Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-10

AUTHORS

D M Abd El-Rehim, S E Pinder, C E Paish, J A Bell, R S Rampaul, R W Blamey, J F R Robertson, R I Nicholson, I O Ellis

ABSTRACT

The epidermal growth factor receptor (EGFR) family plays an important role in breast carcinogenesis. Much interest has been focused recently on its members because of their potential role as prognostic indicators in breast cancer and their involvement in cancer therapy. We have evaluated more than 1500 cases of invasive breast carcinoma immunohistochemically using tissue microarray technology to examine the expression of EGFR family receptor proteins. We have found that 20.1 and 31.8% of cases were positive for EGFR and c-erbB-2, respectively, and 45 and 45.1% of tumours overexpressed for c-erbB-3 and c-erbB-4, respectively. The expression of either EGFR or c-erbB-2 was associated with other bad prognostic features and with poor outcome. Neither c-erbB-3 nor c-erbB-4 had any association with survival. c-erbB-2 had an independent prognostic effect on overall and disease-free survival (DFS) in all cases, as well as in the subset of breast carcinoma patients with nodal metastases. Several hetero- and homodimeric combinations have been reported between the EGFR members. Those dimers can evoke diverse signal transduction pathways with variable cellular responses. We stratified cases according to their co-expression of receptors into distinct groups with different receptor-positive combinations. Patients whose tumours co-expressed c-erbB-2 and c-erbB-3, as well as those whose tumours co-expressed EGFR, c-erbB-2 and c-erbB-4 showed an unfavourable outcome compared with other groups, while combined c-erbB-3 and c-erbB-4 expression was associated with a better outcome. In cases showing expression of one family member only (homodimers), we found a significant association between c-erbB-4 homodimer-expressing tumours and better DFS. In contrast, patients with c-erbB-2 homodimer-expressing tumours had a significant poorer DFS compared with other cases. These data imply that the combined profile expression patterns of the four receptor family members together provide more accurate information on the tumour behaviour than studying the expression of each receptor individually. More... »

PAGES

1532

References to SciGraph publications

  • 1998-11. The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2002-01. Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 1991-03. The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer in BRITISH JOURNAL OF CANCER
  • 1991-03. The long term prognostic significance of c-erbB-2 in primary breast cancer in BRITISH JOURNAL OF CANCER
  • 1998-07. Tissue microarrays for high-throughput molecular profiling of tumor specimens in NATURE MEDICINE
  • 1991-03. c-erbB-2 oncoprotein expression in primary and advanced breast cancer in BRITISH JOURNAL OF CANCER
  • 1998-10. c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer in ONCOGENE
  • 2000-03. c-erbB-4 protein expression in human breast cancer in BRITISH JOURNAL OF CANCER
  • 2003-01. Reliability of Tissue Microarrays in Detecting Protein Expression and Gene Amplification in Breast Cancer in MODERN PATHOLOGY
  • 2000-12. HER2/Neu: mechanisms of dimerization/oligomerization in ONCOGENE
  • 1994-01. Role of epidermal growth factor receptor expression in primary breast cancer: results of a biochemical study and an immunocytochemical study in BREAST CANCER RESEARCH AND TREATMENT
  • 1999-01. Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas in BREAST CANCER RESEARCH AND TREATMENT
  • 1992-12. Expression of the ERBB3 gene product in breast cancer in BRITISH JOURNAL OF CANCER
  • 2001-07. Estrogen receptor-α and C-ERBB-4 expression in breast carcinomas in VIRCHOWS ARCHIV
  • 1998-11. Expression of c-erbB3 protein in primary breast carcinomas in BRITISH JOURNAL OF CANCER
  • 1996-07. C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators in BRITISH JOURNAL OF CANCER
  • 1992-10. The Nottingham prognostic index in primary breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-12. Validation of Tissue Microarray Technology in Breast Carcinoma in LABORATORY INVESTIGATION
  • 1997-06. c-erbB-2 oncoprotein detected by automated quantitative immunocytochemistry in breast carcinomas correlates with patients' overall and disease-free survival in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.bjc.6602184

