Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-09-19

AUTHORS

Bharath Sunchu, Nicole MynYi Lee, Jennifer A. Taylor, Roberto Carlos Segura, Chantal Roubinet, Clemens Cabernard

ABSTRACT

Hybrid cells derived through fertilization or somatic cell fusion recognize and separate chromosomes of different origins. The underlying mechanisms are unknown but could prevent aneuploidy and tumor formation. Here, we acutely induce fusion between Drosophila neural stem cells (neuroblasts; NBs) and differentiating ganglion mother cells (GMCs) in vivo to define how epigenetically distinct chromatin is recognized and segregated. We find that NB-GMC hybrid cells align both endogenous (neuroblast-origin) and ectopic (GMC-origin) chromosomes at the metaphase plate through centrosome derived dual-spindles. Physical separation of endogenous and ectopic chromatin is achieved through asymmetric, microtubule-dependent chromatin retention in interphase and physical boundaries imposed by nuclear envelopes. The chromatin separation mechanisms described here could apply to the first zygotic division in insects, arthropods, and vertebrates or potentially inform biased chromatid segregation in stem cells. More... »

PAGES

953

References to SciGraph publications

  • 2008-02-19. Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development in NEURAL DEVELOPMENT
  • 1999-12-10. Spindle assembly in Drosophila neuroblasts and ganglion mother cells in NATURE CELL BIOLOGY
  • 2010-09. A spindle-independent cleavage furrow positioning pathway in NATURE
  • 2011-03-15. Drosophila neuroblasts retain the daughter centrosome in NATURE COMMUNICATIONS
  • 2005-06-15. Biological implications of cell fusion in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-02-08. Mitotic spindle assembly in animal cells: a fine balancing act in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-04-14. Drosophila melanogaster Neuroblasts: A Model for Asymmetric Stem Cell Divisions in ASYMMETRIC CELL DIVISION IN DEVELOPMENT, DIFFERENTIATION AND CANCER
  • 2005-10. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells in NATURE
  • 2013-05-05. Chromosome-specific nonrandom sister chromatid segregation during stem-cell division in NATURE
  • 2003. Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes in CHROMOSOME RESEARCH
  • 2007-07. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila in NATURE
  • 2017-11-09. Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells in NATURE COMMUNICATIONS
  • 2013-01-27. Centrobin controls mother–daughter centriole asymmetry in Drosophila neuroblasts in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s42003-022-03874-z

    DOI

    http://dx.doi.org/10.1038/s42003-022-03874-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1151122463

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/36123528


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