Naïve human stem cell medium for maintenance of human induced pluripotent stem (iPS) cells in a naïve state View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

ABSTRACT

In vitro studies identified culture conditions to maintain human iPS cells in a naïve state. Culture of primed human iPS cells, embryonic stem cells (ESCs) or blastocyst-derived cells in naïve human stem cell medium generated pluripotent stem cells with features of naïve mouse iPS cells including a preinactivation X chromosome state, upregulation of pluripotency genes and downregulation of lineage commitment genes, and it produced decreases in DNA methylation compared with culture of primed human iPS cells alone. Mouse embryos injected with human naïve iPS cells and grown in female mice showed chimerism and incorporation of the human cells during organogenesis. Next steps include assessing properties of cells derived from naïve iPS cells. More... »

PAGES

1305-1305

References to SciGraph publications

Journal

TITLE

Science-Business eXchange

ISSUE

45

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/scibx.2013.1305

DOI

http://dx.doi.org/10.1038/scibx.2013.1305

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037862651


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