Tamoxifen effects on subjective and psychosexual well-being, in a randomised breast cancer study comparing high-dose and standard-dose chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-05

AUTHORS

M J Mourits, I Böckermann, E G de Vries, A G van der Zee, K A ten Hoor, W T van der Graaf, W J Sluiter, P H Willemse

ABSTRACT

To evaluate the impact of tamoxifen on subjective and psychosexual well-being in breast cancer patients in relation to type of prior chemotherapy and menopausal status. Longitudinal interview study in breast cancer patients during and after adjuvant tamoxifen use. Menopausal status was defined by last menstrual period and serum oestradiol and FSH levels. Gynaecology outpatient clinic, Tertiary Referral Hospital, January 1995 to September 1999. Breast cancer patients <56 years of age, participating in a randomised trial comparing adjuvant high-dose (n=45) and standard-dose (n=53) chemotherapy, followed by radiotherapy and tamoxifen. Relative incidence and correlation of subjective and psychosexual symptoms during and after tamoxifen. During tamoxifen the most frequent complaints were hot flushes (85%), disturbed sleep (55%), vaginal dryness and/or dyspareunia (47%), decreased sexual desire (44%) and musculo-skeletal symptoms (43%). Disturbed sleep correlated with hot flushes (P<0.0005) and concentration problems (P<0.05). Decreased sexual interest correlated with vaginal dryness (P<0.0005) and/or dyspareunia (P<0.0005). In the high-dose group more patients became postmenopausal (95% vs 33%) and more patients reported symptoms than in the standard-dose group (P<0.05). After discontinuation of tamoxifen, symptoms decreased significantly. However, hot flushes, disturbed sleep and vaginal dryness persisted more often in patients who remained postmenopausal after high-dose chemotherapy (P<0.05). Overall, during tamoxifen patients reported many symptoms. More patients become postmenopausal after high-dose chemotherapy, and they remain often symptomatic after tamoxifen. More... »

PAGES

6600294

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6600294

DOI

http://dx.doi.org/10.1038/sj.bjc.6600294

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028114615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12085202


