Detection of polyol accumulation in a new ovarian carcinoma cell line, CABA I: a1H NMR study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-04

AUTHORS

A Ferretti, S D'Ascenzo, A Knijn, E Iorio, V Dolo, A Pavan, F Podo

ABSTRACT

Ovarian carcinomas represent a major form of gynaecological malignancies, whose treatment consists mainly of surgery and chemotherapy. Besides the difficulty of prognosis, therapy of ovarian carcinomas has reached scarce improvement, as a consequence of lack of efficacy and development of drug-resistance. The need of different biochemical and functional parameters has grown, in order to obtain a larger view on processes of biological and clinical significance. In this paper we report novel metabolic features detected in a series of different human ovary carcinoma lines, by (1)H NMR spectroscopy of intact cells and their extracts. Most importantly, a new ovarian adenocarcinoma line CABA I, showed strong signals in the spectral region between 3.5 and 4.0 p.p.m., assigned for the first time to the polyol sorbitol (39+/-11 nmol/10(6) cells). (13)C NMR analyses of these cells incubated with [1-(13)C]-D-glucose demonstrated labelled-sorbitol formation. The other ovarian carcinoma cell lines (OVCAR-3, IGROV 1, SK-OV-3 and OVCA432), showed, in the same spectral region, intense resonances from other metabolites: glutathione (up to 30 nmol/10(6) cells) and myo-inositol (up to 50 nmol/10(6) cells). Biochemical and biological functions are suggested for these compounds in human ovarian carcinoma cells, especially in relation to their possible role in cell detoxification mechanisms during tumour progression. More... »

