Collective exchange processes reveal an active site proton cage in bacteriorhodopsin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-03

AUTHORS

Daniel Friedrich, Florian N. Brünig, Andrew J. Nieuwkoop, Roland R. Netz, Peter Hegemann, Hartmut Oschkinat

ABSTRACT

Proton translocation across membranes is vital to all kingdoms of life. Mechanistically, it relies on characteristic proton flows and modifications of hydrogen bonding patterns, termed protonation dynamics, which can be directly observed by fast magic angle spinning (MAS) NMR. Here, we demonstrate that reversible proton displacement in the active site of bacteriorhodopsin already takes place in its equilibrated dark-state, providing new information on the underlying hydrogen exchange processes. In particular, MAS NMR reveals proton exchange at D85 and the retinal Schiff base, suggesting a tautomeric equilibrium and thus partial ionization of D85. We provide evidence for a proton cage and detect a preformed proton path between D85 and the proton shuttle R82. The protons at D96 and D85 exchange with water, in line with ab initio molecular dynamics simulations. We propose that retinal isomerization makes the observed proton exchange processes irreversible and delivers a proton towards the extracellular release site. More... »

PAGES

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-019-0733-7

DOI

http://dx.doi.org/10.1038/s42003-019-0733-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123785290

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31925324


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Macromolecular and Materials Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteriorhodopsins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalytic Domain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen Bonding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen-Ion Concentration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Dynamics Simulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temperature", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cancer Biology, Dana-Farber Cancer Institute, 360 Longwood Avenue, 02215, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Str. 10, 13125, Berlin, Germany", 
            "Freie Universit\u00e4t Berlin, Institut f\u00fcr Chemie und Biochemie, 14195, Berlin, Germany", 
            "Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, 02138, Cambridge, MA, USA", 
            "Department of Cancer Biology, Dana-Farber Cancer Institute, 360 Longwood Avenue, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Friedrich", 
        "givenName": "Daniel", 
        "id": "sg:person.011171041563.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011171041563.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin, Fachbereich Physik, 14195, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Freie Universit\u00e4t Berlin, Fachbereich Physik, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Br\u00fcnig", 
        "givenName": "Florian N.", 
        "id": "sg:person.011133406730.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011133406730.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Road, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Str. 10, 13125, Berlin, Germany", 
            "Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Road, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nieuwkoop", 
        "givenName": "Andrew J.", 
        "id": "sg:person.0712305130.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712305130.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin, Fachbereich Physik, 14195, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Freie Universit\u00e4t Berlin, Fachbereich Physik, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Netz", 
        "givenName": "Roland R.", 
        "id": "sg:person.01026441344.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026441344.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humboldt-Universit\u00e4t zu Berlin, Institut f\u00fcr Biologie, Invalidenstr. 42, 10115, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7468.d", 
          "name": [
            "Humboldt-Universit\u00e4t zu Berlin, Institut f\u00fcr Biologie, Invalidenstr. 42, 10115, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hegemann", 
        "givenName": "Peter", 
        "id": "sg:person.0660723716.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660723716.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin, Institut f\u00fcr Chemie und Biochemie, 14195, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Robert-R\u00f6ssle-Str. 10, 13125, Berlin, Germany", 
            "Freie Universit\u00e4t Berlin, Institut f\u00fcr Chemie und Biochemie, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oschkinat", 
        "givenName": "Hartmut", 
        "id": "sg:person.01074722221.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074722221.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35020599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030190881", 
          "https://doi.org/10.1038/35020599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10858-015-9904-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013623584", 
          "https://doi.org/10.1007/s10858-015-9904-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00214-009-0565-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026070904", 