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dyspareunia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Edema", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Receptor Modulators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hot Flashes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Menopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mental Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mood Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Musculoskeletal Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sexual Dysfunctions, Psychological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sleep Initiation and Maintenance Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tamoxifen", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Gynaecology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mourits", 
        "givenName": "M J", 
        "id": "sg:person.011605457414.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011605457414.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Gynaecology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6ckermann", 
        "givenName": "I", 
        "id": "sg:person.01060026551.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060026551.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Medical Oncology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Vries", 
        "givenName": "E G", 
        "id": "sg:person.013341607157.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013341607157.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Gynaecology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Zee", 
        "givenName": "A G", 
        "id": "sg:person.013225126734.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013225126734.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Gynaecology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoor", 
        "givenName": "K A ten", 
        "id": "sg:person.014421476103.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014421476103.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Medical Oncology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Graaf", 
        "givenName": "W T", 
        "id": "sg:person.011434417777.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011434417777.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Endocrinology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sluiter", 
        "givenName": "W J", 
        "id": "sg:person.07536130644.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536130644.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Medical Oncology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willemse", 
        "givenName": "P H", 
        "id": "sg:person.014046011234.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014046011234.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1682::aid-cncr14>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001687708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00926239208404354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007743490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016663395", 
          "https://doi.org/10.1038/sj.bjc.6690280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016663395", 
          "https://doi.org/10.1038/sj.bjc.6690280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.1991.00400090120021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020872653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00435972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024510075", 
          "https://doi.org/10.1007/bf00435972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(85)92206-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025220229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(85)92206-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025220229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07357909209024821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025303413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)11423-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033560955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198902233200802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036097878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5122(85)90041-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040534971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)65026-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044672021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19920401)69:7<1729::aid-cncr2820690714>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044811534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.3.210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045734517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00689678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045857025", 
          "https://doi.org/10.1007/bf00689678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.18.1371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049883062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)85012-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051532969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)85011-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052363140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00926239908403998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052709325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jwh.1996.5.445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059289876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/87.18.1372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059819483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-40-1-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064308790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.9.2659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.11.2788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074828989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1989.7.6.803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079175492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082602595", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083059627", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.2.501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083213031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.4.1380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083246629"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-05", 
