Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-03

AUTHORS

Sheri A. C. McDowell, Robin B. E. Luo, Azadeh Arabzadeh, Samuel Doré, Nicolas C. Bennett, Valérie Breton, Elham Karimi, Morteza Rezanejad, Ryan R. Yang, Katherine D. Lach, Marianne S. M. Issac, Bozena Samborska, Lucas J. M. Perus, Dan Moldoveanu, Yuhong Wei, Benoit Fiset, Roni F. Rayes, Ian R. Watson, Lawrence Kazak, Marie-Christine Guiot, Pierre O. Fiset, Jonathan D. Spicer, Andrew J. Dannenberg, Logan A. Walsh, Daniela F. Quail

ABSTRACT

Metastasis is the leading cause of cancer-related deaths, and obesity is associated with increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose tissue induces lung neutrophilia associated with enhanced BC metastasis to this site. Here we show that obesity leads to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung. Mechanistically, neutrophil-produced reactive oxygen species in obese mice increase neutrophil extracellular DNA traps (NETs) and weaken endothelial junctions, facilitating the influx of tumor cells from the peripheral circulation. In vivo treatment with catalase, NET inhibitors or genetic deletion of Nos2 reversed this effect in preclinical models of obesity. Imaging mass cytometry of lung metastasis samples from patients with cancer revealed an enrichment in neutrophils with low catalase levels correlating with elevated body mass index. Our data provide insights into potentially targetable mechanisms that underlie the progression of BC in the obese population. More... »

PAGES

545-562

References to SciGraph publications

  • 2015-06-12. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury in SCIENTIFIC REPORTS
  • 2016-07-06. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards in NATURE COMMUNICATIONS
  • 2007-01-06. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice in TRANSGENIC RESEARCH
  • 2015-07-20. The prognostic landscape of genes and infiltrating immune cells across human cancers in NATURE MEDICINE
  • 2018-11-20. The obese adipose tissue microenvironment in cancer development and progression in NATURE REVIEWS ENDOCRINOLOGY
  • 2006-09-22. Adipocytokines: mediators linking adipose tissue, inflammation and immunity in NATURE REVIEWS IMMUNOLOGY
  • 2015-02-26. Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems in SCIENTIFIC REPORTS
  • 2001-10. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle in NATURE MEDICINE
  • 2012-04-24. Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan in BREAST CANCER RESEARCH
  • 2019-02-06. Neutrophils escort circulating tumour cells to enable cell cycle progression in NATURE
  • 2009-05-17. Netting neutrophils in autoimmune small-vessel vasculitis in NATURE MEDICINE
  • 2019-02-28. Heterogeneity of neutrophils in NATURE REVIEWS IMMUNOLOGY
  • 2019-10-24. Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2005-08. Breast cancer metastasis: markers and models in NATURE REVIEWS CANCER
  • 2020-06-02. Durable and controlled depletion of neutrophils in mice in NATURE COMMUNICATIONS
  • 2016-06-10. Neutrophils in cancer: neutral no more in NATURE REVIEWS CANCER
  • 2004-08. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms in NATURE REVIEWS CANCER
  • 2007-06. The role of junctional adhesion molecules in vascular inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2017-07-24. Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF in NATURE CELL BIOLOGY
  • 2011-11-07. The neutrophil in vascular inflammation in NATURE MEDICINE
  • 2018-02-22. Measurement of Microvascular Endothelial Barrier Dysfunction and Hyperpermeability In Vitro in TRAUMATIC AND ISCHEMIC INJURY
  • 2007-03-25. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s43018-021-00194-9

    DOI

    http://dx.doi.org/10.1038/s43018-021-00194-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1137705299


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McDowell", 
            "givenName": "Sheri A. C.", 
            "id": "sg:person.012042046443.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012042046443.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Human Genetics, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luo", 
            "givenName": "Robin B. E.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arabzadeh", 
            "givenName": "Azadeh", 
            "id": "sg:person.0636705645.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636705645.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Human Genetics, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dor\u00e9", 
