Fatty acid synthesis is required for breast cancer brain metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-04-01

AUTHORS

Gino B. Ferraro, Ahmed Ali, Alba Luengo, David P. Kodack, Amy Deik, Keene L. Abbott, Divya Bezwada, Landry Blanc, Brendan Prideaux, Xin Jin, Jessica M. Posada, Jiang Chen, Christopher R. Chin, Zohreh Amoozgar, Raphael Ferreira, Ivy X. Chen, Kamila Naxerova, Christopher Ng, Anna M. Westermark, Mark Duquette, Sylvie Roberge, Neal I. Lindeman, Costas A. Lyssiotis, Jens Nielsen, David E. Housman, Dan G. Duda, Elena Brachtel, Todd R. Golub, Lewis C. Cantley, John M. Asara, Shawn M. Davidson, Dai Fukumura, Véronique A. Dartois, Clary B. Clish, Rakesh K. Jain, Matthew G. Vander Heiden

ABSTRACT

Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies. More... »

PAGES

414-428

References to SciGraph publications

  • 2019-07-19. FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis in ONCOGENE
  • 2016-08-22. Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer in BMC GENOMICS
  • 2019-09-18. Synaptic proximity enables NMDAR signalling to promote brain metastasis in NATURE
  • 2016-05-18. Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer in NATURE
  • 2016-09-14. Ionic immune suppression within the tumour microenvironment limits T cell effector function in NATURE
  • 2016-09-23. The multifaceted roles of fatty acid synthesis in cancer in NATURE REVIEWS CANCER
  • 2015-11-23. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma in NATURE CELL BIOLOGY
  • 2019-11-28. Brain metastasis in NATURE REVIEWS CANCER
  • 2018-12-17. Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR in SCIENTIFIC REPORTS
  • 2019-02-27. Breast cancer cells rely on environmental pyruvate to shape the metastatic niche in NATURE
  • 2004-01. Plasma and Cerebrospinal Fluid Amino Acids in Epileptic Patients in NEUROCHEMICAL RESEARCH
  • 2006-12-29. Staining protocol for organotypic hippocampal slice cultures in NATURE PROTOCOLS
  • 2020-02-06. Management of brain metastases in breast cancer: a review of current practices and emerging treatments in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-10-19. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth in NATURE
  • 2015-01-26. SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme in ONCOGENE
  • 2019-10-10. The blood–brain barrier and blood–tumour barrier in brain tumours and metastases in NATURE REVIEWS CANCER
  • 2014-12-11. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate in CANCER & METABOLISM
  • 2018-07-13. Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases in NATURE COMMUNICATIONS
  • 2019-01-24. Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method in SCIENTIFIC REPORTS
  • 2018-06-11. STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis in NATURE MEDICINE
  • 2020-12-09. A metastasis map of human cancer cell lines in NATURE
  • 2006-08-17. Sulforhodamine B colorimetric assay for cytotoxicity screening in NATURE PROTOCOLS
  • 2019-01-17. Brain metastases in NATURE REVIEWS DISEASE PRIMERS
  • 2016-06-29. Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM) in METABOLOMICS
  • 2012-04-12. A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue in NATURE PROTOCOLS
  • Journal

    TITLE

    Nature Cancer

    ISSUE

    4

    VOLUME

    2

    Author Affiliations

  • Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  • Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
  • Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
  • Novartis Institutes for BioMedical Research, Cambridge, MA, USA
  • Institut de Chimie & Biologie des Membranes & des Nano-objets, CNRS UMR 5248, Bordeaux, France
  • Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA
  • Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
  • Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
  • Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
  • Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • University of Michigan, Ann Arbor, MI, USA
  • Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA
  • Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
  • Lewis Sigler Institute, Princeton University, Princeton, NJ, USA
  • Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA
  • Dana-Farber Cancer Institute, Boston, MA, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s43018-021-00183-y

    DOI

    http://dx.doi.org/10.1038/s43018-021-00183-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1136852057