    "datePublishedReg": "2002-05-01", 
    "description": "To evaluate the impact of tamoxifen on subjective and psychosexual well-being in breast cancer patients in relation to type of prior chemotherapy and menopausal status. Longitudinal interview study in breast cancer patients during and after adjuvant tamoxifen use. Menopausal status was defined by last menstrual period and serum oestradiol and FSH levels. Gynaecology outpatient clinic, Tertiary Referral Hospital, January 1995 to September 1999. Breast cancer patients <56 years of age, participating in a randomised trial comparing adjuvant high-dose (n=45) and standard-dose (n=53) chemotherapy, followed by radiotherapy and tamoxifen. Relative incidence and correlation of subjective and psychosexual symptoms during and after tamoxifen. During tamoxifen the most frequent complaints were hot flushes (85%), disturbed sleep (55%), vaginal dryness and/or dyspareunia (47%), decreased sexual desire (44%) and musculo-skeletal symptoms (43%). Disturbed sleep correlated with hot flushes (P<0.0005) and concentration problems (P<0.05). Decreased sexual interest correlated with vaginal dryness (P<0.0005) and/or dyspareunia (P<0.0005). In the high-dose group more patients became postmenopausal (95% vs 33%) and more patients reported symptoms than in the standard-dose group (P<0.05). After discontinuation of tamoxifen, symptoms decreased significantly. However, hot flushes, disturbed sleep and vaginal dryness persisted more often in patients who remained postmenopausal after high-dose chemotherapy (P<0.05). Overall, during tamoxifen patients reported many symptoms. More patients become postmenopausal after high-dose chemotherapy, and they remain often symptomatic after tamoxifen.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6600294", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "86"
      }
    ], 
    "name": "Tamoxifen effects on subjective and psychosexual well-being, in a randomised breast cancer study comparing high-dose and standard-dose chemotherapy", 
    "pagination": "6600294", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "85ee6a692e4c3e186741e0b06804336b56de1098bc014ebf570ad8615075bee3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12085202"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6600294"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028114615"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6600294", 
      "https://app.dimensions.ai/details/publication/pub.1028114615"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118332_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/6600294"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600294'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600294'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600294'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600294'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      78 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6600294 schema:about N02ea698d3d384a6587c9d1c54752852a
2 N03cffe242fd349d1ba376bb078d3100b
3 N05893f02123b4029a3b033bb9714d5e8
4 N175cff9ed38345d0af5104905342df2e
5 N1cdf57490ea14bcd9ebc175ff1508dfc
6 N23aef558ba724b2db9a98c005f40891a
7 N42d7da609427436ea9ae8e34c2b9d836
8 N449520b4c568411ab4cd94d3932bcae9
9 N4cf3cf7fd579406fa55798dad2c6d4be
10 N593790f480154344a496d858c0a4a387
11 N6479d60dae934936955df9c1c4d310e0
12 N6ad681956bef462780ff6227183a8d11
13 N99c0bd70e8a34ae09a53d1c37814be2b
14 Na273b60d20094109b994afe6093f7298
15 Nac8a99bd04c34e0888cafaa84d7f7cd9
16 Nb3b51f892bb94e6db24fcc9c0be10663
17 Ne25ee9e708a341be90a12dc5b53aab82
18 Ne5cbf914a29a4696a3f118a2cc65ffe8
19 Ne7ddb4cce1c04ee1a960ae4707874b68
20 Nf74144646aa44c938a7b99f0242b3c74
21 Nfc9fd74ad5c64eba9aa82a85cfb0afd0
22 anzsrc-for:11
23 anzsrc-for:1112
24 schema:author Nb8894c2729334812a2ae8034386a1fc0
25 schema:citation sg:pub.10.1007/bf00435972
26 sg:pub.10.1007/bf00689678
27 sg:pub.10.1038/sj.bjc.6690280
28 https://app.dimensions.ai/details/publication/pub.1082602595
29 https://app.dimensions.ai/details/publication/pub.1083059627
30 https://doi.org/10.1001/archinte.1991.00400090120021
31 https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1682::aid-cncr14>3.0.co;2-0
32 https://doi.org/10.1002/1097-0142(19920401)69:7<1729::aid-cncr2820690714>3.0.co;2-d
33 https://doi.org/10.1016/0378-5122(85)90041-6
34 https://doi.org/10.1016/s0140-6736(05)65026-x
35 https://doi.org/10.1016/s0140-6736(85)92206-8
36 https://doi.org/10.1016/s0140-6736(97)11423-4
37 https://doi.org/10.1016/s0140-6736(98)85011-3
38 https://doi.org/10.1016/s0140-6736(98)85012-5
39 https://doi.org/10.1056/nejm198902233200802
40 https://doi.org/10.1080/00926239208404354
41 https://doi.org/10.1080/00926239908403998
42 https://doi.org/10.1089/jwh.1996.5.445
43 https://doi.org/10.1093/jnci/87.18.1372
44 https://doi.org/10.1093/jnci/90.18.1371
45 https://doi.org/10.1093/jnci/90.3.210
46 https://doi.org/10.1200/jco.1989.7.6.803
47 https://doi.org/10.1200/jco.1998.16.2.501
48 https://doi.org/10.1200/jco.1998.16.4.1380
49 https://doi.org/10.1200/jco.1999.17.9.2659
50 https://doi.org/10.1200/jco.2001.19.11.2788
51 https://doi.org/10.1210/jcem-40-1-19
52 https://doi.org/10.3109/07357909209024821
53 schema:datePublished 2002-05
54 schema:datePublishedReg 2002-05-01
