A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-06-20

AUTHORS

Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente

ABSTRACT

Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to the tissue’s metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient metabolic resources to support growth and proliferation. How endothelial nutrient acquisition and usage are regulated is unknown. Here we show that these processes are instructed by Yes-associated protein 1 (YAP)/WW domain-containing transcription regulator 1 (WWTR1/TAZ)-transcriptional enhanced associate domain (TEAD): a transcriptional module whose function is highly responsive to changes in the tissue environment. ECs lacking YAP/TAZ or their transcriptional partners, TEAD1, 2 and 4 fail to divide, resulting in stunted vascular growth in mice. Conversely, activation of TAZ, the more abundant paralogue in ECs, boosts proliferation, leading to vascular hyperplasia. We find that YAP/TAZ promote angiogenesis by fuelling nutrient-dependent mTORC1 signalling. By orchestrating the transcription of a repertoire of cell-surface transporters, including the large neutral amino acid transporter SLC7A5, YAP/TAZ-TEAD stimulate the import of amino acids and other essential nutrients, thereby enabling mTORC1 activation. Dissociating mTORC1 from these nutrient inputs—elicited by the loss of Rag GTPases—inhibits mTORC1 activity and prevents YAP/TAZ-dependent vascular growth. Together, these findings define a pivotal role for YAP/TAZ-TEAD in controlling endothelial mTORC1 and illustrate the essentiality of coordinated nutrient fluxes in the vasculature. More... »

PAGES

672-682

References to SciGraph publications

  • 2019-03-04. Molecular logic of mTORC1 signalling as a metabolic rheostat in NATURE METABOLISM
  • 2008-09-17. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2016-12-07. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow in NATURE
  • 2018-08-29. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis in NATURE
  • 2003-06-15. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes in NATURE GENETICS
  • 2017-06-07. Nutrient acquisition strategies of mammalian cells in NATURE
  • 2021-04-01. Control of endothelial quiescence by FOXO-regulated metabolites in NATURE CELL BIOLOGY
  • 2013-03-24. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation in NATURE IMMUNOLOGY
  • 2017-05-24. Vascular heterogeneity and specialization in development and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-06-22. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal in NATURE CELL BIOLOGY
  • 2015-11-27. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1 in CELL RESEARCH
  • 2015-08-10. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth in NATURE CELL BIOLOGY
  • 2018-12-13. Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2018-07-26. YAP/TAZ upstream signals and downstream responses in NATURE CELL BIOLOGY
  • 2016-06-27. The Perseus computational platform for comprehensive analysis of (prote)omics data in NATURE METHODS
  • 2008-11-30. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification in NATURE BIOTECHNOLOGY
  • 2018-02-14. A molecular atlas of cell types and zonation in the brain vasculature in NATURE
  • 2018-11-13. mTOR signalling and cellular metabolism are mutual determinants in cancer in NATURE REVIEWS CANCER
  • 2011-04-17. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase in NATURE
  • 2008-07-06. Regulation of TORC1 by Rag GTPases in nutrient response in NATURE CELL BIOLOGY
  • 2016-01-06. FOXO1 couples metabolic activity and growth state in the vascular endothelium in NATURE
  • 2006-12. In-gel digestion for mass spectrometric characterization of proteins and proteomes in NATURE PROTOCOLS
  • Journal

    TITLE

    Nature Metabolism

    ISSUE

    6

    VOLUME

    4

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s42255-022-00584-y

    DOI

    http://dx.doi.org/10.1038/s42255-022-00584-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148802373