PAGES

6600189

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.bjc.6600189

DOI

http://dx.doi.org/10.1038/sj.bjc.6600189

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044221585

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11953869


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indicators and Reagents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sorbitol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Cell Biology, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferretti", 
        "givenName": "A", 
        "id": "sg:person.01012051570.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012051570.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of Experimental Medicine, University of L'Aquila, Via Vetoio-Coppito 2, 67100 L'Aquila, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D'Ascenzo", 
        "givenName": "S", 
        "id": "sg:person.01070543067.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070543067.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Cell Biology, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knijn", 
        "givenName": "A", 
        "id": "sg:person.0743736370.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743736370.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Cell Biology, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iorio", 
        "givenName": "E", 
        "id": "sg:person.01244146423.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244146423.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of Experimental Medicine, University of L'Aquila, Via Vetoio-Coppito 2, 67100 L'Aquila, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dolo", 
        "givenName": "V", 
        "id": "sg:person.01357415052.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357415052.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of Experimental Medicine, University of L'Aquila, Via Vetoio-Coppito 2, 67100 L'Aquila, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pavan", 
        "givenName": "A", 
        "id": "sg:person.01275766165.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275766165.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Superiore di Sanit\u00e0", 
          "id": "https://www.grid.ac/institutes/grid.416651.1", 
          "name": [
            "Laboratory of Cell Biology, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Podo", 
        "givenName": "F", 
        "id": "sg:person.011411540044.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011411540044.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mrm.1910090315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000786915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(99)00322-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003427030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004077811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005581916", 
          "https://doi.org/10.1038/sj.onc.1203839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005581916", 
          "https://doi.org/10.1038/sj.onc.1203839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01480549509014323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007543467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0066-4103(08)60267-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009598693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(99)80016-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011309724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/152165400300001499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011559591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2364(83)90241-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012757681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1492(199911)12:7<413::aid-nbm587>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017036692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1492(199911)12:7<413::aid-nbm587>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017036692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1388-1981(00)00165-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020298101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.19.11429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022719702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4644(20010601)81:3<488::aid-jcb1062>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023969065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci110380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029676460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(90)90364-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031379104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(90)90364-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031379104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1998.71020775.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040597298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1099-1492(200008)13:5<297::aid-nbm648>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043469875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910290418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044127859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1388-1981(99)00071-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047578619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4835(90)90096-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049582749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1731::aid-cncr20>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053602985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5401.496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062563931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1996.84.3.0449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071097935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1996.84.3.0449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071097935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1996.84.3.0449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071097935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2001.94.1.0055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2001.94.1.0055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2001.94.1.0055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074608417", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074805947", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/59.1.