Adjuvant and neoadjuvant therapy for gastric cancer using epirubicin/cisplatin/5-fluorouracil (ECF) and alternative regimens before and after chemoradiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-10

AUTHORS

T Leong, M Michael, K Foo, A Thompson, D Lim Joon, L Weih, S Ngan, R Thomas, J Zalcberg

ABSTRACT

Chemoradiation is now used more commonly for gastric cancer following publication of the US Intergroup trial results that demonstrate an advantage to adjuvant postoperative chemoradiotherapy. However, there remain concerns regarding the toxicity of this treatment, the optimal chemotherapy regimen and the optimal method of radiotherapy delivery. In this prospective study, we evaluated the toxicity and feasibility of an alternative chemoradiation regimen to that used in the Intergroup trial. A total of 26 patients with adenocarcinoma of the stomach were treated with 3D-conformal radiation therapy to a dose of 45 Gy in 25 fractions with concurrent continuous infusional 5-fluorouracil (5-FU). The majority of patients received epirubicin, cisplatin and 5-FU (ECF) as the systemic component given before and after concurrent chemoradiation. The overall rates of observed grade 3 and 4 toxicities were 38 and 15%, respectively. GIT grade 3 toxicity was observed in 19% of patients, while haematologic grade 3 and 4 toxicities were observed in 23%. Our results suggest that this adjuvant regimen can be delivered safely and with acceptable toxicity. This regimen forms the basis of several new studies being developed for postoperative adjuvant therapy of gastric cancer. More... »