    DOI

    http://dx.doi.org/10.1038/sj.bjc.6602184

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002758128

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15480434


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "ErbB Receptors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoenzyme Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Ductal, Lobular, and Medullary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, ErbB-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, ErbB-3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, ErbB-4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "El-Rehim", 
            "givenName": "D M Abd", 
            "id": "sg:person.011125763405.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011125763405.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pinder", 
            "givenName": "S E", 
            "id": "sg:person.014576043464.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576043464.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paish", 
            "givenName": "C E", 
            "id": "sg:person.01232125672.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232125672.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bell", 
            "givenName": "J A", 
            "id": "sg:person.016203754172.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016203754172.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rampaul", 
            "givenName": "R S", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blamey", 
            "givenName": "R W", 
            "id": "sg:person.015650304144.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robertson", 
            "givenName": "J F R", 
            "id": "sg:person.013163325712.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013163325712.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Tenovus Institute, Cardiff, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nicholson", 
            "givenName": "R I", 
            "id": "sg:person.015600601312.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015600601312.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ellis", 
            "givenName": "I O", 
            "id": "sg:person.01054612302.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.271.7.3884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000285441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1992.tb01032.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003509058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.38.11.1225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004578350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1992.420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006183819", 
              "https://doi.org/10.1038/bjc.1992.420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1992.420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006183819", 
              "https://doi.org/10.1038/bjc.1992.420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.43.5.385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009884721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010222506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010222506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012699907", 
              "https://doi.org/10.1038/sj.onc.1203967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012699907", 
              "https://doi.org/10.1038/sj.onc.1203967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1994.tb01269.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016928740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1994.tb01269.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016928740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017174937", 
              "https://doi.org/10.1038/bjc.1991.102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017174937", 
              "https://doi.org/10.1038/bjc.1991.102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.56.4.300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017209896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019793539", 
              "https://doi.org/10.1038/bjc.1991.103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019793539", 
              "https://doi.org/10.1038/bjc.1991.103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023327364", 
              "https://doi.org/10.1038/bjc.1991.101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023327364", 
              "https://doi.org/10.1038/bjc.1991.101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0960-9776(95)90022-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025189405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63075-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027954772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006194700667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028407594", 
              "https://doi.org/10.1023/a:1006194700667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/01.mp.0000047307.96344.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030665397", 
              "https://doi.org/10.1097/01.mp.0000047307.96344.93"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006107016969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031126754", 
              "https://doi.org/10.1023/a:1006107016969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01840834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032983382", 
              "https://doi.org/10.1007/bf01840834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033425444", 
              "https://doi.org/10.1038/bjc.1998.689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033425444", 
              "https://doi.org/10.1038/bjc.1998.689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1054/bjoc.1999.1057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034062010", 
              "https://doi.org/10.1054/bjoc.1999.1057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.10.5276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034449776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(98)00454-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035608196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1013397232011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035735011", 
              "https://doi.org/10.1023/a:1013397232011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037929238", 
              "https://doi.org/10.1038/sj.onc.1202107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037929238", 
              "https://doi.org/10.1038/sj.onc.1202107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1997.283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038456239", 
              "https://doi.org/10.1038/bjc.1997.283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1997.283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038456239", 
