Ontology type: schema:ScholarlyArticle Open Access: True
2003-05
AUTHORSR A Wagenaar-Miller, G Hanley, R Shattuck-Brandt, R N DuBois, R L Bell, L M Matrisian, D W Morgan
ABSTRACTMatrix metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2) are expressed in both sporadic and familial adenomatous colonic polyps and tumours and have been independently shown to play causal roles in intestinal tumour formation in mouse models of colon cancer. The apparent roles of these enzymes in intestinal tumorigenesis led us to examine, in the Min mouse model of colon cancer, if selective COX-2 and MMP inhibitors provide additive or synergistic therapeutic benefits in intestinal tumour prevention. The broad-spectrum MMP inhibitor (A-177430; MMPI) and the selective COX-2 inhibitor (A-285969; COX-2I) both showed dose-dependent inhibition of the number of adenomas in Min mice. Using suboptimal doses, the MMPI reduced tumour multiplicity by 32%, the COX-2I by 48% and, both agents in combination resulted in a 67% decrease compared to control demonstrating a cooperative effect on intestinal tumorigenesis. Apoptosis, proliferation, and angiogenesis were assayed in tumors from each treatment group. These agents in combination allowed for a lowered dosage to be administered to achieve significant biological effects. Clinically, this could potentially reduce side effects associated with currently used MMP and COX-2 inhibitors. Together, these compounds could represent an easily tolerated chemopreventive approach. More... »
PAGES6600867
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6600867
DOIhttp://dx.doi.org/10.1038/sj.bjc.6600867
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1048154879
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12778076
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclooxygenase 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclooxygenase 2 Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclooxygenase Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intestinal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Isoenzymes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Matrix Metalloproteinase Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peptides, Cyclic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prostaglandin-Endoperoxide Synthases",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Vanderbilt University",
"id": "https://www.grid.ac/institutes/grid.152326.1",
"name": [
"Department of Cancer Biology, Vanderbilt University, Nashville TN 37232, USA"
],
"type": "Organization"
},
"familyName": "Wagenaar-Miller",
"givenName": "R A",
"id": "sg:person.0660622516.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660622516.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University",
"id": "https://www.grid.ac/institutes/grid.152326.1",
"name": [
"Division of Animal Care, Vanderbilt University, Nashville TN 37232, USA"
],
"type": "Organization"
},
"familyName": "Hanley",
"givenName": "G",
"id": "sg:person.01036512212.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036512212.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University",
"id": "https://www.grid.ac/institutes/grid.152326.1",
"name": [
"Department of Cancer Biology, Vanderbilt University, Nashville TN 37232, USA",
"Department of Medicine, Vanderbilt University, Nashville TN 37232, USA"
],
"type": "Organization"
},
"familyName": "Shattuck-Brandt",
"givenName": "R",
"id": "sg:person.0752104735.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752104735.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University",
"id": "https://www.grid.ac/institutes/grid.152326.1",
"name": [
"Department of Cancer Biology, Vanderbilt University, Nashville TN 37232, USA",
"Department of Medicine, Vanderbilt University, Nashville TN 37232, USA"
],
"type": "Organization"
},
"familyName": "DuBois",
"givenName": "R N",
"id": "sg:person.0626301614.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Abbott (United States)",
"id": "https://www.grid.ac/institutes/grid.417574.4",
"name": [
"Abbott Laboratories, Abbott Park, IL 60064-3500, USA"
],
"type": "Organization"
},
"familyName": "Bell",
"givenName": "R L",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vanderbilt University",
"id": "https://www.grid.ac/institutes/grid.152326.1",
"name": [
"Department of Cancer Biology, Vanderbilt University, Nashville TN 37232, USA"
],
"type": "Organization"
},
"familyName": "Matrisian",
"givenName": "L M",
"id": "sg:person.014456134577.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014456134577.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Takeda (United States)",
"id": "https://www.grid.ac/institutes/grid.419849.9",
"name": [
"TAP Pharmaceutical Products Inc., Lake Forest, IL 60045, USA"
],
"type": "Organization"
},
"familyName": "Morgan",
"givenName": "D W",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1172/jci6870",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000641829"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.275.15.11397",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002226434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0091-7435(87)90072-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005774426"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/17.8.1757",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007149270"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1206017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008811166",
"https://doi.org/10.1038/sj.onc.1206017"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1206017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008811166",
"https://doi.org/10.1038/sj.onc.1206017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/jhep.2001.23002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011482647"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(19991201)86:11+<2551::aid-cncr12>3.0.co;2-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012740064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81333-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014745301"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/molehr/6.11.1033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015260606"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.11.5544",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016592110"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1098-2744(199903)24:3<177::aid-mc4>3.0.co;2-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017100006"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0016-5085(94)90246-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020082397"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(90)90186-i",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020604215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.2910600415",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021134083"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/mc.2940040617",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021395564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0215(20000715)87:2<276::aid-ijc20>3.0.co;2-l",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021997227"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/85.15.1220",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023195757"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0016-5085(96)70083-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023694261"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci119400",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023711478"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s000110050194",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024514250",