            "givenName": "Samuel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bennett", 
            "givenName": "Nicolas C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Breton", 
            "givenName": "Val\u00e9rie", 
            "id": "sg:person.01222114145.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222114145.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karimi", 
            "givenName": "Elham", 
            "id": "sg:person.012436103651.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012436103651.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Departments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rezanejad", 
            "givenName": "Morteza", 
            "id": "sg:person.012742552511.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742552511.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Ryan R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lach", 
            "givenName": "Katherine D.", 
            "id": "sg:person.014264702507.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014264702507.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Issac", 
            "givenName": "Marianne S. M.", 
            "id": "sg:person.0615262301.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615262301.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Samborska", 
            "givenName": "Bozena", 
            "id": "sg:person.01030261520.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030261520.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perus", 
            "givenName": "Lucas J. M.", 
            "id": "sg:person.015426770605.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015426770605.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Biochemistry, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moldoveanu", 
            "givenName": "Dan", 
            "id": "sg:person.0706724463.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706724463.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wei", 
            "givenName": "Yuhong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fiset", 
            "givenName": "Benoit", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rayes", 
            "givenName": "Roni F.", 
            "id": "sg:person.0577750637.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577750637.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Biochemistry, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watson", 
            "givenName": "Ian R.", 
            "id": "sg:person.0737755005.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737755005.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Biochemistry, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kazak", 
            "givenName": "Lawrence", 
            "id": "sg:person.0702372124.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702372124.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Montreal Neurological Institute, McGill University Health Centre, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
                "Montreal Neurological Institute, McGill University Health Centre, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guiot", 
            "givenName": "Marie-Christine", 
            "id": "sg:person.01327426551.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327426551.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fiset", 
            "givenName": "Pierre O.", 
            "id": "sg:person.01352532122.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352532122.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.63984.30", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada", 
                "Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spicer", 
            "givenName": "Jonathan D.", 
            "id": "sg:person.0712420560.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712420560.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Weill Cornell Medical College, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Medicine, Weill Cornell Medical College, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dannenberg", 
            "givenName": "Andrew J.", 
            "id": "sg:person.01324314373.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324314373.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Human Genetics, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Walsh", 
            "givenName": "Logan A.", 
            "id": "sg:person.01371501141.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371501141.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada", 