              "https://doi.org/10.1038/bjc.1997.283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(05)80897-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039844111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042330888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1050-1738(01)00065-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042473905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19900501)65:9<1980::aid-cncr2820650917>3.0.co;2-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044708548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004280000392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044999730", 
              "https://doi.org/10.1007/s004280000392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3780204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045657100", 
              "https://doi.org/10.1038/labinvest.3780204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3780204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045657100", 
              "https://doi.org/10.1038/labinvest.3780204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00666181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046480098", 
              "https://doi.org/10.1007/bf00666181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00666181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046480098", 
              "https://doi.org/10.1007/bf00666181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(87)90593-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046668239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(87)90593-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046668239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1996.342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047264538", 
              "https://doi.org/10.1038/bjc.1996.342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1996.342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047264538", 
              "https://doi.org/10.1038/bjc.1996.342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2559.1998.00498.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049996043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0798-844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051373741", 
              "https://doi.org/10.1038/nm0798-844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(98)00224-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051726024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/msy.2003.32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051749749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053730818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2885917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062570108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074487689", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.13.14.1939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074543319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074736049", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074829595", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080018509", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082404273", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00101.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082411568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082915087", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083060248", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083124300", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083164610", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-10", 
        "datePublishedReg": "2004-10-01", 
        "description": "The epidermal growth factor receptor (EGFR) family plays an important role in breast carcinogenesis. Much interest has been focused recently on its members because of their potential role as prognostic indicators in breast cancer and their involvement in cancer therapy. We have evaluated more than 1500 cases of invasive breast carcinoma immunohistochemically using tissue microarray technology to examine the expression of EGFR family receptor proteins. We have found that 20.1 and 31.8% of cases were positive for EGFR and c-erbB-2, respectively, and 45 and 45.1% of tumours overexpressed for c-erbB-3 and c-erbB-4, respectively. The expression of either EGFR or c-erbB-2 was associated with other bad prognostic features and with poor outcome. Neither c-erbB-3 nor c-erbB-4 had any association with survival. c-erbB-2 had an independent prognostic effect on overall and disease-free survival (DFS) in all cases, as well as in the subset of breast carcinoma patients with nodal metastases. Several hetero- and homodimeric combinations have been reported between the EGFR members. Those dimers can evoke diverse signal transduction pathways with variable cellular responses. We stratified cases according to their co-expression of receptors into distinct groups with different receptor-positive combinations. Patients whose tumours co-expressed c-erbB-2 and c-erbB-3, as well as those whose tumours co-expressed EGFR, c-erbB-2 and c-erbB-4 showed an unfavourable outcome compared with other groups, while combined c-erbB-3 and c-erbB-4 expression was associated with a better outcome. In cases showing expression of one family member only (homodimers), we found a significant association between c-erbB-4 homodimer-expressing tumours and better DFS. In contrast, patients with c-erbB-2 homodimer-expressing tumours had a significant poorer DFS compared with other cases. These data imply that the combined profile expression patterns of the four receptor family members together provide more accurate information on the tumour behaviour than studying the expression of each receptor individually.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.bjc.6602184", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "91"
          }
        ], 
        "name": "Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma", 
        "pagination": "1532", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0d222d7abb4481118a45f6967e8b8a8754d99c8115f7254044a5f2eed7d1559c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15480434"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0370635"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.bjc.6602184"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1002758128"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.bjc.6602184", 
          "https://app.dimensions.ai/details/publication/pub.1002758128"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118315_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/6602184"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602184'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602184'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602184'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602184'