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079653369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079998605", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080049793", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081853893", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082651900", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.198.3.8628874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082885172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082912466", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083092758", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083116188", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083190695", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083376142", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9781482270105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1108495844"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-04", 
    "datePublishedReg": "2002-04-01", 
    "description": "Ovarian carcinomas represent a major form of gynaecological malignancies, whose treatment consists mainly of surgery and chemotherapy. Besides the difficulty of prognosis, therapy of ovarian carcinomas has reached scarce improvement, as a consequence of lack of efficacy and development of drug-resistance. The need of different biochemical and functional parameters has grown, in order to obtain a larger view on processes of biological and clinical significance. In this paper we report novel metabolic features detected in a series of different human ovary carcinoma lines, by (1)H NMR spectroscopy of intact cells and their extracts. Most importantly, a new ovarian adenocarcinoma line CABA I, showed strong signals in the spectral region between 3.5 and 4.0 p.p.m., assigned for the first time to the polyol sorbitol (39+/-11 nmol/10(6) cells). (13)C NMR analyses of these cells incubated with [1-(13)C]-D-glucose demonstrated labelled-sorbitol formation. The other ovarian carcinoma cell lines (OVCAR-3, IGROV 1, SK-OV-3 and OVCA432), showed, in the same spectral region, intense resonances from other metabolites: glutathione (up to 30 nmol/10(6) cells) and myo-inositol (up to 50 nmol/10(6) cells). Biochemical and biological functions are suggested for these compounds in human ovarian carcinoma cells, especially in relation to their possible role in cell detoxification mechanisms during tumour progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.bjc.6600189", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "86"
      }
    ], 
    "name": "Detection of polyol accumulation in a new ovarian carcinoma cell line, CABA I: a1H NMR study", 
    "pagination": "6600189", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d2a429b3ab0903867c03fb6e0b38b1ba7b6e2ee2f79f8350b08c5f7eb55c452e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11953869"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.bjc.6600189"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044221585"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.bjc.6600189", 
      "https://app.dimensions.ai/details/publication/pub.1044221585"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118336_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/6600189"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600189'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600189'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600189'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600189'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      79 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.bjc.6600189 schema:about N02f4f118bda443689d2933cc3b34dbb4
2 N0f6803b3eef14e10bc04f66ff53732f9
3 N1afdd7aa8e1b47f091c4e7e2609d41db
4 N1ec083f1f7de44699763590dd474a701
5 N237cd26568ec4f5f87fdec1839dcf201
6 N56c863393ca8403faeb9db8b1a7dc44c
7 N6ac063a45e2d4197ba5569e9c6f6c148
8 N89d48a7ef874460bb24f24c5c50e086d
9 Nc653f5d997fc4f28a63ffb8dbb6509ff
10 Ncd133af13b304d94ba9310b26d890035
11 Nd6c3ffef7be143f2b24ce0b1695de5bf
12 Nf2245225560843e0a06be8552a7d4982
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author Ncecdfc96418848f2ad7baa2067ea62af
16 schema:citation sg:pub.10.1038/sj.onc.1203839
17 https://app.dimensions.ai/details/publication/pub.1074608417
18 https://app.dimensions.ai/details/publication/pub.1074805947
19 https://app.dimensions.ai/details/publication/pub.1079998605
20 https://app.dimensions.ai/details/publication/pub.1080049793
21 https://app.dimensions.ai/details/publication/pub.1081853893
22 https://app.dimensions.ai/details/publication/pub.1082651900
23 https://app.dimensions.ai/details/publication/pub.1082912466
24 https://app.dimensions.ai/details/publication/pub.1083092758
25 https://app.dimensions.ai/details/publication/pub.1083116188
26 https://app.dimensions.ai/details/publication/pub.1083190695
27 https://app.dimensions.ai/details/publication/pub.1083376142
28 https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1731::aid-cncr20>3.0.co;2-4
29 https://doi.org/10.1002/(sici)1099-1492(199911)12:7<413::aid-nbm587>3.0.co;2-u
30 https://doi.org/10.1002/1097-4644(20010601)81:3<488::aid-jcb1062>3.0.co;2-4
31 https://doi.org/10.1002/1099-1492(200008)13:5<297::aid-nbm648>3.0.co;2-i
32 https://doi.org/10.1002/mrm.1910090315
33 https://doi.org/10.1002/mrm.1910290418
34 https://doi.org/10.1006/bbrc.1997.7566
35 https://doi.org/10.1016/0006-2952(90)90364-q
36 https://doi.org/10.1016/0014-4835(90)90096-d
37 https://doi.org/10.1016/0022-2364(83)90241-x
38 https://doi.org/10.1016/s0006-2952(99)00322-6
39 https://doi.org/10.1016/s0066-4103(08)60267-7
40 https://doi.org/10.1016/s0090-4295(99)80016-8
41 https://doi.org/10.1016/s1388-1981(00)00165-7
42 https://doi.org/10.1016/s1388-1981(99)00071-2
43 https://doi.org/10.1046/j.1471-4159.1998.71020775.x
44 https://doi.org/10.1074/jbc.273.19.11429
45 https://doi.org/10.1080/152165400300001499
46 https://doi.org/10.1093/jnci/59.1.221
47 https://doi.org/10.1126/science.283.5401.496
48 https://doi.org/10.1148/radiology.198.3.8628874
49 https://doi.org/10.1172/jci110380
