Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-08

AUTHORS

S Gao, J Worm, P Guldberg, H Eiberg, A Krogdahl, J A Sørensen, C-J Liu, J Reibel, E Dabelsteen

ABSTRACT

The DBCCR1 gene at chromosome 9q33 has been identified as a candidate tumour suppressor, which is frequently targeted by promoter hypermethylation in bladder cancer. Here, we studied the possible involvement of DBCCR1 in the development of oral squamous cell carcinoma. DNA from 34 tumours was examined for loss of heterozygosity (LOH) at three markers surrounding DBCCR1 and for hypermethylation of the DBCCR1 promoter, using methylation-specific PCR and methylation-specific melting-curve analysis. LOH was found in 10 of 31 cases (32%), and DBCCR1 hypermethylation was present in 15 of 34 cases (44%). Hypermethylation of DBCCR1 was also present in three of seven epithelial tissues adjacent to the tumours, including two hyperplastic and one histologically normal epithelia. Furthermore, of four oral leukoplakias with dysplasia, one showed LOH at 9q33 and two showed DBCCR1 hypermethylation. These data suggest that LOH at 9q33 and hypermethylation of the DBCCR1 promoter are frequent and possibly early events in oral malignant development. More... »

PAGES

760

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6601980

DOI

http://dx.doi.org/10.1038/sj.bjc.6601980

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052269031

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15226771


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mouth Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precancerous Conditions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, N\u00f8rre Alle 20, DK-2200 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "S", 
        "id": "sg:person.01132717046.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132717046.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Worm", 
        "givenName": "J", 
        "id": "sg:person.0714514241.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714514241.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guldberg", 
        "givenName": "P", 
        "id": "sg:person.0760021664.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Institute of Medical Biochemistry and Genetics, University of Copenhagen, DK-2200 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eiberg", 
        "givenName": "H", 
        "id": "sg:person.01264756060.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264756060.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Pathology, Odense University Hospital, DK-5000 Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krogdahl", 
        "givenName": "A", 
        "id": "sg:person.0632275625.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632275625.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Plastic Surgery, Odense University Hospital, DK-5000 Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00f8rensen", 
        "givenName": "J A", 
        "id": "sg:person.01302255345.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302255345.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mackay Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413593.9", 
          "name": [
            "Department of Dentistry, Mackay Memorial Hospital, Taipei"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "C-J", 
        "id": "sg:person.01220551666.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220551666.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, N\u00f8rre Alle 20, DK-2200 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reibel", 
        "givenName": "J", 
        "id": "sg:person.0735332737.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735332737.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, N\u00f8rre Alle 20, DK-2200 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dabelsteen", 
        "givenName": "E", 
        "id": "sg:person.01074113664.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074113664.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/geno.1997.5165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002490184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005233499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(200003)190:4<407::aid-path546>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006602914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10059-000-0557-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007324517", 
          "https://doi.org/10.1007/s10059-000-0557-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199910)26:2<171::aid-gcc10>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009425331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.15.2990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013818512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2209/tdcpublication.42.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014295471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/6.6.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017883143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19991029)83:3<318::aid-ijc6>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017977233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019236802", 
