Challenges for defining minimal clinically important difference (MCID) after spinal cord injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02

AUTHORS

X Wu, J Liu, L G Tanadini, D P Lammertse, A R Blight, John L K Kramer, G Scivoletto, L Jones, S Kirshblum, R Abel, J Fawcett, E Field-Fote, J Guest, B Levinson, D Maier, K Tansey, N Weidner, W G Tetzlaff, T Hothorn, A Curt, J D Steeves

ABSTRACT

STUDY DESIGN: This is a review article. OBJECTIVES: This study discusses the following: (1) concepts and constraints for the determination of minimal clinically important difference (MCID), (2) the contrasts between MCID and minimal detectable difference (MDD), (3) MCID within the different domains of International Classification of Functioning, disability and health, (4) the roles of clinical investigators and clinical participants in defining MCID and (5) the implementation of MCID in acute versus chronic spinal cord injury (SCI) studies. METHODS: The methods include narrative reviews of SCI outcomes, a 2-day meeting of the authors and statistical methods of analysis representing MDD. RESULTS: The data from SCI study outcomes are dependent on many elements, including the following: the level and severity of SCI, the heterogeneity within each study cohort, the therapeutic target, the nature of the therapy, any confounding influences or comorbidities, the assessment times relative to the date of injury, the outcome measurement instrument and the clinical end-point threshold used to determine a treatment effect. Even if statistically significant differences can be established, this finding does not guarantee that the experimental therapeutic provides a person living with SCI an improved capacity for functional independence and/or an increased quality of life. The MDD statistical concept describes the smallest real change in the specified outcome, beyond measurement error, and it should not be confused with the minimum threshold for demonstrating a clinical benefit or MCID. Unfortunately, MCID and MDD are not uncomplicated estimations; nevertheless, any MCID should exceed the expected MDD plus any probable spontaneous recovery. CONCLUSION: Estimation of an MCID for SCI remains elusive. In the interim, if the target of a therapeutic is the injured spinal cord, it is most desirable that any improvement in neurological status be correlated with a functional (meaningful) benefit. More... »

PAGES

84

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sc.2014.232

    DOI

    http://dx.doi.org/10.1038/sc.2014.232

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042569848

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25510192


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