50 https://doi.org/10.1201/9781482270105
51 https://doi.org/10.3109/01480549509014323
52 https://doi.org/10.3171/jns.1996.84.3.0449
53 https://doi.org/10.3171/jns.2001.94.1.0055
54 schema:datePublished 2002-04
55 schema:datePublishedReg 2002-04-01
56 schema:description Ovarian carcinomas represent a major form of gynaecological malignancies, whose treatment consists mainly of surgery and chemotherapy. Besides the difficulty of prognosis, therapy of ovarian carcinomas has reached scarce improvement, as a consequence of lack of efficacy and development of drug-resistance. The need of different biochemical and functional parameters has grown, in order to obtain a larger view on processes of biological and clinical significance. In this paper we report novel metabolic features detected in a series of different human ovary carcinoma lines, by (1)H NMR spectroscopy of intact cells and their extracts. Most importantly, a new ovarian adenocarcinoma line CABA I, showed strong signals in the spectral region between 3.5 and 4.0 p.p.m., assigned for the first time to the polyol sorbitol (39+/-11 nmol/10(6) cells). (13)C NMR analyses of these cells incubated with [1-(13)C]-D-glucose demonstrated labelled-sorbitol formation. The other ovarian carcinoma cell lines (OVCAR-3, IGROV 1, SK-OV-3 and OVCA432), showed, in the same spectral region, intense resonances from other metabolites: glutathione (up to 30 nmol/10(6) cells) and myo-inositol (up to 50 nmol/10(6) cells). Biochemical and biological functions are suggested for these compounds in human ovarian carcinoma cells, especially in relation to their possible role in cell detoxification mechanisms during tumour progression.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N4baeb870472e41f38d3934d04f5563e1
61 N8fb7b216949143128554f07b34c50218
62 sg:journal.1017082
63 schema:name Detection of polyol accumulation in a new ovarian carcinoma cell line, CABA I: a1H NMR study
64 schema:pagination 6600189
65 schema:productId N083c56bb610847a4ab109ef1934e1cc9
66 N1f3f6d36c9974c41a0c3406437c5175a
67 N74870c1c74cc43558edec16744630d55
68 N8de54deeb37d410a9b691f88412f7025
69 Nb3280900ca8444ff840a87262ab97e9f
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044221585
71 https://doi.org/10.1038/sj.bjc.6600189
72 schema:sdDatePublished 2019-04-11T12:06
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N94fc31f414ba4143ae6bec1027654fad
75 schema:url http://www.nature.com/articles/6600189
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N02f4f118bda443689d2933cc3b34dbb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Disease Progression
81 rdf:type schema:DefinedTerm
82 N083c56bb610847a4ab109ef1934e1cc9 schema:name doi
83 schema:value 10.1038/sj.bjc.6600189
84 rdf:type schema:PropertyValue
85 N0a9e7e594b29425ea53950b9b27df053 rdf:first sg:person.01070543067.73
86 rdf:rest Nbeba5df85c8742c5966a6504ecc79a2e
87 N0f6803b3eef14e10bc04f66ff53732f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Ovarian Neoplasms
89 rdf:type schema:DefinedTerm
90 N1afdd7aa8e1b47f091c4e7e2609d41db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Biomarkers, Tumor
92 rdf:type schema:DefinedTerm
93 N1ec083f1f7de44699763590dd474a701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Hydrogen
95 rdf:type schema:DefinedTerm
96 N1f3f6d36c9974c41a0c3406437c5175a schema:name pubmed_id
97 schema:value 11953869
98 rdf:type schema:PropertyValue
99 N237cd26568ec4f5f87fdec1839dcf201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Tumor Cells, Cultured
101 rdf:type schema:DefinedTerm
102 N2dc9ece2f52143c98885f79131452593 rdf:first sg:person.01275766165.22
103 rdf:rest Nf54ed5661a60470b92acbb49a70e8b62
104 N4baeb870472e41f38d3934d04f5563e1 schema:issueNumber 7
105 rdf:type schema:PublicationIssue
106 N56c863393ca8403faeb9db8b1a7dc44c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Indicators and Reagents
108 rdf:type schema:DefinedTerm
109 N6ac063a45e2d4197ba5569e9c6f6c148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Adenocarcinoma
111 rdf:type schema:DefinedTerm
112 N74870c1c74cc43558edec16744630d55 schema:name nlm_unique_id
113 schema:value 0370635
114 rdf:type schema:PropertyValue
115 N7b5d22e502ce4b8391143425fcc3dd92 rdf:first sg:person.01357415052.97
116 rdf:rest N2dc9ece2f52143c98885f79131452593
117 N89d48a7ef874460bb24f24c5c50e086d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Magnetic Resonance Spectroscopy
119 rdf:type schema:DefinedTerm
120 N8de54deeb37d410a9b691f88412f7025 schema:name dimensions_id
121 schema:value pub.1044221585
122 rdf:type schema:PropertyValue
123 N8fb7b216949143128554f07b34c50218 schema:volumeNumber 86
124 rdf:type schema:PublicationVolume
125 N90c98b1c791a4c22a50f0e81c5dbe93e rdf:first sg:person.01244146423.39
126 rdf:rest N7b5d22e502ce4b8391143425fcc3dd92
127 N94fc31f414ba4143ae6bec1027654fad schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 Nb3280900ca8444ff840a87262ab97e9f schema:name readcube_id
130 schema:value d2a429b3ab0903867c03fb6e0b38b1ba7b6e2ee2f79f8350b08c5f7eb55c452e
131 rdf:type schema:PropertyValue
132 Nbeba5df85c8742c5966a6504ecc79a2e rdf:first sg:person.0743736370.33
133 rdf:rest N90c98b1c791a4c22a50f0e81c5dbe93e
134 Nc653f5d997fc4f28a63ffb8dbb6509ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 Ncd133af13b304d94ba9310b26d890035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Female
139 rdf:type schema:DefinedTerm
140 Ncecdfc96418848f2ad7baa2067ea62af rdf:first sg:person.01012051570.34
141 rdf:rest N0a9e7e594b29425ea53950b9b27df053
142 Nd6c3ffef7be143f2b24ce0b1695de5bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Glutathione
144 rdf:type schema:DefinedTerm
145 Nf2245225560843e0a06be8552a7d4982 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Sorbitol
147 rdf:type schema:DefinedTerm
148 Nf54ed5661a60470b92acbb49a70e8b62 rdf:first sg:person.011411540044.04
149 rdf:rest rdf:nil
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
154 schema:name Oncology and Carcinogenesis
155 rdf:type schema:DefinedTerm
156 sg:journal.1017082 schema:issn 0007-0920
157 1532-1827
158 schema:name British Journal of Cancer
159 rdf:type schema:Periodical
160 sg:person.01012051570.34 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
161 schema:familyName Ferretti
162 schema:givenName A
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012051570.34