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34179825


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fatty Acid Synthases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fatty Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Microenvironment", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferraro", 
            "givenName": "Gino B.", 
            "id": "sg:person.01352030126.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352030126.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ali", 
            "givenName": "Ahmed", 
            "id": "sg:person.013701675251.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701675251.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luengo", 
            "givenName": "Alba", 
            "id": "sg:person.0630210613.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630210613.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Novartis Institutes for BioMedical Research, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.418424.f", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
                "Novartis Institutes for BioMedical Research, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kodack", 
            "givenName": "David P.", 
            "id": "sg:person.01327014576.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327014576.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deik", 
            "givenName": "Amy", 
            "id": "sg:person.01215102434.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215102434.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abbott", 
            "givenName": "Keene L.", 
            "id": "sg:person.07414473673.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07414473673.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bezwada", 
            "givenName": "Divya", 
            "id": "sg:person.015631720577.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015631720577.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Chimie & Biologie des Membranes & des Nano-objets, CNRS UMR 5248, Bordeaux, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA", 
                "Institut de Chimie & Biologie des Membranes & des Nano-objets, CNRS UMR 5248, Bordeaux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blanc", 
            "givenName": "Landry", 
            "id": "sg:person.010514612063.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010514612063.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.176731.5", 
              "name": [
                "The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA", 
                "Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prideaux", 
            "givenName": "Brendan", 
            "id": "sg:person.0725702533.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725702533.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jin", 
            "givenName": "Xin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
                "Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Posada", 
            "givenName": "Jessica M.", 
            "id": "sg:person.016401253227.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016401253227.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Jiang", 
            "id": "sg:person.07423404103.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07423404103.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chin", 
            "givenName": "Christopher R.", 
            "id": "sg:person.01047633034.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047633034.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amoozgar", 
            "givenName": "Zohreh", 
            "id": "sg:person.01170533215.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170533215.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.5371.0", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Raphael", 
            "id": "sg:person.013473610047.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013473610047.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Ivy X.", 
            "id": "sg:person.01366621613.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366621613.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
                "Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naxerova", 
            "givenName": "Kamila", 
            "id": "sg:person.0726641415.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726641415.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ng", 
            "givenName": "Christopher", 
            "id": "sg:person.013747024627.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013747024627.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Westermark", 
            "givenName": "Anna M.", 
            "id": "sg:person.012212470711.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012212470711.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duquette", 
            "givenName": "Mark", 
            "id": "sg:person.015377210103.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015377210103.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roberge", 
            "givenName": "Sylvie", 
            "id": "sg:person.0650746221.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650746221.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lindeman", 
            "givenName": "Neal I.", 
            "id": "sg:person.0747214567.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747214567.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan, Ann Arbor, MI, USA", 
              "id": "http://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA", 
                "University of Michigan, Ann Arbor, MI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lyssiotis", 
            "givenName": "Costas A.", 
            "id": "sg:person.01326033556.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326033556.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.5371.0", 
              "name": [
                "Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nielsen", 
            "givenName": "Jens", 
            "id": "sg:person.065562055.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065562055.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Housman", 
            "givenName": "David E.", 
            "id": "sg:person.01163055771.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163055771.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duda", 
            "givenName": "Dan G.", 
            "id": "sg:person.01237474607.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237474607.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brachtel", 
            "givenName": "Elena", 
