Expansion of CD19-specific chimeric antigen receptor (CAR) T memory stem cells to improve adoptive T cell therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

ABSTRACT

Studies in patient samples and mice suggest increasing the subpopulation of T memory stem cells could help improve the efficacy of CAR-based T cell therapy. In populations of transplanted CD19-specific CAR T cells, a high frequency of cells resembling T memory stem cells correlated with increased expansion and persistence of the CAR T cells. In ex vivo, cultured CAR T cells, IL-7 and IL-15 increased the population of the T memory stem cells compared with IL-2. In tumor-bearing mice, adoptive therapy with IL-7- and IL-15-expanded CAR T cells delayed disease progression and resulted in increased survival compared with therapy using IL-2-expanded CAR T cells. Researchers did not disclose next steps, which could include optimizing CAR T cell culturing conditions to further boost the T memory stem cell subpopulation. More... »

PAGES

659-659

Journal

TITLE

Science-Business eXchange

ISSUE

22

VOLUME

7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/scibx.2014.659

DOI

http://dx.doi.org/10.1038/scibx.2014.659

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007732600


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "datePublished": "2014-06", 
    "datePublishedReg": "2014-06-01", 
    "description": "Studies in patient samples and mice suggest increasing the subpopulation of T memory stem cells could help improve the efficacy of CAR-based T cell therapy. In populations of transplanted CD19-specific CAR T cells, a high frequency of cells resembling T memory stem cells correlated with increased expansion and persistence of the CAR T cells. In ex vivo, cultured CAR T cells, IL-7 and IL-15 increased the population of the T memory stem cells compared with IL-2. In tumor-bearing mice, adoptive therapy with IL-7- and IL-15-expanded CAR T cells delayed disease progression and resulted in increased survival compared with therapy using IL-2-expanded CAR T cells. Researchers did not disclose next steps, which could include optimizing CAR T cell culturing conditions to further boost the T memory stem cell subpopulation.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1038/scibx.2014.659", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1136657", 
        "issn": [
          "1945-3477"
        ], 
        "name": "Science-Business eXchange", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "22", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Expansion of CD19-specific chimeric antigen receptor (CAR) T memory stem cells to improve adoptive T cell therapy", 
    "pagination": "659-659", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "24d53304b86dc23ba1f8b41328d5c923795707100f50ea7262e5ca25666e852e"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/scibx.2014.659"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007732600"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/scibx.2014.659", 
      "https://app.dimensions.ai/details/publication/pub.1007732600"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/scibx/journal/v7/n22/full/scibx.2014.659.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/scibx.2014.659'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/scibx.2014.659'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/scibx.2014.659'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/scibx.2014.659'


 

This table displays all metadata directly associated to this object as RDF triples.

49 TRIPLES      19 PREDICATES      26 URIs      18 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/scibx.2014.659 schema:about anzsrc-for:10
2 anzsrc-for:1004
3 schema:datePublished 2014-06
4 schema:datePublishedReg 2014-06-01
5 schema:description Studies in patient samples and mice suggest increasing the subpopulation of T memory stem cells could help improve the efficacy of CAR-based T cell therapy. In populations of transplanted CD19-specific CAR T cells, a high frequency of cells resembling T memory stem cells correlated with increased expansion and persistence of the CAR T cells. In ex vivo, cultured CAR T cells, IL-7 and IL-15 increased the population of the T memory stem cells compared with IL-2. In tumor-bearing mice, adoptive therapy with IL-7- and IL-15-expanded CAR T cells delayed disease progression and resulted in increased survival compared with therapy using IL-2-expanded CAR T cells. Researchers did not disclose next steps, which could include optimizing CAR T cell culturing conditions to further boost the T memory stem cell subpopulation.
6 schema:genre non_research_article
7 schema:inLanguage en
8 schema:isAccessibleForFree true
9 schema:isPartOf N12ad8135b8b944b698aeda6dbce17346
10 Nc671ef0373e643198d60f0ea320ac933
11 sg:journal.1136657
12 schema:name Expansion of CD19-specific chimeric antigen receptor (CAR) T memory stem cells to improve adoptive T cell therapy
13 schema:pagination 659-659
14 schema:productId N279a677847654726bae3ac03fa4b0261
15 Ndc8f9bc8645c45429bef442847d99b9e
16 Nfce57012d97e41c3819b168e2217cc79
17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007732600
18 https://doi.org/10.1038/scibx.2014.659
19 schema:sdDatePublished 2019-04-11T00:03
20 schema:sdLicense https://scigraph.springernature.com/explorer/license/
21 schema:sdPublisher N439b9ebd32a54829b15e5c639336f43a
22 schema:url http://www.nature.com/scibx/journal/v7/n22/full/scibx.2014.659.html
23 sgo:license sg:explorer/license/
24 sgo:sdDataset articles
25 rdf:type schema:ScholarlyArticle
26 N12ad8135b8b944b698aeda6dbce17346 schema:volumeNumber 7
27 rdf:type schema:PublicationVolume
28 N279a677847654726bae3ac03fa4b0261 schema:name doi
29 schema:value 10.1038/scibx.2014.659
30 rdf:type schema:PropertyValue
31 N439b9ebd32a54829b15e5c639336f43a schema:name Springer Nature - SN SciGraph project
32 rdf:type schema:Organization
33 Nc671ef0373e643198d60f0ea320ac933 schema:issueNumber 22
34 rdf:type schema:PublicationIssue
35 Ndc8f9bc8645c45429bef442847d99b9e schema:name dimensions_id
36 schema:value pub.1007732600
37 rdf:type schema:PropertyValue
38 Nfce57012d97e41c3819b168e2217cc79 schema:name readcube_id
39 schema:value 24d53304b86dc23ba1f8b41328d5c923795707100f50ea7262e5ca25666e852e
40 rdf:type schema:PropertyValue
41 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
42 schema:name Technology
43 rdf:type schema:DefinedTerm
44 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
45 schema:name Medical Biotechnology
46 rdf:type schema:DefinedTerm
47 sg:journal.1136657 schema:issn 1945-3477
48 schema:name Science-Business eXchange
49 rdf:type schema:Periodical
 




Preview window. Press ESC to close (or click here)


...