Study participation rate of patients with acute spinal cord injury early during rehabilitation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04-28

AUTHORS

J Krebs, A Katrin Brust, S Tesini, M Guler, G Mueller, I-M Velstra, A Frotzler

ABSTRACT

Study design:Retrospective observational study.Objectives:To investigate the study participation rate of patients with acute spinal cord injury (SCI) early during rehabilitation after conveying preliminary study information.Setting:Single SCI rehabilitation center in Switzerland.Methods:Newly admitted acute SCI patients receive a flyer to inform them concerning the purpose of clinical research, patient rights and active studies. Upon patient request, detailed study information is given. The rate of patients asking for detailed information (study interest) and the rate of study participation was evaluated from May 2013 to October 2014. Furthermore, the number of patients not withdrawing consent to the utilization of coded health-related data was determined.Results:The flyer was given to 144 of the 183 patients admitted during the observation period. A total of 96 patients (67%) were interested in receiving detailed information, and 71 patients (49%) finally participated in at least one study. The vast majority of patients (that is, 91%) did not withdraw consent for retrospective data analysis. An age over 60 years had a significantly (P⩽0.023) negative effect on study interest and participation, and the consent rate to retrospective data analysis was significantly (P<0.04) lower in patients older than 75 years. Study interest and participation were reduced more than 5 and 14-fold, respectively, in patients older than 60 years.Conclusions:The relatively low (approximately 50%) study participation rates of acute SCI patients should be considered when planning clinical trials. The recruitment of patients older than 60 years may be reduced substantially. More... »

PAGES

738-742

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sc.2015.73

DOI

http://dx.doi.org/10.1038/sc.2015.73

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012033559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25917949


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