Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-16

AUTHORS

Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K. Hedman, Andrew Schork, Karen Page, Daria V. Zhernakova, Yang Wu, James Peters, Niclas Eriksson, Sarah E. Bergen, Thibaud S. Boutin, Andrew D. Bretherick, Stefan Enroth, Anette Kalnapenkis, Jesper R. Gådin, Bianca E. Suur, Yan Chen, Ljubica Matic, Jeremy D. Gale, Julie Lee, Weidong Zhang, Amira Quazi, Mika Ala-Korpela, Seung Hoan Choi, Annique Claringbould, John Danesh, George Davey Smith, Federico de Masi, Sölve Elmståhl, Gunnar Engström, Eric Fauman, Celine Fernandez, Lude Franke, Paul W. Franks, Vilmantas Giedraitis, Chris Haley, Anders Hamsten, Andres Ingason, Åsa Johansson, Peter K. Joshi, Lars Lind, Cecilia M. Lindgren, Steven Lubitz, Tom Palmer, Erin Macdonald-Dunlop, Martin Magnusson, Olle Melander, Karl Michaelsson, Andrew P. Morris, Reedik Mägi, Michael W. Nagle, Peter M. Nilsson, Jan Nilsson, Marju Orho-Melander, Ozren Polasek, Bram Prins, Erik Pålsson, Ting Qi, Marketa Sjögren, Johan Sundström, Praveen Surendran, Urmo Võsa, Thomas Werge, Rasmus Wernersson, Harm-Jan Westra, Jian Yang, Alexandra Zhernakova, Johan Ärnlöv, Jingyuan Fu, J. Gustav Smith, Tõnu Esko, Caroline Hayward, Ulf Gyllensten, Mikael Landen, Agneta Siegbahn, James F. Wilson, Lars Wallentin, Adam S. Butterworth, Michael V. Holmes, Erik Ingelsson, Anders Mälarstig

ABSTRACT

Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health. More... »

PAGES

1135-1148

References to SciGraph publications

  • 2012-03-28. Zhou et al. reply in NATURE GENETICS
  • 2003-06-08. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 in NATURE MEDICINE
  • 2018-09-24. Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome in NATURE GENETICS
  • 2002-06. Novel phosphate-regulating genes in the pathogenesis of renal phosphate wasting disorders in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2017-06-01. Mendelian randomization in cardiometabolic disease: challenges in evaluating causality in NATURE REVIEWS CARDIOLOGY
  • 2015-02-02. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies in NATURE GENETICS
  • 2018-12-04. Identification of 55,000 Replicated DNA Methylation QTL in SCIENTIFIC REPORTS
  • 2013-09-08. Systematic identification of trans eQTLs as putative drivers of known disease associations in NATURE GENETICS
  • 2015-08-10. A gene-based association method for mapping traits using reference transcriptome data in NATURE GENETICS
  • 2017-10-12. Genetic effects on gene expression across human tissues in NATURE
  • 2018-06-06. Genomic atlas of the human plasma proteome in NATURE
  • 2014-08-22. Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs in NATURE COMMUNICATIONS
  • 2016-03-28. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets in NATURE GENETICS
  • 2016-03-04. Onto better TRAILs for cancer treatment in CELL DEATH & DIFFERENTIATION
  • 2019-12-02. Plasma protein patterns as comprehensive indicators of health in NATURE MEDICINE
  • 2018-10-10. The UK Biobank resource with deep phenotyping and genomic data in NATURE
  • 2019-09-20. A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity in NPJ GENOMIC MEDICINE
  • 2019-12-05. Undulating changes in human plasma proteome profiles across the lifespan in NATURE MEDICINE
  • 2016-06-15. Defining the consequences of genetic variation on a proteome-wide scale in NATURE
  • Journal

    TITLE

    Nature Metabolism

    ISSUE

    10

    VOLUME

    2

    Author Affiliations

  • SCALLOP consortium
  • Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
  • Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland
  • Intomics A/S, Kgs. Lyngby, Denmark
  • Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA
  • Neurogenomics Division, The Translational Genomics Research Institute (TGEN), Phoenix, AZ, USA
  • Early Clinical Development, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA
  • Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
  • Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
  • Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK
  • Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
  • Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
  • MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
  • Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala University, Uppsala, Sweden
  • Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
  • Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden
  • Inflammation and Immunology Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA
  • Pfizer Global Product Development, Cambridge, MA, USA
  • NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
  • Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
  • Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK
  • MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
  • Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
  • Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA
  • Department of Clinical Sciences, Lund University Diabetes Center, Malmö, Sweden
  • Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden
  • Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region, Roskilde, Denmark
  • Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
  • Department of Medical Sciences, Uppsala University, Uppsala, Sweden
  • Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
  • Department of Mathematics and Statistics, University of Lancaster, Lancaster, UK
  • North-West University, Hypertension in Africa Research Team (HART), Potchefstroom, South Africa
  • Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
  • Department of Biostatistics, University of Liverpool, Liverpool, UK
  • Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
  • Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden
  • Faculty of Medicine, University of Split, Split, Croatia
  • Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK
  • Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  • The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
  • Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China
  • Department of Neurobiology, Care Sciences and Society (NVS) Division of Family Medicine and Primary Care, Karolinska Institute, Solna, Sweden
  • Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
  • Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden
  • Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden
  • Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
  • National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
  • Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK
  • Department of Medicine, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA, USA
  • Emerging Science & Innovation, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s42255-020-00287-2

    DOI

    http://dx.doi.org/10.1038/s42255-020-00287-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131771940

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33067605


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