          "https://doi.org/10.1038/sj.onc.1204122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019236802", 
          "https://doi.org/10.1038/sj.onc.1204122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.53.4.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022633242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.53.4.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022633242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14219/jada.archive.2001.0382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026747872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s100380170056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027544940", 
          "https://doi.org/10.1007/s100380170056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.11028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027831150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028927430", 
          "https://doi.org/10.1038/sj.onc.1204432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028927430", 
          "https://doi.org/10.1038/sj.onc.1204432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031452153", 
          "https://doi.org/10.1038/sj.onc.1205528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031452153", 
          "https://doi.org/10.1038/sj.onc.1205528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0714.2002.00034.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041471787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.52.37240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043464792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.11592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044058870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.49.1.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044953296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-8375(99)00020-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045829709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(02)00511-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046636774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(02)00511-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046636774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1096-9896(200107)194:3<294::aid-path911>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048413888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074840865", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075173473", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075271929", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082668245", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895703", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-08", 
    "datePublishedReg": "2004-08-01", 
    "description": "The DBCCR1 gene at chromosome 9q33 has been identified as a candidate tumour suppressor, which is frequently targeted by promoter hypermethylation in bladder cancer. Here, we studied the possible involvement of DBCCR1 in the development of oral squamous cell carcinoma. DNA from 34 tumours was examined for loss of heterozygosity (LOH) at three markers surrounding DBCCR1 and for hypermethylation of the DBCCR1 promoter, using methylation-specific PCR and methylation-specific melting-curve analysis. LOH was found in 10 of 31 cases (32%), and DBCCR1 hypermethylation was present in 15 of 34 cases (44%). Hypermethylation of DBCCR1 was also present in three of seven epithelial tissues adjacent to the tumours, including two hyperplastic and one histologically normal epithelia. Furthermore, of four oral leukoplakias with dysplasia, one showed LOH at 9q33 and two showed DBCCR1 hypermethylation. These data suggest that LOH at 9q33 and hypermethylation of the DBCCR1 promoter are frequent and possibly early events in oral malignant development.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6601980", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "91"
      }
    ], 
    "name": "Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma", 
    "pagination": "760", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f8f9b2b9d039c01dc8183d68d8927f6e9d946a0dd9e9b051d35f959325569210"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15226771"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6601980"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052269031"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6601980", 
      "https://app.dimensions.ai/details/publication/pub.1052269031"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118315_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6601980"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601980'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601980'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601980'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601980'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      73 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6601980 schema:about N11cfe99117c34526988eeacba127eb74