                "Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada", 
                "Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Quail", 
            "givenName": "Daniela F.", 
            "id": "sg:person.0605132127.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605132127.92"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/srep08587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027729380", 
              "https://doi.org/10.1038/srep08587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-7526-6_19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101144247", 
              "https://doi.org/10.1007/978-1-4939-7526-6_19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000282210", 
              "https://doi.org/10.1038/nri2096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037811895", 
              "https://doi.org/10.1038/nm.3909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11248-006-9056-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028528600", 
              "https://doi.org/10.1007/s11248-006-9056-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028608744", 
              "https://doi.org/10.1038/nm.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc.2016.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007861418", 
              "https://doi.org/10.1038/nrc.2016.52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-019-0915-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111950413", 
              "https://doi.org/10.1038/s41586-019-0915-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41574-018-0126-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110034930", 
              "https://doi.org/10.1038/s41574-018-0126-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030305729", 
              "https://doi.org/10.1186/bcr3174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090880207", 
              "https://doi.org/10.1038/ncb3578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051827328", 
              "https://doi.org/10.1038/nm.1959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-019-03331-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1122089483", 
              "https://doi.org/10.1007/s00018-019-03331-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1001-1138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036749841", 
              "https://doi.org/10.1038/nm1001-1138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018278870", 
              "https://doi.org/10.1038/nri1937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034942681", 
              "https://doi.org/10.1038/ncomms12150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-020-16596-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1128141673", 
              "https://doi.org/10.1038/s41467-020-16596-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046780586", 
              "https://doi.org/10.1038/nm1565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41577-019-0141-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112435045", 
              "https://doi.org/10.1038/s41577-019-0141-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033699583", 
              "https://doi.org/10.1038/nrc1670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022040392", 
              "https://doi.org/10.1038/nrc1408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep11362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008786328", 
              "https://doi.org/10.1038/srep11362"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-05-03", 
        "datePublishedReg": "2021-05-03", 
        "description": "Metastasis is the leading cause of cancer-related deaths, and obesity is associated with increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose tissue induces lung neutrophilia associated with enhanced BC metastasis to this site. Here we show that obesity leads to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung. Mechanistically, neutrophil-produced reactive oxygen species in obese mice increase neutrophil extracellular DNA traps (NETs) and weaken endothelial junctions, facilitating the influx of tumor cells from the peripheral circulation. In vivo treatment with catalase, NET inhibitors or genetic deletion of Nos2 reversed this effect in preclinical models of obesity. Imaging mass cytometry of lung metastasis samples from patients with cancer revealed an enrichment in neutrophils with low catalase levels correlating with elevated body mass index. Our data provide insights into potentially targetable mechanisms that underlie the progression of BC in the obese population.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s43018-021-00194-9", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.100075247", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1363508", 
