Genetic, parental and lifestyle factors influence telomere length View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-06-09

AUTHORS

Sergio Andreu-Sánchez, Geraldine Aubert, Aida Ripoll-Cladellas, Sandra Henkelman, Daria V. Zhernakova, Trishla Sinha, Alexander Kurilshikov, Maria Carmen Cenit, Marc Jan Bonder, Lude Franke, Cisca Wijmenga, Jingyuan Fu, Monique G. P. van der Wijst, Marta Melé, Peter Lansdorp, Alexandra Zhernakova

ABSTRACT

The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle. More... »

PAGES

565

References to SciGraph publications

  • 2021-03-15. Correction for both common and rare cell types in blood is important to identify genes that correlate with age in BMC GENOMICS
  • 2015-04-30. Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking in EUROPEAN RADIOLOGY
  • 2017-01-16. Massively parallel digital transcriptional profiling of single cells in NATURE COMMUNICATIONS
  • 2018-06-25. Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway in NATURE CELL BIOLOGY
  • 2016-08-22. A reference panel of 64,976 haplotypes for genotype imputation in NATURE GENETICS
  • 2015-04-13. Spatial reconstruction of single-cell gene expression data in NATURE BIOTECHNOLOGY
  • 2019-06-06. Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies in NATURE COMMUNICATIONS
  • 2019-07-01. DNA methylation links prenatal smoking exposure to later life health outcomes in offspring in CLINICAL EPIGENETICS
  • 2013-03-27. Identification of seven loci affecting mean telomere length and their association with disease in NATURE GENETICS
  • 2018-09-24. Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome in NATURE GENETICS
  • 2015-11-11. IL7R gene expression network associates with human healthy ageing in IMMUNITY & AGEING
  • 2015-10-14. DNA methylation, early life environment, and health outcomes in PEDIATRIC RESEARCH
  • 2015-01-31. Aging and DNA methylation in BMC BIOLOGY
  • 2013-01-16. Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2018-12-18. The polygenic nature of telomere length and the anti-ageing properties of lithium in NEUROPSYCHOPHARMACOLOGY
  • 2011-04-05. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells in NATURE COMMUNICATIONS
  • 2015-02-25. Second-generation PLINK: rising to the challenge of larger and richer datasets in GIGASCIENCE
  • 2006-12-21. Flow cytometry and FISH to measure the average length of telomeres (flow FISH) in NATURE PROTOCOLS
  • 1986. Changes in the Human Thymus During Aging in THE HUMAN THYMUS
  • 2010-07-13. A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length in CELL RESEARCH
  • 2014-05-14. Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci in SCIENTIFIC REPORTS
  • 2016-08-29. Next-generation genotype imputation service and methods in NATURE GENETICS
  • 1991-04. Structure and function of telomeres in NATURE
  • 2018-02-22. Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF in CELL DEATH & DIFFERENTIATION
  • 2013-03-19. Telomeres shorten at equivalent rates in somatic tissues of adults in NATURE COMMUNICATIONS
  • 2015-12-10. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data in GENOME BIOLOGY
  • 2009-12-13. Cdk2 suppresses cellular senescence induced by the c-myc oncogene in NATURE CELL BIOLOGY
  • 2009-01-14. BioMart – biological queries made easy in BMC GENOMICS
  • 2007-02. Interleukin-7 receptor expression: intelligent design in NATURE REVIEWS IMMUNOLOGY
  • 2016-12-05. Disease variants alter transcription factor levels and methylation of their binding sites in NATURE GENETICS
  • 2019-12-02. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s42003-022-03521-7

    DOI

    http://dx.doi.org/10.1038/s42003-022-03521-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148543508

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35681050


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Life Style", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Telomere", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
                "Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andreu-S\u00e1nchez", 
            "givenName": "Sergio", 
            "id": "sg:person.015367611505.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015367611505.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Repeat Diagnostics Inc, Vancouver, BC, Canada", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada", 
                "Repeat Diagnostics Inc, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aubert", 
            "givenName": "Geraldine", 
            "id": "sg:person.01153221507.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153221507.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Life Sciences Department, Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10097.3f", 
              "name": [
                "Life Sciences Department, Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ripoll-Cladellas", 
            "givenName": "Aida", 
            "id": "sg:person.010676621313.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010676621313.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Henkelman", 
            "givenName": "Sandra", 
            "id": "sg:person.01040634623.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040634623.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, 197101, St. Petersburg, Russia", 
              "id": "http://www.grid.ac/institutes/grid.35915.3b", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
                "Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, 197101, St. Petersburg, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhernakova", 
            "givenName": "Daria V.", 
            "id": "sg:person.0763077514.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763077514.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sinha", 
            "givenName": "Trishla", 
            "id": "sg:person.016145143724.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016145143724.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurilshikov", 
            "givenName": "Alexander", 
            "id": "sg:person.0675230535.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675230535.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Microbial Ecology, Nutrition, and Health Research Unit, Institute of Agrochemistry and Food Technology (IATA-CSIC), 46980, Paterna-Valencia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.419051.8", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
