CCL-2 as a possible early marker for remission after traumatic spinal cord injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11

AUTHORS

R A Heller, T F Raven, T Swing, K Kunzmann, V Daniel, P Haubruck, M Akbar, P A Grützner, G Schmidmaier, B Biglari, A Moghaddam

ABSTRACT

STUDY DESIGN: Prospective observational study. OBJECTIVES: To describe the correlation between CCL-2, CCL-3, CCL-4 and CXCL-5 serum levels and remission after traumatic spinal cord injury (SCI) in a human protocol compared with animal studies. SETTING: Germany, Rhineland-Palatinate (Rheinland-Pfalz). METHODS: We examined the serum levels of CCL-2, CCL-3, CCL-4 and CXCL-5 over a 12-week period; in particular, at admission and 4, 9 and 12 h, 1 and 3 days and 1, 2, 4, 8 and 12 weeks after trauma. According to our study design, we matched 10 patients with TSCI and neurological remission with 10 patients with an initial ASIA A grade and no neurological remission. In all, 10 patients with vertebral fracture without neurological deficits served as control. Our analysis was performed using a Luminex Cytokine Panel. Multivariate logistic regression models were used to examine the predictive value with respect to neurological remission vs no neurological remission. RESULTS: The results of our study showed differences in the serum expression patterns of CCL-2 in association with the neurological remission (CCL-2 at admission P=0.013). Serum levels of CCL-2 and CCL-4 were significantly different in patients with and without neurological remission. The favored predictive model resulted in an area under the curve (AUC) of 93.1% in the receiver operating characteristic (ROC) analysis. CONCLUSIONS: Our results indicate that peripheral serum analysis is a suitable concept for predicting the patient's potential for neurological remission after TSCI. Furthermore, the initial CCL-2 concentration provides an additional predictive value compared with the NLI (neurological level of injury). Therefore, the present study introduces a promising approach for future monitoring concepts and tracking techniques for current therapies. The results indicate that future investigations with an enlarged sample size are needed in order to develop monitoring, prognostic and scoring systems. More... »