            "id": "sg:person.014115203114.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014115203114.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Golub", 
            "givenName": "Todd R.", 
            "id": "sg:person.01152644406.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152644406.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA", 
                "Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cantley", 
            "givenName": "Lewis C.", 
            "id": "sg:person.013560615677.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013560615677.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asara", 
            "givenName": "John M.", 
            "id": "sg:person.01263225337.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263225337.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lewis Sigler Institute, Princeton University, Princeton, NJ, USA", 
              "id": "http://www.grid.ac/institutes/grid.16750.35", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
                "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Lewis Sigler Institute, Princeton University, Princeton, NJ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davidson", 
            "givenName": "Shawn M.", 
            "id": "sg:person.01037750044.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037750044.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukumura", 
            "givenName": "Dai", 
            "id": "sg:person.01140621416.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140621416.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA", 
              "id": "http://www.grid.ac/institutes/grid.429392.7", 
              "name": [
                "The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA", 
                "Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dartois", 
            "givenName": "V\u00e9ronique A.", 
            "id": "sg:person.01107321105.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107321105.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clish", 
            "givenName": "Clary B.", 
            "id": "sg:person.0764632420.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jain", 
            "givenName": "Rakesh K.", 
            "id": "sg:person.01340416322.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340416322.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana-Farber Cancer Institute, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA", 
                "Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA", 
                "Dana-Farber Cancer Institute, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vander Heiden", 
            "givenName": "Matthew G.", 
            "id": "sg:person.01204736037.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204736037.13"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41467-018-05030-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105500857", 
              "https://doi.org/10.1038/s41467-018-05030-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018334075", 
              "https://doi.org/10.1038/nature19364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032332400", 
              "https://doi.org/10.1038/onc.2014.439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-36293-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110537236", 
              "https://doi.org/10.1038/s41598-018-36293-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41568-019-0205-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1121612558", 
              "https://doi.org/10.1038/s41568-019-0205-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2006.180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022893346", 
              "https://doi.org/10.1038/nprot.2006.180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044110715", 
              "https://doi.org/10.1038/nprot.2012.024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41568-019-0220-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1122943624", 
              "https://doi.org/10.1038/s41568-019-0220-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:nere.0000010461.34920.0c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018124126", 
              "https://doi.org/10.1023/b:nere.0000010461.34920.0c"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-3002-2-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030230764", 
              "https://doi.org/10.1186/2049-3002-2-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2006.179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033256129", 
              "https://doi.org/10.1038/nprot.2006.179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-020-05552-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124654843", 
              "https://doi.org/10.1007/s10549-020-05552-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008577502", 
              "https://doi.org/10.1038/nature15376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032287924", 
              "https://doi.org/10.1038/ncb3272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41572-018-0055-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111488105", 
              "https://doi.org/10.1038/s41572-018-0055-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature18268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023043878", 
              "https://doi.org/10.1038/nature18268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-019-1576-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1121084590", 
              "https://doi.org/10.1038/s41586-019-1576-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-019-0977-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112395501", 
              "https://doi.org/10.1038/s41586-019-0977-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-016-1065-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053661934", 
              "https://doi.org/10.1007/s11306-016-1065-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41388-019-0893-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1118099266", 
              "https://doi.org/10.1038/s41388-019-0893-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc.2016.89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046768702", 
              "https://doi.org/10.1038/nrc.2016.89"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-016-2911-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044276967", 
              "https://doi.org/10.1186/s12864-016-2911-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-020-2969-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1133346189", 
