Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-23

AUTHORS

Tesfahun Dessale Admasu, Krishna Chaithanya Batchu, Li Fang Ng, Amaury Cazenave-Gassiot, Markus R. Wenk, Jan Gruber

ABSTRACT

We report the effect of four lifespan modifying drugs and of synergistic combinations of these drugs on lipid profile in Caenorhabditis elegans. We employ ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) to compare the abundance of lipid species in treated and control animals. Adult nematodes were treated with rapamycin, rifampicin, psora-4 and allantoin and combinations of these compounds and the resulting change in lipid profiles, specifically in those of triacylglycerol (TAG), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were determined. We quantified changes resulting from treatment with the drug combinations relative to untreated controls and relative to animals treated with each constituent single drugs. We further determined the dependence of changes in lipid profiles on genes known to affect lipid metabolism using strains carrying mutations in these pathways. In particular, we determined lipid profiles in a genetic model of caloric restriction (eat-2), a strain lacking homolog of TGFβ (daf-7) and in a strain lacking the SREBP/sbp-1 transcription factor. More... »

PAGES

180231

References to SciGraph publications

  • 2010-03. The genetics of ageing in NATURE
  • 2016-11-09. Ageing, neurodegeneration and brain rejuvenation in NATURE
  • 2017-08-09. Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-12. Metformin improves healthspan and lifespan in mice in NATURE COMMUNICATIONS
  • 2017-05-18. The brain, sirtuins, and ageing in NATURE REVIEWS NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sdata.2018.231

    DOI

    http://dx.doi.org/10.1038/sdata.2018.231

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107795782

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30351306


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