PAGES

1433

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6601311

DOI

http://dx.doi.org/10.1038/sj.bjc.6601311

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017358394

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14562013


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epirubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Conformal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leong", 
        "givenName": "T", 
        "id": "sg:person.0737622114.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737622114.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michael", 
        "givenName": "M", 
        "id": "sg:person.0673420201.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673420201.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foo", 
        "givenName": "K", 
        "id": "sg:person.01216563465.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216563465.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "A", 
        "id": "sg:person.01215142224.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215142224.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joon", 
        "givenName": "D Lim", 
        "id": "sg:person.010377347207.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010377347207.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weih", 
        "givenName": "L", 
        "id": "sg:person.0734571306.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734571306.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ngan", 
        "givenName": "S", 
        "id": "sg:person.011203322044.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011203322044.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "R", 
        "id": "sg:person.07721206642.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07721206642.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zalcberg", 
        "givenName": "J", 
        "id": "sg:person.01262050434.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262050434.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0277-5379(83)90003-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001674376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa010187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004811518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199408253310803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011295011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199903253401202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013881402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0958-3947(05)80004-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017609934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(01)02646-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018814717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.88", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021302636", 
          "https://doi.org/10.1038/bjc.1991.88"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.88", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021302636", 
          "https://doi.org/10.1038/bjc.1991.88"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800750206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022309964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(82)90377-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035073483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(90)90344-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035650014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(80)90164-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037954623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)92464-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038848511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)92464-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038848511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039335865", 
          "https://doi.org/10.1038/sj.bjc.6690243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039335865", 
          "https://doi.org/10.1038/sj.bjc.6690243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00493-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039512903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(99)00076-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039795820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199408000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043280582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199408000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043280582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045469768", 
          "https://doi.org/10.1038/sj.bjc.6690350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045469768", 
          "https://doi.org/10.1038/sj.bjc.6690350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008377101672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02841860151116385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058315962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1986.4.3.425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079503460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1986.4.5.685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079796741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a058932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082599540"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-10", 
    "datePublishedReg": "2003-10-01", 
    "description": "Chemoradiation is now used more commonly for gastric cancer following publication of the US Intergroup trial results that demonstrate an advantage to adjuvant postoperative chemoradiotherapy. However, there remain concerns regarding the toxicity of this treatment, the optimal chemotherapy regimen and the optimal method of radiotherapy delivery. In this prospective study, we evaluated the toxicity and feasibility of an alternative chemoradiation regimen to that used in the Intergroup trial. A total of 26 patients with adenocarcinoma of the stomach were treated with 3D-conformal radiation therapy to a dose of 45 Gy in 25 fractions with concurrent continuous infusional 5-fluorouracil (5-FU). The majority of patients received epirubicin, cisplatin and 5-FU (ECF) as the systemic component given before and after concurrent chemoradiation. The overall rates of observed grade 3 and 4 toxicities were 38 and 15%, respectively. GIT grade 3 toxicity was observed in 19% of patients, while haematologic grade 3 and 4 toxicities were observed in 23%. Our results suggest that this adjuvant regimen can be delivered safely and with acceptable toxicity. This regimen forms the basis of several new studies being developed for postoperative adjuvant therapy of gastric cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6601311", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "89"
      }
    ], 
    "name": "Adjuvant and neoadjuvant therapy for gastric cancer using epirubicin/cisplatin/5-fluorouracil (ECF) and alternative regimens before and after chemoradiation", 
    "pagination": "1433", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "52b3cd1dd829d92bb3188f855beb73b8f393b26128bb7dbdc7481362475551fa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14562013"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6601311"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017358394"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6601311", 
