Ontology type: schema:ScholarlyArticle Open Access: True
2002-04-02
AUTHORSH Ikeda, T Iehara, Y Tsuchida, M Kaneko, J Hata, H Naito, M Iwafuchi, N Ohnuma, H Mugishima, Y Toyoda, M Hamazaki, J Mimaya, S Kondo, K Kawa, A Okada, E Hiyama, S Suita, H Takamatsu
ABSTRACTThe International Neuroblastoma Staging System and Pathology Classification were proposed in 1988 and in 1999, respectively, but their clinical value has not yet been fully studied in new patients. Six hundred and forty-four patients with neuroblastoma treated between January 1995 and December 1999 were analysed by these classifications. The 4-year overall survival rate of patients <12 months of age with INSS stages 1, 2A, 2B, 3 and 4S disease was 98.5%, which was significantly higher than the 73.1% rate in stage 4 patients <12 months (P<0.0001). When patients were ⩾12 months, the 4-year overall survival rate of patients with neuroblastoma at 1, 2A, 2B and 3 stages was 100% and that of patients at stage 4 was 48.5% (P<0.0001). As to the International Neuroblastoma Pathology Classification histology, the 4-year overall survival rate was 98.8% in patients with favourable histology and 60.7% in those with unfavourable histology in the <12 months group (P<0.0001). In the ⩾12 months group, the 4-year oral survival of patients with favourable histology was 95.3% and that of patients with unfavourable histology was 50.6% (P<0.0001). Among biological factors, MYCN amplification, DNA diploidy and 1p deletions were significantly associated with poor prognosis in patients <12 months, as were MYCN amplification and DNA diploidy in patients ⩾12 months of age. Multivariate analysis showed that the INSS stage (stage 4 vs other stages) and International Neuroblastoma Pathology Classification histology (unfavourable vs favourable) were significantly and independently associated with the survival of patients undergoing treatment, stratified by age, stage and MYCN amplification (P=0.0002 and P=0.0051, respectively). More... »
PAGES1110-1116
http://scigraph.springernature.com/pub.10.1038/sj.bjc.6600231
DOIhttp://dx.doi.org/10.1038/sj.bjc.6600231
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1014860322
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11953858
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Age Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child, Preschool",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Amplification",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, myc",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant, Newborn",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "International Cooperation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neuroblastoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ploidies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, 2-1-50 Minami-Koshigaya, 343-8555, Koshigaya, Saitama, Japan",
"id": "http://www.grid.ac/institutes/grid.470088.3",
"name": [
"Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, 2-1-50 Minami-Koshigaya, 343-8555, Koshigaya, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Ikeda",
"givenName": "H",
"id": "sg:person.01226223411.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226223411.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatrics, Kyoto Prefectural University of Medicine, Hirokohji, Kawaramachi-dori, 602-8566, Kamigyo-ku, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Pediatrics, Kyoto Prefectural University of Medicine, Hirokohji, Kawaramachi-dori, 602-8566, Kamigyo-ku, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Iehara",
"givenName": "T",
"id": "sg:person.0702457544.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702457544.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Tsuchida",
"givenName": "Y",
"id": "sg:person.01132671315.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132671315.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pediatric Surgery, University of Tsukuba, 1-1-1, 305-8575, Tennodai, Tsukuba, Japan",
"id": "http://www.grid.ac/institutes/grid.20515.33",
"name": [
"Department of Pediatric Surgery, University of Tsukuba, 1-1-1, 305-8575, Tennodai, Tsukuba, Japan"
],
"type": "Organization"
},
"familyName": "Kaneko",
"givenName": "M",
"id": "sg:person.01174472457.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174472457.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Hata",
"givenName": "J",
"id": "sg:person.012240513442.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012240513442.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Naito",
"givenName": "H",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Iwafuchi",
"givenName": "M",
"id": "sg:person.01045740712.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045740712.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Ohnuma",
"givenName": "N",
"id": "sg:person.0610626743.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610626743.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Mugishima",
"givenName": "H",
"id": "sg:person.0706055415.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706055415.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Toyoda",
"givenName": "Y",
"id": "sg:person.01056114741.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056114741.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Hamazaki",
