Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Youqiong Ye, Qingsong Hu, Hu Chen, Ke Liang, Yuan Yuan, Yu Xiang, Hang Ruan, Zhao Zhang, Anren Song, Huiwen Zhang, Lingxiang Liu, Lixia Diao, Yanyan Lou, Bingying Zhou, Li Wang, Shengtao Zhou, Jianjun Gao, Eric Jonasch, Steven H. Lin, Yang Xia, Chunru Lin, Liuqing Yang, Gordon B. Mills, Han Liang, Leng Han

ABSTRACT

The conventional view holds that hypoxia confers drug resistance. In contrast, here the authors use a multilayer ‘omics data approach to characterize the molecular features associated with tumour hypoxia and identify molecular alterations that correlate with both drug-resistant and drug-sensitive responses to approved drugs.

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42255-019-0045-8

DOI

http://dx.doi.org/10.1038/s42255-019-0045-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112847872


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468 https://www.grid.ac/institutes/grid.461863.e schema:alternateName West China Second University Hospital of Sichuan University
469 schema:name Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
470 rdf:type schema:Organization
471 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
472 schema:name Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, USA
473 Knight Cancer Institute, Oregon Health and Science University, Portland, USA
474 rdf:type schema:Organization
 




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