              "https://doi.org/10.1038/s41586-020-2969-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-36874-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111644275", 
              "https://doi.org/10.1038/s41598-018-36874-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0044-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104478470", 
              "https://doi.org/10.1038/s41591-018-0044-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-04-01", 
        "datePublishedReg": "2021-04-01", 
        "description": "Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s43018-021-00183-y", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7134451", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3933134", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4729236", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2683725", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9655628", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481982", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4444330", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438804", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6918951", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6375798", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4317074", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6618240", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9655351", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8633451", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9011175", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1363508", 
            "issn": [
              "2662-1347"
            ], 
            "name": "Nature Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "keywords": [
          "human epidermal growth factor receptor", 
          "epidermal growth factor receptor", 
          "breast tumors", 
          "growth factor receptor", 
          "brain metastases", 
          "fatty acid synthesis", 
          "metastatic breast cancer growth", 
          "breast cancer brain metastases", 
          "cancer brain metastases", 
          "factor receptor", 
          "breast cancer growth", 
          "breast tumor growth", 
          "acid synthesis", 
          "metastatic sites", 
          "systemic disease", 
          "fatty acid synthase", 
          "brain microenvironment", 
          "breast cancer", 
          "extracranial sites", 
          "therapy resistance", 
          "cancer growth", 
          "tumor growth", 
          "pharmacological inhibition", 
          "lipid availability", 
          "tumors", 
          "brain", 
          "metastasis", 
          "metabolic adaptation", 
          "therapy", 
          "acid synthase", 
          "metabolic dependencies", 
          "receptors", 
          "tissue", 
          "patients", 
          "cancer", 
          "disease", 
          "inhibition", 
          "metabolism", 
          "microenvironment", 
          "phenotype", 
          "synthase", 
          "sites", 
          "differences", 
          "availability", 
          "resistance", 
          "adaptation", 
          "growth", 
          "site-specific dependency", 
          "synthesis", 
          "liability", 
          "dependency", 
          "nutrient availability"
        ], 
        "name": "Fatty acid synthesis is required for breast cancer brain metastasis", 
        "pagination": "414-428", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1136852057"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s43018-021-00183-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34179825"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s43018-021-00183-y", 
          "https://app.dimensions.ai/details/publication/pub.1136852057"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_902.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s43018-021-00183-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00183-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00183-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00183-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s43018-021-00183-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    574 TRIPLES      21 PREDICATES      109 URIs      76 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s43018-021-00183-y schema:about N1211042749454653bfa01783d2f9d8a6
    2 N22f8502f587443d49828e22133483b02
    3 N57187e66d1e743a4af1b4a0cd6f83c1f
    4 N9ef946d37d574db88663577f99c6ab9f
    5 Nb1879274e1ee4037b29f5c18f0f6a5c1
    6 Ncb6fbf46a619418290bad8aabac2f9f1
    7 Nea7b6a6b991e43b8b69aaef1309177a8
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author N23ae0f9d2b0546ea8fed21f818c7f877
    11 schema:citation sg:pub.10.1007/s10549-020-05552-2
    12 sg:pub.10.1007/s11306-016-1065-y
    13 sg:pub.10.1023/b:nere.0000010461.34920.0c
    14 sg:pub.10.1038/nature15376
    15 sg:pub.10.1038/nature18268
    16 sg:pub.10.1038/nature19364
    17 sg:pub.10.1038/ncb3272
    18 sg:pub.10.1038/nprot.2006.179
    19 sg:pub.10.1038/nprot.2006.180
    20 sg:pub.10.1038/nprot.2012.024
    21 sg:pub.10.1038/nrc.2016.89
    22 sg:pub.10.1038/onc.2014.439
    23 sg:pub.10.1038/s41388-019-0893-4
    24 sg:pub.10.1038/s41467-018-05030-w
    25 sg:pub.10.1038/s41568-019-0205-x
    26 sg:pub.10.1038/s41568-019-0220-y
    27 sg:pub.10.1038/s41572-018-0055-y
    28 sg:pub.10.1038/s41586-019-0977-x
    29 sg:pub.10.1038/s41586-019-1576-6
    30 sg:pub.10.1038/s41586-020-2969-2
    31 sg:pub.10.1038/s41591-018-0044-4
    32 sg:pub.10.1038/s41598-018-36293-4
    33 sg:pub.10.1038/s41598-018-36874-3
    34 sg:pub.10.1186/2049-3002-2-23
    35 sg:pub.10.1186/s12864-016-2911-z
    36 schema:datePublished 2021-04-01
    37 schema:datePublishedReg 2021-04-01
    38 schema:description Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.
    39 schema:genre article
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N057cb0b8c261470d96db32b097d786e8
    42 Nf519e12f4a554bdfb454a27b4400bf56
    43 sg:journal.1363508
    44 schema:keywords acid synthase
    45 acid synthesis
    46 adaptation
    47 availability
    48 brain
    49 brain metastases
    50 brain microenvironment
    51 breast cancer
    52 breast cancer brain metastases
    53 breast cancer growth
    54 breast tumor growth
    55 breast tumors
    56 cancer
    57 cancer brain metastases
    58 cancer growth
    59 dependency
    60 differences
    61 disease
    62 epidermal growth factor receptor
    63 extracranial sites
    64 factor receptor
    65 fatty acid synthase
    66 fatty acid synthesis
    67 growth
    68 growth factor receptor
    69 human epidermal growth factor receptor
    70 inhibition
    71 liability
    72 lipid availability
    73 metabolic adaptation
