Phase II trial of carboplatin and etoposide for patients with recurrent high-grade glioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-08-10

AUTHORS

E Franceschi, G Cavallo, L Scopece, A Paioli, A Pession, E Magrini, R Conforti, E Palmerini, S Bartolini, S Rimondini, R Degli Esposti, L Crinò

ABSTRACT

We present the results of a phase II trial of carboplatin and etoposide (CE) combination as first-line chemotherapy in patients with recurrent glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) after surgery and radiotherapy. We assess the activity and the tolerability of this combination. 30 patients with GBM (25) and AA (5) were treated with VP-16 (etoposide) 120 mg m−2 and CBCDA (carboplatin) 100 mg m−2 for 3 days every 4 weeks. Moreover, we performed a retrospective analysis of topoisomerase IIα gene status using chromogenic in situ hybridisation. The median age was 54 years (21–73 years); Eastern Cooperative Oncology Group performance score was 0-1 in 25 patients and 2 in five patients. All patients had been previously treated with surgical resection (21 radical resections) followed by radiation therapy (40–60 Gy). We observed six (20%) complete responses, three (10%) partial responses and 12 (40%) stable diseases, with a response rate of 30%. The median time to progression was 4 months, while progression-free survival at 6 months was 33.3%. The median survival time was 10 months. Neutropenia occurred in 9 patients: four patients had grade 4, two patients grade 3 and three patients grade 2. In the conclusion of this clinical trial, the CE combination has shown activity in recurrent GBM and AA, with a good toxicity profile. Alterations in the copy number of topoisomerase IIα gene seem to be a rare event and in our series do not influence response to the CE combination. More... »

PAGES

1038-1044

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6602105

DOI

http://dx.doi.org/10.1038/sj.bjc.6602105

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008198089

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15305187


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32 schema:description We present the results of a phase II trial of carboplatin and etoposide (CE) combination as first-line chemotherapy in patients with recurrent glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA) after surgery and radiotherapy. We assess the activity and the tolerability of this combination. 30 patients with GBM (25) and AA (5) were treated with VP-16 (etoposide) 120 mg m−2 and CBCDA (carboplatin) 100 mg m−2 for 3 days every 4 weeks. Moreover, we performed a retrospective analysis of topoisomerase IIα gene status using chromogenic in situ hybridisation. The median age was 54 years (21–73 years); Eastern Cooperative Oncology Group performance score was 0-1 in 25 patients and 2 in five patients. All patients had been previously treated with surgical resection (21 radical resections) followed by radiation therapy (40–60 Gy). We observed six (20%) complete responses, three (10%) partial responses and 12 (40%) stable diseases, with a response rate of 30%. The median time to progression was 4 months, while progression-free survival at 6 months was 33.3%. The median survival time was 10 months. Neutropenia occurred in 9 patients: four patients had grade 4, two patients grade 3 and three patients grade 2. In the conclusion of this clinical trial, the CE combination has shown activity in recurrent GBM and AA, with a good toxicity profile. Alterations in the copy number of topoisomerase IIα gene seem to be a rare event and in our series do not influence response to the CE combination.
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39 Eastern Cooperative Oncology Group performance score
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43 age
44 alterations
45 analysis
46 anaplastic astrocytoma
47 astrocytomas
48 better toxicity profile
49 carboplatin
50 chemotherapy
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53 complete response
54 conclusion
55 copy number
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57 disease
58 etoposide
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60 events
61 first-line chemotherapy
62 gene status
63 genes
64 glioblastoma multiforme
65 gliomas
66 grade 2
67 grade 3
68 grade 4
69 high-grade gliomas
70 hybridisation
71 median age
72 median survival time
73 median time
74 months
75 multiforme
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82 performance scores
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84 profile
85 progression
86 progression-free survival
87 radiation therapy
88 radiotherapy
89 rare event
90 rate
91 recurrent glioblastoma multiforme
92 recurrent high-grade glioma
93 resection
94 response
95 response rate
96 results
97 retrospective analysis
98 scores
99 series
100 situ hybridisation
101 stable disease
102 status
103 surgery
104 surgical resection
105 survival
106 survival time
107 therapy
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110 topoisomerase IIα gene
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