Ontology type: schema:ScholarlyArticle Open Access: True
2003-01
AUTHORSK DeLellis, S Ingles, L Kolonel, R McKean-Cowdin, B Henderson, F Stanczyk, N M Probst-Hensch
ABSTRACTThe insulin-like growth factor 1 gene (IGF1) is a strong candidate gene for a breast cancer susceptibility model. We investigated a dinucleotide repeat 969 bp upstream from the transcription start site of the IGF1 gene for possible associations with plasma IGF1 levels and breast cancer risk in a multiethnic group of postmenopausal women. Furthermore, we investigated the relation between race/ethnicity, mean plasma IGF1 levels and breast cancer rates in the Hawaii/Los Angeles Multiethnic Cohort. The mean age-adjusted IGF1 level among Latino-American women, 116 ng ml(-1), was statistically significantly lower than the mean age-adjusted IGF1 levels for each of the three other racial/ethnic groups, African-American, Japanese-American and Non-Latino White women (146, 144 and 145 ng ml(-1), respectively) (P<0.0001). Latino-American women have the lowest breast cancer rates of any racial/ethnic group in the cohort. These results support the investigation of an expansion of the hypothesis for an important role of IGF1 in breast cancer tumorigenesis to different racial/ethnic groups and to postmenopausal women. It is unlikely that any involvement of IGF1 in breast cancer aetiology is mediated by the IGF1 dinucleotide repeat polymorphism, which was not significantly associated with circulating IGF1 levels nor breast cancer risk in this study. Research into relevant determinants of IGF1 levels in the blood must continue. More... »
PAGES6600728
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6600728
DOIhttp://dx.doi.org/10.1038/sj.bjc.6600728
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1030933785
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12610514
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "African Continental Ancestry Group",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Asian Americans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Case-Control Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cohort Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ethnic Groups",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "European Continental Ancestry Group",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hawaii",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hispanic Americans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin-Like Growth Factor I",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Los Angeles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Postmenopause",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Ave., MS 44, Los Angeles CA 90033-0800, USA"
],
"type": "Organization"
},
"familyName": "DeLellis",
"givenName": "K",
"id": "sg:person.01163373176.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163373176.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Ave., MS 44, Los Angeles CA 90033-0800, USA"
],
"type": "Organization"
},
"familyName": "Ingles",
"givenName": "S",
"id": "sg:person.01202315245.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202315245.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Hawaii at Manoa",
"id": "https://www.grid.ac/institutes/grid.410445.0",
"name": [
"Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu HI 96813, USA"
],
"type": "Organization"
},
"familyName": "Kolonel",
"givenName": "L",
"id": "sg:person.01232406320.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232406320.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Ave., MS 44, Los Angeles CA 90033-0800, USA"
],
"type": "Organization"
},
"familyName": "McKean-Cowdin",
"givenName": "R",
"id": "sg:person.0600645042.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600645042.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Ave., MS 44, Los Angeles CA 90033-0800, USA"
],
"type": "Organization"
},
"familyName": "Henderson",
"givenName": "B",
"id": "sg:person.016661354517.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016661354517.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern California",
"id": "https://www.grid.ac/institutes/grid.42505.36",
"name": [
"USC Keck School of Medicine, Obstetrics/Gynecology, 1M2 Women's and Children's Hospital, Los Angeles CA 90089-9032, USA"
],
"type": "Organization"
},
"familyName": "Stanczyk",
"givenName": "F",
"id": "sg:person.012357675257.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012357675257.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Zurich",
"id": "https://www.grid.ac/institutes/grid.412004.3",
"name": [
"University Hospital Z\u00fcrich, Cancer Registry Z\u00fcrich, F SON 6, Sonneggstr. 6, 8091 Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Probst-Hensch",
"givenName": "N M",
"id": "sg:person.01303043745.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303043745.23"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1097/00001648-199809000-00018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000578195"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00001648-199809000-00018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000578195"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00001648-199809000-00018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000578195"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(97)10384-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005480825"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005998832636",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020027805",
"https://doi.org/10.1023/a:1005998832636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0960-0760(94)90109-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020420292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/humrep/14.2.307",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032093096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.aje.a010213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042964777"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1071-5576(95)94690-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054569377"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.83.7.4964",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064321928"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074677026",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075014911",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075121395",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081679874",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/107155769500200604",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090622045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/107155769500200604",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090622045"
],
"type": "CreativeWork"
}
],
"datePublished": "2003-01",
"datePublishedReg": "2003-01-01",
"description": "The insulin-like growth factor 1 gene (IGF1) is a strong candidate gene for a breast cancer susceptibility model. We investigated a dinucleotide repeat 969 bp upstream from the transcription start site of the IGF1 gene for possible associations with plasma IGF1 levels and breast cancer risk in a multiethnic group of postmenopausal women. Furthermore, we investigated the relation between race/ethnicity, mean plasma IGF1 levels and breast cancer rates in the Hawaii/Los Angeles Multiethnic Cohort. The mean age-adjusted IGF1 level among Latino-American women, 116 ng ml(-1), was statistically significantly lower than the mean age-adjusted IGF1 levels for each of the three other racial/ethnic groups, African-American, Japanese-American and Non-Latino White women (146, 144 and 145 ng ml(-1), respectively) (P<0.0001). Latino-American women have the lowest breast cancer rates of any racial/ethnic group in the cohort. These results support the investigation of an expansion of the hypothesis for an important role of IGF1 in breast cancer tumorigenesis to different racial/ethnic groups and to postmenopausal women. It is unlikely that any involvement of IGF1 in breast cancer aetiology is mediated by the IGF1 dinucleotide repeat polymorphism, which was not significantly associated with circulating IGF1 levels nor breast cancer risk in this study. Research into relevant determinants of IGF1 levels in the blood must continue.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.bjc.6600728",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2688701",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2470732",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2471956",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2634359",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5203011",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "88"
}
],
"name": "IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort",
"pagination": "6600728",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"935d8f4962eb012e725b7c4181f05ec0853ce9f151b4a5150aa546251e1a8b09"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12610514"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0370635"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6600728"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1030933785"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6600728",
"https://app.dimensions.ai/details/publication/pub.1030933785"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:50",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29182_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/6600728"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600728'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600728'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600728'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600728'
This table displays all metadata directly associated to this object as RDF triples.
240 TRIPLES
21 PREDICATES
61 URIs
40 LITERALS
28 BLANK NODES