                "Microbial Ecology, Nutrition, and Health Research Unit, Institute of Agrochemistry and Food Technology (IATA-CSIC), 46980, Paterna-Valencia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cenit", 
            "givenName": "Maria Carmen", 
            "id": "sg:person.011464064267.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464064267.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
                "Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany", 
                "European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jan Bonder", 
            "givenName": "Marc", 
            "id": "sg:person.07604232114.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07604232114.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franke", 
            "givenName": "Lude", 
            "id": "sg:person.01344404521.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344404521.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wijmenga", 
            "givenName": "Cisca", 
            "id": "sg:person.01372510466.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372510466.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
                "Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fu", 
            "givenName": "Jingyuan", 
            "id": "sg:person.01316140701.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316140701.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Wijst", 
            "givenName": "Monique G. P.", 
            "id": "sg:person.0617441150.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617441150.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Life Sciences Department, Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10097.3f", 
              "name": [
                "Life Sciences Department, Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mel\u00e9", 
            "givenName": "Marta", 
            "id": "sg:person.011526330120.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011526330120.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Hematology and Medical Genetics, University of British Columbia, Vancouver, BC, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada", 
                "European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands", 
                "Departments of Hematology and Medical Genetics, University of British Columbia, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lansdorp", 
            "givenName": "Peter", 
            "id": "sg:person.013371511617.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013371511617.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhernakova", 
            "givenName": "Alexandra", 
            "id": "sg:person.01133243663.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133243663.61"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ncomms14049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019155899", 
              "https://doi.org/10.1038/ncomms14049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0224-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107129402", 
              "https://doi.org/10.1038/s41588-018-0224-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009985365", 
              "https://doi.org/10.1038/nri2023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009318815", 
              "https://doi.org/10.1038/nbt.3192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-82480-7_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053233785", 
              "https://doi.org/10.1007/978-3-642-82480-7_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002714621", 
              "https://doi.org/10.1038/ng.2528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/350569a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000415071", 
              "https://doi.org/10.1038/350569a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41418-018-0072-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101164275", 
              "https://doi.org/10.1038/s41418-018-0072-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025378212", 
              "https://doi.org/10.1038/ng.3721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-019-10443-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1116848560", 
              "https://doi.org/10.1038/s41467-019-10443-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2012.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000460270", 
              "https://doi.org/10.1038/ejhg.2012.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0844-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025156179", 
              "https://doi.org/10.1186/s13059-015-0844-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-020-07344-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1136413428", 
              "https://doi.org/10.1186/s12864-020-07344-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41556-018-0127-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105071575", 
              "https://doi.org/10.1038/s41556-018-0127-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028672919", 
              "https://doi.org/10.1038/ncb2004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2010.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051566543", 
              "https://doi.org/10.1038/cr.2010.107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms2602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043076458", 
              "https://doi.org/10.1038/ncomms2602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-015-0118-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029450603", 
              "https://doi.org/10.1186/s12915-015-0118-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005327822", 
              "https://doi.org/10.1038/ncomms1272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep04954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034967149", 
              "https://doi.org/10.1038/srep04954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13148-019-0683-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1117679678", 
              "https://doi.org/10.1186/s13148-019-0683-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2006.263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034695080", 
              "https://doi.org/10.1038/nprot.2006.263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41386-018-0289-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110452985", 
              "https://doi.org/10.1038/s41386-018-0289-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050700099", 