     

    This table displays all metadata directly associated to this object as RDF triples.

    362 TRIPLES      21 PREDICATES      98 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.bjc.6602184 schema:about N05895fa84c334f53bb2bc02bda466365
    2 N13e436dbe4c0443bb2a6fd677d2d133c
    3 N1ecbfac881a44eb3840ef17db152ae1e
    4 N4c487ac6c3d1493ba05f524d03bb4e2a
    5 N527f9759c4f64d4ba7f9370bb346172c
    6 N53de8b12e6104a0f9adf1c68c0eaa309
    7 N620d87d24dc44742b5dbb0e516ce051f
    8 N6ceb6993ce22403ebf8520feecd39b7f
    9 N858d40488ae742e3ae78fce43b4534bb
    10 N99837a70233b477291dee8fd5c524c32
    11 N9ffd2f3b49f44a6d84e5dd54f4e5353b
    12 Na8f410d1e8114787b9e809f11be95ed3
    13 Nbb59dd2d1e4e450c9714ea8c5626d630
    14 Nc381b60ab30046688e942c81e64d81c9
    15 Ncaad35367c9e4589aa80a5662f2050a1
    16 Ndc9b555b27c34461afb2f10bb8dbd55d
    17 Nf304efbd7c624a2ca52992b6cf0f88ed
    18 Nf359c9de034448e3b33d6985375a7245
    19 anzsrc-for:11
    20 anzsrc-for:1112
    21 schema:author Nb7d5feec1ea84a14b9b623ec3dc3b088
    22 schema:citation sg:pub.10.1007/bf00666181
    23 sg:pub.10.1007/bf01840834
    24 sg:pub.10.1007/s004280000392
    25 sg:pub.10.1023/a:1006107016969
    26 sg:pub.10.1023/a:1006194700667
    27 sg:pub.10.1023/a:1013397232011
    28 sg:pub.10.1038/bjc.1991.101
    29 sg:pub.10.1038/bjc.1991.102
    30 sg:pub.10.1038/bjc.1991.103
    31 sg:pub.10.1038/bjc.1992.420
    32 sg:pub.10.1038/bjc.1996.342
    33 sg:pub.10.1038/bjc.1997.283
    34 sg:pub.10.1038/bjc.1998.689
    35 sg:pub.10.1038/labinvest.3780204
    36 sg:pub.10.1038/nm0798-844
    37 sg:pub.10.1038/sj.onc.1202107
    38 sg:pub.10.1038/sj.onc.1203967
    39 sg:pub.10.1054/bjoc.1999.1057
    40 sg:pub.10.1097/01.mp.0000047307.96344.93
    41 https://app.dimensions.ai/details/publication/pub.1074487689
    42 https://app.dimensions.ai/details/publication/pub.1074736049
    43 https://app.dimensions.ai/details/publication/pub.1074829595
    44 https://app.dimensions.ai/details/publication/pub.1080018509
    45 https://app.dimensions.ai/details/publication/pub.1082404273
    46 https://app.dimensions.ai/details/publication/pub.1082915087
    47 https://app.dimensions.ai/details/publication/pub.1083060248
    48 https://app.dimensions.ai/details/publication/pub.1083124300
    49 https://app.dimensions.ai/details/publication/pub.1083164610
    50 https://doi.org/10.1002/1097-0142(19900501)65:9<1980::aid-cncr2820650917>3.0.co;2-u
    51 https://doi.org/10.1002/j.1460-2075.1995.tb00101.x
    52 https://doi.org/10.1002/path.1003
    53 https://doi.org/10.1002/path.1370
    54 https://doi.org/10.1016/0960-9776(95)90022-5
    55 https://doi.org/10.1016/s0002-9440(10)63075-1
    56 https://doi.org/10.1016/s0002-9610(05)80897-9
    57 https://doi.org/10.1016/s0014-5793(98)00224-5
    58 https://doi.org/10.1016/s0140-6736(87)90593-9
    59 https://doi.org/10.1016/s0378-1119(98)00454-5
    60 https://doi.org/10.1016/s1050-1738(01)00065-2
    61 https://doi.org/10.1046/j.1365-2559.1998.00498.x
    62 https://doi.org/10.1067/msy.2003.32
    63 https://doi.org/10.1074/jbc.271.7.3884
    64 https://doi.org/10.1096/fasebj.13.14.1939
    65 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
    66 https://doi.org/10.1111/j.1365-2559.1992.tb01032.x
    67 https://doi.org/10.1111/j.1365-2559.1994.tb01269.x
    68 https://doi.org/10.1126/science.2885917
    69 https://doi.org/10.1128/mcb.16.10.5276
    70 https://doi.org/10.1136/jcp.38.11.1225
    71 https://doi.org/10.1136/jcp.43.5.385
    72 https://doi.org/10.1136/jcp.56.4.300
    73 schema:datePublished 2004-10
    74 schema:datePublishedReg 2004-10-01
    75 schema:description The epidermal growth factor receptor (EGFR) family plays an important role in breast carcinogenesis. Much interest has been focused recently on its members because of their potential role as prognostic indicators in breast cancer and their involvement in cancer therapy. We have evaluated more than 1500 cases of invasive breast carcinoma immunohistochemically using tissue microarray technology to examine the expression of EGFR family receptor proteins. We have found that 20.1 and 31.8% of cases were positive for EGFR and c-erbB-2, respectively, and 45 and 45.1% of tumours overexpressed for c-erbB-3 and c-erbB-4, respectively. The expression of either EGFR or c-erbB-2 was associated with other bad prognostic features and with poor outcome. Neither c-erbB-3 nor c-erbB-4 had any association with survival. c-erbB-2 had an independent prognostic effect on overall and disease-free survival (DFS) in all cases, as well as in the subset of breast carcinoma patients with nodal metastases. Several hetero- and homodimeric combinations have been reported between the EGFR members. Those dimers can evoke diverse signal transduction pathways with variable cellular responses. We stratified cases according to their co-expression of receptors into distinct groups with different receptor-positive combinations. Patients whose tumours co-expressed c-erbB-2 and c-erbB-3, as well as those whose tumours co-expressed EGFR, c-erbB-2 and c-erbB-4 showed an unfavourable outcome compared with other groups, while combined c-erbB-3 and c-erbB-4 expression was associated with a better outcome. In cases showing expression of one family member only (homodimers), we found a significant association between c-erbB-4 homodimer-expressing tumours and better DFS. In contrast, patients with c-erbB-2 homodimer-expressing tumours had a significant poorer DFS compared with other cases. These data imply that the combined profile expression patterns of the four receptor family members together provide more accurate information on the tumour behaviour than studying the expression of each receptor individually.