      "https://app.dimensions.ai/details/publication/pub.1017358394"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29212_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6601311"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601311'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601311'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601311'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601311'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      70 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6601311 schema:about N15e1ae3d3bfc48ce9618849b04fe3382
2 N1ddc48e5f12b486e985292333d18ccfd
3 N24ab401b1e4d4610983723a8def9ae9e
4 N5edccc113c634f3bab980e45ba251276
5 N7406e58182414eb585b42ac5ecde79f6
6 N740f4d567b0f4903a2cf894eae14c071
7 N7e1c17f0d19f4176bb1db741f7848e84
8 N8b8eb80cbc8646f3a4baa0e50a058aac
9 N98c67fabbf0a4b4a86fdefe98765839a
10 Nb44f8854d9384f35842e956e43fdacd3
11 Nb5220e1eeb144a1d90a712b69312d02c
12 Nbf0ad3348270452e8651d9ea1abb2c14
13 Nc582bbad27224bbc82f286a89e6e6fd7
14 Ndeed7ae0a0454e04b5fa35bf8154af04
15 Ne151ea0ccb464ab78475ed75339047a9
16 Ne2c810a8ba144467a819877d73296330
17 Neb20cb62a534464e994ffbefb4b56586
18 Nf6238f639c264937aa60ae093f709124
19 Nfefd42ee9c9b4acf95cfd31b4d15a4ee
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N27f62405aa614b56a8296ce9135a7083
23 schema:citation sg:pub.10.1038/bjc.1991.88
24 sg:pub.10.1038/sj.bjc.6690243
25 sg:pub.10.1038/sj.bjc.6690350
26 https://doi.org/10.1002/bjs.1800750206
27 https://doi.org/10.1016/0277-5379(83)90003-2
28 https://doi.org/10.1016/0360-3016(80)90164-9
29 https://doi.org/10.1016/0360-3016(82)90377-7
30 https://doi.org/10.1016/0360-3016(90)90344-j
31 https://doi.org/10.1016/s0140-6736(94)92464-3
32 https://doi.org/10.1016/s0360-3016(01)02646-3
33 https://doi.org/10.1016/s0360-3016(97)00493-8
34 https://doi.org/10.1016/s0958-3947(05)80004-4
35 https://doi.org/10.1016/s0959-8049(99)00076-3
36 https://doi.org/10.1023/a:1008377101672
37 https://doi.org/10.1056/nejm199408253310803
38 https://doi.org/10.1056/nejm199903253401202
39 https://doi.org/10.1056/nejmoa010187
40 https://doi.org/10.1080/02841860151116385
41 https://doi.org/10.1093/oxfordjournals.annonc.a058932
42 https://doi.org/10.1097/00000658-199408000-00009
43 https://doi.org/10.1200/jco.1986.4.3.425
44 https://doi.org/10.1200/jco.1986.4.5.685
45 schema:datePublished 2003-10
46 schema:datePublishedReg 2003-10-01
47 schema:description Chemoradiation is now used more commonly for gastric cancer following publication of the US Intergroup trial results that demonstrate an advantage to adjuvant postoperative chemoradiotherapy. However, there remain concerns regarding the toxicity of this treatment, the optimal chemotherapy regimen and the optimal method of radiotherapy delivery. In this prospective study, we evaluated the toxicity and feasibility of an alternative chemoradiation regimen to that used in the Intergroup trial. A total of 26 patients with adenocarcinoma of the stomach were treated with 3D-conformal radiation therapy to a dose of 45 Gy in 25 fractions with concurrent continuous infusional 5-fluorouracil (5-FU). The majority of patients received epirubicin, cisplatin and 5-FU (ECF) as the systemic component given before and after concurrent chemoradiation. The overall rates of observed grade 3 and 4 toxicities were 38 and 15%, respectively. GIT grade 3 toxicity was observed in 19% of patients, while haematologic grade 3 and 4 toxicities were observed in 23%. Our results suggest that this adjuvant regimen can be delivered safely and with acceptable toxicity. This regimen forms the basis of several new studies being developed for postoperative adjuvant therapy of gastric cancer.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N388dc62fe03949e6ade17e411fe39436
52 N679da3d035e2488e82def6782107ccd9
53 sg:journal.1017082
54 schema:name Adjuvant and neoadjuvant therapy for gastric cancer using epirubicin/cisplatin/5-fluorouracil (ECF) and alternative regimens before and after chemoradiation
55 schema:pagination 1433
56 schema:productId N05f063e8093e43b59739d2e0ac6f4ab2
57 N10287aa891a44680b03c38f0f0edf2ea
58 N2841555d0a5e4a40b8fcc79ba6a45ffb
59 N348323c5991a49a1bb3a282453bb34f5
60 N984a896ba5e94e4db8a23e0a58bff087
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017358394
62 https://doi.org/10.1038/sj.bjc.6601311
63 schema:sdDatePublished 2019-04-11T11:55
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N51568291eea2483e8587066209beef31
66 schema:url https://www.nature.com/articles/6601311
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N05f063e8093e43b59739d2e0ac6f4ab2 schema:name readcube_id
71 schema:value 52b3cd1dd829d92bb3188f855beb73b8f393b26128bb7dbdc7481362475551fa
72 rdf:type schema:PropertyValue
73 N10287aa891a44680b03c38f0f0edf2ea schema:name doi
74 schema:value 10.1038/sj.bjc.6601311
75 rdf:type schema:PropertyValue
76 N15e1ae3d3bfc48ce9618849b04fe3382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Antineoplastic Combined Chemotherapy Protocols
78 rdf:type schema:DefinedTerm
79 N1ddc48e5f12b486e985292333d18ccfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Neoadjuvant Therapy
81 rdf:type schema:DefinedTerm
82 N24ab401b1e4d4610983723a8def9ae9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Stomach Neoplasms
84 rdf:type schema:DefinedTerm
85 N27f62405aa614b56a8296ce9135a7083 rdf:first sg:person.0737622114.17
86 rdf:rest Nb35813b9ea11417c81dd0b2df78ed2b7
87 N2841555d0a5e4a40b8fcc79ba6a45ffb schema:name dimensions_id
88 schema:value pub.1017358394
89 rdf:type schema:PropertyValue
90 N2e4fe8dc5d804167999ec46beed70b96 rdf:first sg:person.01262050434.01
91 rdf:rest rdf:nil
92 N31ae62d8bd4d45459acd3c95a4216b65 rdf:first sg:person.01215142224.98
93 rdf:rest N5f4b53acf70c4a8fbc4c0fc2695e0cfd
94 N348323c5991a49a1bb3a282453bb34f5 schema:name pubmed_id
95 schema:value 14562013
96 rdf:type schema:PropertyValue
97 N388dc62fe03949e6ade17e411fe39436 schema:volumeNumber 89
98 rdf:type schema:PublicationVolume
99 N3cd8394c0ae74e41b73991ca350c02a7 rdf:first sg:person.0734571306.25
100 rdf:rest Nb60659df4e4f442c825cc31037a7799b
101 N51568291eea2483e8587066209beef31 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N5edccc113c634f3bab980e45ba251276 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Combined Modality Therapy
105 rdf:type schema:DefinedTerm
106 N5f4b53acf70c4a8fbc4c0fc2695e0cfd rdf:first sg:person.010377347207.91
107 rdf:rest N3cd8394c0ae74e41b73991ca350c02a7
108 N679da3d035e2488e82def6782107ccd9 schema:issueNumber 8
109 rdf:type schema:PublicationIssue
110 N7406e58182414eb585b42ac5ecde79f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Epirubicin
112 rdf:type schema:DefinedTerm
113 N740f4d567b0f4903a2cf894eae14c071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Aged
115 rdf:type schema:DefinedTerm
116 N7e1c17f0d19f4176bb1db741f7848e84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Radiotherapy, Conformal
118 rdf:type schema:DefinedTerm
119 N8b8eb80cbc8646f3a4baa0e50a058aac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N8fe896ec520b4646b2880473765f8b7f rdf:first sg:person.01216563465.56
123 rdf:rest N31ae62d8bd4d45459acd3c95a4216b65
124 N984a896ba5e94e4db8a23e0a58bff087 schema:name nlm_unique_id
125 schema:value 0370635
126 rdf:type schema:PropertyValue
