Negative human papillomavirus testing in normal smears selects a population at low risk for developing high-grade cervical lesions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-05

AUTHORS

C Clavel, C Quereux, J Cucherousset, J M Nou, J-P Bory, M Lorenzato, M Polette, P Birembaut, P Nazeyrollas, R Gabriel, S Caudroy

ABSTRACT

High-risk human papillomaviruses (HR-HPV) are the necessary cause of cervical carcinomas and there is an increasing interest in using HR-HPV DNA detection in adjunction to cytological examination for primary cervical screening. To determine whether women with a normal smear negative for HR-HPV DNA detection with the Hybrid Capture II assay might represent a low-risk population for developing a high-grade squamous intraepithelial lesion (HSIL), 4401 women have been followed in a period of 12-72 months (median=34 months). During this follow-up, four HSIL and one microinvasive carcinoma have been detected in this cohort (three in the cohort of 3526 women >29 years). The global negative predictive value (NPV) of double-negative tests is thus of 99.9% (ninety-five percent confidence interval (95% CI): 99.8-100%), whereas cytology alone gives an NPV of 99.2% (95% CI: 98.9-99.5%). If we obtain a second negative HR-HPV test 1-2 years after the initial test, the NPV is 100%. The NPV is also of 100% in the cohort of women >49 years. We conclude that all these women could be safely screened at longer intervals between 3 and 5 years. This policy will offset the increased costs induced by an additional HR-HPV testing in primary screening. More... »

PAGES

1803

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6601726

DOI

http://dx.doi.org/10.1038/sj.bjc.6601726

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027833388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15150605


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Probes, HPV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mass Screening", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Papillomaviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Papillomavirus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Cervical Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaginal Smears", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clavel", 
        "givenName": "C", 
        "id": "sg:person.0643310356.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643310356.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire De Reims", 
          "id": "https://www.grid.ac/institutes/grid.139510.f", 
          "name": [
            "Department of Obstetrics and Gynaecology, CHU de Reims, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quereux", 
        "givenName": "C", 
        "id": "sg:person.01104206462.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104206462.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cucherousset", 
        "givenName": "J", 
        "id": "sg:person.0702760720.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702760720.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nou", 
        "givenName": "J M", 
        "id": "sg:person.01067276017.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067276017.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire De Reims", 
          "id": "https://www.grid.ac/institutes/grid.139510.f", 
          "name": [
            "Department of Obstetrics and Gynaecology, CHU de Reims, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bory", 
        "givenName": "J-P", 
        "id": "sg:person.0735437553.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735437553.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lorenzato", 
        "givenName": "M", 
        "id": "sg:person.0636621017.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636621017.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polette", 
        "givenName": "M", 
        "id": "sg:person.01044464125.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044464125.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Birembaut", 
        "givenName": "P", 
        "id": "sg:person.01160712525.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160712525.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire De Reims", 
          "id": "https://www.grid.ac/institutes/grid.139510.f", 
          "name": [
            "Department of Statistics, CHU de Reims, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nazeyrollas", 
        "givenName": "P", 
        "id": "sg:person.0755046446.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755046446.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire De Reims", 
          "id": "https://www.grid.ac/institutes/grid.139510.f", 
          "name": [
            "Department of Obstetrics and Gynaecology, CHU de Reims, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gabriel", 
        "givenName": "R", 
        "id": "sg:person.01053330147.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053330147.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire Pol Bouin, H\u00f4pital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caudroy", 
        "givenName": "S", 
        "id": "sg:person.01074463554.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074463554.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00006250-199203000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002663186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006250-199203000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002663186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91086-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003190771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91086-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003190771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9378(95)90026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007635472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1447-0756.1996.tb01081.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010275901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011080887", 
          "https://doi.org/10.1038/sj.bjc.6690730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011080887", 