          "https://doi.org/10.1007/s00214-009-0565-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35020607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024406717", 
          "https://doi.org/10.1038/35020607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/257028a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015235004", 
          "https://doi.org/10.1038/257028a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep16450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034432463", 
          "https://doi.org/10.1038/srep16450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35020614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047455269", 
          "https://doi.org/10.1038/35020614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004423904", 
          "https://doi.org/10.1038/17579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10858-015-9911-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005528278", 
          "https://doi.org/10.1007/s10858-015-9911-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-01-03", 
    "datePublishedReg": "2020-01-03", 
    "description": "Proton translocation across membranes is vital to all kingdoms of life. Mechanistically, it relies on characteristic proton flows and modifications of hydrogen bonding patterns, termed protonation dynamics, which can be directly observed by fast magic angle spinning (MAS) NMR. Here, we demonstrate that reversible proton displacement in the active site of bacteriorhodopsin already takes place in its equilibrated dark-state, providing new information on the underlying hydrogen exchange processes. In particular, MAS NMR reveals proton exchange at D85 and the retinal Schiff base, suggesting a tautomeric equilibrium and thus partial ionization of D85. We provide evidence for a proton cage and detect a preformed proton path between D85 and the proton shuttle R82. The protons at D96 and D85 exchange with water, in line with ab initio molecular dynamics simulations. We propose that retinal isomerization makes the observed proton exchange processes irreversible and delivers a proton towards the extracellular release site.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s42003-019-0733-7", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1300829", 
        "issn": [
          "2399-3642"
        ], 
        "name": "Communications Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "proton cage", 
      "ab initio molecular dynamics simulations", 
      "initio molecular dynamics simulations", 
      "hydrogen bonding patterns", 
      "exchange process", 
      "fast magic angle", 
      "hydrogen exchange processes", 
      "proton exchange process", 
      "molecular dynamics simulations", 
      "MAS NMR", 
      "Schiff base", 
      "magic angle", 
      "proton displacement", 
      "bonding patterns", 
      "tautomeric equilibrium", 
      "proton exchange", 
      "protonation dynamics", 
      "active site", 
      "dynamics simulations", 
      "retinal Schiff base", 
      "NMR", 
      "proton translocation", 
      "proton path", 
      "kingdoms of life", 
      "retinal isomerization", 
      "protons", 
      "partial ionization", 
      "proton flow", 
      "bacteriorhodopsin", 
      "isomerization", 
      "cages", 
      "ionization", 
      "D85", 
      "water", 
      "exchange", 
      "sites", 
      "modification", 
      "process", 
      "membrane", 
      "equilibrium", 
      "R82", 
      "angle", 
      "base", 
      "D96", 
      "dynamics", 
      "simulations", 
      "place", 
      "new information", 
      "path", 
      "displacement", 
      "lines", 
      "information", 
      "patterns", 
      "evidence", 
      "translocation", 
      "flow", 
      "release sites", 
      "Mechanistically", 
      "life", 
      "Kingdom"
    ], 
    "name": "Collective exchange processes reveal an active site proton cage in bacteriorhodopsin", 
    "pagination": "4", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1123785290"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s42003-019-0733-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31925324"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s42003-019-0733-7", 
      "https://app.dimensions.ai/details/publication/pub.1123785290"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_869.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s42003-019-0733-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0733-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0733-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0733-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0733-7'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      104 URIs      87 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s42003-019-0733-7 schema:about N3296c67f15b34f4dbebade7279af3aa0
2 N3bf65177794e442f88b9ac95bc9464f7
3 N511a592c3e644483a32251f7bd955cf6
4 N6c1a64312fa84896ae896e91ec9e0785
5 N7954187dca984752abec6e4adf3138bb
6 N8f5238ad3d4a4c54ad6d31ea508b6cf5
7 Nbfd4f7fb71404a2abbe1daeeef7b25cf
8 Ncc01018735d3406d82d28528896eb8e1
9 Nd164155d8e644df6ad3c831fad196917
10 Nd40bf36e1eb243e4b84b27b9a7772a96
11 anzsrc-for:03
12 anzsrc-for:0303
13 schema:author N0244aa66a0b549b49cec6a535ac2798b
14 schema:citation sg:pub.10.1007/s00214-009-0565-5
15 sg:pub.10.1007/s10858-015-9904-0