            "issn": [
              "2662-1347"
            ], 
            "name": "Nature Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "keywords": [
          "neutrophil extracellular DNA traps", 
          "elevated body mass index", 
          "body mass index", 
          "obese adipose tissue", 
          "cancer-related death", 
          "breast cancer metastasis", 
          "cancer cell extravasation", 
          "progression of BC", 
          "extracellular DNA traps", 
          "lung neutrophilia", 
          "vascular dysfunction", 
          "mass index", 
          "obese population", 
          "peripheral circulation", 
          "preclinical models", 
          "preclinical studies", 
          "BC metastasis", 
          "metastasis samples", 
          "vivo treatment", 
          "targetable mechanism", 
          "adipose tissue", 
          "catalase levels", 
          "NET inhibitor", 
          "cell extravasation", 
          "genetic deletion", 
          "obesity", 
          "cancer metastasis", 
          "vascular integrity", 
          "tumor cells", 
          "metastasis", 
          "endothelial adhesion", 
          "oxidative stress", 
          "reactive oxygen species", 
          "low catalase levels", 
          "mass cytometry", 
          "neutrophils", 
          "endothelial junctions", 
          "DNA traps", 
          "oxygen species", 
          "neutrophilia", 
          "patients", 
          "dysfunction", 
          "NOS2", 
          "extravasation", 
          "lung", 
          "cancer", 
          "impairment", 
          "progression", 
          "cytometry", 
          "death", 
          "Mechanistically", 
          "transmigration", 
          "treatment", 
          "inhibitors", 
          "cause", 
          "tissue", 
          "influx", 
          "catalase", 
          "cells", 
          "population", 
          "circulation", 
          "index", 
          "levels", 
          "deletion", 
          "study", 
          "loss", 
          "effect", 
          "mechanism", 
          "junction", 
          "adhesion", 
          "samples", 
          "stress", 
          "data", 
          "sites", 
          "integrity", 
          "BC", 
          "insights", 
          "model", 
          "enrichment", 
          "species", 
          "traps", 
          "neutrophil-dependent impairment", 
          "obese mice increase neutrophil extracellular DNA traps", 
          "mice increase neutrophil extracellular DNA traps", 
          "increase neutrophil extracellular DNA traps", 
          "lung metastasis samples", 
          "Neutrophil oxidative stress", 
          "obesity-associated vascular dysfunction", 
          "metastatic transmigration"
        ], 
        "name": "Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration", 
        "pagination": "545-562", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1137705299"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s43018-021-00194-9"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s43018-021-00194-9", 
          "https://app.dimensions.ai/details/publication/pub.1137705299"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T19:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_919.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s43018-021-00194-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00194-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00194-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00194-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00194-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    425 TRIPLES      22 PREDICATES      136 URIs      106 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s43018-021-00194-9 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N57d6df7ae3b745f192d3673cb1b29252
    4 schema:citation sg:pub.10.1007/978-1-4939-7526-6_19
    5 sg:pub.10.1007/s00018-019-03331-x
    6 sg:pub.10.1007/s11248-006-9056-9
    7 sg:pub.10.1038/ncb3578
    8 sg:pub.10.1038/ncomms12150
    9 sg:pub.10.1038/nm.1959
    10 sg:pub.10.1038/nm.2514
    11 sg:pub.10.1038/nm.3909
