cells. The present study was undertaken to explore the clinicopathological significance of intraepithelial CD8+ T cells using 371 consecutively sampled human colorectal carcinomas. By univariate analysis, we noted that the survival curves by intraepithelial CD8+ T cells became separated only after 1 to 2 years postoperation. Multivariate analyses revealed that the beneficial effect of this factor becomes significant only after a longer (more than 2 year), but not after a shorter (less than 2 year) follow-up period. Furthermore, the number of intraepithelial CD8+ T cells was significantly higher in patients alive for more than 5 years than in patients who either died of cancer after a curative operation or patients who underwent a noncurative operation. Patients' cancer-specific death long after a curative operation is thought to be caused by the growth of micrometastases in other organs or near the primary sites. The effects of intraepithelial CD8+ T cells, therefore, may be mediated by suppression of micrometastasis, rather than suppression of growth in the primary tumour. In conclusion, our data support a hypothesis on the presence of systemic immunosurveillance against micrometastasis of cancer cells. More... »
PAGES1711-1717
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6602201
DOIhttp://dx.doi.org/10.1038/sj.bjc.6602201
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1011870228
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15494715
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CD8-Positive T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma in Situ",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphatic Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Count",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes, Tumor-Infiltrating",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Chiba",
"givenName": "T",
"id": "sg:person.014121531052.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014121531052.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Mito Medical Center, Ibaraki, Japan",
"id": "http://www.grid.ac/institutes/grid.410845.c",
"name": [
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"Department of Pathology, Mito Medical Center, Ibaraki, Japan"
],
"type": "Organization"
},
"familyName": "Ohtani",
"givenName": "H",
"id": "sg:person.01213261602.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213261602.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Mizoi",
"givenName": "T",
"id": "sg:person.01300271751.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300271751.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Naito",
"givenName": "Y",
"id": "sg:person.01313634776.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313634776.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Sato",
"givenName": "E",
"id": "sg:person.016462137272.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016462137272.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Nagura",
"givenName": "H",
"id": "sg:person.0723362470.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku Rosai Hospital, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.417058.f",
"name": [
"Department of Surgery, Tohoku Rosai Hospital, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Ohuchi",
"givenName": "A",
"id": "sg:person.011000116421.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011000116421.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Miyagi Cancer Center, Natori, Japan",
"id": "http://www.grid.ac/institutes/grid.419939.f",
"name": [
"Department of Surgery, Miyagi Cancer Center, Natori, Japan"
],
"type": "Organization"
},
"familyName": "Ohuchi",
"givenName": "K",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Shiiba",
"givenName": "K",
"id": "sg:person.011165063714.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011165063714.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Kurokawa",
"givenName": "Y",
"id": "sg:person.01311272713.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311272713.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Satomi",
"givenName": "S",
"id": "sg:person.01120650620.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120650620.28"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/35077246",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024176319",
"https://doi.org/10.1038/35077246"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s005350170031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009858161",
"https://doi.org/10.1007/s005350170031"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/86297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022248670",
"https://doi.org/10.1038/86297"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1255",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007479553",
"https://doi.org/10.1038/nrc1255"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1102-991",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013709887",
"https://doi.org/10.1038/ni1102-991"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1102-999",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044871830",
"https://doi.org/10.1038/ni1102-999"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.3700055",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023117869",
"https://doi.org/10.1038/labinvest.3700055"
],
"type": "CreativeWork"
}
],
"datePublished": "2004-10-19",
"datePublishedReg": "2004-10-19",
"description": "T-cell infiltration into human cancer tissues can be a manifestation of host immune responses to cancer cells. The present study was undertaken to explore the clinicopathological significance of intraepithelial CD8+ T cells using 371 consecutively sampled human colorectal carcinomas. By univariate analysis, we noted that the survival curves by intraepithelial CD8+ T cells became separated only after 1 to 2 years postoperation. Multivariate analyses revealed that the beneficial effect of this factor becomes significant only after a longer (more than 2 year), but not after a shorter (less than 2 year) follow-up period. Furthermore, the number of intraepithelial CD8+ T cells was significantly higher in patients alive for more than 5 years than in patients who either died of cancer after a curative operation or patients who underwent a noncurative operation. Patients' cancer-specific death long after a curative operation is thought to be caused by the growth of micrometastases in other organs or near the primary sites. The effects of intraepithelial CD8+ T cells, therefore, may be mediated by suppression of micrometastasis, rather than suppression of growth in the primary tumour. In conclusion, our data support a hypothesis on the presence of systemic immunosurveillance against micrometastasis of cancer cells.",
"genre": "article",
"id": "sg:pub.10.1038/sj.bjc.6602201",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "91"
}
],
"keywords": [
"intraepithelial CD8",
"cancer-specific death",
"T cells",
"human colorectal carcinoma",
"curative operation",
"colorectal carcinoma",
"T cell infiltration",
"cancer cells",
"host immune response",
"growth of micrometastases",
"human cancer tissues",
"noncurative operation",
"systemic immunosurveillance",
"years postoperation",
"prognostic factors",
"clinicopathological significance",
"primary tumor",
"univariate analysis",
"immune response",
"CD8",
"cancer tissues",
"primary site",
"survival curves",
"possible association",
"multivariate analysis",
"micrometastasis",
"patients",
"beneficial effects",
"suppression of growth",
"carcinoma",
"present study",
"cells",
"suppression",
"micrometastases",
"postoperation",
"immunosurveillance",
"tumors",
"cancer",
"death",
"infiltration",
"manifestations",
"period",
"factors",
"organs",
"tissue",
"association",
"conclusion",
"effect",
"years",
"response",
"significance",
"study",
"analysis",
"hypothesis",
"presence",
"growth",
"data",
"sites",
"number",
"curves",
"operation"
],
"name": "Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis",
"pagination": "1711-1717",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1011870228"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6602201"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"15494715"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6602201",
"https://app.dimensions.ai/details/publication/pub.1011870228"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_392.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/sj.bjc.6602201"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602201'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602201'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602201'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602201'
This table displays all metadata directly associated to this object as RDF triples.
305 TRIPLES
21 PREDICATES
111 URIs
96 LITERALS
25 BLANK NODES