    74 metabolic dependencies
    75 metabolism
    76 metastasis
    77 metastatic breast cancer growth
    78 metastatic sites
    79 microenvironment
    80 nutrient availability
    81 patients
    82 pharmacological inhibition
    83 phenotype
    84 receptors
    85 resistance
    86 site-specific dependency
    87 sites
    88 synthase
    89 synthesis
    90 systemic disease
    91 therapy
    92 therapy resistance
    93 tissue
    94 tumor growth
    95 tumors
    96 schema:name Fatty acid synthesis is required for breast cancer brain metastasis
    97 schema:pagination 414-428
    98 schema:productId N91b84553c77b4f6e810b735167d3b879
    99 N9d4ee59c00a645bb987df7885f39e6bf
    100 Nab85903ada59437598e4c96ec364a83b
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1136852057
    102 https://doi.org/10.1038/s43018-021-00183-y
    103 schema:sdDatePublished 2022-11-24T21:08
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher Nb5def8c9c16d45f587e95948cb0a797c
    106 schema:url https://doi.org/10.1038/s43018-021-00183-y
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N057cb0b8c261470d96db32b097d786e8 schema:volumeNumber 2
    111 rdf:type schema:PublicationVolume
    112 N1211042749454653bfa01783d2f9d8a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Humans
    114 rdf:type schema:DefinedTerm
    115 N16696ed4f2df49ca9af3369b15a0d18d rdf:first sg:person.01037750044.74
    116 rdf:rest N927d0ea6f989434d9cd3c7822bba03f8
    117 N17b232c2a5744d84852a4f3d5b4e19a8 rdf:first sg:person.01163055771.35
    118 rdf:rest N9d5360d3481347c7b469ea4ffafe7eed
    119 N18940cd09a524be097221256194ef38a rdf:first sg:person.01107321105.49
    120 rdf:rest N9dd9865123fc48f6a87380fb90e073b9
    121 N22f8502f587443d49828e22133483b02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Fatty Acid Synthases
    123 rdf:type schema:DefinedTerm
    124 N23ae0f9d2b0546ea8fed21f818c7f877 rdf:first sg:person.01352030126.29
    125 rdf:rest Ne398532b93a64d5f96270d6b0ef545a7
    126 N2f419e2da1134afc92721efbbc95dd6a rdf:first sg:person.0650746221.85
    127 rdf:rest N34b92b433ac5442a93547a71eea6d891
    128 N34b92b433ac5442a93547a71eea6d891 rdf:first sg:person.0747214567.71
    129 rdf:rest N3cce34b3ab944780897fdc73add0a511
    130 N3cce34b3ab944780897fdc73add0a511 rdf:first sg:person.01326033556.41
    131 rdf:rest Ndc06f779b0114de88df2353844739184
    132 N3d1060c46e61429aa29f5666d1df9b61 rdf:first sg:person.014115203114.16
    133 rdf:rest N3fa1b68939d546e5b95aa1cae83a3c6f
    134 N3fa1b68939d546e5b95aa1cae83a3c6f rdf:first sg:person.01152644406.14
    135 rdf:rest N5c2e7f58384f425a8ba1417bb676a125
    136 N448b919a736a4339a7df3466a3adb805 rdf:first sg:person.01170533215.46
    137 rdf:rest N7a2b7fd5be454defa9621ebac08e89c5
    138 N4736634f4731408fb18cae84df4f058f rdf:first sg:person.012212470711.89
    139 rdf:rest Na8eaaec5903649e3885c613d1437278e
    140 N4d2da853244d4089a1ef9585097f2560 rdf:first sg:person.01366621613.08
    141 rdf:rest Ne1bfe9103add49eb9135b6e84326449b
    142 N4d7e2a2c69f84595a550874b234ca93d rdf:first sg:person.01327014576.23
    143 rdf:rest Ne2a56a1e02264d49aad96e9a86959434
    144 N508fbdae282f4866be6935b179d65654 rdf:first sg:person.013747024627.76
    145 rdf:rest N4736634f4731408fb18cae84df4f058f
    146 N57187e66d1e743a4af1b4a0cd6f83c1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Tumor Microenvironment
    148 rdf:type schema:DefinedTerm
    149 N5c2e7f58384f425a8ba1417bb676a125 rdf:first sg:person.013560615677.26
    150 rdf:rest N69065f5df81c4de0860286c1605de745
    151 N69065f5df81c4de0860286c1605de745 rdf:first sg:person.01263225337.08
    152 rdf:rest N16696ed4f2df49ca9af3369b15a0d18d
    153 N6921d0e9b5054d73b157cce971265dcd rdf:first sg:person.01340416322.96
    154 rdf:rest Naaf7ba2c572c4d70b9cda645a1bb8fc7
    155 N7a2b7fd5be454defa9621ebac08e89c5 rdf:first sg:person.013473610047.95
    156 rdf:rest N4d2da853244d4089a1ef9585097f2560
    157 N85fc60bdf15742d6a8bb88496ad9c2c9 rdf:first sg:person.01047633034.09
    158 rdf:rest N448b919a736a4339a7df3466a3adb805
    159 N87d8a43f0edb4992866637a8d48f1d66 rdf:first sg:person.07414473673.40
    160 rdf:rest N8b9089168d124b51955c4bbad1e21a51
    161 N8b9089168d124b51955c4bbad1e21a51 rdf:first sg:person.015631720577.62
    162 rdf:rest Na4fc382dfd594242a54b266f1d55a5ee
    163 N91b84553c77b4f6e810b735167d3b879 schema:name doi
    164 schema:value 10.1038/s43018-021-00183-y
    165 rdf:type schema:PropertyValue
    166 N927d0ea6f989434d9cd3c7822bba03f8 rdf:first sg:person.01140621416.09
    167 rdf:rest N18940cd09a524be097221256194ef38a
    168 N9735be402df04efe9a8a9050316e9ee1 rdf:first sg:person.0630210613.91
    169 rdf:rest N4d7e2a2c69f84595a550874b234ca93d
    170 N9d4ee59c00a645bb987df7885f39e6bf schema:name dimensions_id
    171 schema:value pub.1136852057
    172 rdf:type schema:PropertyValue
    173 N9d5360d3481347c7b469ea4ffafe7eed rdf:first sg:person.01237474607.21
    174 rdf:rest N3d1060c46e61429aa29f5666d1df9b61
    175 N9dd9865123fc48f6a87380fb90e073b9 rdf:first sg:person.0764632420.16
    176 rdf:rest N6921d0e9b5054d73b157cce971265dcd
    177 N9ef946d37d574db88663577f99c6ab9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Brain Neoplasms
    179 rdf:type schema:DefinedTerm
    180 Na4fc382dfd594242a54b266f1d55a5ee rdf:first sg:person.010514612063.55
    181 rdf:rest Nedc6da7804294f88bc4fc54e1010174c
    182 Na5dfbfbc9bf54b0199ae0e084f9ea620 rdf:first sg:person.07423404103.07
    183 rdf:rest N85fc60bdf15742d6a8bb88496ad9c2c9
    184 Na8eaaec5903649e3885c613d1437278e rdf:first sg:person.015377210103.15
    185 rdf:rest N2f419e2da1134afc92721efbbc95dd6a
    186 Naaf7ba2c572c4d70b9cda645a1bb8fc7 rdf:first sg:person.01204736037.13
    187 rdf:rest rdf:nil
    188 Nab85903ada59437598e4c96ec364a83b schema:name pubmed_id
    189 schema:value 34179825
    190 rdf:type schema:PropertyValue
    191 Nb1879274e1ee4037b29f5c18f0f6a5c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Fatty Acids
    193 rdf:type schema:DefinedTerm
    194 Nb20a3d6e85ac4e9190b1dcd1baef2b82 rdf:first sg:person.016401253227.06
    195 rdf:rest Na5dfbfbc9bf54b0199ae0e084f9ea620
    196 Nb5def8c9c16d45f587e95948cb0a797c schema:name Springer Nature - SN SciGraph project
    197 rdf:type schema:Organization
    198 Ncb6fbf46a619418290bad8aabac2f9f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Female
    200 rdf:type schema:DefinedTerm
    201 Ndc06f779b0114de88df2353844739184 rdf:first sg:person.065562055.72
    202 rdf:rest N17b232c2a5744d84852a4f3d5b4e19a8
    203 Ne1bfe9103add49eb9135b6e84326449b rdf:first sg:person.0726641415.87
    204 rdf:rest N508fbdae282f4866be6935b179d65654
    205 Ne2a56a1e02264d49aad96e9a86959434 rdf:first sg:person.01215102434.89