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35726026


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acyltransferases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mechanistic Target of Rapamycin Complex 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nutrients", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TEA Domain Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "YAP-Signaling Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ong", 
            "givenName": "Yu Ting", 
            "id": "sg:person.01226266152.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226266152.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany", 
              "id": "http://www.grid.ac/institutes/grid.419491.0", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
                "Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
                "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andrade", 
            "givenName": "Jorge", 
            "id": "sg:person.015275645427.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015275645427.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Armbruster", 
            "givenName": "Max", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shi", 
            "givenName": "Chenyue", 
            "id": "sg:person.016707557234.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016707557234.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany", 
              "id": "http://www.grid.ac/institutes/grid.419491.0", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
                "Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
                "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castro", 
            "givenName": "Marco", 
            "id": "sg:person.010452100572.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010452100572.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA", 
                "Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Costa", 
            "givenName": "Ana S. H.", 
            "id": "sg:person.012711401047.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012711401047.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sugino", 
            "givenName": "Toshiya", 
            "id": "sg:person.010532422425.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010532422425.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute, VIB and KU Leuven, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute, VIB and KU Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eelen", 
            "givenName": "Guy", 
            "id": "sg:person.01313265732.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313265732.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zimmermann", 
            "givenName": "Barbara", 
            "id": "sg:person.01115467712.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115467712.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilhelm", 
            "givenName": "Kerstin", 
            "id": "sg:person.01321722065.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321722065.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany", 
              "id": "http://www.grid.ac/institutes/grid.419491.0", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
                "Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
                "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Joseph", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Shuichi", 
            "id": "sg:person.01064657132.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064657132.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guenther", 
            "givenName": "Stefan", 
            "id": "sg:person.01132772332.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132772332.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schneider", 
            "givenName": "Andre", 
            "id": "sg:person.01064022110.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064022110.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5608.b", 
              "name": [
                "Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zanconato", 
            "givenName": "Francesca", 
            "id": "sg:person.01306435351.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306435351.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biochemistry II, Goethe University, Frankfurt (Main), Germany", 
              "id": "http://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute of Biochemistry II, Goethe University, Frankfurt (Main), Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaulich", 
            "givenName": "Manuel", 
            "id": "sg:person.0705162750.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705162750.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.267313.2", 
              "name": [
                "Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pan", 
            "givenName": "Duojia", 
            "id": "sg:person.014100556557.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014100556557.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418032.c", 
              "name": [
                "Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braun", 
            "givenName": "Thomas", 
            "id": "sg:person.01040300527.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040300527.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vascular Patterning Laboratory, Center for Cancer Biology, VIB and KU Leuven, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
                "Integrative Vascular Biology Laboratory, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany", 
                "DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany", 