          "https://doi.org/10.1038/sj.bjc.6690730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/95.1.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013772271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)14955-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017480758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.1998.00436.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021236161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021762873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1989.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022777795", 
          "https://doi.org/10.1038/bjc.1989.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1989.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022777795", 
          "https://doi.org/10.1038/bjc.1989.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.1845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026908086", 
          "https://doi.org/10.1054/bjoc.2001.1845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029090078", 
          "https://doi.org/10.1038/sj.bjc.6600918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029090078", 
          "https://doi.org/10.1038/sj.bjc.6600918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029133681", 
          "https://doi.org/10.1038/modpathol.3880048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029133681", 
          "https://doi.org/10.1038/modpathol.3880048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.325.7364.572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030217039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030753299", 
          "https://doi.org/10.1038/nrc798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030753299", 
          "https://doi.org/10.1038/nrc798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20001120)89:6<529::aid-ijc11>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032190437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20001120)89:6<529::aid-ijc11>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032190437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.1.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032505822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.10.818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035613927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.52.6.342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036850429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041726872", 
          "https://doi.org/10.1038/sj.bjc.6690523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041726872", 
          "https://doi.org/10.1038/sj.bjc.6690523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199210293271804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045679955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.1994.04020073.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047353674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.1994.04020073.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047353674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.1994.04020073.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047353674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048285848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)12490-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049129112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/87.11.796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059819308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074704912", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075318940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083330971", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-05", 
    "datePublishedReg": "2004-05-01", 
    "description": "High-risk human papillomaviruses (HR-HPV) are the necessary cause of cervical carcinomas and there is an increasing interest in using HR-HPV DNA detection in adjunction to cytological examination for primary cervical screening. To determine whether women with a normal smear negative for HR-HPV DNA detection with the Hybrid Capture II assay might represent a low-risk population for developing a high-grade squamous intraepithelial lesion (HSIL), 4401 women have been followed in a period of 12-72 months (median=34 months). During this follow-up, four HSIL and one microinvasive carcinoma have been detected in this cohort (three in the cohort of 3526 women >29 years). The global negative predictive value (NPV) of double-negative tests is thus of 99.9% (ninety-five percent confidence interval (95% CI): 99.8-100%), whereas cytology alone gives an NPV of 99.2% (95% CI: 98.9-99.5%). If we obtain a second negative HR-HPV test 1-2 years after the initial test, the NPV is 100%. The NPV is also of 100% in the cohort of women >49 years. We conclude that all these women could be safely screened at longer intervals between 3 and 5 years. This policy will offset the increased costs induced by an additional HR-HPV testing in primary screening.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6601726", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "90"
      }
    ], 
    "name": "Negative human papillomavirus testing in normal smears selects a population at low risk for developing high-grade cervical lesions", 
    "pagination": "1803", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8496f028b2cb714f7823479889a1806630a2a697bd093574dce02b18f86eb8de"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15150605"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6601726"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027833388"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6601726", 
      "https://app.dimensions.ai/details/publication/pub.1027833388"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29219_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6601726"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601726'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601726'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601726'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601726'