              "https://doi.org/10.1038/ng.3643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00330-015-3796-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042198327", 
              "https://doi.org/10.1007/s00330-015-3796-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12979-015-0048-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040337542", 
              "https://doi.org/10.1186/s12979-015-0048-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pr.2015.193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023221150", 
              "https://doi.org/10.1038/pr.2015.193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-10-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051697715", 
              "https://doi.org/10.1186/1471-2164-10-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13742-015-0047-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037894462", 
              "https://doi.org/10.1186/s13742-015-0047-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-019-13448-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123047705", 
              "https://doi.org/10.1038/s41467-019-13448-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006258085", 
              "https://doi.org/10.1038/ng.3656"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-06-09", 
        "datePublishedReg": "2022-06-09", 
        "description": "The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s42003-022-03521-7", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4138555", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6946765", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9995308", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9461086", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6622959", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9461173", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4057294", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3799964", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.10012784", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9732045", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1300829", 
            "issn": [
              "2399-3642"
            ], 
            "name": "Communications Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "keywords": [
          "telomere repeats", 
          "gene expression", 
          "single-cell RNA-sequencing data", 
          "genome-wide methylation patterns", 
          "nonsense-mediated decay", 
          "specific gene expression", 
          "RNA-sequencing data", 
          "differential gene expression", 
          "blood cell types", 
          "flow-FISH method", 
          "methylation patterns", 
          "cell types", 
          "host genetics", 
          "genetics", 
          "biological aging", 
          "specific variations", 
          "intrinsic factors", 
          "specific differences", 
          "expression", 
          "epigenetics", 
          "genes", 
          "repeats", 
          "biology", 
          "pathway", 
          "T cells", 
          "variation", 
          "parental age", 
          "translation", 
          "average length", 
          "markers", 
          "factors", 
          "role", 
          "length", 
          "patterns", 
          "aging", 
          "individuals", 
          "association", 
          "types", 
          "lifestyle", 
          "study", 
          "differences", 
          "sex", 
          "data", 
          "decay", 
          "maternal", 
          "relation", 
          "top", 
          "association of maternal", 
          "age", 
          "method", 
          "lifestyle factors", 
          "perinatal factors", 
          "smoking", 
          "participants"
        ], 
        "name": "Genetic, parental and lifestyle factors influence telomere length", 
        "pagination": "565", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1148543508"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s42003-022-03521-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35681050"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s42003-022-03521-7", 
          "https://app.dimensions.ai/details/publication/pub.1148543508"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:50", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_956.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s42003-022-03521-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-022-03521-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-022-03521-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-022-03521-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-022-03521-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    425 TRIPLES      21 PREDICATES      118 URIs      79 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s42003-022-03521-7 schema:about N185876d1f3464649985c692f388963aa
    2 N190e5db2280a466b9978dfbc2c355042
    3 N1b89d0bd8f26411da782d9dd92647344
    4 N1f7fc65d77b8414d831a87911cdcad4a
    5 N6ff560d681c249d3ac478fc1db25a4ba
    6 Nb38b83cece704fdfb0079da500d73d1b
    7 Nc5911450b18f41118fd9bbef94211a74
    8 Nfae1db0f12854097ad8b68b938eafc3b
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author N6f09104c20734b63b22fc52a7c6c877a
    12 schema:citation sg:pub.10.1007/978-3-642-82480-7_2
    13 sg:pub.10.1007/s00330-015-3796-y
    14 sg:pub.10.1038/350569a0
    15 sg:pub.10.1038/cr.2010.107
    16 sg:pub.10.1038/ejhg.2012.303
    17 sg:pub.10.1038/nbt.3192
    18 sg:pub.10.1038/ncb2004
    19 sg:pub.10.1038/ncomms1272
    20 sg:pub.10.1038/ncomms14049
    21 sg:pub.10.1038/ncomms2602
    22 sg:pub.10.1038/ng.2528
    23 sg:pub.10.1038/ng.3643
    24 sg:pub.10.1038/ng.3656
    25 sg:pub.10.1038/ng.3721
    26 sg:pub.10.1038/nprot.2006.263
    27 sg:pub.10.1038/nri2023
    28 sg:pub.10.1038/pr.2015.193
    29 sg:pub.10.1038/s41386-018-0289-0
    30 sg:pub.10.1038/s41418-018-0072-0
    31 sg:pub.10.1038/s41467-019-10443-2
    32 sg:pub.10.1038/s41467-019-13448-z
    33 sg:pub.10.1038/s41556-018-0127-y
    34 sg:pub.10.1038/s41588-018-0224-7
    35 sg:pub.10.1038/srep04954
    36 sg:pub.10.1186/1471-2164-10-22
    37 sg:pub.10.1186/s12864-020-07344-w
    38 sg:pub.10.1186/s12915-015-0118-4
    39 sg:pub.10.1186/s12979-015-0048-6
    40 sg:pub.10.1186/s13059-015-0844-5
    41 sg:pub.10.1186/s13148-019-0683-4
    42 sg:pub.10.1186/s13742-015-0047-8
    43 schema:datePublished 2022-06-09
    44 schema:datePublishedReg 2022-06-09
    45 schema:description The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.