55 schema:description To evaluate the impact of tamoxifen on subjective and psychosexual well-being in breast cancer patients in relation to type of prior chemotherapy and menopausal status. Longitudinal interview study in breast cancer patients during and after adjuvant tamoxifen use. Menopausal status was defined by last menstrual period and serum oestradiol and FSH levels. Gynaecology outpatient clinic, Tertiary Referral Hospital, January 1995 to September 1999. Breast cancer patients <56 years of age, participating in a randomised trial comparing adjuvant high-dose (n=45) and standard-dose (n=53) chemotherapy, followed by radiotherapy and tamoxifen. Relative incidence and correlation of subjective and psychosexual symptoms during and after tamoxifen. During tamoxifen the most frequent complaints were hot flushes (85%), disturbed sleep (55%), vaginal dryness and/or dyspareunia (47%), decreased sexual desire (44%) and musculo-skeletal symptoms (43%). Disturbed sleep correlated with hot flushes (P<0.0005) and concentration problems (P<0.05). Decreased sexual interest correlated with vaginal dryness (P<0.0005) and/or dyspareunia (P<0.0005). In the high-dose group more patients became postmenopausal (95% vs 33%) and more patients reported symptoms than in the standard-dose group (P<0.05). After discontinuation of tamoxifen, symptoms decreased significantly. However, hot flushes, disturbed sleep and vaginal dryness persisted more often in patients who remained postmenopausal after high-dose chemotherapy (P<0.05). Overall, during tamoxifen patients reported many symptoms. More patients become postmenopausal after high-dose chemotherapy, and they remain often symptomatic after tamoxifen.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N5c726887e574403281f09d04f6f98db4
60 N90dc7e71465440dfa38577377d462fcd
61 sg:journal.1017082
62 schema:name Tamoxifen effects on subjective and psychosexual well-being, in a randomised breast cancer study comparing high-dose and standard-dose chemotherapy
63 schema:pagination 6600294
64 schema:productId N355fde51c0ad44a0a87f46b7e97efa7e
65 N587b87556dbd4e74970355a6586e579c
66 N6e82091cce4d4bfcb50d50775f1ff46f
67 N70a2defb851f4eb38bbb3a47ebc1e3fa
68 Nf308095396c24be89c20e70c72a63a12
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028114615
70 https://doi.org/10.1038/sj.bjc.6600294
71 schema:sdDatePublished 2019-04-11T12:05
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N293b3029de004107be8805e13ee31053
74 schema:url https://www.nature.com/articles/6600294
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N02ea698d3d384a6587c9d1c54752852a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Mental Disorders
80 rdf:type schema:DefinedTerm
81 N03cffe242fd349d1ba376bb078d3100b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Hot Flashes
83 rdf:type schema:DefinedTerm
84 N05893f02123b4029a3b033bb9714d5e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Quality of Life
86 rdf:type schema:DefinedTerm
87 N175cff9ed38345d0af5104905342df2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Adult
89 rdf:type schema:DefinedTerm
90 N1cdf57490ea14bcd9ebc175ff1508dfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Chemotherapy, Adjuvant
92 rdf:type schema:DefinedTerm
93 N219cfaded8804af19d89ab4efe7aeb7a rdf:first sg:person.013341607157.98
94 rdf:rest N3207f7c57f4f49258713abdc7102344b
95 N23aef558ba724b2db9a98c005f40891a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Estrogen Receptor Modulators
97 rdf:type schema:DefinedTerm
98 N268e472e588843e7b253223445dabccb rdf:first sg:person.01060026551.93
99 rdf:rest N219cfaded8804af19d89ab4efe7aeb7a
100 N293b3029de004107be8805e13ee31053 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N3207f7c57f4f49258713abdc7102344b rdf:first sg:person.013225126734.46
103 rdf:rest N51af59093fee49bdbc87a17f3846cf90
104 N33efab4f2c434aa6bebbe1a2199a626a rdf:first sg:person.014046011234.60
105 rdf:rest rdf:nil
106 N355fde51c0ad44a0a87f46b7e97efa7e schema:name doi
107 schema:value 10.1038/sj.bjc.6600294
108 rdf:type schema:PropertyValue
109 N42d7da609427436ea9ae8e34c2b9d836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Middle Aged
111 rdf:type schema:DefinedTerm
112 N449520b4c568411ab4cd94d3932bcae9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 N4cf3cf7fd579406fa55798dad2c6d4be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Edema
117 rdf:type schema:DefinedTerm
118 N51af59093fee49bdbc87a17f3846cf90 rdf:first sg:person.014421476103.14
119 rdf:rest Na2f45c611fbc4c61a94d273c8934e895
120 N587b87556dbd4e74970355a6586e579c schema:name readcube_id
121 schema:value 85ee6a692e4c3e186741e0b06804336b56de1098bc014ebf570ad8615075bee3
122 rdf:type schema:PropertyValue
123 N593790f480154344a496d858c0a4a387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mood Disorders
125 rdf:type schema:DefinedTerm
126 N5c726887e574403281f09d04f6f98db4 schema:issueNumber 10
127 rdf:type schema:PublicationIssue
128 N6479d60dae934936955df9c1c4d310e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 N6ad681956bef462780ff6227183a8d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Menopause
133 rdf:type schema:DefinedTerm
134 N6e82091cce4d4bfcb50d50775f1ff46f schema:name pubmed_id
135 schema:value 12085202
136 rdf:type schema:PropertyValue
137 N70a2defb851f4eb38bbb3a47ebc1e3fa schema:name dimensions_id
138 schema:value pub.1028114615
139 rdf:type schema:PropertyValue
140 N90dc7e71465440dfa38577377d462fcd schema:volumeNumber 86
141 rdf:type schema:PublicationVolume
142 N99c0bd70e8a34ae09a53d1c37814be2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Breast Neoplasms
144 rdf:type schema:DefinedTerm
145 Na273b60d20094109b994afe6093f7298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Incidence
147 rdf:type schema:DefinedTerm
148 Na2f45c611fbc4c61a94d273c8934e895 rdf:first sg:person.011434417777.06
149 rdf:rest Ned7895d437a343048577304adf9354a2
150 Nac8a99bd04c34e0888cafaa84d7f7cd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Sleep Initiation and Maintenance Disorders
152 rdf:type schema:DefinedTerm
153 Nb3b51f892bb94e6db24fcc9c0be10663 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Sexual Dysfunctions, Psychological
155 rdf:type schema:DefinedTerm
156 Nb8894c2729334812a2ae8034386a1fc0 rdf:first sg:person.011605457414.50
157 rdf:rest N268e472e588843e7b253223445dabccb
158 Ne25ee9e708a341be90a12dc5b53aab82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Musculoskeletal Diseases
160 rdf:type schema:DefinedTerm
161 Ne5cbf914a29a4696a3f118a2cc65ffe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Combined Modality Therapy
163 rdf:type schema:DefinedTerm
164 Ne7ddb4cce1c04ee1a960ae4707874b68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Tamoxifen
166 rdf:type schema:DefinedTerm
167 Ned7895d437a343048577304adf9354a2 rdf:first sg:person.07536130644.45
168 rdf:rest N33efab4f2c434aa6bebbe1a2199a626a
169 Nf308095396c24be89c20e70c72a63a12 schema:name nlm_unique_id
170 schema:value 0370635
171 rdf:type schema:PropertyValue
172 Nf74144646aa44c938a7b99f0242b3c74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Antineoplastic Agents, Hormonal
174 rdf:type schema:DefinedTerm