"https://doi.org/10.1007/s000110050194"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1205291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025648405",
"https://doi.org/10.1038/sj.onc.1205291"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1205291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025648405",
"https://doi.org/10.1038/sj.onc.1205291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-5793(01)03118-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027657853"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.94.4.1402",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027673974"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-894x(98)00597-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028560850"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m202334200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034052588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.00-0573fje",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034875402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.pharmtox.42.082301.164620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035353840"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/70995",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035528462",
"https://doi.org/10.1038/70995"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/pmed.1995.1017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035605009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci9621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036717477"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0215(19981123)78:5<629::aid-ijc17>3.0.co;2-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036835834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/94.4.252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038358517"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039076536",
"https://doi.org/10.1038/nrc745"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039076536",
"https://doi.org/10.1038/nrc745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m010787200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040142841"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/mc.2940100404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040313867"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-5793(95)00085-n",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041152015"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-5793(99)01328-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043086334"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.2001.4637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045517923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1098-2744(199708)19:4<225::aid-mc2>3.0.co;2-b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045659507"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/79534",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047088421",
"https://doi.org/10.1038/79534"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/79534",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047088421",
"https://doi.org/10.1038/79534"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81988-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048354178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0304-419x(00)00006-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048691102"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.95.2.681",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049749921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1067100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062445674"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1350108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062477270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.2296722",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062530812"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074591552",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2000.18.5.1135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074597179"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074626018",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074693351",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074993532",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075198230",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077328484",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077405183",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079637248",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082446080",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082504432",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082554704",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082886161",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082886166",
"type": "CreativeWork"
}
],
"datePublished": "2003-05",
"datePublishedReg": "2003-05-01",
"description": "Matrix metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2) are expressed in both sporadic and familial adenomatous colonic polyps and tumours and have been independently shown to play causal roles in intestinal tumour formation in mouse models of colon cancer. The apparent roles of these enzymes in intestinal tumorigenesis led us to examine, in the Min mouse model of colon cancer, if selective COX-2 and MMP inhibitors provide additive or synergistic therapeutic benefits in intestinal tumour prevention. The broad-spectrum MMP inhibitor (A-177430; MMPI) and the selective COX-2 inhibitor (A-285969; COX-2I) both showed dose-dependent inhibition of the number of adenomas in Min mice. Using suboptimal doses, the MMPI reduced tumour multiplicity by 32%, the COX-2I by 48% and, both agents in combination resulted in a 67% decrease compared to control demonstrating a cooperative effect on intestinal tumorigenesis. Apoptosis, proliferation, and angiogenesis were assayed in tumors from each treatment group. These agents in combination allowed for a lowered dosage to be administered to achieve significant biological effects. Clinically, this could potentially reduce side effects associated with currently used MMP and COX-2 inhibitors. Together, these compounds could represent an easily tolerated chemopreventive approach.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.bjc.6600867",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2438863",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2471659",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2682553",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "88"
}
],
"name": "Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction",
"pagination": "6600867",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e566dbe6a8cf819d1cb8a0ac07bbfbdae3b93c8422c34c78f1b6d928ddde33de"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12778076"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0370635"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6600867"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1048154879"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6600867",
"https://app.dimensions.ai/details/publication/pub.1048154879"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29200_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/6600867"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600867'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600867'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600867'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600867'
This table displays all metadata directly associated to this object as RDF triples.
348 TRIPLES
21 PREDICATES
102 URIs
34 LITERALS
22 BLANK NODES