    46 schema:genre article
    47 schema:isAccessibleForFree true
    48 schema:isPartOf N5aea682e4927422db323a89e31cf3c03
    49 Nca889bf7897842968075be5eb11f257c
    50 sg:journal.1300829
    51 schema:keywords RNA-sequencing data
    52 T cells
    53 age
    54 aging
    55 association
    56 association of maternal
    57 average length
    58 biological aging
    59 biology
    60 blood cell types
    61 cell types
    62 data
    63 decay
    64 differences
    65 differential gene expression
    66 epigenetics
    67 expression
    68 factors
    69 flow-FISH method
    70 gene expression
    71 genes
    72 genetics
    73 genome-wide methylation patterns
    74 host genetics
    75 individuals
    76 intrinsic factors
    77 length
    78 lifestyle
    79 lifestyle factors
    80 markers
    81 maternal
    82 method
    83 methylation patterns
    84 nonsense-mediated decay
    85 parental age
    86 participants
    87 pathway
    88 patterns
    89 perinatal factors
    90 relation
    91 repeats
    92 role
    93 sex
    94 single-cell RNA-sequencing data
    95 smoking
    96 specific differences
    97 specific gene expression
    98 specific variations
    99 study
    100 telomere repeats
    101 top
    102 translation
    103 types
    104 variation
    105 schema:name Genetic, parental and lifestyle factors influence telomere length
    106 schema:pagination 565
    107 schema:productId N482b2f899ac24940b471c5b6a7cdd637
    108 N7ca4962861884c0abf7e49f18fd2a59c
    109 Ndd10cdee8a7248f5b40a1b77ff352dd4
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1148543508
    111 https://doi.org/10.1038/s42003-022-03521-7
    112 schema:sdDatePublished 2022-10-01T06:50
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N86a607cca56746f29ab569d7ed70e989
    115 schema:url https://doi.org/10.1038/s42003-022-03521-7
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N011d37a750dd42f59be2e9fbdc9c1576 rdf:first sg:person.0763077514.08
    120 rdf:rest Ne57a6437f9ca41e6a9b3343a1e5cd276
    121 N0f2029200d884e16968be68ecbade279 rdf:first sg:person.01316140701.98
    122 rdf:rest N846ac3c823bb40079fc3394b10daee47
    123 N185876d1f3464649985c692f388963aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Female
    125 rdf:type schema:DefinedTerm
    126 N190e5db2280a466b9978dfbc2c355042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Humans
    128 rdf:type schema:DefinedTerm
    129 N1b89d0bd8f26411da782d9dd92647344 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Aging
    131 rdf:type schema:DefinedTerm
    132 N1f7fc65d77b8414d831a87911cdcad4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Life Style
    134 rdf:type schema:DefinedTerm
    135 N24db171e2ff044a2a5363c416d42dc65 rdf:first sg:person.013371511617.13
    136 rdf:rest Nfa3a825594894aa7aee4104d370d5cb6
    137 N482b2f899ac24940b471c5b6a7cdd637 schema:name pubmed_id
    138 schema:value 35681050
    139 rdf:type schema:PropertyValue
    140 N4d24d147b599408fae533323f5ac58fd rdf:first sg:person.07604232114.41
    141 rdf:rest Nf48041487220442794b401ce508f2af5
    142 N5aea682e4927422db323a89e31cf3c03 schema:volumeNumber 5
    143 rdf:type schema:PublicationVolume
    144 N6b64242a10544f4aade91f4d0dea5896 rdf:first sg:person.010676621313.61
    145 rdf:rest Nbfb13e2daa38460f828e4c6e12a3d6f6
    146 N6f09104c20734b63b22fc52a7c6c877a rdf:first sg:person.015367611505.51
    147 rdf:rest Nd2f08475ddcc425592700f78c0f35fbe
    148 N6ff560d681c249d3ac478fc1db25a4ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Telomere
    150 rdf:type schema:DefinedTerm
    151 N73cb8c5895e542d7b115ca45806e132c rdf:first sg:person.0675230535.53
    152 rdf:rest Nf054420696884c7c9844d564a55f6ed0
    153 N7ca4962861884c0abf7e49f18fd2a59c schema:name doi
    154 schema:value 10.1038/s42003-022-03521-7
    155 rdf:type schema:PropertyValue
    156 N846ac3c823bb40079fc3394b10daee47 rdf:first sg:person.0617441150.00
    157 rdf:rest Ne9f764d47970429695ea33251b2666a9
    158 N86a607cca56746f29ab569d7ed70e989 schema:name Springer Nature - SN SciGraph project
    159 rdf:type schema:Organization
    160 Nb38b83cece704fdfb0079da500d73d1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Epigenesis, Genetic
    162 rdf:type schema:DefinedTerm
    163 Nbfb13e2daa38460f828e4c6e12a3d6f6 rdf:first sg:person.01040634623.05
    164 rdf:rest N011d37a750dd42f59be2e9fbdc9c1576
    165 Nc5911450b18f41118fd9bbef94211a74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Pregnancy
    167 rdf:type schema:DefinedTerm
    168 Nca889bf7897842968075be5eb11f257c schema:issueNumber 1
    169 rdf:type schema:PublicationIssue
    170 Nd2f08475ddcc425592700f78c0f35fbe rdf:first sg:person.01153221507.50
    171 rdf:rest N6b64242a10544f4aade91f4d0dea5896