    206 rdf:rest N87d8a43f0edb4992866637a8d48f1d66
    207 Ne398532b93a64d5f96270d6b0ef545a7 rdf:first sg:person.013701675251.01
    208 rdf:rest N9735be402df04efe9a8a9050316e9ee1
    209 Nea7b6a6b991e43b8b69aaef1309177a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Breast Neoplasms
    211 rdf:type schema:DefinedTerm
    212 Nedc6da7804294f88bc4fc54e1010174c rdf:first sg:person.0725702533.78
    213 rdf:rest Nf733666768a24b33971af95368576b07
    214 Nf3d7f9b5e45941fca87fdc46ca236c04 schema:affiliation grid-institutes:grid.66859.34
    215 schema:familyName Jin
    216 schema:givenName Xin
    217 rdf:type schema:Person
    218 Nf519e12f4a554bdfb454a27b4400bf56 schema:issueNumber 4
    219 rdf:type schema:PublicationIssue
    220 Nf733666768a24b33971af95368576b07 rdf:first Nf3d7f9b5e45941fca87fdc46ca236c04
    221 rdf:rest Nb20a3d6e85ac4e9190b1dcd1baef2b82
    222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Medical and Health Sciences
    224 rdf:type schema:DefinedTerm
    225 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Oncology and Carcinogenesis
    227 rdf:type schema:DefinedTerm
    228 sg:grant.2438804 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    229 rdf:type schema:MonetaryGrant
    230 sg:grant.2481982 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.2683725 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.3933134 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.4317074 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.4444330 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.4729236 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.6375798 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.6618240 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.6918951 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.7134451 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    249 rdf:type schema:MonetaryGrant
    250 sg:grant.8633451 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    251 rdf:type schema:MonetaryGrant
    252 sg:grant.9011175 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    253 rdf:type schema:MonetaryGrant
    254 sg:grant.9655351 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    255 rdf:type schema:MonetaryGrant
    256 sg:grant.9655628 http://pending.schema.org/fundedItem sg:pub.10.1038/s43018-021-00183-y
    257 rdf:type schema:MonetaryGrant
    258 sg:journal.1363508 schema:issn 2662-1347
    259 schema:name Nature Cancer
    260 schema:publisher Springer Nature
    261 rdf:type schema:Periodical
    262 sg:person.01037750044.74 schema:affiliation grid-institutes:grid.16750.35
    263 schema:familyName Davidson
    264 schema:givenName Shawn M.
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037750044.74
    266 rdf:type schema:Person
    267 sg:person.01047633034.09 schema:affiliation grid-institutes:grid.116068.8
    268 schema:familyName Chin
    269 schema:givenName Christopher R.
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047633034.09
    271 rdf:type schema:Person
    272 sg:person.010514612063.55 schema:affiliation grid-institutes:None
    273 schema:familyName Blanc
    274 schema:givenName Landry
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010514612063.55
    276 rdf:type schema:Person
    277 sg:person.01107321105.49 schema:affiliation grid-institutes:grid.429392.7
    278 schema:familyName Dartois
    279 schema:givenName Véronique A.
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107321105.49
    281 rdf:type schema:Person
    282 sg:person.01140621416.09 schema:affiliation grid-institutes:grid.32224.35
    283 schema:familyName Fukumura
    284 schema:givenName Dai
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140621416.09
    286 rdf:type schema:Person
    287 sg:person.01152644406.14 schema:affiliation grid-institutes:grid.66859.34
    288 schema:familyName Golub
    289 schema:givenName Todd R.
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152644406.14
    291 rdf:type schema:Person
    292 sg:person.01163055771.35 schema:affiliation grid-institutes:grid.116068.8
    293 schema:familyName Housman
    294 schema:givenName David E.
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163055771.35
    296 rdf:type schema:Person
    297 sg:person.01170533215.46 schema:affiliation grid-institutes:grid.32224.35
    298 schema:familyName Amoozgar
    299 schema:givenName Zohreh
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170533215.46
    301 rdf:type schema:Person
    302 sg:person.01204736037.13 schema:affiliation grid-institutes:grid.65499.37
    303 schema:familyName Vander Heiden
    304 schema:givenName Matthew G.
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204736037.13
    306 rdf:type schema:Person
    307 sg:person.01215102434.89 schema:affiliation grid-institutes:grid.66859.34
    308 schema:familyName Deik
    309 schema:givenName Amy
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215102434.89
    311 rdf:type schema:Person
    312 sg:person.012212470711.89 schema:affiliation grid-institutes:grid.116068.8
    313 schema:familyName Westermark
    314 schema:givenName Anna M.
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012212470711.89
    316 rdf:type schema:Person
    317 sg:person.01237474607.21 schema:affiliation grid-institutes:grid.32224.35
    318 schema:familyName Duda
    319 schema:givenName Dan G.
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237474607.21
    321 rdf:type schema:Person
    322 sg:person.01263225337.08 schema:affiliation grid-institutes:grid.38142.3c
    323 schema:familyName Asara
    324 schema:givenName John M.
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263225337.08
    326 rdf:type schema:Person
    327 sg:person.01326033556.41 schema:affiliation grid-institutes:grid.214458.e
    328 schema:familyName Lyssiotis
    329 schema:givenName Costas A.
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326033556.41
    331 rdf:type schema:Person
    332 sg:person.01327014576.23 schema:affiliation grid-institutes:grid.418424.f
    333 schema:familyName Kodack
    334 schema:givenName David P.
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327014576.23
    336 rdf:type schema:Person
    337 sg:person.01340416322.96 schema:affiliation grid-institutes:grid.32224.35
    338 schema:familyName Jain
    339 schema:givenName Rakesh K.
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340416322.96
    341 rdf:type schema:Person
    342 sg:person.013473610047.95 schema:affiliation grid-institutes:grid.5371.0
    343 schema:familyName Ferreira
    344 schema:givenName Raphael
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013473610047.95
    346 rdf:type schema:Person
    347 sg:person.01352030126.29 schema:affiliation grid-institutes:grid.32224.35