    76 schema:genre research_article
    77 schema:inLanguage en
    78 schema:isAccessibleForFree true
    79 schema:isPartOf N8c4379603c024d93aafd50b945d926ff
    80 Neb8ab109eef0435b8d0739048700f328
    81 sg:journal.1017082
    82 schema:name Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
    83 schema:pagination 1532
    84 schema:productId N8926cee52ebd40e2b0e10fa94a3fb3b2
    85 Na1c14a0df9f94a8c8b16a66cfb175858
    86 Na218e546381f48fa99842fcf3ab4092b
    87 Naf2fcbc5579244439715c8b07969adcb
    88 Nffd89a0ad78a49a5b4d4281badb68bd5
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002758128
    90 https://doi.org/10.1038/sj.bjc.6602184
    91 schema:sdDatePublished 2019-04-11T12:04
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher Nf162dd124c5f43e69ca4377b8c4862c4
    94 schema:url https://www.nature.com/articles/6602184
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N05895fa84c334f53bb2bc02bda466365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Neoplasms, Ductal, Lobular, and Medullary
    100 rdf:type schema:DefinedTerm
    101 N13e436dbe4c0443bb2a6fd677d2d133c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Breast Neoplasms
    103 rdf:type schema:DefinedTerm
    104 N1c4346ee5d554113af303cec0ffba9d7 rdf:first Na0afed4f17b2415aa8df1a85792ab6d2
    105 rdf:rest N253a68696b9946b7a6725aae1be06998
    106 N1ecbfac881a44eb3840ef17db152ae1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Female
    108 rdf:type schema:DefinedTerm
    109 N253a68696b9946b7a6725aae1be06998 rdf:first sg:person.015650304144.58
    110 rdf:rest N90575334426c41efa7f75e2c9a0e3bc3
    111 N4c487ac6c3d1493ba05f524d03bb4e2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Prognosis
    113 rdf:type schema:DefinedTerm
    114 N527f9759c4f64d4ba7f9370bb346172c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Prospective Studies
    116 rdf:type schema:DefinedTerm
    117 N53bf85cff6cb46069c104e1ca2fc8c1b rdf:first sg:person.015600601312.02
    118 rdf:rest N5ce387f87d714e9aa396bae0b22b82d2
    119 N53de8b12e6104a0f9adf1c68c0eaa309 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Survival Rate
    121 rdf:type schema:DefinedTerm
    122 N595f691cbb6d49f1961327604a589d5c rdf:first sg:person.01232125672.63
    123 rdf:rest Nd125d58ac4cd4dcbb03b06cbe717887d
    124 N5ce387f87d714e9aa396bae0b22b82d2 rdf:first sg:person.01054612302.65
    125 rdf:rest rdf:nil
    126 N620d87d24dc44742b5dbb0e516ce051f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Immunoenzyme Techniques
    128 rdf:type schema:DefinedTerm
    129 N6ceb6993ce22403ebf8520feecd39b7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Receptor, ErbB-3
    131 rdf:type schema:DefinedTerm
    132 N858d40488ae742e3ae78fce43b4534bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Adolescent
    134 rdf:type schema:DefinedTerm
    135 N8926cee52ebd40e2b0e10fa94a3fb3b2 schema:name nlm_unique_id
    136 schema:value 0370635
    137 rdf:type schema:PropertyValue
    138 N8c4379603c024d93aafd50b945d926ff schema:issueNumber 8
    139 rdf:type schema:PublicationIssue
    140 N90575334426c41efa7f75e2c9a0e3bc3 rdf:first sg:person.013163325712.61
    141 rdf:rest N53bf85cff6cb46069c104e1ca2fc8c1b
    142 N92741a3513f94bb18ead159c91bca443 schema:name Tenovus Institute, Cardiff, UK
    143 rdf:type schema:Organization
    144 N99837a70233b477291dee8fd5c524c32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name ErbB Receptors
    146 rdf:type schema:DefinedTerm
    147 N9ffd2f3b49f44a6d84e5dd54f4e5353b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Adenocarcinoma
    149 rdf:type schema:DefinedTerm
    150 Na0afed4f17b2415aa8df1a85792ab6d2 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    151 schema:familyName Rampaul
    152 schema:givenName R S
    153 rdf:type schema:Person
    154 Na1c14a0df9f94a8c8b16a66cfb175858 schema:name doi
    155 schema:value 10.1038/sj.bjc.6602184
    156 rdf:type schema:PropertyValue
    157 Na218e546381f48fa99842fcf3ab4092b schema:name pubmed_id
    158 schema:value 15480434
    159 rdf:type schema:PropertyValue
    160 Na8f410d1e8114787b9e809f11be95ed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Aged
    162 rdf:type schema:DefinedTerm
    163 Naf2fcbc5579244439715c8b07969adcb schema:name readcube_id
    164 schema:value 0d222d7abb4481118a45f6967e8b8a8754d99c8115f7254044a5f2eed7d1559c
    165 rdf:type schema:PropertyValue
    166 Nb7d5feec1ea84a14b9b623ec3dc3b088 rdf:first sg:person.011125763405.36
    167 rdf:rest Nd7bf8bf282a247b98969589a9519baae
    168 Nbb59dd2d1e4e450c9714ea8c5626d630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Adult
    170 rdf:type schema:DefinedTerm
    171 Nc381b60ab30046688e942c81e64d81c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Receptor, ErbB-2
    173 rdf:type schema:DefinedTerm
    174 Ncaad35367c9e4589aa80a5662f2050a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Receptor, ErbB-4
    176 rdf:type schema:DefinedTerm