"givenName": "M",
"id": "sg:person.01022304015.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022304015.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Mimaya",
"givenName": "J",
"id": "sg:person.015573362034.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015573362034.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Kondo",
"givenName": "S",
"id": "sg:person.01133205413.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133205413.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Kawa",
"givenName": "K",
"id": "sg:person.0614775633.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614775633.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Okada",
"givenName": "A",
"id": "sg:person.0725725344.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725725344.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Hiyama",
"givenName": "E",
"id": "sg:person.0665415724.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665415724.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Suita",
"givenName": "S",
"id": "sg:person.01073504134.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073504134.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan",
"id": "http://www.grid.ac/institutes/grid.410822.d",
"name": [
"Study Group of Neuroblastoma, Gunma Children's Medical Center, 377 Shimohakoda, Hokkitsu, 377-8577, Seta-gun, Gunma, Japan"
],
"type": "Organization"
},
"familyName": "Takamatsu",
"givenName": "H",
"id": "sg:person.015441261761.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015441261761.72"
],
"type": "Person"
}
],
"datePublished": "2002-04-02",
"datePublishedReg": "2002-04-02",
"description": "The International Neuroblastoma Staging System and Pathology Classification were proposed in 1988 and in 1999, respectively, but their clinical value has not yet been fully studied in new patients. Six hundred and forty-four patients with neuroblastoma treated between January 1995 and December 1999 were analysed by these classifications. The 4-year overall survival rate of patients <12 months of age with INSS stages 1, 2A, 2B, 3 and 4S disease was 98.5%, which was significantly higher than the 73.1% rate in stage 4 patients <12 months (P<0.0001). When patients were \u2a7e12 months, the 4-year overall survival rate of patients with neuroblastoma at 1, 2A, 2B and 3 stages was 100% and that of patients at stage 4 was 48.5% (P<0.0001). As to the International Neuroblastoma Pathology Classification histology, the 4-year overall survival rate was 98.8% in patients with favourable histology and 60.7% in those with unfavourable histology in the <12 months group (P<0.0001). In the \u2a7e12 months group, the 4-year oral survival of patients with favourable histology was 95.3% and that of patients with unfavourable histology was 50.6% (P<0.0001). Among biological factors, MYCN amplification, DNA diploidy and 1p deletions were significantly associated with poor prognosis in patients <12 months, as were MYCN amplification and DNA diploidy in patients \u2a7e12 months of age. Multivariate analysis showed that the INSS stage (stage 4 vs other stages) and International Neuroblastoma Pathology Classification histology (unfavourable vs favourable) were significantly and independently associated with the survival of patients undergoing treatment, stratified by age, stage and MYCN amplification (P=0.0002 and P=0.0051, respectively).",
"genre": "article",
"id": "sg:pub.10.1038/sj.bjc.6600231",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "86"
}
],
"keywords": [
"overall survival rate",
"International Neuroblastoma Staging System",
"months of age",
"MYCN amplification",
"survival rate",
"staging system",
"unfavourable histology",
"favorable histology",
"DNA diploidy",
"months group",
"INSS stage 1",
"stage 4 patients",
"survival of patients",
"pathology classification",
"poor prognosis",
"INSS stage",
"new patients",
"clinical value",
"patients",
"multivariate analysis",
"histology",
"months",
"stage 4",
"neuroblastoma",
"stage 1",
"age",
"survival",
"biological factors",
"prognosis",
"group",
"disease",
"rate",
"diploidy",
"treatment",
"amplification",
"stage",
"classification",
"factors",
"deletion",
"experience",
"analysis",
"values",
"system"
],
"name": "Experience with International Neuroblastoma Staging System and Pathology Classification",
"pagination": "1110-1116",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1014860322"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.bjc.6600231"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11953858"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.bjc.6600231",
"https://app.dimensions.ai/details/publication/pub.1014860322"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_360.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/sj.bjc.6600231"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600231'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600231'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600231'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600231'
This table displays all metadata directly associated to this object as RDF triples.
303 TRIPLES
20 PREDICATES
86 URIs
78 LITERALS
25 BLANK NODES