16 sg:pub.10.1007/s10858-015-9911-1
17 sg:pub.10.1038/17579
18 sg:pub.10.1038/257028a0
19 sg:pub.10.1038/35020599
20 sg:pub.10.1038/35020607
21 sg:pub.10.1038/35020614
22 sg:pub.10.1038/srep16450
23 schema:datePublished 2020-01-03
24 schema:datePublishedReg 2020-01-03
25 schema:description Proton translocation across membranes is vital to all kingdoms of life. Mechanistically, it relies on characteristic proton flows and modifications of hydrogen bonding patterns, termed protonation dynamics, which can be directly observed by fast magic angle spinning (MAS) NMR. Here, we demonstrate that reversible proton displacement in the active site of bacteriorhodopsin already takes place in its equilibrated dark-state, providing new information on the underlying hydrogen exchange processes. In particular, MAS NMR reveals proton exchange at D85 and the retinal Schiff base, suggesting a tautomeric equilibrium and thus partial ionization of D85. We provide evidence for a proton cage and detect a preformed proton path between D85 and the proton shuttle R82. The protons at D96 and D85 exchange with water, in line with ab initio molecular dynamics simulations. We propose that retinal isomerization makes the observed proton exchange processes irreversible and delivers a proton towards the extracellular release site.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N30e61707cfed4c8b9ca46267264581da
29 Nb2823d619d0a427e9f6d349e4d830605
30 sg:journal.1300829
31 schema:keywords D85
32 D96
33 Kingdom
34 MAS NMR
35 Mechanistically
36 NMR
37 R82
38 Schiff base
39 ab initio molecular dynamics simulations
40 active site
41 angle
42 bacteriorhodopsin
43 base
44 bonding patterns
45 cages
46 displacement
47 dynamics
48 dynamics simulations
49 equilibrium
50 evidence
51 exchange
52 exchange process
53 fast magic angle
54 flow
55 hydrogen bonding patterns
56 hydrogen exchange processes
57 information
58 initio molecular dynamics simulations
59 ionization
60 isomerization
61 kingdoms of life
62 life
63 lines
64 magic angle
65 membrane
66 modification
67 molecular dynamics simulations
68 new information
69 partial ionization
70 path
71 patterns
72 place
73 process
74 proton cage
75 proton displacement
76 proton exchange
77 proton exchange process
78 proton flow
79 proton path
80 proton translocation
81 protonation dynamics
82 protons
83 release sites
84 retinal Schiff base
85 retinal isomerization
86 simulations
87 sites
88 tautomeric equilibrium
89 translocation
90 water
91 schema:name Collective exchange processes reveal an active site proton cage in bacteriorhodopsin
92 schema:pagination 4
93 schema:productId N3ac90f9c368d4845a64fc467b151fbd4
94 N5d8d5dd03be54aec8a6de1c2e9940a62
95 Nc836add0fd45419da236979fe8f98f3e
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123785290
97 https://doi.org/10.1038/s42003-019-0733-7
98 schema:sdDatePublished 2022-12-01T06:41
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N1ef47b71e03d41039f4b7bdf0ee3485d
101 schema:url https://doi.org/10.1038/s42003-019-0733-7
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N0244aa66a0b549b49cec6a535ac2798b rdf:first sg:person.011171041563.37
106 rdf:rest Na1db741f57dd44dd9d88d6134dbf8b34
107 N17628c0eaca4436783839cd546d1f35b rdf:first sg:person.01026441344.41
108 rdf:rest N600e92026f9846d19bbc93cb9cb9985e
109 N1ef47b71e03d41039f4b7bdf0ee3485d schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N30e61707cfed4c8b9ca46267264581da schema:issueNumber 1
112 rdf:type schema:PublicationIssue
113 N3296c67f15b34f4dbebade7279af3aa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Protons
115 rdf:type schema:DefinedTerm
116 N3ac90f9c368d4845a64fc467b151fbd4 schema:name pubmed_id
117 schema:value 31925324
118 rdf:type schema:PropertyValue
119 N3bf65177794e442f88b9ac95bc9464f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Temperature
121 rdf:type schema:DefinedTerm
122 N4e09871a8a34426f9d2f55b6cc919c6c rdf:first sg:person.01074722221.42
123 rdf:rest rdf:nil
124 N511a592c3e644483a32251f7bd955cf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Protein Conformation
126 rdf:type schema:DefinedTerm
127 N5d8d5dd03be54aec8a6de1c2e9940a62 schema:name dimensions_id
128 schema:value pub.1123785290
129 rdf:type schema:PropertyValue
130 N600e92026f9846d19bbc93cb9cb9985e rdf:first sg:person.0660723716.59
131 rdf:rest N4e09871a8a34426f9d2f55b6cc919c6c
132 N6c1a64312fa84896ae896e91ec9e0785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Molecular Dynamics Simulation
134 rdf:type schema:DefinedTerm
135 N7954187dca984752abec6e4adf3138bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Hydrogen-Ion Concentration
137 rdf:type schema:DefinedTerm
138 N8f5238ad3d4a4c54ad6d31ea508b6cf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Bacteriorhodopsins
140 rdf:type schema:DefinedTerm
141 Na1db741f57dd44dd9d88d6134dbf8b34 rdf:first sg:person.011133406730.36
142 rdf:rest Nc90cff46d108414b886fde38537365e5
143 Nb2823d619d0a427e9f6d349e4d830605 schema:volumeNumber 3
144 rdf:type schema:PublicationVolume
145 Nbfd4f7fb71404a2abbe1daeeef7b25cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Hydrogen Bonding
147 rdf:type schema:DefinedTerm
148 Nc836add0fd45419da236979fe8f98f3e schema:name doi
149 schema:value 10.1038/s42003-019-0733-7
150 rdf:type schema:PropertyValue
151 Nc90cff46d108414b886fde38537365e5 rdf:first sg:person.0712305130.58
152 rdf:rest N17628c0eaca4436783839cd546d1f35b