                "Vascular Patterning Laboratory, Center for Cancer Biology, VIB and KU Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerhardt", 
            "givenName": "Holger", 
            "id": "sg:person.0754535466.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754535466.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Efeyan", 
            "givenName": "Alejo", 
            "id": "sg:person.01276434177.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276434177.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus, Denmark", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute, VIB and KU Leuven, Leuven, Belgium", 
                "Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates", 
                "Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carmeliet", 
            "givenName": "Peter", 
            "id": "sg:person.01033041553.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IFOM-ETS, the AIRC Institute of Molecular Oncology, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy", 
                "IFOM-ETS, the AIRC Institute of Molecular Oncology, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piccolo", 
            "givenName": "Stefano", 
            "id": "sg:person.01271730410.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271730410.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.10772.33", 
              "name": [
                "UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grosso", 
            "givenName": "Ana Rita", 
            "id": "sg:person.0727530002.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727530002.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany", 
                "Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
                "Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany", 
                "DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Potente", 
            "givenName": "Michael", 
            "id": "sg:person.01336144700.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336144700.82"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41556-021-00637-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1136841935", 
              "https://doi.org/10.1038/s41556-021-00637-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022417218", 
              "https://doi.org/10.1038/ncb3216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027608848", 
              "https://doi.org/10.1186/gb-2008-9-9-r137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014377811", 
              "https://doi.org/10.1038/ng1180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033245681", 
              "https://doi.org/10.1038/ncb1753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041823426", 
              "https://doi.org/10.1038/nature09917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41580-018-0086-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110584108", 
              "https://doi.org/10.1038/s41580-018-0086-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41568-018-0074-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109817252", 
              "https://doi.org/10.1038/s41568-018-0074-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018806814", 
              "https://doi.org/10.1038/ni.2556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2006.468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047515505", 
              "https://doi.org/10.1038/nprot.2006.468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049469421", 
              "https://doi.org/10.1038/nbt.1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2017.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085575671", 
              "https://doi.org/10.1038/nrm.2017.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25739", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101019934", 
              "https://doi.org/10.1038/nature25739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature20602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036853890", 
              "https://doi.org/10.1038/nature20602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41556-018-0142-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105714124", 
              "https://doi.org/10.1038/s41556-018-0142-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2015.140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030759336", 
              "https://doi.org/10.1038/cr.2015.140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005301092", 
              "https://doi.org/10.1038/ncb1748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085889874", 
              "https://doi.org/10.1038/nature22379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0466-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106387008", 
              "https://doi.org/10.1038/s41586-018-0466-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032398342", 
              "https://doi.org/10.1038/nmeth.3901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000797964", 
              "https://doi.org/10.1038/nature16498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s42255-019-0038-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112508465", 
              "https://doi.org/10.1038/s42255-019-0038-7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-06-20", 
        "datePublishedReg": "2022-06-20", 