    12 sg:pub.10.1038/nm1001-1138
    13 sg:pub.10.1038/nm1565
    14 sg:pub.10.1038/nrc.2016.52
    15 sg:pub.10.1038/nrc1408
    16 sg:pub.10.1038/nrc1670
    17 sg:pub.10.1038/nri1937
    18 sg:pub.10.1038/nri2096
    19 sg:pub.10.1038/s41467-020-16596-9
    20 sg:pub.10.1038/s41574-018-0126-x
    21 sg:pub.10.1038/s41577-019-0141-8
    22 sg:pub.10.1038/s41586-019-0915-y
    23 sg:pub.10.1038/srep08587
    24 sg:pub.10.1038/srep11362
    25 sg:pub.10.1186/bcr3174
    26 schema:datePublished 2021-05-03
    27 schema:datePublishedReg 2021-05-03
    28 schema:description Metastasis is the leading cause of cancer-related deaths, and obesity is associated with increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose tissue induces lung neutrophilia associated with enhanced BC metastasis to this site. Here we show that obesity leads to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung. Mechanistically, neutrophil-produced reactive oxygen species in obese mice increase neutrophil extracellular DNA traps (NETs) and weaken endothelial junctions, facilitating the influx of tumor cells from the peripheral circulation. In vivo treatment with catalase, NET inhibitors or genetic deletion of Nos2 reversed this effect in preclinical models of obesity. Imaging mass cytometry of lung metastasis samples from patients with cancer revealed an enrichment in neutrophils with low catalase levels correlating with elevated body mass index. Our data provide insights into potentially targetable mechanisms that underlie the progression of BC in the obese population.
    29 schema:genre article
    30 schema:inLanguage en
    31 schema:isAccessibleForFree true
    32 schema:isPartOf N116872af740d434db6ba5266167848d6
    33 N4ee801ccd0a845afadc236feefbb63b2
    34 sg:journal.1363508
    35 schema:keywords BC
    36 BC metastasis
    37 DNA traps
    38 Mechanistically
    39 NET inhibitor
    40 NOS2
    41 Neutrophil oxidative stress
    42 adhesion
    43 adipose tissue
    44 body mass index
    45 breast cancer metastasis
    46 cancer
    47 cancer cell extravasation
    48 cancer metastasis
    49 cancer-related death
    50 catalase
    51 catalase levels
    52 cause
    53 cell extravasation
    54 cells
    55 circulation
    56 cytometry
    57 data
    58 death
    59 deletion
    60 dysfunction
    61 effect
    62 elevated body mass index
    63 endothelial adhesion
    64 endothelial junctions
    65 enrichment
    66 extracellular DNA traps
    67 extravasation
    68 genetic deletion
    69 impairment
    70 increase neutrophil extracellular DNA traps
    71 index
    72 influx
    73 inhibitors
    74 insights
    75 integrity
    76 junction
    77 levels
    78 loss
    79 low catalase levels
    80 lung
    81 lung metastasis samples
    82 lung neutrophilia
    83 mass cytometry
    84 mass index
    85 mechanism
    86 metastasis
    87 metastasis samples
    88 metastatic transmigration
    89 mice increase neutrophil extracellular DNA traps
    90 model
    91 neutrophil extracellular DNA traps
    92 neutrophil-dependent impairment
    93 neutrophilia
    94 neutrophils
    95 obese adipose tissue
    96 obese mice increase neutrophil extracellular DNA traps
    97 obese population
    98 obesity
    99 obesity-associated vascular dysfunction
    100 oxidative stress
    101 oxygen species
    102 patients
    103 peripheral circulation
    104 population
    105 preclinical models
    106 preclinical studies
    107 progression
    108 progression of BC
    109 reactive oxygen species
    110 samples
    111 sites
    112 species
    113 stress
    114 study
    115 targetable mechanism
    116 tissue
    117 transmigration
    118 traps
    119 treatment
    120 tumor cells
    121 vascular dysfunction
    122 vascular integrity
    123 vivo treatment
    124 schema:name Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration
    125 schema:pagination 545-562
    126 schema:productId N3fa9c412721e499da0f6c000c4514664
    127 N9f795b9c47494389a5c7ff15c51b64eb
    128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1137705299
    129 https://doi.org/10.1038/s43018-021-00194-9
    130 schema:sdDatePublished 2022-01-01T19:01
    131 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    132 schema:sdPublisher N7db75d249168423dbf92df335ee1abf8
    133 schema:url https://doi.org/10.1038/s43018-021-00194-9
    134 sgo:license sg:explorer/license/
    135 sgo:sdDataset articles
    136 rdf:type schema:ScholarlyArticle
    137 N07d51f7a800343d781bef0fc586a7cff schema:affiliation grid-institutes:grid.14709.3b
