A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

B Biglari, T Swing, C Child, A Büchler, F Westhauser, T Bruckner, T Ferbert, H Jürgen Gerner, A Moghaddam

ABSTRACT

STUDY DESIGN: Serum levels of interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) were measured over a 12-week period in 23 patients with spinal cord injury (SCI) with and without neurological improvement. OBJECTIVES: To determine the course of IL-1β and TNF-α in patients with SCI and observe a possible relationship between improvements in neurological functioning and cytokine levels. SETTING: All patients were treated at the BG Trauma Centre, Ludwigshafen, Germany. All lab work was done at the University Hospital, Heidelberg. METHODS: Spinal cord injury was classified according to the American Spinal Injury Association (ASIA) impairment scale (AIS) in 23 patients. TNF-α and IL-1β levels were measured upon arrival at the hospital, after 4 h, 9 h and 12 h, on days 1 and 3 and at the end of weeks 1, 2, 4, 8 and 12. RESULTS: Temporal changes in TNF-α and IL-1β in SCI patients were seen. Patients with AIS improvement (Group 1) had significantly lower TNF-α levels at 9 h compared with patients without AIS improvement (Group 2; P<0.01). The course of IL-1β fluctuated greatly between 4 h and week 1 in the groups; however, between 2 and 12 weeks post trauma, there was an overall decline in both groups. CONCLUSION: Measuring serum levels of TNF-α and IL-1β over time could be useful in tracking the course of SCI. Our data show differences in measured cytokines over a 12-week period for SCI patients with and without neurological improvement. More... »

PAGES

510-514

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sc.2015.28

DOI

http://dx.doi.org/10.1038/sc.2015.28

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029817907

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25753492


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