PAGES

1002-1009

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sc.2017.69

DOI

http://dx.doi.org/10.1038/sc.2017.69

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086080239

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28631748


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Area Under Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokine CCL2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokine CCL3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokine CCL4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokine CXCL5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Registries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Cord Injuries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heller", 
        "givenName": "R A", 
        "id": "sg:person.010720664345.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010720664345.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Aschaffenburg Trauma and Orthopaedic Research Group, Center for Trauma Surgery, Orthopedics and Sports Medicine Aschaffenburg-Alzenau, Aschaffenburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raven", 
        "givenName": "T F", 
        "id": "sg:person.01300703323.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300703323.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Swing", 
        "givenName": "T", 
        "id": "sg:person.01345345207.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345345207.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute for Medical Biometry and Informatics, Heidelberg University Hospital, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kunzmann", 
        "givenName": "K", 
        "id": "sg:person.01265206225.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265206225.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daniel", 
        "givenName": "V", 
        "id": "sg:person.01240304374.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240304374.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haubruck", 
        "givenName": "P", 
        "id": "sg:person.01372177051.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372177051.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Spine Center, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akbar", 
        "givenName": "M", 
        "id": "sg:person.01052422023.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052422023.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Berufsgenossenschaftliche Unfallklinik Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.418303.d", 
          "name": [
            "Department of Paraplegiology, Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00fctzner", 
        "givenName": "P A", 
        "id": "sg:person.01060715001.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060715001.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidmaier", 
        "givenName": "G", 
        "id": "sg:person.01244254735.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244254735.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Berufsgenossenschaftliche Unfallklinik Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.418303.d", 
          "name": [
            "Department of Paraplegiology, Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Biglari", 
        "givenName": "B", 
        "id": "sg:person.01231116607.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231116607.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Aschaffenburg Trauma and Orthopaedic Research Group, Center for Trauma Surgery, Orthopedics and Sports Medicine Aschaffenburg-Alzenau, Aschaffenburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moghaddam", 
        "givenName": "A", 
        "id": "sg:person.01240435544.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240435544.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1177/0300060514559794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000641990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300060514559794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000641990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms16047900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001009725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.injury.2010.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002418175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2009.1150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004832982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2015.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005007245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2015.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005007245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2015.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005007245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2013.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007977983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sc.2013.130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014025350", 
          "https://doi.org/10.1038/sc.2013.130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-12-77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014582441", 
          "https://doi.org/10.1186/1471-2105-12-77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-12-77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014582441", 
          "https://doi.org/10.1186/1471-2105-12-77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-4-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015446658", 
          "https://doi.org/10.1186/1742-2094-4-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sc.2016.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017606592", 
          "https://doi.org/10.1038/sc.2016.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025776924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025776924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.burns.2012.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027199764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/brs.0b013e3181b613c7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028160693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/brs.0b013e3181b613c7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028160693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/204577211x13207446293695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028244425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sc.2015.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029817907", 
          "https://doi.org/10.1038/sc.2015.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2010.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031466909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awp144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035851374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2012.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036282039", 
          "https://doi.org/10.1038/labinvest.2012.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sc.2012.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036967907", 