 

This table displays all metadata directly associated to this object as RDF triples.

306 TRIPLES      21 PREDICATES      73 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6601726 schema:about N05831f925a4a42129b31483b9ae989cb
2 N281dd8c80bb6413fba9f96b6d32e8355
3 N3999421af693410b95b49e47e7c79e1d
4 N42d55ad047414215b55d16ec13ed039d
5 N524d81710a68404b8fecf69600e77a46
6 N5333de6760774752bfdf4886c4f35f02
7 N581ab20d9b3c40dabddc469d4c402b4e
8 N5ab021773db24a9bae5f435f55fd32be
9 N688b183afde44aef864219a40fd8c0bf
10 N78d19c5ba94942418e7f14211b92e763
11 Na1e6e14156344677a42f9e6913ae8630
12 Nc2558c96ea804965bd2201d9f8a703d4
13 Nd3671555c1564b6a8f3fd6a9b3fd3990
14 Nd5cada48d4554ceabd7a5470ea8e70c9
15 Ne4d26006989141a7a4e7ea4418608ddd
16 Ne68eb92cc07c4dfa8342b77589683e73
17 anzsrc-for:11
18 anzsrc-for:1117
19 schema:author N55225c7ef35b40dc890ca7c671332d46
20 schema:citation sg:pub.10.1038/bjc.1989.236
21 sg:pub.10.1038/modpathol.3880048
22 sg:pub.10.1038/nrc798
23 sg:pub.10.1038/sj.bjc.6600918
24 sg:pub.10.1038/sj.bjc.6690523
25 sg:pub.10.1038/sj.bjc.6690730
26 sg:pub.10.1054/bjoc.2001.1845
27 https://app.dimensions.ai/details/publication/pub.1074704912
28 https://app.dimensions.ai/details/publication/pub.1075318940
29 https://app.dimensions.ai/details/publication/pub.1083330971
30 https://doi.org/10.1001/jama.283.1.87
31 https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f
32 https://doi.org/10.1002/1097-0215(20001120)89:6<529::aid-ijc11>3.0.co;2-g
33 https://doi.org/10.1002/ijc.10735
34 https://doi.org/10.1016/0002-9378(95)90026-8
35 https://doi.org/10.1016/s0140-6736(03)14955-0
36 https://doi.org/10.1016/s0140-6736(95)91086-7
37 https://doi.org/10.1016/s0140-6736(98)12490-x
38 https://doi.org/10.1046/j.1365-2559.1998.00436.x
39 https://doi.org/10.1046/j.1525-1438.1994.04020073.x
40 https://doi.org/10.1056/nejm199210293271804
41 https://doi.org/10.1093/jnci/87.11.796
42 https://doi.org/10.1093/jnci/92.10.818
43 https://doi.org/10.1093/jnci/95.1.46
44 https://doi.org/10.1097/00006250-199203000-00002
45 https://doi.org/10.1111/j.1447-0756.1996.tb01081.x
46 https://doi.org/10.1136/bmj.325.7364.572
47 https://doi.org/10.3322/canjclin.52.6.342
48 schema:datePublished 2004-05
49 schema:datePublishedReg 2004-05-01
50 schema:description High-risk human papillomaviruses (HR-HPV) are the necessary cause of cervical carcinomas and there is an increasing interest in using HR-HPV DNA detection in adjunction to cytological examination for primary cervical screening. To determine whether women with a normal smear negative for HR-HPV DNA detection with the Hybrid Capture II assay might represent a low-risk population for developing a high-grade squamous intraepithelial lesion (HSIL), 4401 women have been followed in a period of 12-72 months (median=34 months). During this follow-up, four HSIL and one microinvasive carcinoma have been detected in this cohort (three in the cohort of 3526 women >29 years). The global negative predictive value (NPV) of double-negative tests is thus of 99.9% (ninety-five percent confidence interval (95% CI): 99.8-100%), whereas cytology alone gives an NPV of 99.2% (95% CI: 98.9-99.5%). If we obtain a second negative HR-HPV test 1-2 years after the initial test, the NPV is 100%. The NPV is also of 100% in the cohort of women >49 years. We conclude that all these women could be safely screened at longer intervals between 3 and 5 years. This policy will offset the increased costs induced by an additional HR-HPV testing in primary screening.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N4b8cb09d674345e0b7fdc83f3d4281ae
55 N70685d89b86c4335913dd871800de573
56 sg:journal.1017082
57 schema:name Negative human papillomavirus testing in normal smears selects a population at low risk for developing high-grade cervical lesions
58 schema:pagination 1803
59 schema:productId N1a0f038ee02041f5a0ce5e00b9de901f
60 N3656252054cd4af9a818efc96f67689f
61 N82d686b3330b4c538bf0aeb0d48a6d83
62 Nb197ade94f7640588dc9bce40ca24c7f
63 Nb36bb0d6de05419f89e6b354fa3f2eb5
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027833388
65 https://doi.org/10.1038/sj.bjc.6601726
66 schema:sdDatePublished 2019-04-11T11:57
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nf0235a2d2cb8424eb2e8b4567b101a70
69 schema:url https://www.nature.com/articles/6601726
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N05831f925a4a42129b31483b9ae989cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Vaginal Smears
75 rdf:type schema:DefinedTerm
76 N184a9c7b27d947d386298fedab2aa38e schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
77 rdf:type schema:Organization
78 N1a0f038ee02041f5a0ce5e00b9de901f schema:name pubmed_id
79 schema:value 15150605
80 rdf:type schema:PropertyValue
81 N281dd8c80bb6413fba9f96b6d32e8355 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Mass Screening
83 rdf:type schema:DefinedTerm
84 N310f8dc6543c4103ac9e0f24493ba20c rdf:first sg:person.01053330147.54
85 rdf:rest Nac8639539f2441efb4cc26b04cbf3a7a
86 N35b22e043346414d86dec0e586b5a43d rdf:first sg:person.0636621017.10
87 rdf:rest N7dfaf6cc7471483ea9662474041f8ab6
88 N3656252054cd4af9a818efc96f67689f schema:name nlm_unique_id
89 schema:value 0370635
90 rdf:type schema:PropertyValue
91 N37e43b95f0304575bc259df28a803c4e rdf:first sg:person.01160712525.16
92 rdf:rest N8929939fc8364be683d4efc291c7f4c2
93 N3999421af693410b95b49e47e7c79e1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Papillomaviridae
95 rdf:type schema:DefinedTerm