        "description": "Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to the tissue\u2019s metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient metabolic resources to support growth and proliferation. How endothelial nutrient acquisition and usage are regulated is unknown. Here we show that these processes are instructed by Yes-associated protein 1 (YAP)/WW domain-containing transcription regulator 1 (WWTR1/TAZ)-transcriptional enhanced associate domain (TEAD): a transcriptional module whose function is highly responsive to changes in the tissue environment. ECs lacking YAP/TAZ or their transcriptional partners, TEAD1, 2 and 4 fail to divide, resulting in stunted vascular growth in mice. Conversely, activation of TAZ, the more abundant paralogue in ECs, boosts proliferation, leading to vascular hyperplasia. We find that YAP/TAZ promote angiogenesis by fuelling nutrient-dependent mTORC1 signalling. By orchestrating the transcription of a repertoire of cell-surface transporters, including the large neutral amino acid transporter SLC7A5, YAP/TAZ-TEAD stimulate the import of amino acids and other essential nutrients, thereby enabling mTORC1 activation. Dissociating mTORC1 from these nutrient inputs\u2014elicited by the loss of Rag GTPases\u2014inhibits mTORC1 activity and prevents YAP/TAZ-dependent vascular growth. Together, these findings define a pivotal role for YAP/TAZ-TEAD in controlling endothelial mTORC1 and illustrate the essentiality of coordinated nutrient fluxes in the vasculature.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s42255-022-00584-y", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8454824", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438853", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3786462", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7506739", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7819709", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1336254", 
            "issn": [
              "2522-5812"
            ], 
            "name": "Nature Metabolism", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "keywords": [
          "YAP/TAZ-TEAD", 
          "YAP/TAZ", 
          "Yes-associated protein 1", 
          "nutrient acquisition", 
          "transcription regulator 1", 
          "cell surface transporters", 
          "endothelial cells", 
          "activation of TAZ", 
          "nutrient-deficient sites", 
          "associate domain", 
          "transcriptional partners", 
          "transcriptional modules", 
          "sufficient metabolic resources", 
          "mTORC1 signaling", 
          "metabolic resources", 
          "vascular growth", 
          "amino acids", 
          "new blood vessels", 
          "TAZ", 
          "protein 1", 
          "transporter SLC7A5", 
          "essential nutrients", 
          "nutrient fluxes", 
          "regulator 1", 
          "tissue environment", 
          "amino acid transporter SLC7A5", 
          "pivotal role", 
          "proliferation", 
          "paralogues", 
          "growth", 
          "angiogenesis", 
          "activation", 
          "transcription", 
          "TEAD1", 
          "signaling", 
          "SLC7A5", 
          "essentiality", 
          "transporters", 
          "nutrients", 
          "repertoire", 
          "cells", 
          "import", 
          "blood vessels", 
          "domain", 
          "RAG", 
          "tissue", 
          "sites", 
          "acid", 
          "role", 
          "mice", 
          "activity", 
          "vascular hyperplasia", 
          "function", 
          "partners", 
          "acquisition", 
          "process", 
          "vasculature", 
          "loss", 
          "environment", 
          "changes", 
          "resources", 
          "findings", 
          "flux", 
          "module", 
          "vessels", 
          "one", 
          "hyperplasia", 
          "usage"
        ], 
        "name": "A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth", 
        "pagination": "672-682", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1148802373"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s42255-022-00584-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35726026"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s42255-022-00584-y", 
          "https://app.dimensions.ai/details/publication/pub.1148802373"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_919.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s42255-022-00584-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42255-022-00584-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42255-022-00584-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42255-022-00584-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42255-022-00584-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    469 TRIPLES      21 PREDICATES      124 URIs      94 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s42255-022-00584-y schema:about N0b83e66d00054b65adb9b0572e76da78
    2 N37f29293bebb485fbc9e6b4396208b45
    3 N47d96b8a30df47aa9d4db84331bd77ae
    4 N55b5d9c79e4b41a889581781839fd3d8
    5 N58e63af4161b46a0b506ecd220cc429a
    6 N8043836235774feaa370d38c851f2c53
    7 Nb245ba1ad5cf4259bfb1e040a814267a
    8 Nea53b1803dd745dc8e8d3b5cc775a3b8
    9 Nf444cb5add40435184932757e65d08ab
    10 anzsrc-for:06
    11 anzsrc-for:0601
    12 schema:author Nbb0287f9922b4b0d8eb11166db391f49
    13 schema:citation sg:pub.10.1038/cr.2015.140
    14 sg:pub.10.1038/nature09917
    15 sg:pub.10.1038/nature16498
    16 sg:pub.10.1038/nature20602
    17 sg:pub.10.1038/nature22379
    18 sg:pub.10.1038/nature25739
    19 sg:pub.10.1038/nbt.1511
    20 sg:pub.10.1038/ncb1748
    21 sg:pub.10.1038/ncb1753
    22 sg:pub.10.1038/ncb3216
    23 sg:pub.10.1038/ng1180
    24 sg:pub.10.1038/ni.2556
    25 sg:pub.10.1038/nmeth.3901
    26 sg:pub.10.1038/nprot.2006.468
    27 sg:pub.10.1038/nrm.2017.36
    28 sg:pub.10.1038/s41556-018-0142-z
    29 sg:pub.10.1038/s41556-021-00637-6
    30 sg:pub.10.1038/s41568-018-0074-8
    31 sg:pub.10.1038/s41580-018-0086-y
    32 sg:pub.10.1038/s41586-018-0466-7
    33 sg:pub.10.1038/s42255-019-0038-7
    34 sg:pub.10.1186/gb-2008-9-9-r137
    35 schema:datePublished 2022-06-20
    36 schema:datePublishedReg 2022-06-20