          "https://doi.org/10.1038/sc.2012.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2000.tb00248.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036999950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037357872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1039109764", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-61261-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039109764", 
          "https://doi.org/10.1007/978-3-642-61261-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-61261-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039109764", 
          "https://doi.org/10.1007/978-3-642-61261-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/63.4.350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039303339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-11-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040749290", 
          "https://doi.org/10.1186/1742-2094-11-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sc.2016.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042919252", 
          "https://doi.org/10.1038/sc.2016.104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047030522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047030522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.wneu.2013.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047331740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0159764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047381132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-04898-2_110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047407700", 
          "https://doi.org/10.1007/978-3-642-04898-2_110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2015.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047855391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pain.2010.02.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050060604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pain.2010.02.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050060604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2015.4192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051088078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62365-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051174357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apmr.2014.10.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052515277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2009.1080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059301071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2015.4294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059302274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000430319.32247.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064436944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000430319.32247.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064436944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.6.aospine1252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.6.aospine1252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.6.aospine1252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.6.aospine1252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.6.aospine1252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.6.aospine1252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2008.25.11.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2008.25.11.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2008.25.11.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2008.25.11.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2008.25.11.e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc/2008/25/7/e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc/2008/25/7/e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc/2008/25/7/e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc/2008/25/7/e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc/2008/25/7/e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083195"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11", 
    "datePublishedReg": "2017-11-01", 
    "description": "STUDY DESIGN: Prospective observational study.\nOBJECTIVES: To describe the correlation between CCL-2, CCL-3, CCL-4 and CXCL-5 serum levels and remission after traumatic spinal cord injury (SCI) in a human protocol compared with animal studies.\nSETTING: Germany, Rhineland-Palatinate (Rheinland-Pfalz).\nMETHODS: We examined the serum levels of CCL-2, CCL-3, CCL-4 and CXCL-5 over a 12-week period; in particular, at admission and 4, 9 and 12\u2009h, 1 and 3 days and 1, 2, 4, 8 and 12 weeks after trauma. According to our study design, we matched 10 patients with TSCI and neurological remission with 10 patients with an initial ASIA A grade and no neurological remission. In all, 10 patients with vertebral fracture without neurological deficits served as control. Our analysis was performed using a Luminex Cytokine Panel. Multivariate logistic regression models were used to examine the predictive value with respect to neurological remission vs no neurological remission.\nRESULTS: The results of our study showed differences in the serum expression patterns of CCL-2 in association with the neurological remission (CCL-2 at admission P=0.013). Serum levels of CCL-2 and CCL-4 were significantly different in patients with and without neurological remission. The favored predictive model resulted in an area under the curve (AUC) of 93.1% in the receiver operating characteristic (ROC) analysis.\nCONCLUSIONS: Our results indicate that peripheral serum analysis is a suitable concept for predicting the patient's potential for neurological remission after TSCI. Furthermore, the initial CCL-2 concentration provides an additional predictive value compared with the NLI (neurological level of injury). Therefore, the present study introduces a promising approach for future monitoring concepts and tracking techniques for current therapies. The results indicate that future investigations with an enlarged sample size are needed in order to develop monitoring, prognostic and scoring systems.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sc.2017.69", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1077060", 
        "issn": [
          "1362-4393", 
          "1476-5624"
        ], 
        "name": "Spinal Cord", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "CCL-2 as a possible early marker for remission after traumatic spinal cord injury", 
    "pagination": "1002-1009", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "488dbea1a991f7cdd08320ce542198e0d690682a181e6b11929e39959e7f04d3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28631748"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9609749"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sc.2017.69"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1086080239"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sc.2017.69", 
      "https://app.dimensions.ai/details/publication/pub.1086080239"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/sc/journal/v55/n11/full/sc201769a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sc.2017.69'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sc.2017.69'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sc.2017.69'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sc.2017.69'