    138 schema:familyName Fiset
    139 schema:givenName Benoit
    140 rdf:type schema:Person
    141 N085722a05af142f4becfdd9a04998fb3 rdf:first sg:person.0737755005.26
    142 rdf:rest N81167c2e932749efa3e3846fbd8abb1f
    143 N09541074266741f38c036b8cedbf52e8 schema:affiliation grid-institutes:grid.14709.3b
    144 schema:familyName Luo
    145 schema:givenName Robin B. E.
    146 rdf:type schema:Person
    147 N116872af740d434db6ba5266167848d6 schema:volumeNumber 2
    148 rdf:type schema:PublicationVolume
    149 N141fdaa0644648428cda986ccb0e98c0 rdf:first N09541074266741f38c036b8cedbf52e8
    150 rdf:rest N6b1807c867f34640bf7f4c1535985d44
    151 N18d98e8614ab486c915f36e06d052d04 rdf:first N07d51f7a800343d781bef0fc586a7cff
    152 rdf:rest Nfd30e00ec3df4f0c90b6e963df3bbed2
    153 N3a9ef03f707d45e6be38106d870043f6 rdf:first sg:person.0712420560.53
    154 rdf:rest Ne9a6878996a54e9bb86ed95a13944083
    155 N3fa9c412721e499da0f6c000c4514664 schema:name doi
    156 schema:value 10.1038/s43018-021-00194-9
    157 rdf:type schema:PropertyValue
    158 N40de315420e748d49ef9eacfe6281501 rdf:first sg:person.0605132127.92
    159 rdf:rest rdf:nil
    160 N4ee801ccd0a845afadc236feefbb63b2 schema:issueNumber 5
    161 rdf:type schema:PublicationIssue
    162 N55564f6823ee4b329f75bd630081bb9b rdf:first Nfb39a96fbc9642a2b9b2200b1c910c4f
    163 rdf:rest N18d98e8614ab486c915f36e06d052d04
    164 N57d6df7ae3b745f192d3673cb1b29252 rdf:first sg:person.012042046443.81
    165 rdf:rest N141fdaa0644648428cda986ccb0e98c0
    166 N5b66531d705d4699a5bcb29cf2bf7993 rdf:first Nfa317e69cc8b4e87a556d3fed9a11928
    167 rdf:rest N65ad549af693429aae7256ffa9b8c62a
    168 N5c1d896782d8481f9bc76eb43ff27d54 rdf:first sg:person.0706724463.63
    169 rdf:rest N55564f6823ee4b329f75bd630081bb9b
    170 N65ad549af693429aae7256ffa9b8c62a rdf:first sg:person.014264702507.43
    171 rdf:rest N6d2e76524c1f4a19953edb3bd479a33e
    172 N6b1807c867f34640bf7f4c1535985d44 rdf:first sg:person.0636705645.03
    173 rdf:rest Nb24bf1f608514369b83763aeab81dbe1
    174 N6d2e76524c1f4a19953edb3bd479a33e rdf:first sg:person.0615262301.15
    175 rdf:rest N705a2975de5648b7a5d5fc2276a25511
    176 N705a2975de5648b7a5d5fc2276a25511 rdf:first sg:person.01030261520.59
    177 rdf:rest Ncaf89695e3ea4e2d86783e88c63847c9
    178 N7db75d249168423dbf92df335ee1abf8 schema:name Springer Nature - SN SciGraph project
    179 rdf:type schema:Organization
    180 N81167c2e932749efa3e3846fbd8abb1f rdf:first sg:person.0702372124.46
    181 rdf:rest Ne3652d04df6546a9bbc5386932d9be31
    182 N811f2af653c542969ffee8efb26b88fa rdf:first sg:person.012742552511.70
    183 rdf:rest N5b66531d705d4699a5bcb29cf2bf7993
    184 N9f795b9c47494389a5c7ff15c51b64eb schema:name dimensions_id
    185 schema:value pub.1137705299
    186 rdf:type schema:PropertyValue
    187 Na29c6f11422c4161be3dcb1a01724006 rdf:first sg:person.012436103651.04
    188 rdf:rest N811f2af653c542969ffee8efb26b88fa
    189 Nb11845df7a7d44e593190cc7d79ff9b9 rdf:first Nca088e7d44d949ee8a0f070305ed72a8
    190 rdf:rest Nddb2828b2f3447d99049fd376cc6a5aa
    191 Nb24bf1f608514369b83763aeab81dbe1 rdf:first Nbac5008afb704845967de12def0d3d7c
    192 rdf:rest Nb11845df7a7d44e593190cc7d79ff9b9
    193 Nbac5008afb704845967de12def0d3d7c schema:affiliation grid-institutes:grid.14709.3b
    194 schema:familyName Doré
    195 schema:givenName Samuel
    196 rdf:type schema:Person
    197 Nca088e7d44d949ee8a0f070305ed72a8 schema:affiliation grid-institutes:grid.14709.3b
    198 schema:familyName Bennett
    199 schema:givenName Nicolas C.
    200 rdf:type schema:Person
    201 Ncaf89695e3ea4e2d86783e88c63847c9 rdf:first sg:person.015426770605.02
    202 rdf:rest N5c1d896782d8481f9bc76eb43ff27d54
    203 Ncf9080fe5f674066aabfddd5737fde8d rdf:first sg:person.01352532122.58
    204 rdf:rest N3a9ef03f707d45e6be38106d870043f6
    205 Ndbe72b37801b4594805fa3b0f49d9ee9 rdf:first sg:person.01371501141.49
    206 rdf:rest N40de315420e748d49ef9eacfe6281501
    207 Nddb2828b2f3447d99049fd376cc6a5aa rdf:first sg:person.01222114145.97
    208 rdf:rest Na29c6f11422c4161be3dcb1a01724006
    209 Ne3652d04df6546a9bbc5386932d9be31 rdf:first sg:person.01327426551.42
    210 rdf:rest Ncf9080fe5f674066aabfddd5737fde8d
    211 Ne9a6878996a54e9bb86ed95a13944083 rdf:first sg:person.01324314373.66
    212 rdf:rest Ndbe72b37801b4594805fa3b0f49d9ee9
    213 Nfa317e69cc8b4e87a556d3fed9a11928 schema:affiliation grid-institutes:grid.14709.3b
    214 schema:familyName Yang
    215 schema:givenName Ryan R.