2 N1900cb3e4f8d4365b8d849c88f41dcf1
3 N1a2e8c868bc141afb8e1a36d87a18401
4 N21f44b6d6c9b411bbe73b4883c803b44
5 N33ef98ee63d24ef086e6a8fd180fae37
6 N4267331dab2549f786bef143a5d5c584
7 N56530a15d46b4ba4ac23080cb3702acc
8 N667a9247e0a243b0907ef22629e892b3
9 N8b63134109194d09a3f2ccd480ff9646
10 N93f2bb80978e4b5a831a863ac008e385
11 Nb022609bc5124f44a75462e50d655112
12 Nb6273e38c7b4460789fc14c696cd58da
13 Nd20d4fda77e94b809e67da4ddeafca8f
14 Nd95d1ab4b4e341019d53892b44f0d80c
15 Ne36c0401bd254368918148dcd4f9c0fc
16 Ne91a6c3d6ac64a2fb2d07433f1a239b5
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N7bbc760005304565af2479c8eaa5156e
20 schema:citation sg:pub.10.1007/s100380170056
21 sg:pub.10.1007/s10059-000-0557-8
22 sg:pub.10.1038/sj.onc.1204122
23 sg:pub.10.1038/sj.onc.1204432
24 sg:pub.10.1038/sj.onc.1205528
25 https://app.dimensions.ai/details/publication/pub.1074840865
26 https://app.dimensions.ai/details/publication/pub.1075173473
27 https://app.dimensions.ai/details/publication/pub.1075271929
28 https://app.dimensions.ai/details/publication/pub.1082668245
29 https://app.dimensions.ai/details/publication/pub.1082895703
30 https://doi.org/10.1002/(sici)1096-9896(200003)190:4<407::aid-path546>3.0.co;2-d
31 https://doi.org/10.1002/(sici)1097-0215(19991029)83:3<318::aid-ijc6>3.0.co;2-v
32 https://doi.org/10.1002/(sici)1098-2264(199910)26:2<171::aid-gcc10>3.0.co;2-b
33 https://doi.org/10.1002/1096-9896(200107)194:3<294::aid-path911>3.0.co;2-q
34 https://doi.org/10.1002/cncr.10211
35 https://doi.org/10.1002/ijc.11028
36 https://doi.org/10.1002/ijc.11592
37 https://doi.org/10.1006/geno.1997.5165
38 https://doi.org/10.1016/s0304-3835(02)00511-6
39 https://doi.org/10.1016/s1368-8375(99)00020-2
40 https://doi.org/10.1034/j.1600-0714.2002.00034.x
41 https://doi.org/10.1074/jbc.274.52.37240
42 https://doi.org/10.1093/hmg/6.6.913
43 https://doi.org/10.1093/nar/22.15.2990
44 https://doi.org/10.1136/mp.53.4.165
45 https://doi.org/10.14219/jada.archive.2001.0382
46 https://doi.org/10.2209/tdcpublication.42.159
47 https://doi.org/10.3322/canjclin.49.1.8
48 schema:datePublished 2004-08
49 schema:datePublishedReg 2004-08-01
50 schema:description The DBCCR1 gene at chromosome 9q33 has been identified as a candidate tumour suppressor, which is frequently targeted by promoter hypermethylation in bladder cancer. Here, we studied the possible involvement of DBCCR1 in the development of oral squamous cell carcinoma. DNA from 34 tumours was examined for loss of heterozygosity (LOH) at three markers surrounding DBCCR1 and for hypermethylation of the DBCCR1 promoter, using methylation-specific PCR and methylation-specific melting-curve analysis. LOH was found in 10 of 31 cases (32%), and DBCCR1 hypermethylation was present in 15 of 34 cases (44%). Hypermethylation of DBCCR1 was also present in three of seven epithelial tissues adjacent to the tumours, including two hyperplastic and one histologically normal epithelia. Furthermore, of four oral leukoplakias with dysplasia, one showed LOH at 9q33 and two showed DBCCR1 hypermethylation. These data suggest that LOH at 9q33 and hypermethylation of the DBCCR1 promoter are frequent and possibly early events in oral malignant development.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N3939b1666c664c7c9392b735ff07626b
55 Nd346ae268bce4f20bf56337550bf9f0d
56 sg:journal.1017082
57 schema:name Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma
58 schema:pagination 760
59 schema:productId N26c90d6816c44eb794b56f47e1c0f682
60 N3e15df2f967448079297df4fa2d01013
61 N3e40de03f73c49aa822bfa8b85439ed3
62 Nb9cb9270c30445d390bce63386e6b7af
63 Nbaee87f1c0404d6d8cc5d48300a70360
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052269031
65 https://doi.org/10.1038/sj.bjc.6601980
66 schema:sdDatePublished 2019-04-11T12:04
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nbbc9135facf24f1ea38b882dedcbd0ac
69 schema:url https://www.nature.com/articles/6601980
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N01e89d0d687843b58bf5965186add6f3 rdf:first sg:person.0714514241.20
74 rdf:rest N8e8e19fe88df4a858879b29892a4b52f
75 N073b9f92971549b6b7424db5620d12ae rdf:first sg:person.01302255345.34
76 rdf:rest N1a573356673143c7a18a0b375df0094d
77 N11cfe99117c34526988eeacba127eb74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Genes, Tumor Suppressor
79 rdf:type schema:DefinedTerm
80 N18c7a1aec0ec45f5be3e437b55c0c7f9 rdf:first sg:person.01074113664.20
81 rdf:rest rdf:nil
82 N1900cb3e4f8d4365b8d849c88f41dcf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Aged
84 rdf:type schema:DefinedTerm
85 N1a2e8c868bc141afb8e1a36d87a18401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Middle Aged
87 rdf:type schema:DefinedTerm
88 N1a573356673143c7a18a0b375df0094d rdf:first sg:person.01220551666.34
89 rdf:rest N260c204308c94aaaa2f0f1fb9c33331b