 

This table displays all metadata directly associated to this object as RDF triples.

356 TRIPLES      21 PREDICATES      88 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sc.2017.69 schema:about N048d0baa0dd741bea6d76dc6c32f3099
2 N06c3c75686be4f9a8e006e91039f702f
3 N0a072c784b4a45f7a2b3404c949261f2
4 N2e1c13e7b0bc4643b285b08d4aaaff6c
5 N38088113d35243dfb3064cc071952722
6 N3c577bed2988471d82c96f1b0a33d6c3
7 N5cb8f8d2b744487c86b427692b3c7386
8 N69da2c99196a4403a3463691d8a9c223
9 N6d18a96ed45a4bb38802bb0ea43eef28
10 N70e5cec3911a4b318d888ec32fc47b5d
11 N7f0f568b48fc43658df75cf3cdeda732
12 N81c346739c5f452a9fd48e0b60c13527
13 N894c159cc5604177a83ed9fafe453736
14 N8d46213dc5354206b5d9e1583847f04a
15 Na1e9790e741a4d10addd8b48d0f27c99
16 Na7b4474850724f40b915cbf627810811
17 Nba403d6fd11e4f0b802ae114e620c637
18 Nd476c4daa4774f4bbe18bc4faddb52d2
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N9142ac48191b4e1eb3902ce466c96de3
22 schema:citation sg:pub.10.1007/978-3-642-04898-2_110
23 sg:pub.10.1007/978-3-642-61261-9
24 sg:pub.10.1038/labinvest.2012.80
25 sg:pub.10.1038/sc.2012.139
26 sg:pub.10.1038/sc.2013.130
27 sg:pub.10.1038/sc.2015.28
28 sg:pub.10.1038/sc.2016.104
29 sg:pub.10.1038/sc.2016.44
30 sg:pub.10.1186/1471-2105-12-77
31 sg:pub.10.1186/1742-2094-11-10
32 sg:pub.10.1186/1742-2094-4-12
33 https://app.dimensions.ai/details/publication/pub.1039109764
34 https://doi.org/10.1002/jnr.22411
35 https://doi.org/10.1002/jnr.22474
36 https://doi.org/10.1016/j.apmr.2014.10.021
37 https://doi.org/10.1016/j.burns.2012.07.022
38 https://doi.org/10.1016/j.expneurol.2015.04.008
39 https://doi.org/10.1016/j.immuni.2013.02.012
40 https://doi.org/10.1016/j.injury.2010.11.017
41 https://doi.org/10.1016/j.jnutbio.2010.12.002
42 https://doi.org/10.1016/j.pain.2010.02.025
43 https://doi.org/10.1016/j.urology.2015.10.017
44 https://doi.org/10.1016/j.wneu.2013.03.012
45 https://doi.org/10.1016/s0002-9440(10)62365-6
46 https://doi.org/10.1084/jem.20041918
47 https://doi.org/10.1089/neu.2009.1080
48 https://doi.org/10.1089/neu.2009.1150
49 https://doi.org/10.1089/neu.2015.4192
50 https://doi.org/10.1089/neu.2015.4294
51 https://doi.org/10.1093/brain/awp144
52 https://doi.org/10.1093/jnen/63.4.350
53 https://doi.org/10.1097/brs.0b013e3181b613c7
54 https://doi.org/10.1111/j.1750-3639.2000.tb00248.x
55 https://doi.org/10.1177/0300060514559794
56 https://doi.org/10.1179/204577211x13207446293695
57 https://doi.org/10.1227/01.neu.0000430319.32247.7f
58 https://doi.org/10.1371/journal.pone.0159764
59 https://doi.org/10.3171/2012.6.aospine1252
60 https://doi.org/10.3171/foc.2008.25.11.e2
61 https://doi.org/10.3171/foc/2008/25/7/e2
62 https://doi.org/10.3390/ijms16047900
63 schema:datePublished 2017-11
64 schema:datePublishedReg 2017-11-01
65 schema:description STUDY DESIGN: Prospective observational study. OBJECTIVES: To describe the correlation between CCL-2, CCL-3, CCL-4 and CXCL-5 serum levels and remission after traumatic spinal cord injury (SCI) in a human protocol compared with animal studies. SETTING: Germany, Rhineland-Palatinate (Rheinland-Pfalz). METHODS: We examined the serum levels of CCL-2, CCL-3, CCL-4 and CXCL-5 over a 12-week period; in particular, at admission and 4, 9 and 12 h, 1 and 3 days and 1, 2, 4, 8 and 12 weeks after trauma. According to our study design, we matched 10 patients with TSCI and neurological remission with 10 patients with an initial ASIA A grade and no neurological remission. In all, 10 patients with vertebral fracture without neurological deficits served as control. Our analysis was performed using a Luminex Cytokine Panel. Multivariate logistic regression models were used to examine the predictive value with respect to neurological remission vs no neurological remission. RESULTS: The results of our study showed differences in the serum expression patterns of CCL-2 in association with the neurological remission (CCL-2 at admission P=0.013). Serum levels of CCL-2 and CCL-4 were significantly different in patients with and without neurological remission. The favored predictive model resulted in an area under the curve (AUC) of 93.1% in the receiver operating characteristic (ROC) analysis. CONCLUSIONS: Our results indicate that peripheral serum analysis is a suitable concept for predicting the patient's potential for neurological remission after TSCI. Furthermore, the initial CCL-2 concentration provides an additional predictive value compared with the NLI (neurological level of injury). Therefore, the present study introduces a promising approach for future monitoring concepts and tracking techniques for current therapies. The results indicate that future investigations with an enlarged sample size are needed in order to develop monitoring, prognostic and scoring systems.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N8c5aabccad56467ba81b783a94904943
70 Nd82c4951e0084a519501f132c22bfaa6
71 sg:journal.1077060
72 schema:name CCL-2 as a possible early marker for remission after traumatic spinal cord injury