    216 rdf:type schema:Person
    217 Nfb39a96fbc9642a2b9b2200b1c910c4f schema:affiliation grid-institutes:grid.14709.3b
    218 schema:familyName Wei
    219 schema:givenName Yuhong
    220 rdf:type schema:Person
    221 Nfd30e00ec3df4f0c90b6e963df3bbed2 rdf:first sg:person.0577750637.25
    222 rdf:rest N085722a05af142f4becfdd9a04998fb3
    223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Medical and Health Sciences
    225 rdf:type schema:DefinedTerm
    226 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    227 schema:name Oncology and Carcinogenesis
    228 rdf:type schema:DefinedTerm
    229 sg:grant.100075247 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00194-9
    230 rdf:type schema:MonetaryGrant
    231 sg:journal.1363508 schema:issn 2662-1347
    232 schema:name Nature Cancer
    233 schema:publisher Springer Nature
    234 rdf:type schema:Periodical
    235 sg:person.01030261520.59 schema:affiliation grid-institutes:grid.14709.3b
    236 schema:familyName Samborska
    237 schema:givenName Bozena
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030261520.59
    239 rdf:type schema:Person
    240 sg:person.012042046443.81 schema:affiliation grid-institutes:grid.14709.3b
    241 schema:familyName McDowell
    242 schema:givenName Sheri A. C.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012042046443.81
    244 rdf:type schema:Person
    245 sg:person.01222114145.97 schema:affiliation grid-institutes:grid.14709.3b
    246 schema:familyName Breton
    247 schema:givenName Valérie
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222114145.97
    249 rdf:type schema:Person
    250 sg:person.012436103651.04 schema:affiliation grid-institutes:grid.14709.3b
    251 schema:familyName Karimi
    252 schema:givenName Elham
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012436103651.04
    254 rdf:type schema:Person
    255 sg:person.012742552511.70 schema:affiliation grid-institutes:grid.17063.33
    256 schema:familyName Rezanejad
    257 schema:givenName Morteza
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742552511.70
    259 rdf:type schema:Person
    260 sg:person.01324314373.66 schema:affiliation grid-institutes:grid.5386.8
    261 schema:familyName Dannenberg
    262 schema:givenName Andrew J.
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324314373.66
    264 rdf:type schema:Person
    265 sg:person.01327426551.42 schema:affiliation grid-institutes:None
    266 schema:familyName Guiot
    267 schema:givenName Marie-Christine
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327426551.42
    269 rdf:type schema:Person
    270 sg:person.01352532122.58 schema:affiliation grid-institutes:grid.14709.3b
    271 schema:familyName Fiset
    272 schema:givenName Pierre O.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352532122.58
    274 rdf:type schema:Person
    275 sg:person.01371501141.49 schema:affiliation grid-institutes:grid.14709.3b
    276 schema:familyName Walsh
    277 schema:givenName Logan A.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371501141.49
    279 rdf:type schema:Person
    280 sg:person.014264702507.43 schema:affiliation grid-institutes:grid.14709.3b
    281 schema:familyName Lach
    282 schema:givenName Katherine D.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014264702507.43
    284 rdf:type schema:Person
    285 sg:person.015426770605.02 schema:affiliation grid-institutes:grid.14709.3b
    286 schema:familyName Perus
    287 schema:givenName Lucas J. M.
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015426770605.02
    289 rdf:type schema:Person
    290 sg:person.0577750637.25 schema:affiliation grid-institutes:grid.14709.3b
    291 schema:familyName Rayes
    292 schema:givenName Roni F.
