Preliminary design of a new degradable medical device to prevent the formation and recurrence of intrauterine adhesions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-05-22

AUTHORS

Salome Leprince, Stéphanie Huberlant, Lucie Allegre, Sophie Warembourg, Isabelle Leteuff, Audrey Bethry, Cedric Paniagua, Hubert Taillades, Renaud De Tayrac, Jean Coudane, Vincent Letouzey, Xavier Garric

ABSTRACT

Intrauterine adhesions lead to partial or complete obliteration of the uterine cavity and have life-changing consequences for women. The leading cause of adhesions is believed to be loss of stroma resulting from trauma to the endometrium after surgery. Adhesions are formed when lost stroma is replaced by fibrous tissue that join the uterine walls. Few effective intrauterine anti-adhesion barriers for gynecological surgery exist. We designed a degradable anti-adhesion medical device prototype to prevent adhesion formation and recurrence and restore uterine morphology. We focused on ideal degradation time for complete uterine re-epithelialization for optimal anti-adhesion effect and clinical usability. We developed a triblock copolymer prototype [poly(lactide) combined with high molecular mass poly(ethylene oxide)]. Comparative pre-clinical studies demonstrated in vivo anti-adhesion efficacy. Ease of introduction and optimal deployment in a human uterus confirmed clinical usability. This article provides preliminary data to develop an intrauterine medical device and conduct a clinical trial. More... »

PAGES

196

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-019-0447-x

DOI

http://dx.doi.org/10.1038/s42003-019-0447-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1115039883

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31123719


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32 schema:description Intrauterine adhesions lead to partial or complete obliteration of the uterine cavity and have life-changing consequences for women. The leading cause of adhesions is believed to be loss of stroma resulting from trauma to the endometrium after surgery. Adhesions are formed when lost stroma is replaced by fibrous tissue that join the uterine walls. Few effective intrauterine anti-adhesion barriers for gynecological surgery exist. We designed a degradable anti-adhesion medical device prototype to prevent adhesion formation and recurrence and restore uterine morphology. We focused on ideal degradation time for complete uterine re-epithelialization for optimal anti-adhesion effect and clinical usability. We developed a triblock copolymer prototype [poly(lactide) combined with high molecular mass poly(ethylene oxide)]. Comparative pre-clinical studies demonstrated in vivo anti-adhesion efficacy. Ease of introduction and optimal deployment in a human uterus confirmed clinical usability. This article provides preliminary data to develop an intrauterine medical device and conduct a clinical trial.
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39 adhesion formation
40 anti-adhesion barrier
41 anti-adhesion effect
42 anti-adhesion efficacy
43 article
44 barriers
45 cause
46 cause of adhesions
47 cavity
48 clinical trials
49 clinical usability
50 complete obliteration
51 consequences
52 data
53 degradation time
54 deployment
55 design
56 device prototype
57 devices
58 ease
59 ease of introduction
60 effect
61 efficacy
62 endometrium
63 fibrous tissue
64 formation
65 gynecological surgery
66 human uterus
67 intrauterine adhesions
68 introduction
69 life-changing consequences
70 loss
71 medical device prototype
72 medical devices
73 morphology
74 obliteration
75 optimal deployment
76 pre-clinical studies
77 preliminary data
78 preliminary design
79 prototype
80 recurrence
81 stroma
82 study
83 surgery
84 time
85 tissue
86 trauma
87 trials
88 usability
89 uterine cavity
90 uterine morphology
91 uterine wall
92 uterus
93 wall
94 women
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