90 N21f44b6d6c9b411bbe73b4883c803b44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Precancerous Conditions
92 rdf:type schema:DefinedTerm
93 N260c204308c94aaaa2f0f1fb9c33331b rdf:first sg:person.0735332737.20
94 rdf:rest N18c7a1aec0ec45f5be3e437b55c0c7f9
95 N26c90d6816c44eb794b56f47e1c0f682 schema:name doi
96 schema:value 10.1038/sj.bjc.6601980
97 rdf:type schema:PropertyValue
98 N33ef98ee63d24ef086e6a8fd180fae37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Tumor Suppressor Proteins
100 rdf:type schema:DefinedTerm
101 N3939b1666c664c7c9392b735ff07626b schema:issueNumber 4
102 rdf:type schema:PublicationIssue
103 N3e15df2f967448079297df4fa2d01013 schema:name nlm_unique_id
104 schema:value 0370635
105 rdf:type schema:PropertyValue
106 N3e40de03f73c49aa822bfa8b85439ed3 schema:name dimensions_id
107 schema:value pub.1052269031
108 rdf:type schema:PropertyValue
109 N4267331dab2549f786bef143a5d5c584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Loss of Heterozygosity
111 rdf:type schema:DefinedTerm
112 N43ff6297c2df4c9bb8fdedad5b67f19c rdf:first sg:person.01264756060.61
113 rdf:rest Nc0d240f4dde64272ac1ec5ef5ff6f52a
114 N56530a15d46b4ba4ac23080cb3702acc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cell Transformation, Neoplastic
116 rdf:type schema:DefinedTerm
117 N667a9247e0a243b0907ef22629e892b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Chromosomes, Human, Pair 9
119 rdf:type schema:DefinedTerm
120 N7bbc760005304565af2479c8eaa5156e rdf:first sg:person.01132717046.08
121 rdf:rest N01e89d0d687843b58bf5965186add6f3
122 N8b63134109194d09a3f2ccd480ff9646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Adult
124 rdf:type schema:DefinedTerm
125 N8e8e19fe88df4a858879b29892a4b52f rdf:first sg:person.0760021664.46
126 rdf:rest N43ff6297c2df4c9bb8fdedad5b67f19c
127 N93f2bb80978e4b5a831a863ac008e385 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 Nb022609bc5124f44a75462e50d655112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 Nb6273e38c7b4460789fc14c696cd58da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Promoter Regions, Genetic
135 rdf:type schema:DefinedTerm
136 Nb9cb9270c30445d390bce63386e6b7af schema:name readcube_id
137 schema:value f8f9b2b9d039c01dc8183d68d8927f6e9d946a0dd9e9b051d35f959325569210
138 rdf:type schema:PropertyValue
139 Nbaee87f1c0404d6d8cc5d48300a70360 schema:name pubmed_id
140 schema:value 15226771
141 rdf:type schema:PropertyValue
142 Nbbc9135facf24f1ea38b882dedcbd0ac schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nc0d240f4dde64272ac1ec5ef5ff6f52a rdf:first sg:person.0632275625.63
145 rdf:rest N073b9f92971549b6b7424db5620d12ae
146 Nd20d4fda77e94b809e67da4ddeafca8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name DNA Methylation
148 rdf:type schema:DefinedTerm
149 Nd346ae268bce4f20bf56337550bf9f0d schema:volumeNumber 91
150 rdf:type schema:PublicationVolume
151 Nd95d1ab4b4e341019d53892b44f0d80c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Carcinoma, Squamous Cell
153 rdf:type schema:DefinedTerm
154 Ne36c0401bd254368918148dcd4f9c0fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mouth Neoplasms
156 rdf:type schema:DefinedTerm
157 Ne91a6c3d6ac64a2fb2d07433f1a239b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Male
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
164 schema:name Oncology and Carcinogenesis
165 rdf:type schema:DefinedTerm
166 sg:journal.1017082 schema:issn 0007-0920
167 1532-1827
168 schema:name British Journal of Cancer
169 rdf:type schema:Periodical
170 sg:person.01074113664.20 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
171 schema:familyName Dabelsteen
172 schema:givenName E
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074113664.20
174 rdf:type schema:Person
175 sg:person.01132717046.08 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
176 schema:familyName Gao
177 schema:givenName S
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132717046.08
179 rdf:type schema:Person
180 sg:person.01220551666.34 schema:affiliation https://www.grid.ac/institutes/grid.413593.9
181 schema:familyName Liu
182 schema:givenName C-J
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220551666.34
184 rdf:type schema:Person
185 sg:person.01264756060.61 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
186 schema:familyName Eiberg
187 schema:givenName H
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264756060.61
189 rdf:type schema:Person
190 sg:person.01302255345.34 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
191 schema:familyName Sørensen
192 schema:givenName J A
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302255345.34
194 rdf:type schema:Person
195 sg:person.0632275625.63 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
196 schema:familyName Krogdahl
197 schema:givenName A
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632275625.63
199 rdf:type schema:Person
200 sg:person.0714514241.20 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
201 schema:familyName Worm
202 schema:givenName J