96 N42d55ad047414215b55d16ec13ed039d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Adolescent
98 rdf:type schema:DefinedTerm
99 N4616b9bdbf334418856b364fe15c98b9 schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
100 rdf:type schema:Organization
101 N4a5d74798b6342b39b9da82bb2f39dd7 rdf:first sg:person.0702760720.21
102 rdf:rest N825f84c14d51431a8951b8c153ae6996
103 N4b8cb09d674345e0b7fdc83f3d4281ae schema:volumeNumber 90
104 rdf:type schema:PublicationVolume
105 N524d81710a68404b8fecf69600e77a46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N5333de6760774752bfdf4886c4f35f02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Female
110 rdf:type schema:DefinedTerm
111 N55225c7ef35b40dc890ca7c671332d46 rdf:first sg:person.0643310356.57
112 rdf:rest N878a1870f92542779a7f26a3e73a63e6
113 N581ab20d9b3c40dabddc469d4c402b4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Carcinoma, Squamous Cell
115 rdf:type schema:DefinedTerm
116 N5ab021773db24a9bae5f435f55fd32be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Aged
118 rdf:type schema:DefinedTerm
119 N688b183afde44aef864219a40fd8c0bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Longitudinal Studies
121 rdf:type schema:DefinedTerm
122 N70685d89b86c4335913dd871800de573 schema:issueNumber 9
123 rdf:type schema:PublicationIssue
124 N78d19c5ba94942418e7f14211b92e763 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name DNA Probes, HPV
126 rdf:type schema:DefinedTerm
127 N7dfaf6cc7471483ea9662474041f8ab6 rdf:first sg:person.01044464125.88
128 rdf:rest N37e43b95f0304575bc259df28a803c4e
129 N825f84c14d51431a8951b8c153ae6996 rdf:first sg:person.01067276017.59
130 rdf:rest N93e56ef259fc408b85bd7f13442ab03a
131 N82d686b3330b4c538bf0aeb0d48a6d83 schema:name doi
132 schema:value 10.1038/sj.bjc.6601726
133 rdf:type schema:PropertyValue
134 N872e2d765980485e8541690bcf34dc2c schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
135 rdf:type schema:Organization
136 N878a1870f92542779a7f26a3e73a63e6 rdf:first sg:person.01104206462.76
137 rdf:rest N4a5d74798b6342b39b9da82bb2f39dd7
138 N8929939fc8364be683d4efc291c7f4c2 rdf:first sg:person.0755046446.47
139 rdf:rest N310f8dc6543c4103ac9e0f24493ba20c
140 N93e56ef259fc408b85bd7f13442ab03a rdf:first sg:person.0735437553.29
141 rdf:rest N35b22e043346414d86dec0e586b5a43d
142 Na1e6e14156344677a42f9e6913ae8630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Predictive Value of Tests
144 rdf:type schema:DefinedTerm
145 Nac8639539f2441efb4cc26b04cbf3a7a rdf:first sg:person.01074463554.00
146 rdf:rest rdf:nil
147 Nb197ade94f7640588dc9bce40ca24c7f schema:name readcube_id
148 schema:value 8496f028b2cb714f7823479889a1806630a2a697bd093574dce02b18f86eb8de
149 rdf:type schema:PropertyValue
150 Nb36bb0d6de05419f89e6b354fa3f2eb5 schema:name dimensions_id
151 schema:value pub.1027833388
152 rdf:type schema:PropertyValue
153 Nb9b320eddf0446bf93240681f9cbd78a schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
154 rdf:type schema:Organization
155 Nc2558c96ea804965bd2201d9f8a703d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Papillomavirus Infections
157 rdf:type schema:DefinedTerm
158 Ncf5d01b5fc5e4cedb5cee612a22d3f61 schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
159 rdf:type schema:Organization
160 Nd3671555c1564b6a8f3fd6a9b3fd3990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Uterine Cervical Neoplasms
162 rdf:type schema:DefinedTerm
163 Nd5cada48d4554ceabd7a5470ea8e70c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Middle Aged
165 rdf:type schema:DefinedTerm
166 Ne4d26006989141a7a4e7ea4418608ddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Adult
168 rdf:type schema:DefinedTerm
169 Ne5988fed7bc5429093b37ff8b54a068f schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
170 rdf:type schema:Organization
171 Ne68eb92cc07c4dfa8342b77589683e73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Risk Factors
173 rdf:type schema:DefinedTerm
174 Nf0235a2d2cb8424eb2e8b4567b101a70 schema:name Springer Nature - SN SciGraph project
175 rdf:type schema:Organization
176 Nf05a6b8468e649cc984c0f30c17f7992 schema:name Laboratoire Pol Bouin, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims 51100, France
177 rdf:type schema:Organization
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
182 schema:name Public Health and Health Services
183 rdf:type schema:DefinedTerm
184 sg:journal.1017082 schema:issn 0007-0920
185 1532-1827
186 schema:name British Journal of Cancer
187 rdf:type schema:Periodical
188 sg:person.01044464125.88 schema:affiliation N184a9c7b27d947d386298fedab2aa38e
189 schema:familyName Polette
190 schema:givenName M
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044464125.88
192 rdf:type schema:Person
193 sg:person.01053330147.54 schema:affiliation https://www.grid.ac/institutes/grid.139510.f
194 schema:familyName Gabriel
195 schema:givenName R
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053330147.54
197 rdf:type schema:Person
198 sg:person.01067276017.59 schema:affiliation Nf05a6b8468e649cc984c0f30c17f7992
199 schema:familyName Nou
200 schema:givenName J M
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067276017.59
202 rdf:type schema:Person
203 sg:person.01074463554.00 schema:affiliation Ncf5d01b5fc5e4cedb5cee612a22d3f61
204 schema:familyName Caudroy
205 schema:givenName S
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074463554.00
207 rdf:type schema:Person
208 sg:person.01104206462.76 schema:affiliation https://www.grid.ac/institutes/grid.139510.f
209 schema:familyName Quereux
210 schema:givenName C