    177 Nd125d58ac4cd4dcbb03b06cbe717887d rdf:first sg:person.016203754172.26
    178 rdf:rest N1c4346ee5d554113af303cec0ffba9d7
    179 Nd7bf8bf282a247b98969589a9519baae rdf:first sg:person.014576043464.09
    180 rdf:rest N595f691cbb6d49f1961327604a589d5c
    181 Ndc9b555b27c34461afb2f10bb8dbd55d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Neoplasm Invasiveness
    183 rdf:type schema:DefinedTerm
    184 Neb8ab109eef0435b8d0739048700f328 schema:volumeNumber 91
    185 rdf:type schema:PublicationVolume
    186 Nf162dd124c5f43e69ca4377b8c4862c4 schema:name Springer Nature - SN SciGraph project
    187 rdf:type schema:Organization
    188 Nf304efbd7c624a2ca52992b6cf0f88ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Middle Aged
    190 rdf:type schema:DefinedTerm
    191 Nf359c9de034448e3b33d6985375a7245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Humans
    193 rdf:type schema:DefinedTerm
    194 Nffd89a0ad78a49a5b4d4281badb68bd5 schema:name dimensions_id
    195 schema:value pub.1002758128
    196 rdf:type schema:PropertyValue
    197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Medical and Health Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Oncology and Carcinogenesis
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1017082 schema:issn 0007-0920
    204 1532-1827
    205 schema:name British Journal of Cancer
    206 rdf:type schema:Periodical
    207 sg:person.01054612302.65 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    208 schema:familyName Ellis
    209 schema:givenName I O
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65
    211 rdf:type schema:Person
    212 sg:person.011125763405.36 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    213 schema:familyName El-Rehim
    214 schema:givenName D M Abd
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011125763405.36
    216 rdf:type schema:Person
    217 sg:person.01232125672.63 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    218 schema:familyName Paish
    219 schema:givenName C E
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232125672.63
    221 rdf:type schema:Person
    222 sg:person.013163325712.61 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    223 schema:familyName Robertson
    224 schema:givenName J F R
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013163325712.61
    226 rdf:type schema:Person
    227 sg:person.014576043464.09 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    228 schema:familyName Pinder
    229 schema:givenName S E
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576043464.09
    231 rdf:type schema:Person
    232 sg:person.015600601312.02 schema:affiliation N92741a3513f94bb18ead159c91bca443
    233 schema:familyName Nicholson
    234 schema:givenName R I
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015600601312.02
    236 rdf:type schema:Person
    237 sg:person.015650304144.58 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    238 schema:familyName Blamey
    239 schema:givenName R W
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58
    241 rdf:type schema:Person
    242 sg:person.016203754172.26 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    243 schema:familyName Bell
    244 schema:givenName J A
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016203754172.26
    246 rdf:type schema:Person
    247 sg:pub.10.1007/bf00666181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046480098
    248 https://doi.org/10.1007/bf00666181
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/bf01840834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032983382
    251 https://doi.org/10.1007/bf01840834
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s004280000392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044999730
    254 https://doi.org/10.1007/s004280000392
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1023/a:1006107016969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031126754
    257 https://doi.org/10.1023/a:1006107016969
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1023/a:1006194700667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028407594
    260 https://doi.org/10.1023/a:1006194700667
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1023/a:1013397232011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035735011
    263 https://doi.org/10.1023/a:1013397232011
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/bjc.1991.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023327364
    266 https://doi.org/10.1038/bjc.1991.101
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/bjc.1991.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017174937
    269 https://doi.org/10.1038/bjc.1991.102
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/bjc.1991.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019793539
    272 https://doi.org/10.1038/bjc.1991.103
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/bjc.1992.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006183819
    275 https://doi.org/10.1038/bjc.1992.420
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/bjc.1996.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047264538
    278 https://doi.org/10.1038/bjc.1996.342
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/bjc.1997.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038456239
    281 https://doi.org/10.1038/bjc.1997.283
