Small molecule conversion of human embryonic stem cells (hESCs) into neural stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

ABSTRACT

A cocktail of small molecule inhibitors could be used to convert hESCs into neural stem cells to model diseases and enable cell-based therapies. In cell culture, a cocktail containing small molecule inhibitors of glycogen dependent kinase 3 (GSK3), transforming growth factor-β receptor 1 (TGFBR1; ALK5) and Notch signaling converted hESCs into neural stem cells. Culture medium containing leukemia inhibitory factor (LIF) plus the GSK3 and TGFBR1 inhibitors preserved the neural stem cell state. Next steps include developing protocols to make other self-renewing, tissue-specific precursor cells. More... »

PAGES

558-558

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/scibx.2011.558

DOI

http://dx.doi.org/10.1038/scibx.2011.558

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023123323


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