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104206462.76
212 rdf:type schema:Person
213 sg:person.01160712525.16 schema:affiliation Nb9b320eddf0446bf93240681f9cbd78a
214 schema:familyName Birembaut
215 schema:givenName P
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160712525.16
217 rdf:type schema:Person
218 sg:person.0636621017.10 schema:affiliation N872e2d765980485e8541690bcf34dc2c
219 schema:familyName Lorenzato
220 schema:givenName M
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636621017.10
222 rdf:type schema:Person
223 sg:person.0643310356.57 schema:affiliation N4616b9bdbf334418856b364fe15c98b9
224 schema:familyName Clavel
225 schema:givenName C
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643310356.57
227 rdf:type schema:Person
228 sg:person.0702760720.21 schema:affiliation Ne5988fed7bc5429093b37ff8b54a068f
229 schema:familyName Cucherousset
230 schema:givenName J
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702760720.21
232 rdf:type schema:Person
233 sg:person.0735437553.29 schema:affiliation https://www.grid.ac/institutes/grid.139510.f
234 schema:familyName Bory
235 schema:givenName J-P
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735437553.29
237 rdf:type schema:Person
238 sg:person.0755046446.47 schema:affiliation https://www.grid.ac/institutes/grid.139510.f
239 schema:familyName Nazeyrollas
240 schema:givenName P
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755046446.47
242 rdf:type schema:Person
243 sg:pub.10.1038/bjc.1989.236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022777795
244 https://doi.org/10.1038/bjc.1989.236
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/modpathol.3880048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029133681
247 https://doi.org/10.1038/modpathol.3880048
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nrc798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030753299
250 https://doi.org/10.1038/nrc798
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/sj.bjc.6600918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029090078
253 https://doi.org/10.1038/sj.bjc.6600918
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/sj.bjc.6690523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041726872
256 https://doi.org/10.1038/sj.bjc.6690523
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.bjc.6690730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011080887
259 https://doi.org/10.1038/sj.bjc.6690730
260 rdf:type schema:CreativeWork
261 sg:pub.10.1054/bjoc.2001.1845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026908086
262 https://doi.org/10.1054/bjoc.2001.1845
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1074704912 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1075318940 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083330971 schema:CreativeWork
267 https://doi.org/10.1001/jama.283.1.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032505822
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1021762873
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/1097-0215(20001120)89:6<529::aid-ijc11>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1032190437
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/ijc.10735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048285848
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/0002-9378(95)90026-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007635472
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0140-6736(03)14955-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017480758
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0140-6736(95)91086-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003190771
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0140-6736(98)12490-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049129112
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1046/j.1365-2559.1998.00436.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021236161
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1046/j.1525-1438.1994.04020073.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047353674
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1056/nejm199210293271804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045679955
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1093/jnci/87.11.796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819308
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1093/jnci/92.10.818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035613927
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1093/jnci/95.1.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013772271
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/00006250-199203000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002663186
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1447-0756.1996.tb01081.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010275901
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1136/bmj.325.7364.572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030217039
300 rdf:type schema:CreativeWork
301 https://doi.org/10.3322/canjclin.52.6.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036850429
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.139510.f schema:alternateName Centre Hospitalier Universitaire De Reims
304 schema:name Department of Obstetrics and Gynaecology, CHU de Reims, Reims 51100, France
305 Department of Statistics, CHU de Reims, Reims 51100, France
306 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...