    172 Nd6838c1da4f745d59eeb0fdc71ceeba1 rdf:first sg:person.01372510466.28
    173 rdf:rest N0f2029200d884e16968be68ecbade279
    174 Ndd10cdee8a7248f5b40a1b77ff352dd4 schema:name dimensions_id
    175 schema:value pub.1148543508
    176 rdf:type schema:PropertyValue
    177 Ne57a6437f9ca41e6a9b3343a1e5cd276 rdf:first sg:person.016145143724.76
    178 rdf:rest N73cb8c5895e542d7b115ca45806e132c
    179 Ne9f764d47970429695ea33251b2666a9 rdf:first sg:person.011526330120.45
    180 rdf:rest N24db171e2ff044a2a5363c416d42dc65
    181 Nf054420696884c7c9844d564a55f6ed0 rdf:first sg:person.011464064267.08
    182 rdf:rest N4d24d147b599408fae533323f5ac58fd
    183 Nf48041487220442794b401ce508f2af5 rdf:first sg:person.01344404521.43
    184 rdf:rest Nd6838c1da4f745d59eeb0fdc71ceeba1
    185 Nfa3a825594894aa7aee4104d370d5cb6 rdf:first sg:person.01133243663.61
    186 rdf:rest rdf:nil
    187 Nfae1db0f12854097ad8b68b938eafc3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Parents
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Biological Sciences
    192 rdf:type schema:DefinedTerm
    193 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    194 schema:name Genetics
    195 rdf:type schema:DefinedTerm
    196 sg:grant.10012784 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    197 rdf:type schema:MonetaryGrant
    198 sg:grant.3799964 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    199 rdf:type schema:MonetaryGrant
    200 sg:grant.4057294 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    201 rdf:type schema:MonetaryGrant
    202 sg:grant.4138555 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.6622959 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.6946765 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.9461086 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.9461173 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.9732045 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.9995308 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-022-03521-7
    215 rdf:type schema:MonetaryGrant
    216 sg:journal.1300829 schema:issn 2399-3642
    217 schema:name Communications Biology
    218 schema:publisher Springer Nature
    219 rdf:type schema:Periodical
    220 sg:person.01040634623.05 schema:affiliation grid-institutes:grid.4830.f
    221 schema:familyName Henkelman
    222 schema:givenName Sandra
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040634623.05
    224 rdf:type schema:Person
    225 sg:person.010676621313.61 schema:affiliation grid-institutes:grid.10097.3f
    226 schema:familyName Ripoll-Cladellas
    227 schema:givenName Aida
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010676621313.61
    229 rdf:type schema:Person
    230 sg:person.01133243663.61 schema:affiliation grid-institutes:grid.4494.d
    231 schema:familyName Zhernakova
    232 schema:givenName Alexandra
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133243663.61
    234 rdf:type schema:Person
    235 sg:person.011464064267.08 schema:affiliation grid-institutes:grid.419051.8
    236 schema:familyName Cenit
    237 schema:givenName Maria Carmen
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464064267.08
    239 rdf:type schema:Person
    240 sg:person.011526330120.45 schema:affiliation grid-institutes:grid.10097.3f
    241 schema:familyName Melé
    242 schema:givenName Marta
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011526330120.45
    244 rdf:type schema:Person
    245 sg:person.01153221507.50 schema:affiliation grid-institutes:None
    246 schema:familyName Aubert
    247 schema:givenName Geraldine
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153221507.50
    249 rdf:type schema:Person
    250 sg:person.01316140701.98 schema:affiliation grid-institutes:grid.4494.d
    251 schema:familyName Fu
    252 schema:givenName Jingyuan
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316140701.98
    254 rdf:type schema:Person
    255 sg:person.013371511617.13 schema:affiliation grid-institutes:grid.17091.3e
    256 schema:familyName Lansdorp
    257 schema:givenName Peter
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013371511617.13
    259 rdf:type schema:Person
    260 sg:person.01344404521.43 schema:affiliation grid-institutes:grid.4494.d
    261 schema:familyName Franke
    262 schema:givenName Lude
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344404521.43
    264 rdf:type schema:Person
    265 sg:person.01372510466.28 schema:affiliation grid-institutes:grid.4494.d
    266 schema:familyName Wijmenga
    267 schema:givenName Cisca
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372510466.28
    269 rdf:type schema:Person
    270 sg:person.015367611505.51 schema:affiliation grid-institutes:grid.4494.d
    271 schema:familyName Andreu-Sánchez