    348 schema:familyName Ferraro
    349 schema:givenName Gino B.
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352030126.29
    351 rdf:type schema:Person
    352 sg:person.013560615677.26 schema:affiliation grid-institutes:grid.5386.8
    353 schema:familyName Cantley
    354 schema:givenName Lewis C.
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013560615677.26
    356 rdf:type schema:Person
    357 sg:person.01366621613.08 schema:affiliation grid-institutes:grid.32224.35
    358 schema:familyName Chen
    359 schema:givenName Ivy X.
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366621613.08
    361 rdf:type schema:Person
    362 sg:person.013701675251.01 schema:affiliation grid-institutes:grid.66859.34
    363 schema:familyName Ali
    364 schema:givenName Ahmed
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701675251.01
    366 rdf:type schema:Person
    367 sg:person.013747024627.76 schema:affiliation grid-institutes:grid.116068.8
    368 schema:familyName Ng
    369 schema:givenName Christopher
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013747024627.76
    371 rdf:type schema:Person
    372 sg:person.014115203114.16 schema:affiliation grid-institutes:grid.32224.35
    373 schema:familyName Brachtel
    374 schema:givenName Elena
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014115203114.16
    376 rdf:type schema:Person
    377 sg:person.015377210103.15 schema:affiliation grid-institutes:grid.32224.35
    378 schema:familyName Duquette
    379 schema:givenName Mark
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015377210103.15
    381 rdf:type schema:Person
    382 sg:person.015631720577.62 schema:affiliation grid-institutes:grid.32224.35
    383 schema:familyName Bezwada
    384 schema:givenName Divya
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015631720577.62
    386 rdf:type schema:Person
    387 sg:person.016401253227.06 schema:affiliation grid-institutes:grid.62560.37
    388 schema:familyName Posada
    389 schema:givenName Jessica M.
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016401253227.06
    391 rdf:type schema:Person
    392 sg:person.0630210613.91 schema:affiliation grid-institutes:grid.116068.8
    393 schema:familyName Luengo
    394 schema:givenName Alba
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630210613.91
    396 rdf:type schema:Person
    397 sg:person.0650746221.85 schema:affiliation grid-institutes:grid.32224.35
    398 schema:familyName Roberge
    399 schema:givenName Sylvie
    400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650746221.85
    401 rdf:type schema:Person
    402 sg:person.065562055.72 schema:affiliation grid-institutes:grid.5371.0
    403 schema:familyName Nielsen
    404 schema:givenName Jens
    405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065562055.72
    406 rdf:type schema:Person
    407 sg:person.0725702533.78 schema:affiliation grid-institutes:grid.176731.5
    408 schema:familyName Prideaux
    409 schema:givenName Brendan
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725702533.78
    411 rdf:type schema:Person
    412 sg:person.0726641415.87 schema:affiliation grid-institutes:grid.32224.35
    413 schema:familyName Naxerova
    414 schema:givenName Kamila
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726641415.87
    416 rdf:type schema:Person
    417 sg:person.07414473673.40 schema:affiliation grid-institutes:grid.116068.8
    418 schema:familyName Abbott
    419 schema:givenName Keene L.
    420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07414473673.40
    421 rdf:type schema:Person
    422 sg:person.07423404103.07 schema:affiliation grid-institutes:grid.32224.35
    423 schema:familyName Chen
    424 schema:givenName Jiang
    425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07423404103.07
    426 rdf:type schema:Person
    427 sg:person.0747214567.71 schema:affiliation grid-institutes:grid.62560.37
    428 schema:familyName Lindeman
    429 schema:givenName Neal I.
    430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747214567.71
    431 rdf:type schema:Person
    432 sg:person.0764632420.16 schema:affiliation grid-institutes:grid.66859.34
    433 schema:familyName Clish
    434 schema:givenName Clary B.
    435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16
    436 rdf:type schema:Person
    437 sg:pub.10.1007/s10549-020-05552-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124654843
    438 https://doi.org/10.1007/s10549-020-05552-2
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1007/s11306-016-1065-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1053661934
    441 https://doi.org/10.1007/s11306-016-1065-y
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1023/b:nere.0000010461.34920.0c schema:sameAs https://app.dimensions.ai/details/publication/pub.1018124126
    444 https://doi.org/10.1023/b:nere.0000010461.34920.0c
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/nature15376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008577502
    447 https://doi.org/10.1038/nature15376
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nature18268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023043878
    450 https://doi.org/10.1038/nature18268
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/nature19364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018334075
    453 https://doi.org/10.1038/nature19364
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/ncb3272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032287924
    456 https://doi.org/10.1038/ncb3272
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1038/nprot.2006.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033256129
    459 https://doi.org/10.1038/nprot.2006.179
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1038/nprot.2006.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022893346
    462 https://doi.org/10.1038/nprot.2006.180
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1038/nprot.2012.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044110715
    465 https://doi.org/10.1038/nprot.2012.024
    466 rdf:type schema:CreativeWork
    467 sg:pub.10.1038/nrc.2016.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046768702
    468 https://doi.org/10.1038/nrc.2016.89
    469 rdf:type schema:CreativeWork
    470 sg:pub.10.1038/onc.2014.439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032332400
    471 https://doi.org/10.1038/onc.2014.439
    472 rdf:type schema:CreativeWork
    473 sg:pub.10.1038/s41388-019-0893-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1118099266
    474 https://doi.org/10.1038/s41388-019-0893-4
    475 rdf:type schema:CreativeWork
