Small molecules that prevent teratoma formation in human pluripotent stem cell–derived therapies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

ABSTRACT

Small molecules that are selectively toxic to human pluripotent stem cells could help decrease the tumorigenicity risk of stem cell–derived therapies. Residual, undifferentiated stem cells in stem cell–derived cell therapies can lead to teratoma formation. In mixed cultures of differentiated human cells and undifferentiated human stem cells, small molecule inhibitors of survivin (BIRC5), such as sepantronium, and small molecule inhibitors of B cell CLL lymphoma 10 (BCL10) selectively induced apoptosis in undifferentiated cells. In a mixture of differentiated human cells and undifferentiated human stem cells injected into mice, none of the cell mixtures pretreated with sepantronium or another small molecule survivin inhibitor developed teratomas, whereas all the untreated cell mixtures did. Next steps include developing more specific inhibitors of survivin and BCL10. More... »

PAGES

943-943

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/scibx.2013.943

DOI

http://dx.doi.org/10.1038/scibx.2013.943

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038722553


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1303669110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025733494"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-09", 
    "datePublishedReg": "2013-09-01", 
    "description": "Small molecules that are selectively toxic to human pluripotent stem cells could help decrease the tumorigenicity risk of stem cell\u2013derived therapies. Residual, undifferentiated stem cells in stem cell\u2013derived cell therapies can lead to teratoma formation. In mixed cultures of differentiated human cells and undifferentiated human stem cells, small molecule inhibitors of survivin (BIRC5), such as sepantronium, and small molecule inhibitors of B cell CLL lymphoma 10 (BCL10) selectively induced apoptosis in undifferentiated cells. In a mixture of differentiated human cells and undifferentiated human stem cells injected into mice, none of the cell mixtures pretreated with sepantronium or another small molecule survivin inhibitor developed teratomas, whereas all the untreated cell mixtures did. Next steps include developing more specific inhibitors of survivin and BCL10.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1038/scibx.2013.943", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1136657", 
        "issn": [
          "1945-3477"
        ], 
        "name": "Science-Business eXchange", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "34", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Small molecules that prevent teratoma formation in human pluripotent stem cell\u2013derived therapies", 
    "pagination": "943-943", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b8753b8a40e2242360e3b27d071687ee773a483d2d93ed05bd55162d720c6f8b"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/scibx.2013.943"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038722553"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/scibx.2013.943", 
      "https://app.dimensions.ai/details/publication/pub.1038722553"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/scibx/journal/v6/n34/full/scibx.2013.943.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/scibx.2013.943'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/scibx.2013.943'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/scibx.2013.943'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/scibx.2013.943'


 

This table displays all metadata directly associated to this object as RDF triples.

52 TRIPLES      20 PREDICATES      27 URIs      18 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/scibx.2013.943 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:citation https://doi.org/10.1073/pnas.1303669110
4 schema:datePublished 2013-09
5 schema:datePublishedReg 2013-09-01
6 schema:description Small molecules that are selectively toxic to human pluripotent stem cells could help decrease the tumorigenicity risk of stem cell–derived therapies. Residual, undifferentiated stem cells in stem cell–derived cell therapies can lead to teratoma formation. In mixed cultures of differentiated human cells and undifferentiated human stem cells, small molecule inhibitors of survivin (BIRC5), such as sepantronium, and small molecule inhibitors of B cell CLL lymphoma 10 (BCL10) selectively induced apoptosis in undifferentiated cells. In a mixture of differentiated human cells and undifferentiated human stem cells injected into mice, none of the cell mixtures pretreated with sepantronium or another small molecule survivin inhibitor developed teratomas, whereas all the untreated cell mixtures did. Next steps include developing more specific inhibitors of survivin and BCL10.
7 schema:genre non_research_article
8 schema:inLanguage en
9 schema:isAccessibleForFree true
10 schema:isPartOf Nc1dcd0589c824b3898f58049f901418e
11 Ned88ec32313b47fc8ee5ba6992d6b3be
12 sg:journal.1136657
13 schema:name Small molecules that prevent teratoma formation in human pluripotent stem cell–derived therapies
14 schema:pagination 943-943
15 schema:productId N180aec46f47a47caa0f619226dda6db7
16 Nca7544b706664e0aa18f733859504b70
17 Nf51cc4c7e2d54db382b436975012cec2
18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038722553
19 https://doi.org/10.1038/scibx.2013.943
20 schema:sdDatePublished 2019-04-10T13:56
21 schema:sdLicense https://scigraph.springernature.com/explorer/license/
22 schema:sdPublisher N7e745b65d38649409ed576615399f60b
23 schema:url http://www.nature.com/scibx/journal/v6/n34/full/scibx.2013.943.html
24 sgo:license sg:explorer/license/
25 sgo:sdDataset articles
26 rdf:type schema:ScholarlyArticle
27 N180aec46f47a47caa0f619226dda6db7 schema:name readcube_id
28 schema:value b8753b8a40e2242360e3b27d071687ee773a483d2d93ed05bd55162d720c6f8b
29 rdf:type schema:PropertyValue
30 N7e745b65d38649409ed576615399f60b schema:name Springer Nature - SN SciGraph project
31 rdf:type schema:Organization
32 Nc1dcd0589c824b3898f58049f901418e schema:volumeNumber 6
33 rdf:type schema:PublicationVolume
34 Nca7544b706664e0aa18f733859504b70 schema:name doi
35 schema:value 10.1038/scibx.2013.943
36 rdf:type schema:PropertyValue
37 Ned88ec32313b47fc8ee5ba6992d6b3be schema:issueNumber 34
38 rdf:type schema:PublicationIssue
39 Nf51cc4c7e2d54db382b436975012cec2 schema:name dimensions_id
40 schema:value pub.1038722553
41 rdf:type schema:PropertyValue
42 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
43 schema:name Biological Sciences
44 rdf:type schema:DefinedTerm
45 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
46 schema:name Biochemistry and Cell Biology
47 rdf:type schema:DefinedTerm
48 sg:journal.1136657 schema:issn 1945-3477
49 schema:name Science-Business eXchange
50 rdf:type schema:Periodical
51 https://doi.org/10.1073/pnas.1303669110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025733494
52 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...