    272 schema:givenName Sergio
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015367611505.51
    274 rdf:type schema:Person
    275 sg:person.016145143724.76 schema:affiliation grid-institutes:grid.4494.d
    276 schema:familyName Sinha
    277 schema:givenName Trishla
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016145143724.76
    279 rdf:type schema:Person
    280 sg:person.0617441150.00 schema:affiliation grid-institutes:grid.4494.d
    281 schema:familyName van der Wijst
    282 schema:givenName Monique G. P.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617441150.00
    284 rdf:type schema:Person
    285 sg:person.0675230535.53 schema:affiliation grid-institutes:grid.4494.d
    286 schema:familyName Kurilshikov
    287 schema:givenName Alexander
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675230535.53
    289 rdf:type schema:Person
    290 sg:person.07604232114.41 schema:affiliation grid-institutes:grid.4709.a
    291 schema:familyName Jan Bonder
    292 schema:givenName Marc
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07604232114.41
    294 rdf:type schema:Person
    295 sg:person.0763077514.08 schema:affiliation grid-institutes:grid.35915.3b
    296 schema:familyName Zhernakova
    297 schema:givenName Daria V.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763077514.08
    299 rdf:type schema:Person
    300 sg:pub.10.1007/978-3-642-82480-7_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053233785
    301 https://doi.org/10.1007/978-3-642-82480-7_2
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s00330-015-3796-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1042198327
    304 https://doi.org/10.1007/s00330-015-3796-y
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/350569a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000415071
    307 https://doi.org/10.1038/350569a0
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/cr.2010.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051566543
    310 https://doi.org/10.1038/cr.2010.107
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/ejhg.2012.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000460270
    313 https://doi.org/10.1038/ejhg.2012.303
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nbt.3192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009318815
    316 https://doi.org/10.1038/nbt.3192
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/ncb2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028672919
    319 https://doi.org/10.1038/ncb2004
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/ncomms1272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005327822
    322 https://doi.org/10.1038/ncomms1272
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/ncomms14049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019155899
    325 https://doi.org/10.1038/ncomms14049
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/ncomms2602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043076458
    328 https://doi.org/10.1038/ncomms2602
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/ng.2528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002714621
    331 https://doi.org/10.1038/ng.2528
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/ng.3643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050700099
    334 https://doi.org/10.1038/ng.3643
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/ng.3656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006258085
    337 https://doi.org/10.1038/ng.3656
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/ng.3721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025378212
    340 https://doi.org/10.1038/ng.3721
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nprot.2006.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034695080
    343 https://doi.org/10.1038/nprot.2006.263
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nri2023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009985365
    346 https://doi.org/10.1038/nri2023
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/pr.2015.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023221150
    349 https://doi.org/10.1038/pr.2015.193
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/s41386-018-0289-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110452985
    352 https://doi.org/10.1038/s41386-018-0289-0
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/s41418-018-0072-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101164275
    355 https://doi.org/10.1038/s41418-018-0072-0
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/s41467-019-10443-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1116848560
    358 https://doi.org/10.1038/s41467-019-10443-2