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577750637.25
    294 rdf:type schema:Person
    295 sg:person.0605132127.92 schema:affiliation grid-institutes:grid.14709.3b
    296 schema:familyName Quail
    297 schema:givenName Daniela F.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605132127.92
    299 rdf:type schema:Person
    300 sg:person.0615262301.15 schema:affiliation grid-institutes:grid.14709.3b
    301 schema:familyName Issac
    302 schema:givenName Marianne S. M.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615262301.15
    304 rdf:type schema:Person
    305 sg:person.0636705645.03 schema:affiliation grid-institutes:grid.14709.3b
    306 schema:familyName Arabzadeh
    307 schema:givenName Azadeh
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636705645.03
    309 rdf:type schema:Person
    310 sg:person.0702372124.46 schema:affiliation grid-institutes:grid.14709.3b
    311 schema:familyName Kazak
    312 schema:givenName Lawrence
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702372124.46
    314 rdf:type schema:Person
    315 sg:person.0706724463.63 schema:affiliation grid-institutes:grid.14709.3b
    316 schema:familyName Moldoveanu
    317 schema:givenName Dan
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706724463.63
    319 rdf:type schema:Person
    320 sg:person.0712420560.53 schema:affiliation grid-institutes:grid.63984.30
    321 schema:familyName Spicer
    322 schema:givenName Jonathan D.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712420560.53
    324 rdf:type schema:Person
    325 sg:person.0737755005.26 schema:affiliation grid-institutes:grid.14709.3b
    326 schema:familyName Watson
    327 schema:givenName Ian R.
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737755005.26
    329 rdf:type schema:Person
    330 sg:pub.10.1007/978-1-4939-7526-6_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101144247
    331 https://doi.org/10.1007/978-1-4939-7526-6_19
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/s00018-019-03331-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1122089483
    334 https://doi.org/10.1007/s00018-019-03331-x
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/s11248-006-9056-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028528600
    337 https://doi.org/10.1007/s11248-006-9056-9
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/ncb3578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090880207
    340 https://doi.org/10.1038/ncb3578
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/ncomms12150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034942681
    343 https://doi.org/10.1038/ncomms12150
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nm.1959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051827328
    346 https://doi.org/10.1038/nm.1959
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nm.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028608744
    349 https://doi.org/10.1038/nm.2514
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nm.3909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037811895
    352 https://doi.org/10.1038/nm.3909
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nm1001-1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036749841
    355 https://doi.org/10.1038/nm1001-1138
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nm1565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046780586
    358 https://doi.org/10.1038/nm1565
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nrc.2016.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007861418
    361 https://doi.org/10.1038/nrc.2016.52
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nrc1408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022040392
    364 https://doi.org/10.1038/nrc1408
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nrc1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033699583
    367 https://doi.org/10.1038/nrc1670
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nri1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018278870
    370 https://doi.org/10.1038/nri1937
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nri2096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000282210
    373 https://doi.org/10.1038/nri2096
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/s41467-020-16596-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128141673
    376 https://doi.org/10.1038/s41467-020-16596-9
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/s41574-018-0126-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1110034930
    379 https://doi.org/10.1038/s41574-018-0126-x
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/s41577-019-0141-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112435045
    382 https://doi.org/10.1038/s41577-019-0141-8
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/s41586-019-0915-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1111950413
    385 https://doi.org/10.1038/s41586-019-0915-y
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/srep08587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027729380
    388 https://doi.org/10.1038/srep08587
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/srep11362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008786328
    391 https://doi.org/10.1038/srep11362
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1186/bcr3174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030305729
    394 https://doi.org/10.1186/bcr3174
    395 rdf:type schema:CreativeWork
    396 grid-institutes:None schema:alternateName Montreal Neurological Institute, McGill University Health Centre, Montreal, Quebec, Canada
    397 schema:name Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    398 Montreal Neurological Institute, McGill University Health Centre, Montreal, Quebec, Canada
    399 rdf:type schema:Organization
    400 grid-institutes:grid.14709.3b schema:alternateName Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    401 Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    402 Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    403 Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    404 Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    405 Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    406 Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
    407 schema:name Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    408 Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    409 Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    410 Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    411 Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    412 Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    413 Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
    414 rdf:type schema:Organization
    415 grid-institutes:grid.17063.33 schema:alternateName Departments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada
    416 schema:name Departments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada
    417 rdf:type schema:Organization
    418 grid-institutes:grid.5386.8 schema:alternateName Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    419 schema:name Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    420 rdf:type schema:Organization
    421 grid-institutes:grid.63984.30 schema:alternateName Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada
    422 schema:name Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    423 Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada
    424 Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
    425 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...