    37 schema:description Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to the tissue’s metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient metabolic resources to support growth and proliferation. How endothelial nutrient acquisition and usage are regulated is unknown. Here we show that these processes are instructed by Yes-associated protein 1 (YAP)/WW domain-containing transcription regulator 1 (WWTR1/TAZ)-transcriptional enhanced associate domain (TEAD): a transcriptional module whose function is highly responsive to changes in the tissue environment. ECs lacking YAP/TAZ or their transcriptional partners, TEAD1, 2 and 4 fail to divide, resulting in stunted vascular growth in mice. Conversely, activation of TAZ, the more abundant paralogue in ECs, boosts proliferation, leading to vascular hyperplasia. We find that YAP/TAZ promote angiogenesis by fuelling nutrient-dependent mTORC1 signalling. By orchestrating the transcription of a repertoire of cell-surface transporters, including the large neutral amino acid transporter SLC7A5, YAP/TAZ-TEAD stimulate the import of amino acids and other essential nutrients, thereby enabling mTORC1 activation. Dissociating mTORC1 from these nutrient inputs—elicited by the loss of Rag GTPases—inhibits mTORC1 activity and prevents YAP/TAZ-dependent vascular growth. Together, these findings define a pivotal role for YAP/TAZ-TEAD in controlling endothelial mTORC1 and illustrate the essentiality of coordinated nutrient fluxes in the vasculature.
    38 schema:genre article
    39 schema:isAccessibleForFree true
    40 schema:isPartOf N04aee859cf8b4b1cb28083750fd44e31
    41 N42cfbb279d2d45dfad81ee90d0d20d60
    42 sg:journal.1336254
    43 schema:keywords RAG
    44 SLC7A5
    45 TAZ
    46 TEAD1
    47 YAP/TAZ
    48 YAP/TAZ-TEAD
    49 Yes-associated protein 1
    50 acid
    51 acquisition
    52 activation
    53 activation of TAZ
    54 activity
    55 amino acid transporter SLC7A5
    56 amino acids
    57 angiogenesis
    58 associate domain
    59 blood vessels
    60 cell surface transporters
    61 cells
    62 changes
    63 domain
    64 endothelial cells
    65 environment
    66 essential nutrients
    67 essentiality
    68 findings
    69 flux
    70 function
    71 growth
    72 hyperplasia
    73 import
    74 loss
    75 mTORC1 signaling
    76 metabolic resources
    77 mice
    78 module
    79 new blood vessels
    80 nutrient acquisition
    81 nutrient fluxes
    82 nutrient-deficient sites
    83 nutrients
    84 one
    85 paralogues
    86 partners
    87 pivotal role
    88 process
    89 proliferation
    90 protein 1
    91 regulator 1
    92 repertoire
    93 resources
    94 role
    95 signaling
    96 sites
    97 sufficient metabolic resources
    98 tissue
    99 tissue environment
    100 transcription
    101 transcription regulator 1
    102 transcriptional modules
    103 transcriptional partners
    104 transporter SLC7A5
    105 transporters
    106 usage
    107 vascular growth
    108 vascular hyperplasia
    109 vasculature
    110 vessels
    111 schema:name A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth
    112 schema:pagination 672-682
    113 schema:productId N0db7e81c8b1e496ea48ca1303bade81e
    114 N447044780e5e449fb3414f8345d385e6
    115 Nc3ff8d322d2a4968ba006e75685b86c4
    116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1148802373
    117 https://doi.org/10.1038/s42255-022-00584-y
    118 schema:sdDatePublished 2022-11-24T21:08
    119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    120 schema:sdPublisher N2b7e934858774234a6dea06efd224428
    121 schema:url https://doi.org/10.1038/s42255-022-00584-y
    122 sgo:license sg:explorer/license/
    123 sgo:sdDataset articles
    124 rdf:type schema:ScholarlyArticle
    125 N04aee859cf8b4b1cb28083750fd44e31 schema:issueNumber 6
    126 rdf:type schema:PublicationIssue
    127 N05fb2e65a8d94246ae29cb2eec26bc35 rdf:first sg:person.015275645427.71
    128 rdf:rest N2794d9b7ce114baea1a3117fd589d7aa
    129 N0b83e66d00054b65adb9b0572e76da78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Endothelial Cells
    131 rdf:type schema:DefinedTerm
    132 N0db7e81c8b1e496ea48ca1303bade81e schema:name dimensions_id
    133 schema:value pub.1148802373
    134 rdf:type schema:PropertyValue
    135 N14949af8f474481c8159ea44736e6724 rdf:first sg:person.01064022110.30
    136 rdf:rest N2039ac10f28147de90e006a0b8bb1393
    137 N2039ac10f28147de90e006a0b8bb1393 rdf:first sg:person.01306435351.42
    138 rdf:rest N76167ad786c448ccbdeb503fe4c9ac76
    139 N213a13d8ea274abc8fbcd68a539ab9f4 rdf:first sg:person.01271730410.35
    140 rdf:rest Nc0d400baeddf4e52a0b3d6d2b29c4ba5
    141 N2794d9b7ce114baea1a3117fd589d7aa rdf:first Ne6b31c75ed7a41348b2979da01c6225f
    142 rdf:rest Nce06b57efdce4b4eb3b69342798e4f1e
    143 N27ccca74770448c6b1d1a6b1d82bfeae schema:affiliation grid-institutes:grid.419491.0
    144 schema:familyName Lim
    145 schema:givenName Joseph
    146 rdf:type schema:Person
    147 N2af20fe3d851435892344c3c205b5646 rdf:first sg:person.01064657132.60
    148 rdf:rest N427a6c3fc4fd4994b292632d9ddc5172
    149 N2b7e934858774234a6dea06efd224428 schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 N2c12ce0fcf20476eb66b92e65b82dcfb rdf:first sg:person.01115467712.12
    152 rdf:rest Nff625539ee7a41b7bdba18847dcc54f9
    153 N37f29293bebb485fbc9e6b4396208b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name TEA Domain Transcription Factors
    155 rdf:type schema:DefinedTerm
    156 N427a6c3fc4fd4994b292632d9ddc5172 rdf:first sg:person.01132772332.58
    157 rdf:rest N14949af8f474481c8159ea44736e6724
    158 N42cfbb279d2d45dfad81ee90d0d20d60 schema:volumeNumber 4
    159 rdf:type schema:PublicationVolume
    160 N447044780e5e449fb3414f8345d385e6 schema:name doi
    161 schema:value 10.1038/s42255-022-00584-y