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/s41467-019-13448-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1123047705
    361 https://doi.org/10.1038/s41467-019-13448-z
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/s41556-018-0127-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1105071575
    364 https://doi.org/10.1038/s41556-018-0127-y
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/s41588-018-0224-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107129402
    367 https://doi.org/10.1038/s41588-018-0224-7
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/srep04954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034967149
    370 https://doi.org/10.1038/srep04954
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1186/1471-2164-10-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051697715
    373 https://doi.org/10.1186/1471-2164-10-22
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1186/s12864-020-07344-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1136413428
    376 https://doi.org/10.1186/s12864-020-07344-w
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1186/s12915-015-0118-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029450603
    379 https://doi.org/10.1186/s12915-015-0118-4
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1186/s12979-015-0048-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040337542
    382 https://doi.org/10.1186/s12979-015-0048-6
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1186/s13059-015-0844-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025156179
    385 https://doi.org/10.1186/s13059-015-0844-5
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1186/s13148-019-0683-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117679678
    388 https://doi.org/10.1186/s13148-019-0683-4
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1186/s13742-015-0047-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037894462
    391 https://doi.org/10.1186/s13742-015-0047-8
    392 rdf:type schema:CreativeWork
    393 grid-institutes:None schema:alternateName Repeat Diagnostics Inc, Vancouver, BC, Canada
    394 schema:name Repeat Diagnostics Inc, Vancouver, BC, Canada
    395 Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada
    396 rdf:type schema:Organization
    397 grid-institutes:grid.10097.3f schema:alternateName Life Sciences Department, Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain
    398 schema:name Life Sciences Department, Barcelona Supercomputing Center, 08034, Barcelona, Catalonia, Spain
    399 rdf:type schema:Organization
    400 grid-institutes:grid.17091.3e schema:alternateName Departments of Hematology and Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    401 schema:name Departments of Hematology and Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    402 European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands
    403 Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada
    404 rdf:type schema:Organization
    405 grid-institutes:grid.35915.3b schema:alternateName Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, 197101, St. Petersburg, Russia
    406 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    407 Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, 197101, St. Petersburg, Russia
    408 rdf:type schema:Organization
    409 grid-institutes:grid.419051.8 schema:alternateName Microbial Ecology, Nutrition, and Health Research Unit, Institute of Agrochemistry and Food Technology (IATA-CSIC), 46980, Paterna-Valencia, Spain
    410 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    411 Microbial Ecology, Nutrition, and Health Research Unit, Institute of Agrochemistry and Food Technology (IATA-CSIC), 46980, Paterna-Valencia, Spain
    412 rdf:type schema:Organization
    413 grid-institutes:grid.4494.d schema:alternateName Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    414 Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    415 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    416 Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    417 rdf:type schema:Organization
    418 grid-institutes:grid.4709.a schema:alternateName European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany
    419 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    420 Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany
    421 European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany
    422 rdf:type schema:Organization
    423 grid-institutes:grid.4830.f schema:alternateName European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands
    424 schema:name European Research Institute for the Biology of Ageing, University of Groningen, Groningen, the Netherlands
    425 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...