    476 sg:pub.10.1038/s41467-018-05030-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1105500857
    477 https://doi.org/10.1038/s41467-018-05030-w
    478 rdf:type schema:CreativeWork
    479 sg:pub.10.1038/s41568-019-0205-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1121612558
    480 https://doi.org/10.1038/s41568-019-0205-x
    481 rdf:type schema:CreativeWork
    482 sg:pub.10.1038/s41568-019-0220-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1122943624
    483 https://doi.org/10.1038/s41568-019-0220-y
    484 rdf:type schema:CreativeWork
    485 sg:pub.10.1038/s41572-018-0055-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1111488105
    486 https://doi.org/10.1038/s41572-018-0055-y
    487 rdf:type schema:CreativeWork
    488 sg:pub.10.1038/s41586-019-0977-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1112395501
    489 https://doi.org/10.1038/s41586-019-0977-x
    490 rdf:type schema:CreativeWork
    491 sg:pub.10.1038/s41586-019-1576-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121084590
    492 https://doi.org/10.1038/s41586-019-1576-6
    493 rdf:type schema:CreativeWork
    494 sg:pub.10.1038/s41586-020-2969-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1133346189
    495 https://doi.org/10.1038/s41586-020-2969-2
    496 rdf:type schema:CreativeWork
    497 sg:pub.10.1038/s41591-018-0044-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104478470
    498 https://doi.org/10.1038/s41591-018-0044-4
    499 rdf:type schema:CreativeWork
    500 sg:pub.10.1038/s41598-018-36293-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110537236
    501 https://doi.org/10.1038/s41598-018-36293-4
    502 rdf:type schema:CreativeWork
    503 sg:pub.10.1038/s41598-018-36874-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111644275
    504 https://doi.org/10.1038/s41598-018-36874-3
    505 rdf:type schema:CreativeWork
    506 sg:pub.10.1186/2049-3002-2-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030230764
    507 https://doi.org/10.1186/2049-3002-2-23
    508 rdf:type schema:CreativeWork
    509 sg:pub.10.1186/s12864-016-2911-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044276967
    510 https://doi.org/10.1186/s12864-016-2911-z
    511 rdf:type schema:CreativeWork
    512 grid-institutes:None schema:alternateName Institut de Chimie & Biologie des Membranes & des Nano-objets, CNRS UMR 5248, Bordeaux, France
    513 schema:name Institut de Chimie & Biologie des Membranes & des Nano-objets, CNRS UMR 5248, Bordeaux, France
    514 The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA
    515 rdf:type schema:Organization
    516 grid-institutes:grid.116068.8 schema:alternateName Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    517 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    518 schema:name Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    519 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    520 rdf:type schema:Organization
    521 grid-institutes:grid.16750.35 schema:alternateName Lewis Sigler Institute, Princeton University, Princeton, NJ, USA
    522 schema:name Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    523 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    524 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    525 Lewis Sigler Institute, Princeton University, Princeton, NJ, USA
    526 rdf:type schema:Organization
    527 grid-institutes:grid.176731.5 schema:alternateName Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA
    528 schema:name Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, USA
    529 The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA
    530 rdf:type schema:Organization
    531 grid-institutes:grid.214458.e schema:alternateName University of Michigan, Ann Arbor, MI, USA
    532 schema:name Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    533 University of Michigan, Ann Arbor, MI, USA
    534 rdf:type schema:Organization
    535 grid-institutes:grid.32224.35 schema:alternateName Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    536 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    537 Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    538 schema:name Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    539 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    540 Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    541 rdf:type schema:Organization
    542 grid-institutes:grid.38142.3c schema:alternateName Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    543 schema:name Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    544 rdf:type schema:Organization
    545 grid-institutes:grid.418424.f schema:alternateName Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    546 schema:name Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    547 Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    548 rdf:type schema:Organization
    549 grid-institutes:grid.429392.7 schema:alternateName Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA
    550 schema:name Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA
    551 The Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA
    552 rdf:type schema:Organization
    553 grid-institutes:grid.5371.0 schema:alternateName Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
    554 schema:name Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
    555 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    556 rdf:type schema:Organization
    557 grid-institutes:grid.5386.8 schema:alternateName Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA
    558 schema:name Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    559 Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA
    560 rdf:type schema:Organization
    561 grid-institutes:grid.62560.37 schema:alternateName Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
    562 schema:name Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
    563 Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    564 rdf:type schema:Organization
    565 grid-institutes:grid.65499.37 schema:alternateName Dana-Farber Cancer Institute, Boston, MA, USA
    566 schema:name Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    567 Dana-Farber Cancer Institute, Boston, MA, USA
    568 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    569 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    570 rdf:type schema:Organization
    571 grid-institutes:grid.66859.34 schema:alternateName Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    572 schema:name Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    573 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    574 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...