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/bjc.1998.689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033425444
    284 https://doi.org/10.1038/bjc.1998.689
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/labinvest.3780204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045657100
    287 https://doi.org/10.1038/labinvest.3780204
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nm0798-844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051373741
    290 https://doi.org/10.1038/nm0798-844
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/sj.onc.1202107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037929238
    293 https://doi.org/10.1038/sj.onc.1202107
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/sj.onc.1203967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012699907
    296 https://doi.org/10.1038/sj.onc.1203967
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1054/bjoc.1999.1057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034062010
    299 https://doi.org/10.1054/bjoc.1999.1057
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1097/01.mp.0000047307.96344.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030665397
    302 https://doi.org/10.1097/01.mp.0000047307.96344.93
    303 rdf:type schema:CreativeWork
    304 https://app.dimensions.ai/details/publication/pub.1074487689 schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1074736049 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1074829595 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1080018509 schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1082404273 schema:CreativeWork
    309 https://app.dimensions.ai/details/publication/pub.1082915087 schema:CreativeWork
    310 https://app.dimensions.ai/details/publication/pub.1083060248 schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1083124300 schema:CreativeWork
    312 https://app.dimensions.ai/details/publication/pub.1083164610 schema:CreativeWork
    313 https://doi.org/10.1002/1097-0142(19900501)65:9<1980::aid-cncr2820650917>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1044708548
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1002/j.1460-2075.1995.tb00101.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082411568
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1002/path.1003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053730818
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1002/path.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042330888
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/0960-9776(95)90022-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025189405
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0002-9440(10)63075-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027954772
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0002-9610(05)80897-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039844111
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s0014-5793(98)00224-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051726024
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s0140-6736(87)90593-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046668239
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/s0378-1119(98)00454-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035608196
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s1050-1738(01)00065-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042473905
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1046/j.1365-2559.1998.00498.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049996043
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1067/msy.2003.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051749749
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1074/jbc.271.7.3884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000285441
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1096/fasebj.13.14.1939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074543319
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222506
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1111/j.1365-2559.1992.tb01032.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509058
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1111/j.1365-2559.1994.tb01269.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016928740
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1126/science.2885917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570108
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1128/mcb.16.10.5276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034449776
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1136/jcp.38.11.1225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004578350
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1136/jcp.43.5.385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009884721
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1136/jcp.56.4.300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017209896
    358 rdf:type schema:CreativeWork
    359 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
    360 schema:name Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    361 Department of Surgery, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    362 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...