    162 rdf:type schema:PropertyValue
    163 N461630f45a6d4fdda9311aa6b20110f2 rdf:first sg:person.0754535466.06
    164 rdf:rest Nf578b53007434a449a4715992af62291
    165 N47d96b8a30df47aa9d4db84331bd77ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Animals
    167 rdf:type schema:DefinedTerm
    168 N55b5d9c79e4b41a889581781839fd3d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name YAP-Signaling Proteins
    170 rdf:type schema:DefinedTerm
    171 N57287b311d5b420cb78a9a0b0d6e7a13 rdf:first sg:person.01033041553.19
    172 rdf:rest N213a13d8ea274abc8fbcd68a539ab9f4
    173 N58e63af4161b46a0b506ecd220cc429a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Mice
    175 rdf:type schema:DefinedTerm
    176 N76167ad786c448ccbdeb503fe4c9ac76 rdf:first sg:person.0705162750.04
    177 rdf:rest N7928c9b0909c4d4086d51c33b23e9483
    178 N7928c9b0909c4d4086d51c33b23e9483 rdf:first sg:person.014100556557.22
    179 rdf:rest Nf9ba7ba07f504688ae18c1ed682930b0
    180 N8043836235774feaa370d38c851f2c53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Trans-Activators
    182 rdf:type schema:DefinedTerm
    183 Nb245ba1ad5cf4259bfb1e040a814267a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Mechanistic Target of Rapamycin Complex 1
    185 rdf:type schema:DefinedTerm
    186 Nbb0287f9922b4b0d8eb11166db391f49 rdf:first sg:person.01226266152.74
    187 rdf:rest N05fb2e65a8d94246ae29cb2eec26bc35
    188 Nc0d400baeddf4e52a0b3d6d2b29c4ba5 rdf:first sg:person.0727530002.89
    189 rdf:rest Nf1651f0ffa9e4145badac523c81f9a37
    190 Nc3ff8d322d2a4968ba006e75685b86c4 schema:name pubmed_id
    191 schema:value 35726026
    192 rdf:type schema:PropertyValue
    193 Nc753d67fb60a4ce08abad4e2f5f3647f rdf:first N27ccca74770448c6b1d1a6b1d82bfeae
    194 rdf:rest N2af20fe3d851435892344c3c205b5646
    195 Nce06b57efdce4b4eb3b69342798e4f1e rdf:first sg:person.016707557234.61
    196 rdf:rest Nf4862d26b34f4fc499faf422803e7960
    197 Nd8eaf086e5fe4ab09756d7b4fb401618 rdf:first sg:person.01313265732.75
    198 rdf:rest N2c12ce0fcf20476eb66b92e65b82dcfb
    199 Ndbc1d82f73b2480482810638f2791da9 rdf:first sg:person.012711401047.34
    200 rdf:rest Ne2e83fde540b4cddbd0baba70bbc8ad4
    201 Ne2e83fde540b4cddbd0baba70bbc8ad4 rdf:first sg:person.010532422425.68
    202 rdf:rest Nd8eaf086e5fe4ab09756d7b4fb401618
    203 Ne6b31c75ed7a41348b2979da01c6225f schema:affiliation grid-institutes:grid.418032.c
    204 schema:familyName Armbruster
    205 schema:givenName Max
    206 rdf:type schema:Person
    207 Nea53b1803dd745dc8e8d3b5cc775a3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Acyltransferases
    209 rdf:type schema:DefinedTerm
    210 Nf1651f0ffa9e4145badac523c81f9a37 rdf:first sg:person.01336144700.82
    211 rdf:rest rdf:nil
    212 Nf444cb5add40435184932757e65d08ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Nutrients
    214 rdf:type schema:DefinedTerm
    215 Nf4862d26b34f4fc499faf422803e7960 rdf:first sg:person.010452100572.32
    216 rdf:rest Ndbc1d82f73b2480482810638f2791da9
    217 Nf578b53007434a449a4715992af62291 rdf:first sg:person.01276434177.74
    218 rdf:rest N57287b311d5b420cb78a9a0b0d6e7a13
    219 Nf9ba7ba07f504688ae18c1ed682930b0 rdf:first sg:person.01040300527.03
    220 rdf:rest N461630f45a6d4fdda9311aa6b20110f2
    221 Nff625539ee7a41b7bdba18847dcc54f9 rdf:first sg:person.01321722065.66
    222 rdf:rest Nc753d67fb60a4ce08abad4e2f5f3647f
    223 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Biological Sciences
    225 rdf:type schema:DefinedTerm
    226 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    227 schema:name Biochemistry and Cell Biology
    228 rdf:type schema:DefinedTerm
    229 sg:grant.2438853 http://pending.schema.org/fundedItem sg:pub.10.1038/s42255-022-00584-y
    230 rdf:type schema:MonetaryGrant
    231 sg:grant.3786462 http://pending.schema.org/fundedItem sg:pub.10.1038/s42255-022-00584-y
    232 rdf:type schema:MonetaryGrant
    233 sg:grant.7506739 http://pending.schema.org/fundedItem sg:pub.10.1038/s42255-022-00584-y
    234 rdf:type schema:MonetaryGrant
    235 sg:grant.7819709 http://pending.schema.org/fundedItem sg:pub.10.1038/s42255-022-00584-y
    236 rdf:type schema:MonetaryGrant
    237 sg:grant.8454824 http://pending.schema.org/fundedItem sg:pub.10.1038/s42255-022-00584-y
    238 rdf:type schema:MonetaryGrant
    239 sg:journal.1336254 schema:issn 2522-5812
    240 schema:name Nature Metabolism
    241 schema:publisher Springer Nature
    242 rdf:type schema:Periodical
    243 sg:person.01033041553.19 schema:affiliation grid-institutes:None
    244 schema:familyName Carmeliet
    245 schema:givenName Peter
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19
    247 rdf:type schema:Person
    248 sg:person.01040300527.03 schema:affiliation grid-institutes:grid.418032.c
    249 schema:familyName Braun
    250 schema:givenName Thomas
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040300527.03
    252 rdf:type schema:Person
    253 sg:person.010452100572.32 schema:affiliation grid-institutes:grid.419491.0
    254 schema:familyName Castro
    255 schema:givenName Marco
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010452100572.32
    257 rdf:type schema:Person
    258 sg:person.010532422425.68 schema:affiliation grid-institutes:grid.418032.c
    259 schema:familyName Sugino
    260 schema:givenName Toshiya
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010532422425.68
    262 rdf:type schema:Person
    263 sg:person.01064022110.30 schema:affiliation grid-institutes:grid.418032.c
    264 schema:familyName Schneider
    265 schema:givenName Andre
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064022110.30
    267 rdf:type schema:Person
    268 sg:person.01064657132.60 schema:affiliation grid-institutes:grid.418032.c
    269 schema:familyName Watanabe
    270 schema:givenName Shuichi