175 Nfc9fd74ad5c64eba9aa82a85cfb0afd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Dyspareunia
177 rdf:type schema:DefinedTerm
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
182 schema:name Oncology and Carcinogenesis
183 rdf:type schema:DefinedTerm
184 sg:journal.1017082 schema:issn 0007-0920
185 1532-1827
186 schema:name British Journal of Cancer
187 rdf:type schema:Periodical
188 sg:person.01060026551.93 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
189 schema:familyName Böckermann
190 schema:givenName I
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060026551.93
192 rdf:type schema:Person
193 sg:person.011434417777.06 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
194 schema:familyName van der Graaf
195 schema:givenName W T
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011434417777.06
197 rdf:type schema:Person
198 sg:person.011605457414.50 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
199 schema:familyName Mourits
200 schema:givenName M J
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011605457414.50
202 rdf:type schema:Person
203 sg:person.013225126734.46 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
204 schema:familyName van der Zee
205 schema:givenName A G
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013225126734.46
207 rdf:type schema:Person
208 sg:person.013341607157.98 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
209 schema:familyName de Vries
210 schema:givenName E G
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013341607157.98
212 rdf:type schema:Person
213 sg:person.014046011234.60 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
214 schema:familyName Willemse
215 schema:givenName P H
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014046011234.60
217 rdf:type schema:Person
218 sg:person.014421476103.14 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
219 schema:familyName Hoor
220 schema:givenName K A ten
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014421476103.14
222 rdf:type schema:Person
223 sg:person.07536130644.45 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
224 schema:familyName Sluiter
225 schema:givenName W J
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536130644.45
227 rdf:type schema:Person
228 sg:pub.10.1007/bf00435972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024510075
229 https://doi.org/10.1007/bf00435972
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/bf00689678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045857025
232 https://doi.org/10.1007/bf00689678
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/sj.bjc.6690280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016663395
235 https://doi.org/10.1038/sj.bjc.6690280
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1082602595 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1083059627 schema:CreativeWork
239 https://doi.org/10.1001/archinte.1991.00400090120021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020872653
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1682::aid-cncr14>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001687708
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/1097-0142(19920401)69:7<1729::aid-cncr2820690714>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1044811534
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0378-5122(85)90041-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040534971
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0140-6736(05)65026-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044672021
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0140-6736(85)92206-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025220229
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0140-6736(97)11423-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033560955
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0140-6736(98)85011-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052363140
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0140-6736(98)85012-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051532969
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejm198902233200802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036097878
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1080/00926239208404354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007743490
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1080/00926239908403998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052709325
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1089/jwh.1996.5.445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059289876
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/jnci/87.18.1372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819483
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/jnci/90.18.1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049883062
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/jnci/90.3.210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045734517
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1200/jco.1989.7.6.803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079175492
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1200/jco.1998.16.2.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083213031
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1200/jco.1998.16.4.1380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083246629
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1200/jco.1999.17.9.2659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549896
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1200/jco.2001.19.11.2788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074828989
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1210/jcem-40-1-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064308790
282 rdf:type schema:CreativeWork
283 https://doi.org/10.3109/07357909209024821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025303413
284 rdf:type schema:CreativeWork
285 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
286 schema:name Department of Endocrinology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
287 Department of Gynaecology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
288 Department of Medical Oncology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...