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714514241.20
204 rdf:type schema:Person
205 sg:person.0735332737.20 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
206 schema:familyName Reibel
207 schema:givenName J
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735332737.20
209 rdf:type schema:Person
210 sg:person.0760021664.46 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
211 schema:familyName Guldberg
212 schema:givenName P
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46
214 rdf:type schema:Person
215 sg:pub.10.1007/s100380170056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027544940
216 https://doi.org/10.1007/s100380170056
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s10059-000-0557-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007324517
219 https://doi.org/10.1007/s10059-000-0557-8
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/sj.onc.1204122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019236802
222 https://doi.org/10.1038/sj.onc.1204122
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.onc.1204432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028927430
225 https://doi.org/10.1038/sj.onc.1204432
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/sj.onc.1205528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031452153
228 https://doi.org/10.1038/sj.onc.1205528
229 rdf:type schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1074840865 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1075173473 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1075271929 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082668245 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082895703 schema:CreativeWork
235 https://doi.org/10.1002/(sici)1096-9896(200003)190:4<407::aid-path546>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1006602914
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/(sici)1097-0215(19991029)83:3<318::aid-ijc6>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1017977233
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/(sici)1098-2264(199910)26:2<171::aid-gcc10>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1009425331
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/1096-9896(200107)194:3<294::aid-path911>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1048413888
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/cncr.10211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005233499
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/ijc.11028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027831150
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/ijc.11592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044058870
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1006/geno.1997.5165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002490184
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0304-3835(02)00511-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046636774
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s1368-8375(99)00020-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045829709
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1034/j.1600-0714.2002.00034.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041471787
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1074/jbc.274.52.37240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043464792
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/hmg/6.6.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017883143
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/nar/22.15.2990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013818512
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1136/mp.53.4.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022633242
264 rdf:type schema:CreativeWork
265 https://doi.org/10.14219/jada.archive.2001.0382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026747872
266 rdf:type schema:CreativeWork
267 https://doi.org/10.2209/tdcpublication.42.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014295471
268 rdf:type schema:CreativeWork
269 https://doi.org/10.3322/canjclin.49.1.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044953296
270 rdf:type schema:CreativeWork
271 https://www.grid.ac/institutes/grid.413593.9 schema:alternateName Mackay Memorial Hospital
272 schema:name Department of Dentistry, Mackay Memorial Hospital, Taipei
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
275 schema:name Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Nørre Alle 20, DK-2200 Copenhagen, Denmark
276 Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark
277 Institute of Medical Biochemistry and Genetics, University of Copenhagen, DK-2200 Copenhagen, Denmark
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
280 schema:name Department of Pathology, Odense University Hospital, DK-5000 Odense, Denmark
281 Department of Plastic Surgery, Odense University Hospital, DK-5000 Odense, Denmark
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...