The roles of serum alkaline and bone alkaline phosphatase levels in predicting heterotopic ossification following spinal cord injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

M Citak, D Grasmücke, E M Suero, O Cruciger, R Meindl, T A Schildhauer, M Aach

ABSTRACT

STUDY DESIGN: Retrospective chart review. OBJECTIVES: To analyze the usefulness of serum alkaline phosphatase (AP) and bone alkaline phosphatase (BAP), as well as C-reactive protein (CRP) levels in predicting heterotopic ossification (HO). SETTING: Department of Spinal Cord Injury and Department of General and Trauma Surgery, BG-University Hospital Bergmannsheil, Ruhr University Bochum, Germany. METHODS: Between January 2003 and December 2013, 87 patients with HO around the hips met the inclusion criteria and were included in the study. Alkaline phosphatase, CRP and BAP were assessed and interpreted at the time of HO diagnosis and after radiation therapy in all patients. RESULTS: At the time of HO diagnosis, 49 out of 87 patients (49.4%) had elevated alkaline phosphatase levels and 39 out of 87 patients (44.8%) had elevated BAP levels. Elevated CRP values were found in 67 patients (77.0%). Within 3 days after single-dose radiation therapy, elevated AP levels persisted in 38 patients (43.7%) and elevated BAP levels in 28 patients (32.2%). CONCLUSIONS: The results obtained show that the determination of CRP, AP and BAP levels may not be considered a reliable screening method for early HO detection, subsequent to spinal cord injury. More... »

PAGES

368-370

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sc.2015.211

DOI

http://dx.doi.org/10.1038/sc.2015.211

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031709245

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26643987


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