Identification of compounds that selectively kill cancer stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08

ABSTRACT

A study in cultured cancer stem cells and mouse xenografts identified compounds that could help kill cancer stem cells that are resistant to chemotherapy. Mammary epithelial cells with cancer stem cell–like properties were generated and used to screen a 16,000-compound small molecule library. Thirty-two compounds were identified that were more toxic to breast cancer stem cells than to non–stem cell types of tumor cells. The most potent of the compounds—salinomycin, a generic veterinary antibiotic—decreased cancer stem cell levels 20-fold compared with mock treatment. In mouse xenografts, salinomycin-treated cancer stem cells had lower metastatic capacity than mock-treated controls. Next steps include developing drug-like derivatives of salinomycin or other compounds identified in the screen and conducting further xenograft experiments. More... »

PAGES

1295-1295

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/scibx.2009.1295

DOI

http://dx.doi.org/10.1038/scibx.2009.1295

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007993459


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