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064657132.60
    272 rdf:type schema:Person
    273 sg:person.01115467712.12 schema:affiliation grid-institutes:grid.418032.c
    274 schema:familyName Zimmermann
    275 schema:givenName Barbara
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115467712.12
    277 rdf:type schema:Person
    278 sg:person.01132772332.58 schema:affiliation grid-institutes:grid.418032.c
    279 schema:familyName Guenther
    280 schema:givenName Stefan
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132772332.58
    282 rdf:type schema:Person
    283 sg:person.01226266152.74 schema:affiliation grid-institutes:grid.418032.c
    284 schema:familyName Ong
    285 schema:givenName Yu Ting
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226266152.74
    287 rdf:type schema:Person
    288 sg:person.012711401047.34 schema:affiliation grid-institutes:grid.59734.3c
    289 schema:familyName Costa
    290 schema:givenName Ana S. H.
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012711401047.34
    292 rdf:type schema:Person
    293 sg:person.01271730410.35 schema:affiliation grid-institutes:None
    294 schema:familyName Piccolo
    295 schema:givenName Stefano
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271730410.35
    297 rdf:type schema:Person
    298 sg:person.01276434177.74 schema:affiliation grid-institutes:grid.7719.8
    299 schema:familyName Efeyan
    300 schema:givenName Alejo
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276434177.74
    302 rdf:type schema:Person
    303 sg:person.01306435351.42 schema:affiliation grid-institutes:grid.5608.b
    304 schema:familyName Zanconato
    305 schema:givenName Francesca
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306435351.42
    307 rdf:type schema:Person
    308 sg:person.01313265732.75 schema:affiliation grid-institutes:grid.5596.f
    309 schema:familyName Eelen
    310 schema:givenName Guy
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313265732.75
    312 rdf:type schema:Person
    313 sg:person.01321722065.66 schema:affiliation grid-institutes:grid.418032.c
    314 schema:familyName Wilhelm
    315 schema:givenName Kerstin
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321722065.66
    317 rdf:type schema:Person
    318 sg:person.01336144700.82 schema:affiliation grid-institutes:grid.452396.f
    319 schema:familyName Potente
    320 schema:givenName Michael
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336144700.82
    322 rdf:type schema:Person
    323 sg:person.014100556557.22 schema:affiliation grid-institutes:grid.267313.2
    324 schema:familyName Pan
    325 schema:givenName Duojia
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014100556557.22
    327 rdf:type schema:Person
    328 sg:person.015275645427.71 schema:affiliation grid-institutes:grid.419491.0
    329 schema:familyName Andrade
    330 schema:givenName Jorge
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015275645427.71
    332 rdf:type schema:Person
    333 sg:person.016707557234.61 schema:affiliation grid-institutes:grid.418032.c
    334 schema:familyName Shi
    335 schema:givenName Chenyue
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016707557234.61
    337 rdf:type schema:Person
    338 sg:person.0705162750.04 schema:affiliation grid-institutes:grid.7839.5
    339 schema:familyName Kaulich
    340 schema:givenName Manuel
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705162750.04
    342 rdf:type schema:Person
    343 sg:person.0727530002.89 schema:affiliation grid-institutes:grid.10772.33
    344 schema:familyName Grosso
    345 schema:givenName Ana Rita
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727530002.89
    347 rdf:type schema:Person
    348 sg:person.0754535466.06 schema:affiliation grid-institutes:grid.5596.f
    349 schema:familyName Gerhardt
    350 schema:givenName Holger
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754535466.06
    352 rdf:type schema:Person
    353 sg:pub.10.1038/cr.2015.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030759336
    354 https://doi.org/10.1038/cr.2015.140
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nature09917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041823426
    357 https://doi.org/10.1038/nature09917
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nature16498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000797964
    360 https://doi.org/10.1038/nature16498
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nature20602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036853890
    363 https://doi.org/10.1038/nature20602
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nature22379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085889874
    366 https://doi.org/10.1038/nature22379
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nature25739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101019934
    369 https://doi.org/10.1038/nature25739
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/nbt.1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469421
    372 https://doi.org/10.1038/nbt.1511
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/ncb1748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005301092
    375 https://doi.org/10.1038/ncb1748
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ncb1753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033245681
    378 https://doi.org/10.1038/ncb1753
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/ncb3216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022417218
    381 https://doi.org/10.1038/ncb3216
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/ng1180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014377811
    384 https://doi.org/10.1038/ng1180
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/ni.2556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018806814