73 schema:pagination 1002-1009
74 schema:productId N17e183c0ad8f45e5afd92220f98444d4
75 N20e1470363de4640a967ee3e289fc17f
76 N48a8d16e207d4687b2f452b10ceb58d7
77 Nc3699da1ffbb4e238c9ebb8f83badccd
78 Nf6b48155502046afbf88a1493262985a
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086080239
80 https://doi.org/10.1038/sc.2017.69
81 schema:sdDatePublished 2019-04-10T14:47
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N8cddefa201be4722ad86e775e8c91e68
84 schema:url http://www.nature.com/sc/journal/v55/n11/full/sc201769a.html
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N02ca50f37b1149dd93409ff66ed24948 rdf:first sg:person.01052422023.45
89 rdf:rest N7626b4485953416fa80a8e61dae66368
90 N048d0baa0dd741bea6d76dc6c32f3099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Chemokine CXCL5
92 rdf:type schema:DefinedTerm
93 N06c3c75686be4f9a8e006e91039f702f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Chemokine CCL4
95 rdf:type schema:DefinedTerm
96 N0a072c784b4a45f7a2b3404c949261f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Spinal Cord Injuries
98 rdf:type schema:DefinedTerm
99 N17e183c0ad8f45e5afd92220f98444d4 schema:name pubmed_id
100 schema:value 28631748
101 rdf:type schema:PropertyValue
102 N20e1470363de4640a967ee3e289fc17f schema:name doi
103 schema:value 10.1038/sc.2017.69
104 rdf:type schema:PropertyValue
105 N2e1c13e7b0bc4643b285b08d4aaaff6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Male
107 rdf:type schema:DefinedTerm
108 N38088113d35243dfb3064cc071952722 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adult
110 rdf:type schema:DefinedTerm
111 N3c577bed2988471d82c96f1b0a33d6c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Female
113 rdf:type schema:DefinedTerm
114 N3dfe495ef5914eb9a6118c0fadbe0647 rdf:first sg:person.01231116607.25
115 rdf:rest Neecfb9bb8b9245988f7358a0d320af13
116 N48a8d16e207d4687b2f452b10ceb58d7 schema:name readcube_id
117 schema:value 488dbea1a991f7cdd08320ce542198e0d690682a181e6b11929e39959e7f04d3
118 rdf:type schema:PropertyValue
119 N4cc43bc5eda54bdfac8aba80d76d7dbd rdf:first sg:person.01345345207.58
120 rdf:rest Nd0d51d97cbdd428f97fdf7556b8c71e0
121 N4dc6fa6be43149edb7166829f6925094 rdf:first sg:person.01240304374.43
122 rdf:rest Ndb44a6de74af4417b974526906412442
123 N5cb8f8d2b744487c86b427692b3c7386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Biomarkers
125 rdf:type schema:DefinedTerm
126 N69da2c99196a4403a3463691d8a9c223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Chemokine CCL2
128 rdf:type schema:DefinedTerm
129 N6d18a96ed45a4bb38802bb0ea43eef28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 N704a3e76774041d1b468aded4cd99146 rdf:first sg:person.01244254735.23
133 rdf:rest N3dfe495ef5914eb9a6118c0fadbe0647
134 N70e5cec3911a4b318d888ec32fc47b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Logistic Models
136 rdf:type schema:DefinedTerm
137 N7626b4485953416fa80a8e61dae66368 rdf:first sg:person.01060715001.02
138 rdf:rest N704a3e76774041d1b468aded4cd99146
139 N7f0f568b48fc43658df75cf3cdeda732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Odds Ratio
141 rdf:type schema:DefinedTerm
142 N81c346739c5f452a9fd48e0b60c13527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name ROC Curve
144 rdf:type schema:DefinedTerm
145 N894c159cc5604177a83ed9fafe453736 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Multivariate Analysis
147 rdf:type schema:DefinedTerm
148 N8bf5ae946b2c4407a91eeeae7277af28 rdf:first sg:person.01300703323.98
149 rdf:rest N4cc43bc5eda54bdfac8aba80d76d7dbd
150 N8c5aabccad56467ba81b783a94904943 schema:volumeNumber 55
151 rdf:type schema:PublicationVolume
152 N8cddefa201be4722ad86e775e8c91e68 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 N8d46213dc5354206b5d9e1583847f04a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Prospective Studies
156 rdf:type schema:DefinedTerm
157 N9142ac48191b4e1eb3902ce466c96de3 rdf:first sg:person.010720664345.66
158 rdf:rest N8bf5ae946b2c4407a91eeeae7277af28
159 Na1e9790e741a4d10addd8b48d0f27c99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Registries
161 rdf:type schema:DefinedTerm
162 Na7b4474850724f40b915cbf627810811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Chemokine CCL3
164 rdf:type schema:DefinedTerm
165 Nba403d6fd11e4f0b802ae114e620c637 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Area Under Curve
167 rdf:type schema:DefinedTerm
168 Nc3699da1ffbb4e238c9ebb8f83badccd schema:name nlm_unique_id
169 schema:value 9609749
170 rdf:type schema:PropertyValue
171 Nd0d51d97cbdd428f97fdf7556b8c71e0 rdf:first sg:person.01265206225.54
172 rdf:rest N4dc6fa6be43149edb7166829f6925094
173 Nd476c4daa4774f4bbe18bc4faddb52d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Time Factors
175 rdf:type schema:DefinedTerm
176 Nd8134efa5f6a481b8cef608400c489fc schema:name Aschaffenburg Trauma and Orthopaedic Research Group, Center for Trauma Surgery, Orthopedics and Sports Medicine Aschaffenburg-Alzenau, Aschaffenburg, Germany