164 rdf:type schema:Person
165 sg:person.01070543067.73 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
166 schema:familyName D'Ascenzo
167 schema:givenName S
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070543067.73
169 rdf:type schema:Person
170 sg:person.011411540044.04 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
171 schema:familyName Podo
172 schema:givenName F
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011411540044.04
174 rdf:type schema:Person
175 sg:person.01244146423.39 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
176 schema:familyName Iorio
177 schema:givenName E
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244146423.39
179 rdf:type schema:Person
180 sg:person.01275766165.22 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
181 schema:familyName Pavan
182 schema:givenName A
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275766165.22
184 rdf:type schema:Person
185 sg:person.01357415052.97 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
186 schema:familyName Dolo
187 schema:givenName V
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357415052.97
189 rdf:type schema:Person
190 sg:person.0743736370.33 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
191 schema:familyName Knijn
192 schema:givenName A
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743736370.33
194 rdf:type schema:Person
195 sg:pub.10.1038/sj.onc.1203839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005581916
196 https://doi.org/10.1038/sj.onc.1203839
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1074608417 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1074805947 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1079998605 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1080049793 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1081853893 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1082651900 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1082912466 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1083092758 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1083116188 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1083190695 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1083376142 schema:CreativeWork
209 https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1731::aid-cncr20>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053602985
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/(sici)1099-1492(199911)12:7<413::aid-nbm587>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1017036692
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/1097-4644(20010601)81:3<488::aid-jcb1062>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023969065
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/1099-1492(200008)13:5<297::aid-nbm648>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1043469875
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/mrm.1910090315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000786915
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/mrm.1910290418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044127859
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1006/bbrc.1997.7566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004077811
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0006-2952(90)90364-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1031379104
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0014-4835(90)90096-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1049582749
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0022-2364(83)90241-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012757681
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0006-2952(99)00322-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003427030
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0066-4103(08)60267-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009598693
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0090-4295(99)80016-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011309724
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s1388-1981(00)00165-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020298101
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s1388-1981(99)00071-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047578619
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1046/j.1471-4159.1998.71020775.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040597298
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.273.19.11429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022719702
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1080/152165400300001499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011559591
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/jnci/59.1.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079653369
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1126/science.283.5401.496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563931
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1148/radiology.198.3.8628874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082885172
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1172/jci110380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029676460
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1201/9781482270105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1108495844
254 rdf:type schema:CreativeWork
255 https://doi.org/10.3109/01480549509014323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007543467
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3171/jns.1996.84.3.0449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071097935
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3171/jns.2001.94.1.0055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071099820
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.158820.6 schema:alternateName University of L'Aquila
262 schema:name Department of Experimental Medicine, University of L'Aquila, Via Vetoio-Coppito 2, 67100 L'Aquila, Italy
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.416651.1 schema:alternateName Istituto Superiore di Sanità
265 schema:name Laboratory of Cell Biology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...