    387 https://doi.org/10.1038/ni.2556
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/nmeth.3901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032398342
    390 https://doi.org/10.1038/nmeth.3901
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nprot.2006.468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047515505
    393 https://doi.org/10.1038/nprot.2006.468
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nrm.2017.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085575671
    396 https://doi.org/10.1038/nrm.2017.36
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/s41556-018-0142-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1105714124
    399 https://doi.org/10.1038/s41556-018-0142-z
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/s41556-021-00637-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1136841935
    402 https://doi.org/10.1038/s41556-021-00637-6
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/s41568-018-0074-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109817252
    405 https://doi.org/10.1038/s41568-018-0074-8
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/s41580-018-0086-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1110584108
    408 https://doi.org/10.1038/s41580-018-0086-y
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/s41586-018-0466-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106387008
    411 https://doi.org/10.1038/s41586-018-0466-7
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/s42255-019-0038-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112508465
    414 https://doi.org/10.1038/s42255-019-0038-7
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
    417 https://doi.org/10.1186/gb-2008-9-9-r137
    418 rdf:type schema:CreativeWork
    419 grid-institutes:None schema:alternateName IFOM-ETS, the AIRC Institute of Molecular Oncology, Milan, Italy
    420 Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus, Denmark
    421 schema:name Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
    422 Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy
    423 IFOM-ETS, the AIRC Institute of Molecular Oncology, Milan, Italy
    424 Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus, Denmark
    425 Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute, VIB and KU Leuven, Leuven, Belgium
    426 rdf:type schema:Organization
    427 grid-institutes:grid.10772.33 schema:alternateName UCIBIO – Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal
    428 schema:name UCIBIO – Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Caparica, Portugal
    429 rdf:type schema:Organization
    430 grid-institutes:grid.267313.2 schema:alternateName Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
    431 schema:name Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
    432 rdf:type schema:Organization
    433 grid-institutes:grid.418032.c schema:alternateName Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    434 Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    435 schema:name Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    436 Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    437 rdf:type schema:Organization
    438 grid-institutes:grid.419491.0 schema:alternateName Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
    439 schema:name Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    440 Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Berlin, Germany
    441 Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
    442 rdf:type schema:Organization
    443 grid-institutes:grid.452396.f schema:alternateName DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany
    444 schema:name Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    445 Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Berlin, Germany
    446 DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany
    447 Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
    448 rdf:type schema:Organization
    449 grid-institutes:grid.5596.f schema:alternateName Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute, VIB and KU Leuven, Leuven, Belgium
    450 Vascular Patterning Laboratory, Center for Cancer Biology, VIB and KU Leuven, Leuven, Belgium
    451 schema:name Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Berlin, Germany
    452 DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany
    453 Integrative Vascular Biology Laboratory, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
    454 Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute, VIB and KU Leuven, Leuven, Belgium
    455 Vascular Patterning Laboratory, Center for Cancer Biology, VIB and KU Leuven, Leuven, Belgium
    456 rdf:type schema:Organization
    457 grid-institutes:grid.5608.b schema:alternateName Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy
    458 schema:name Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy
    459 rdf:type schema:Organization
    460 grid-institutes:grid.59734.3c schema:alternateName Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    461 schema:name Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    462 Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    463 rdf:type schema:Organization
    464 grid-institutes:grid.7719.8 schema:alternateName Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre, Madrid, Spain
    465 schema:name Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre, Madrid, Spain
    466 rdf:type schema:Organization
    467 grid-institutes:grid.7839.5 schema:alternateName Institute of Biochemistry II, Goethe University, Frankfurt (Main), Germany
    468 schema:name Institute of Biochemistry II, Goethe University, Frankfurt (Main), Germany
    469 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...