177 rdf:type schema:Organization
178 Nd82c4951e0084a519501f132c22bfaa6 schema:issueNumber 11
179 rdf:type schema:PublicationIssue
180 Ndb44a6de74af4417b974526906412442 rdf:first sg:person.01372177051.59
181 rdf:rest N02ca50f37b1149dd93409ff66ed24948
182 Neecfb9bb8b9245988f7358a0d320af13 rdf:first sg:person.01240435544.36
183 rdf:rest rdf:nil
184 Nf6b48155502046afbf88a1493262985a schema:name dimensions_id
185 schema:value pub.1086080239
186 rdf:type schema:PropertyValue
187 Nfd5372d3988e427eb11f81d0865f6aee schema:name Aschaffenburg Trauma and Orthopaedic Research Group, Center for Trauma Surgery, Orthopedics and Sports Medicine Aschaffenburg-Alzenau, Aschaffenburg, Germany
188 rdf:type schema:Organization
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 sg:journal.1077060 schema:issn 1362-4393
196 1476-5624
197 schema:name Spinal Cord
198 rdf:type schema:Periodical
199 sg:person.01052422023.45 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
200 schema:familyName Akbar
201 schema:givenName M
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052422023.45
203 rdf:type schema:Person
204 sg:person.01060715001.02 schema:affiliation https://www.grid.ac/institutes/grid.418303.d
205 schema:familyName Grützner
206 schema:givenName P A
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060715001.02
208 rdf:type schema:Person
209 sg:person.010720664345.66 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
210 schema:familyName Heller
211 schema:givenName R A
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010720664345.66
213 rdf:type schema:Person
214 sg:person.01231116607.25 schema:affiliation https://www.grid.ac/institutes/grid.418303.d
215 schema:familyName Biglari
216 schema:givenName B
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231116607.25
218 rdf:type schema:Person
219 sg:person.01240304374.43 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
220 schema:familyName Daniel
221 schema:givenName V
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240304374.43
223 rdf:type schema:Person
224 sg:person.01240435544.36 schema:affiliation Nd8134efa5f6a481b8cef608400c489fc
225 schema:familyName Moghaddam
226 schema:givenName A
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240435544.36
228 rdf:type schema:Person
229 sg:person.01244254735.23 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
230 schema:familyName Schmidmaier
231 schema:givenName G
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244254735.23
233 rdf:type schema:Person
234 sg:person.01265206225.54 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
235 schema:familyName Kunzmann
236 schema:givenName K
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265206225.54
238 rdf:type schema:Person
239 sg:person.01300703323.98 schema:affiliation Nfd5372d3988e427eb11f81d0865f6aee
240 schema:familyName Raven
241 schema:givenName T F
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300703323.98
243 rdf:type schema:Person
244 sg:person.01345345207.58 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
245 schema:familyName Swing
246 schema:givenName T
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345345207.58
248 rdf:type schema:Person
249 sg:person.01372177051.59 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
250 schema:familyName Haubruck
251 schema:givenName P
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372177051.59
253 rdf:type schema:Person
254 sg:pub.10.1007/978-3-642-04898-2_110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047407700
255 https://doi.org/10.1007/978-3-642-04898-2_110
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/978-3-642-61261-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039109764
258 https://doi.org/10.1007/978-3-642-61261-9
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/labinvest.2012.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036282039
261 https://doi.org/10.1038/labinvest.2012.80
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/sc.2012.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036967907
264 https://doi.org/10.1038/sc.2012.139
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/sc.2013.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014025350
267 https://doi.org/10.1038/sc.2013.130
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/sc.2015.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029817907
270 https://doi.org/10.1038/sc.2015.28
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/sc.2016.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042919252
273 https://doi.org/10.1038/sc.2016.104
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/sc.2016.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017606592
276 https://doi.org/10.1038/sc.2016.44
277 rdf:type schema:CreativeWork
278 sg:pub.10.1186/1471-2105-12-77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014582441
279 https://doi.org/10.1186/1471-2105-12-77
280 rdf:type schema:CreativeWork