127 N98c67fabbf0a4b4a86fdefe98765839a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Adult
129 rdf:type schema:DefinedTerm
130 Nb35813b9ea11417c81dd0b2df78ed2b7 rdf:first sg:person.0673420201.89
131 rdf:rest N8fe896ec520b4646b2880473765f8b7f
132 Nb44f8854d9384f35842e956e43fdacd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Chemotherapy, Adjuvant
134 rdf:type schema:DefinedTerm
135 Nb5220e1eeb144a1d90a712b69312d02c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Middle Aged
137 rdf:type schema:DefinedTerm
138 Nb60659df4e4f442c825cc31037a7799b rdf:first sg:person.011203322044.11
139 rdf:rest Nf177eadfe80f491da3467ecf14fccca9
140 Nbf0ad3348270452e8651d9ea1abb2c14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cisplatin
142 rdf:type schema:DefinedTerm
143 Nc582bbad27224bbc82f286a89e6e6fd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Ndeed7ae0a0454e04b5fa35bf8154af04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Adenocarcinoma
148 rdf:type schema:DefinedTerm
149 Ne151ea0ccb464ab78475ed75339047a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Fluorouracil
151 rdf:type schema:DefinedTerm
152 Ne2c810a8ba144467a819877d73296330 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Drug Administration Schedule
154 rdf:type schema:DefinedTerm
155 Neb20cb62a534464e994ffbefb4b56586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aged, 80 and over
157 rdf:type schema:DefinedTerm
158 Nf177eadfe80f491da3467ecf14fccca9 rdf:first sg:person.07721206642.38
159 rdf:rest N2e4fe8dc5d804167999ec46beed70b96
160 Nf6238f639c264937aa60ae093f709124 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Infusions, Intravenous
162 rdf:type schema:DefinedTerm
163 Nfefd42ee9c9b4acf95cfd31b4d15a4ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Humans
165 rdf:type schema:DefinedTerm
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
170 schema:name Oncology and Carcinogenesis
171 rdf:type schema:DefinedTerm
172 sg:journal.1017082 schema:issn 0007-0920
173 1532-1827
174 schema:name British Journal of Cancer
175 rdf:type schema:Periodical
176 sg:person.010377347207.91 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
177 schema:familyName Joon
178 schema:givenName D Lim
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010377347207.91
180 rdf:type schema:Person
181 sg:person.011203322044.11 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
182 schema:familyName Ngan
183 schema:givenName S
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011203322044.11
185 rdf:type schema:Person
186 sg:person.01215142224.98 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
187 schema:familyName Thompson
188 schema:givenName A
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215142224.98
190 rdf:type schema:Person
191 sg:person.01216563465.56 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
192 schema:familyName Foo
193 schema:givenName K
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216563465.56
195 rdf:type schema:Person
196 sg:person.01262050434.01 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
197 schema:familyName Zalcberg
198 schema:givenName J
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262050434.01
200 rdf:type schema:Person
201 sg:person.0673420201.89 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
202 schema:familyName Michael
203 schema:givenName M
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673420201.89
205 rdf:type schema:Person
206 sg:person.0734571306.25 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
207 schema:familyName Weih
208 schema:givenName L
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734571306.25
210 rdf:type schema:Person
211 sg:person.0737622114.17 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
212 schema:familyName Leong
213 schema:givenName T
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737622114.17
215 rdf:type schema:Person
216 sg:person.07721206642.38 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
217 schema:familyName Thomas
218 schema:givenName R
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07721206642.38
220 rdf:type schema:Person
221 sg:pub.10.1038/bjc.1991.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021302636
222 https://doi.org/10.1038/bjc.1991.88
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.bjc.6690243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039335865
225 https://doi.org/10.1038/sj.bjc.6690243
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/sj.bjc.6690350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045469768
228 https://doi.org/10.1038/sj.bjc.6690350
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/bjs.1800750206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022309964
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0277-5379(83)90003-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001674376
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0360-3016(80)90164-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037954623
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0360-3016(82)90377-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035073483
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0360-3016(90)90344-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1035650014
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0140-6736(94)92464-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038848511
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0360-3016(01)02646-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018814717
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0360-3016(97)00493-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039512903
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s0958-3947(05)80004-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017609934
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0959-8049(99)00076-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039795820
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1023/a:1008377101672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303582
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejm199408253310803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011295011
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1056/nejm199903253401202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013881402
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejmoa010187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004811518
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1080/02841860151116385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058315962
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/oxfordjournals.annonc.a058932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082599540
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/00000658-199408000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043280582
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1200/jco.1986.4.3.425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079503460
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1200/jco.1986.4.5.685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079796741
267 rdf:type schema:CreativeWork
268 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
269 schema:name Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, Victoria 3002, Australia
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...