153 Ncc01018735d3406d82d28528896eb8e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Models, Molecular
155 rdf:type schema:DefinedTerm
156 Nd164155d8e644df6ad3c831fad196917 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Magnetic Resonance Spectroscopy
158 rdf:type schema:DefinedTerm
159 Nd40bf36e1eb243e4b84b27b9a7772a96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Catalytic Domain
161 rdf:type schema:DefinedTerm
162 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
163 schema:name Chemical Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:0303 schema:inDefinedTermSet anzsrc-for:
166 schema:name Macromolecular and Materials Chemistry
167 rdf:type schema:DefinedTerm
168 sg:journal.1300829 schema:issn 2399-3642
169 schema:name Communications Biology
170 schema:publisher Springer Nature
171 rdf:type schema:Periodical
172 sg:person.01026441344.41 schema:affiliation grid-institutes:grid.14095.39
173 schema:familyName Netz
174 schema:givenName Roland R.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026441344.41
176 rdf:type schema:Person
177 sg:person.01074722221.42 schema:affiliation grid-institutes:grid.14095.39
178 schema:familyName Oschkinat
179 schema:givenName Hartmut
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074722221.42
181 rdf:type schema:Person
182 sg:person.011133406730.36 schema:affiliation grid-institutes:grid.14095.39
183 schema:familyName Brünig
184 schema:givenName Florian N.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011133406730.36
186 rdf:type schema:Person
187 sg:person.011171041563.37 schema:affiliation grid-institutes:grid.65499.37
188 schema:familyName Friedrich
189 schema:givenName Daniel
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011171041563.37
191 rdf:type schema:Person
192 sg:person.0660723716.59 schema:affiliation grid-institutes:grid.7468.d
193 schema:familyName Hegemann
194 schema:givenName Peter
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660723716.59
196 rdf:type schema:Person
197 sg:person.0712305130.58 schema:affiliation grid-institutes:grid.430387.b
198 schema:familyName Nieuwkoop
199 schema:givenName Andrew J.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712305130.58
201 rdf:type schema:Person
202 sg:pub.10.1007/s00214-009-0565-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026070904
203 https://doi.org/10.1007/s00214-009-0565-5
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s10858-015-9904-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013623584
206 https://doi.org/10.1007/s10858-015-9904-0
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s10858-015-9911-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005528278
209 https://doi.org/10.1007/s10858-015-9911-1
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/17579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004423904
212 https://doi.org/10.1038/17579
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/257028a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015235004
215 https://doi.org/10.1038/257028a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/35020599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030190881
218 https://doi.org/10.1038/35020599
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/35020607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024406717
221 https://doi.org/10.1038/35020607
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/35020614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047455269
224 https://doi.org/10.1038/35020614
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/srep16450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034432463
227 https://doi.org/10.1038/srep16450
228 rdf:type schema:CreativeWork
229 grid-institutes:grid.14095.39 schema:alternateName Freie Universität Berlin, Fachbereich Physik, 14195, Berlin, Germany
230 Freie Universität Berlin, Institut für Chemie und Biochemie, 14195, Berlin, Germany
231 schema:name Freie Universität Berlin, Fachbereich Physik, 14195, Berlin, Germany
232 Freie Universität Berlin, Institut für Chemie und Biochemie, 14195, Berlin, Germany
233 Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany
234 rdf:type schema:Organization
235 grid-institutes:grid.430387.b schema:alternateName Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Road, 08854, Piscataway, NJ, USA
236 schema:name Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Road, 08854, Piscataway, NJ, USA
237 Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany
238 rdf:type schema:Organization
239 grid-institutes:grid.65499.37 schema:alternateName Department of Cancer Biology, Dana-Farber Cancer Institute, 360 Longwood Avenue, 02215, Boston, MA, USA
240 schema:name Department of Cancer Biology, Dana-Farber Cancer Institute, 360 Longwood Avenue, 02215, Boston, MA, USA
241 Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, 02138, Cambridge, MA, USA
242 Freie Universität Berlin, Institut für Chemie und Biochemie, 14195, Berlin, Germany
243 Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany
244 rdf:type schema:Organization
245 grid-institutes:grid.7468.d schema:alternateName Humboldt-Universität zu Berlin, Institut für Biologie, Invalidenstr. 42, 10115, Berlin, Germany
246 schema:name Humboldt-Universität zu Berlin, Institut für Biologie, Invalidenstr. 42, 10115, Berlin, Germany
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...