281 sg:pub.10.1186/1742-2094-11-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040749290
282 https://doi.org/10.1186/1742-2094-11-10
283 rdf:type schema:CreativeWork
284 sg:pub.10.1186/1742-2094-4-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015446658
285 https://doi.org/10.1186/1742-2094-4-12
286 rdf:type schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1039109764 schema:CreativeWork
288 https://doi.org/10.1002/jnr.22411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047030522
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/jnr.22474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037357872
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.apmr.2014.10.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052515277
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.burns.2012.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027199764
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.expneurol.2015.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047855391
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.immuni.2013.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007977983
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.injury.2010.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002418175
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.jnutbio.2010.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031466909
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.pain.2010.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050060604
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.urology.2015.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005007245
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.wneu.2013.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047331740
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0002-9440(10)62365-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051174357
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1084/jem.20041918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025776924
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1089/neu.2009.1080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059301071
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1089/neu.2009.1150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004832982
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1089/neu.2015.4192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051088078
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1089/neu.2015.4294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059302274
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1093/brain/awp144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035851374
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1093/jnen/63.4.350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039303339
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1097/brs.0b013e3181b613c7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028160693
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1111/j.1750-3639.2000.tb00248.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036999950
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1177/0300060514559794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000641990
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1179/204577211x13207446293695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028244425
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1227/01.neu.0000430319.32247.7f schema:sameAs https://app.dimensions.ai/details/publication/pub.1064436944
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1371/journal.pone.0159764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047381132
337 rdf:type schema:CreativeWork
338 https://doi.org/10.3171/2012.6.aospine1252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071077823
339 rdf:type schema:CreativeWork
340 https://doi.org/10.3171/foc.2008.25.11.e2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083059
341 rdf:type schema:CreativeWork
342 https://doi.org/10.3171/foc/2008/25/7/e2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083195
343 rdf:type schema:CreativeWork
344 https://doi.org/10.3390/ijms16047900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001009725
345 rdf:type schema:CreativeWork
346 https://www.grid.ac/institutes/grid.418303.d schema:alternateName Berufsgenossenschaftliche Unfallklinik Ludwigshafen
347 schema:name Department of Paraplegiology, Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Ludwigshafen, Germany
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
350 schema:name Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany
351 Institute for Medical Biometry and Informatics, Heidelberg University Hospital, Heidelberg, Germany
352 Spine Center, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
355 schema:name Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
356 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...